TWI634112B - Cot調節劑及其使用方法 - Google Patents

Cot調節劑及其使用方法 Download PDF

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Publication number
TWI634112B
TWI634112B TW105121281A TW105121281A TWI634112B TW I634112 B TWI634112 B TW I634112B TW 105121281 A TW105121281 A TW 105121281A TW 105121281 A TW105121281 A TW 105121281A TW I634112 B TWI634112 B TW I634112B
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Taiwan
Prior art keywords
alkyl
heteroaryl
aryl
cycloalkyl
heterocyclyl
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TW105121281A
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Chinese (zh)
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TW201712005A (zh
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伊麗莎白M 貝肯
格雅特力 巴藍
堅鴻 周
克里斯多幅T 克萊克
傑瑞米J 柯特爾
穆松 金
索爾斯坦A 柯許伯格
約翰O 林克
蓋瑞 菲利浦斯
史考特D 施若德爾
尼爾H 斯奎爾斯
克爾柯L 史蒂芬斯
詹姆士G 泰勒
納森E 萊特
西拉M 力普菲爾
威廉J 瓦特金恩斯
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基利科學股份有限公司
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    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/44Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
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TW105121281A 2015-07-06 2016-07-05 Cot調節劑及其使用方法 TWI634112B (zh)

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US201562189158P 2015-07-06 2015-07-06
US62/189,158 2015-07-06
US201562269060P 2015-12-17 2015-12-17
US62/269,060 2015-12-17

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI770527B (zh) * 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540343B2 (en) 2011-07-06 2017-01-10 Gilead Sciences, Inc. Compounds for the treatment of HIV
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
IL293770B2 (en) 2015-07-06 2023-07-01 Gilead Sciences Inc Modulators of cot and methods of using them
MX2017017124A (es) 2015-07-06 2018-03-09 Gilead Sciences Inc 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).
ES2800339T3 (es) 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
BR112018071678B1 (pt) 2016-08-19 2021-01-26 Gilead Sciences, Inc. compostos terapêuticos úteis para o tratamento profilático ou terapêutico de uma infecção por vírus hiv e suas composições farmacêuticas
EA036921B1 (ru) * 2017-02-10 2021-01-15 Джилид Сайэнс, Инк. Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
TWI687415B (zh) 2017-08-17 2020-03-11 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
JPWO2019065516A1 (ja) * 2017-09-26 2020-09-10 日本曹達株式会社 キノリン化合物および農園芸用殺菌剤
PL3752495T3 (pl) 2018-02-15 2024-01-15 Gilead Sciences, Inc. Pochodne pirydynowe i ich zastosowanie do leczenia infekcji hiv
TWI823164B (zh) 2018-02-16 2023-11-21 美商基利科學股份有限公司 用於製備有療效化合物之方法及中間物
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CN110294660B (zh) * 2018-03-23 2021-09-24 中国农业大学 一种含碳碳三键和/或碳氮三键的不饱和有机化合物的还原氘化方法
CN108658996A (zh) * 2018-06-25 2018-10-16 中国药科大学 一种氘代Fiduxosin的制备方法
CA3216031A1 (en) 2018-07-16 2020-01-23 Gilead Sciences, Inc. Capsid inhibitors for the treatment of hiv
CN114206892A (zh) 2019-08-09 2022-03-18 爱杜西亚药品有限公司 (2-乙酰氨基)硫代-β-D-吡喃半乳糖苷衍生物
JP7612662B2 (ja) 2019-08-09 2025-01-14 イドルシア・ファーマシューティカルズ・リミテッド (ヘテロ)アリール-メチル-チオ-ベータ-d-ガラクトピラノシド誘導体
UA128909C2 (uk) 2019-08-15 2024-11-20 Ідорсія Фармасьютікалз Лтд 2-гідроксициклоалкан-1-карбамоїльні похідні
WO2021038068A1 (en) 2019-08-29 2021-03-04 Idorsia Pharmaceuticals Ltd Alpha-d-galactopyranoside derivatives
TWI854067B (zh) 2019-11-26 2024-09-01 美商基利科學股份有限公司 預防hiv之蛋白殼抑制劑
JP2023520650A (ja) * 2020-03-30 2023-05-18 ギリアード サイエンシーズ, インコーポレイテッド (S)-6-(((1-(ビシクロ[1.1.1]ペンタン-1-イル)-1H-1,2,3-トリアゾール-4-イル)2-メチル-1-オキソ-1,2-ジヒドロイソキノリン-5-イル)メチル)))アミノ)8-クロロ-(ネオペンチルアミノ)キノリン-3-カルボニトリルCot阻害剤化合物の固体形態
CN119390681A (zh) * 2020-04-02 2025-02-07 吉利德科学公司 用于制备cot抑制剂化合物的方法
TW202502766A (zh) 2020-06-25 2025-01-16 美商基利科學股份有限公司 用於治療hiv之蛋白殼抑制劑
TWI890869B (zh) 2020-10-06 2025-07-21 瑞士商愛杜西亞製藥有限公司 α-D-吡喃半乳糖苷之螺衍生物
WO2022090544A1 (en) 2020-11-02 2022-05-05 Idorsia Pharmaceuticals Ltd Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives
EP4291556B1 (en) 2021-02-09 2025-04-23 Idorsia Pharmaceuticals Ltd Hydroxyheterocycloalkane-carbamoyl derivatives
IL305581A (en) 2021-03-03 2023-10-01 Idorsia Pharmaceuticals Ltd Triazolyl-methyl-converted alpha-D-galactopyranoside histories
TW202304435A (zh) * 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療nash之方法
CA3220429A1 (en) * 2021-06-11 2022-12-15 Neuronascent, Inc. Methods and compositions for lipid formulation of lipophilic small molecule therapies of the heterocyclic type
TW202342448A (zh) 2021-12-03 2023-11-01 美商基利科學股份有限公司 用於hiv病毒感染之治療性化合物
EP4440702B1 (en) 2021-12-03 2025-05-21 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
EP4440701A1 (en) 2021-12-03 2024-10-09 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
WO2024245157A1 (zh) * 2023-05-30 2024-12-05 浙江星浩澎博医药有限公司 氮杂喹啉环衍生物
WO2024249983A1 (en) * 2023-06-02 2024-12-05 Westol, Llc 2,8-dihydroxyquinoline glucuronide derivatives with enhanced properties for use as anticancer, antiviral, antimicrobial, and other therapeutic applications
WO2025020886A1 (zh) * 2023-07-27 2025-01-30 浙江星浩澎博医药有限公司 氮杂喹唑啉环衍生物及其用途
KR102732584B1 (ko) 2024-03-28 2024-11-21 (주)신한티이씨 전기 배전반의 화재 위험 감지 및 진압용 소화 장치

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043960A1 (en) * 1997-04-03 1998-10-08 American Cyanamid Company Substituted 3-cyano quinolines

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930837A (en) 1971-12-31 1976-01-06 Ici Australia Limited 3-chloro-5-acetamidaisoquinoline as a herbicide
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
NL7800191A (nl) 1977-01-10 1978-07-12 Ciba Geigy Anthelmintisch preparaat.
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
JP2634438B2 (ja) 1988-07-26 1997-07-23 三井東圧化学株式会社 不斉ビスオキサゾリルピリジン誘導体およびその製造方法
DE4014171A1 (de) 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
GB9310700D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Novel composition
NZ503079A (en) 1997-08-28 2002-07-26 Nissan Chemical Ind Ltd Cyanoacrylate-containing antibacterial and antifungal agents, algicides and antifouling agents
ATE360634T1 (de) 1998-07-10 2007-05-15 Massachusetts Inst Technology Ligande für metalle und verbesserte metall- katalysierte verfahren, die darauf basieren
DK2253620T3 (da) * 1998-09-29 2014-03-31 Wyeth Holdings Llc Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
NZ535365A (en) 2002-03-20 2006-07-28 Bristol Myers Squibb Co Phosphate prodrugs of fluorooxindoles
JP2006515341A (ja) 2003-03-03 2006-05-25 エフ.ホフマン−ラ ロシュ アーゲー 5−ht6調節物質として使用するための2,5−および2,6−置換テトラヒドロイソキノリン
BRPI0413667A (pt) 2003-08-19 2006-10-24 Wyeth Corp Processo para a preparação de 4-amino-3-carbonitrilas de quinolina
US7399865B2 (en) 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
TW200529846A (en) * 2004-02-20 2005-09-16 Wyeth Corp 3-quinolinecarbonitrile protein kinase inhibitors
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2006247520A1 (en) * 2005-05-18 2006-11-23 Wyeth 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same
EP1881981A1 (en) * 2005-05-18 2008-01-30 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same
EP1957464A1 (en) 2005-10-28 2008-08-20 Abbott Laboratories INDAZOLE DERIVATIVES THAT INHIBIT TRPVl RECEPTOR
US8008481B2 (en) 2006-03-31 2011-08-30 Ericsson Anna M Indazole compounds
EP2086960B1 (en) 2006-11-09 2014-03-05 Probiodrug AG Novel inhibitors of glutaminyl cyclase
WO2008092292A1 (en) 2007-01-17 2008-08-07 The Hong Kong University Of Science And Technology Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2
GB0820856D0 (en) 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
GB0922302D0 (en) 2009-12-22 2010-02-03 Imp Innovations Ltd Compounds
BR112012022801B8 (pt) 2010-03-09 2019-10-29 Dana Farber Cancer Inst Inc método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer
KR101562347B1 (ko) 2010-06-09 2015-10-22 티안진 헤메이 바이오-텍 컴퍼니 리미티드 시아노퀴놀린 유도체
US9453021B2 (en) 2011-05-10 2016-09-27 Kyowa Hakko Kirin Co., Ltd. Pyrimidodiazepinone compound
US9173395B2 (en) 2011-07-04 2015-11-03 Bayer Intellectual Property Gmbh Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
CN103889951B (zh) 2011-10-27 2016-12-14 大正制药株式会社 唑类衍生物
BR112014011351B1 (pt) 2011-11-11 2021-02-17 Gilead Apollo, Llc. inibidores de acc e usos dos mesmos
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN103483363B (zh) 2012-06-13 2016-12-21 上海赛迦化工产品有限公司 多样性的手性氨基硼酸及其制备方法和应用
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
CN103408572B (zh) 2013-07-12 2015-12-02 上海工程技术大学 手性氨基硼酸衍生物及其制备方法和应用
CN108947867A (zh) 2013-12-12 2018-12-07 卡利拉制药公司 双环烷基化合物及合成
EP3114107B1 (en) 2014-03-07 2020-07-22 Recurium IP Holdings, LLC Propellane derivates and synthesis
US9701661B2 (en) * 2014-07-11 2017-07-11 Northwestern University 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
US10308609B2 (en) 2014-09-17 2019-06-04 Zeno Royalties & Milestones, LLC Bicyclic compounds
ES2731602T3 (es) 2014-09-24 2019-11-18 Gilead Sciences Inc Métodos para tratar la enfermedad hepática
CA3100432C (en) 2014-12-23 2023-08-08 Gilead Sciences, Inc. Processes for preparing ask1 inhibitors
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
JP2018501276A (ja) 2015-01-09 2018-01-18 ギリアド アポロ, エルエルシー 非アルコール性脂肪肝疾患の処置のためのacc阻害剤併用療法
EP3852036A1 (en) 2015-01-16 2021-07-21 3M Innovative Properties Co. Systems and methods for selecting grid actions to improve grid outcomes
MX2017017124A (es) * 2015-07-06 2018-03-09 Gilead Sciences Inc 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).
IL293770B2 (en) * 2015-07-06 2023-07-01 Gilead Sciences Inc Modulators of cot and methods of using them
DK3398598T3 (da) 2015-12-31 2022-07-11 Hitgen Inc Sulfonamidderivat og fremstillingsmetode og anvendelse deraf
CN119977993A (zh) 2016-03-02 2025-05-13 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
WO2017221944A1 (ja) 2016-06-21 2017-12-28 パナソニックヘルスケアホールディングス株式会社 カタラーゼ阻害剤及びカタラーゼ阻害剤を用いるアナライトの測定方法
ES2800339T3 (es) 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
CN106512014A (zh) 2016-10-27 2017-03-22 武汉大学 肿瘤进展位点2在治疗脂肪肝和ⅱ型糖尿病中的功能和应用
KR102485620B1 (ko) 2017-03-03 2023-01-09 길리애드 사이언시즈, 인코포레이티드 Acc 억제제 및 그의 고체 형태를 제조하는 방법
SI3600309T1 (sl) 2017-03-28 2022-10-28 Gilead Sciences, Inc. Terapevtske kombinacije za zdravljenje bolezni jeter
JP2020516627A (ja) 2017-04-12 2020-06-11 ギリアード サイエンシーズ, インコーポレイテッド 肝疾患を処置する方法
WO2019071216A1 (en) 2017-10-06 2019-04-11 Gilead Sciences, Inc. POLYTHERAPY COMPRISING AN ACC INHIBITOR
US11524005B2 (en) 2019-02-19 2022-12-13 Gilead Sciences, Inc. Solid forms of FXR agonists
EP3934615A4 (en) 2019-03-08 2023-01-25 The Regents Of The University Of California ACNE TREATMENT COMPOSITIONS AND METHODS
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
JP2023520650A (ja) 2020-03-30 2023-05-18 ギリアード サイエンシーズ, インコーポレイテッド (S)-6-(((1-(ビシクロ[1.1.1]ペンタン-1-イル)-1H-1,2,3-トリアゾール-4-イル)2-メチル-1-オキソ-1,2-ジヒドロイソキノリン-5-イル)メチル)))アミノ)8-クロロ-(ネオペンチルアミノ)キノリン-3-カルボニトリルCot阻害剤化合物の固体形態
CN119390681A (zh) 2020-04-02 2025-02-07 吉利德科学公司 用于制备cot抑制剂化合物的方法
TW202304435A (zh) 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療nash之方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043960A1 (en) * 1997-04-03 1998-10-08 American Cyanamid Company Substituted 3-cyano quinolines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Green et al, J. Med. Chem., 2007, 50, p4728-4745 *
Kaila et al, Bioorganic & Medicinal Chemistry, 2007, 15, p6425-6442 *
Wu et al, Bioorganic & Medicinal Chemistry Letters, 2009, 19, p3485-3488 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI770527B (zh) * 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法

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CN114380799B (zh) 2024-10-01
US11066414B2 (en) 2021-07-20
EP3191470A1 (en) 2017-07-19
JP2018193405A (ja) 2018-12-06

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