ES2872076T3 - Derivado de 4,6-diamino-quinolina-3-carbonitrilo en forma de modulador de cáncer Osaka tiroides (Cot) para el tratamiento de la enfermedad inflamatoria - Google Patents
Derivado de 4,6-diamino-quinolina-3-carbonitrilo en forma de modulador de cáncer Osaka tiroides (Cot) para el tratamiento de la enfermedad inflamatoria Download PDFInfo
- Publication number
- ES2872076T3 ES2872076T3 ES18186568T ES18186568T ES2872076T3 ES 2872076 T3 ES2872076 T3 ES 2872076T3 ES 18186568 T ES18186568 T ES 18186568T ES 18186568 T ES18186568 T ES 18186568T ES 2872076 T3 ES2872076 T3 ES 2872076T3
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- alkyl
- heterocyclyl
- heteroaryl
- aryl
- cycloalkyl
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- 0 *C(*)N(*)c(c(C*N)c1*)cc2c1ncc(C#N)c2N(*)* Chemical compound *C(*)N(*)c(c(C*N)c1*)cc2c1ncc(C#N)c2N(*)* 0.000 description 6
- YYVKEQKMAQKGES-UHFFFAOYSA-N BNC1=CCc2cccc(C=O)c2S1 Chemical compound BNC1=CCc2cccc(C=O)c2S1 YYVKEQKMAQKGES-UHFFFAOYSA-N 0.000 description 1
- CJBNAOGSFQQDAG-MRVPVSSYSA-N C[C@](C(C(O)(O)O)(O)O)(C1=CC=CCC1)O Chemical compound C[C@](C(C(O)(O)O)(O)O)(C1=CC=CCC1)O CJBNAOGSFQQDAG-MRVPVSSYSA-N 0.000 description 1
- HCWVWBRZUQOGOW-UHFFFAOYSA-N C[N+](c(cc1Cl)cc(C2=O)c1NC=C2C#N)([O-])[OH2+] Chemical compound C[N+](c(cc1Cl)cc(C2=O)c1NC=C2C#N)([O-])[OH2+] HCWVWBRZUQOGOW-UHFFFAOYSA-N 0.000 description 1
- YZCKEZOXXZNSIE-UHFFFAOYSA-N C[N+](c(cc1Cl)cc(C2=O)c1NC=C2N)([O-])[OH2+] Chemical compound C[N+](c(cc1Cl)cc(C2=O)c1NC=C2N)([O-])[OH2+] YZCKEZOXXZNSIE-UHFFFAOYSA-N 0.000 description 1
- XHKQEQPRGFDOIC-UHFFFAOYSA-N N#CC(CNc(c(Cl)c1)c2cc1[N+](O)=O)=C2Cl Chemical compound N#CC(CNc(c(Cl)c1)c2cc1[N+](O)=O)=C2Cl XHKQEQPRGFDOIC-UHFFFAOYSA-N 0.000 description 1
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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- A61K31/47—Quinolines; Isoquinolines
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189158P | 2015-07-06 | 2015-07-06 | |
| US201562269060P | 2015-12-17 | 2015-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2872076T3 true ES2872076T3 (es) | 2021-11-02 |
Family
ID=56411943
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES21162393T Active ES3034100T3 (en) | 2015-07-06 | 2016-06-30 | 4,6-diamino-quinoline-3-carbonitrile derivatives as cancer osaka thyroid (cot) modulators for treating crohn's disease and ulcerative colitis |
| ES18186568T Active ES2872076T3 (es) | 2015-07-06 | 2016-06-30 | Derivado de 4,6-diamino-quinolina-3-carbonitrilo en forma de modulador de cáncer Osaka tiroides (Cot) para el tratamiento de la enfermedad inflamatoria |
| ES16738976T Active ES2734713T3 (es) | 2015-07-06 | 2016-06-30 | Moduladores Cot y métodos de utilización de los mismos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES21162393T Active ES3034100T3 (en) | 2015-07-06 | 2016-06-30 | 4,6-diamino-quinoline-3-carbonitrile derivatives as cancer osaka thyroid (cot) modulators for treating crohn's disease and ulcerative colitis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16738976T Active ES2734713T3 (es) | 2015-07-06 | 2016-06-30 | Moduladores Cot y métodos de utilización de los mismos |
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Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013006738A1 (en) | 2011-07-06 | 2013-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of hiv |
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