TWI565706B - 用於製備包括反－７－酮基－６－（磺酸氧基）－１，６－二氮雜雙環［３，２，１］辛烷－２－甲醯胺之雜環化合物及其鹽類之方法 - Google Patents

用於製備包括反－７－酮基－６－（磺酸氧基）－１，６－二氮雜雙環［３，２，１］辛烷－２－甲醯胺之雜環化合物及其鹽類之方法 Download PDF

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TWI565706B
TWI565706B TW101121652A TW101121652A TWI565706B TW I565706 B TWI565706 B TW I565706B TW 101121652 A TW101121652 A TW 101121652A TW 101121652 A TW101121652 A TW 101121652A TW I565706 B TWI565706 B TW I565706B
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mmol
mixture
solution
diazabicyclo
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TW101121652A
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TW201317238A (zh
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艾利斯塔 約翰 波伊德
珍奈 海倫 卻利曼
麥可 高登
尤里Ｂ 凱歐研
葛拉罕 理查 洛頓
大衛 妙奈
安德魯 約翰 菲利普
賽貝巴 拉卡
梅蘭妮 希孟 隆伸
亞歷山大 泰歐佛
曉 宏 周
馬漢德拉Ｇ 德迪雅
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阿斯特捷利康公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
TW101121652A 2011-06-17 2012-06-15 用於製備包括反－７－酮基－６－（磺酸氧基）－１，６－二氮雜雙環［３，２，１］辛烷－２－甲醯胺之雜環化合物及其鹽類之方法 TWI565706B (zh)

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US201161498522P 2011-06-17 2011-06-17

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TWI565706B true TWI565706B (zh) 2017-01-11

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US (4) US8829191B2 (ko)
EP (1) EP2721005B1 (ko)
JP (2) JP6023800B2 (ko)
KR (1) KR102143660B1 (ko)
CN (2) CN103649051B (ko)
AR (1) AR086972A1 (ko)
AU (1) AU2012270051B2 (ko)
BR (1) BR112013032415B1 (ko)
CA (1) CA2780403C (ko)
ES (1) ES2560404T3 (ko)
HK (1) HK1196615A1 (ko)
IL (1) IL229815A (ko)
MX (1) MX361020B (ko)
MY (1) MY165730A (ko)
RU (2) RU2610091C2 (ko)
SG (1) SG195289A1 (ko)
TW (1) TWI565706B (ko)
WO (1) WO2012172368A1 (ko)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
SG191831A1 (en) * 2011-03-31 2013-08-30 Kaneka Corp Process for preparing cyclic amine compounds
MX361020B (es) * 2011-06-17 2018-11-26 Pfizer Anti Infectives Ab Procesos para preparar compuestos heterociclicos, incluida trans-7-oxo-6-(sulfooxi)-1,6-diazabiciclo [3,2,1]octano-2-carboxam ida y sales de la misma.
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
US8969570B2 (en) * 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
US8933233B2 (en) 2012-03-30 2015-01-13 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors
TW201343646A (zh) 2012-03-30 2013-11-01 Cubist Pharm Inc 異□唑β－內醯胺酶抑制劑
SG10201605368UA (en) 2012-05-30 2016-08-30 Meiji Seika Pharma Co Ltd NOVEL β-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME
SG11201503427TA (en) * 2012-11-01 2015-06-29 Kaneka Corp Process for producing optically active bicyclic urea compound
UA111925C2 (uk) * 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
KR101763056B1 (ko) * 2013-03-08 2017-07-28 욱크하르트 리미티드 (2s,5r)-2-카복스아미도-7-옥소-6-설포옥시-1,6-디아자-비사이클로[3.2.1]옥탄의 나트륨염을 위한 방법
US9862718B2 (en) * 2013-03-08 2018-01-09 Wockhardt Limited Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation
US9120795B2 (en) 2013-03-14 2015-09-01 Cubist Pharmaceuticals, Inc. Crystalline form of a β-lactamase inhibitor
US10000491B2 (en) * 2013-09-24 2018-06-19 Meiji Seika Pharma Co., Ltd. Process for producing diazabicyclooctane derivative and intermediate thereof
WO2015051101A1 (en) 2013-10-02 2015-04-09 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
CN111153903A (zh) * 2013-10-08 2020-05-15 明治制果药业株式会社 二氮杂二环辛烷衍生物的结晶及其制备方法和应用以及医药组合物
WO2015110966A1 (en) * 2014-01-21 2015-07-30 Wockhardt Limited 7-oxo-1,6-diazabicyclo[3.2.1 ]octane derivatives and their use as antibacterial agents
EP3116875A1 (en) * 2014-03-14 2017-01-18 Wockhardt Limited A process for preparation of sodium (2s, 5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate
WO2016089718A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Process for the preparation of tert-butyl 4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
JP6779787B2 (ja) 2014-12-05 2020-11-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法
WO2017025526A1 (en) * 2015-08-10 2017-02-16 Sandoz Ag Form c of avibactam sodium
CN106749242B (zh) * 2015-11-23 2021-04-02 上海医药工业研究院 阿维巴坦中间体的制备方法
CN105348173B (zh) * 2015-12-02 2017-12-15 中山奕安泰医药科技有限公司 不对称催化氢化法合成阿维巴坦中间体5的方法
WO2017136254A1 (en) * 2016-02-04 2017-08-10 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
GB201602145D0 (en) * 2016-02-05 2016-03-23 Achieve Pharma Uk Ltd Salt
CN105753867B (zh) * 2016-03-24 2018-03-27 齐鲁制药有限公司 一种改进的阿维巴坦钠中间体化合物的制备方法
CN107325096B (zh) * 2016-04-29 2020-11-03 正大天晴药业集团股份有限公司 一种阿维巴坦单钠盐的结晶
CA3026322C (en) 2016-06-03 2023-08-15 Medshine Discovery Inc. Novel b-lactamase inhibitors
CN107540601B (zh) * 2016-06-28 2019-07-19 新发药业有限公司 5r-苄氧氨基哌啶-2s-甲酸酯及其草酸盐的便捷制备方法
CN107540600B (zh) * 2016-06-28 2019-07-09 新发药业有限公司 一种阿维巴坦中间体生产废液的回收利用方法
CN109641901B (zh) * 2016-08-26 2022-12-09 桑多斯股份公司 阿维巴坦游离酸
CN106432060A (zh) * 2016-09-27 2017-02-22 海口南陆医药科技股份有限公司 一种阿维巴坦钠关键中间体的手性异构体的制备方法
CN106565712A (zh) * 2016-09-30 2017-04-19 天津津泰生物医药技术有限公司 一种阿维巴坦钠中间体的制备方法
CN107880042A (zh) * 2016-09-30 2018-04-06 上海复星星泰医药科技有限公司 阿维巴坦钠及其中间体化合物的制备方法
CN108239089B (zh) * 2016-12-27 2020-05-22 浙江医药股份有限公司新昌制药厂 一种阿维巴坦钠的合成方法
CN108264480B (zh) * 2016-12-30 2020-12-11 上海星泰医药科技有限公司 阿维巴坦钠中间体的制备方法
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法
US10434089B2 (en) 2017-01-25 2019-10-08 The Johns Hopkins University Avibactam and carbapenems antibacterial agents
US10919893B2 (en) 2017-02-08 2021-02-16 Sandoz Ag Process for the preparation of crystalline form C of avibactam sodium
CN106831772B (zh) * 2017-03-04 2019-12-17 丽珠医药集团股份有限公司 一种阿维巴坦中间体的合成方法
WO2019016393A1 (en) 2017-07-21 2019-01-24 Antabio Sas CHEMICAL COMPOUNDS
CN109400521B (zh) * 2017-08-18 2020-05-08 新发药业有限公司 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法
CN107417686B (zh) * 2017-09-19 2020-04-28 北京化工大学 一种阿维巴坦钠的合成方法
CN109678856B (zh) 2017-10-18 2020-09-25 新发药业有限公司 一种阿维巴坦中间体的制备方法
CN109678855B (zh) * 2017-10-18 2020-07-17 新发药业有限公司 一种阿维巴坦中间体的制备方法
CN107941969B (zh) * 2017-11-07 2021-03-02 中山奕安泰医药科技有限公司 (2s,5r)-苯氧胺基哌啶-2-甲酰胺的检测方法
CN107941944B (zh) * 2017-11-23 2020-09-15 中山奕安泰医药科技有限公司 一种(2s,5r)-苄氧胺基哌啶-2-甲酸乙酯草酸盐的检测方法
EP3719020B1 (en) 2017-12-01 2022-09-21 Qilu Pharmaceutical Co., Ltd. Crystal form of beta-lactamase inhibitor and preparation method therefor
CN109912499B (zh) * 2017-12-12 2021-04-27 江苏奥赛康药业有限公司 阿维巴坦中间体及其制备方法
CN109928970B (zh) * 2017-12-19 2020-04-28 新发药业有限公司 一种瑞利巴坦中间体的简便制备方法
CN109956941B (zh) * 2017-12-25 2020-08-04 新发药业有限公司 一种阿维巴坦的简便制备方法
CN109970625B (zh) * 2017-12-28 2021-02-26 新发药业有限公司 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法
CN108373442B (zh) * 2018-03-29 2020-07-03 台州职业技术学院 一种阿维巴坦中间异构体的回收方法
CN108409736B (zh) * 2018-05-16 2019-11-08 齐鲁天和惠世制药有限公司 一种喷雾干燥制备无定型阿维巴坦钠的方法
EP3572411A1 (en) 2018-05-21 2019-11-27 Antabio SAS Thiazole derivatives as metallo-beta-lactamase inhibitors
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CA3113606A1 (en) * 2018-09-21 2020-03-26 Api Corporation Method for producing amino acid derivatives
CN111072660B (zh) * 2018-10-22 2021-05-18 新发药业有限公司 一种瑞来巴坦的简便制备方法
CN109516987B (zh) * 2018-12-26 2020-07-24 江西富祥药业股份有限公司 一种阿维巴坦中间体制备方法
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020572A1 (en) * 2002-01-28 2005-01-27 Aventis Pharma S.A. Heterocyclic compounds as inhibitors of beta-lactamases
CN101918407A (zh) * 2008-01-18 2010-12-15 默沙东公司 β-内酰胺酶抑制剂
WO2011042560A1 (en) * 2009-10-09 2011-04-14 Novexel Sa Polymorphic and pseudopolymorphic forms of a pharmaceutical compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ATE372966T1 (de) 1994-03-25 2007-09-15 Isotechnika Inc Verbesserung der effektivität von arzneimitteln duren deuterierung
TW473479B (en) 1997-12-19 2002-01-21 Takeda Chemical Industries Ltd Phosphonocephem derivatives, their production and use
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
ES2323759T3 (es) 2000-08-10 2009-07-24 Takeda Pharmaceutical Company Limited Compuesto de fosfonocefem.
US7491724B2 (en) * 2003-10-17 2009-02-17 Incyte Corporation Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
RU2007147413A (ru) * 2005-05-24 2009-06-27 Астразенека Аб (Se) Аминопиперидинхинолины и их азаизостерические аналоги с антибактериальной активностью
US20080081829A1 (en) 2006-09-28 2008-04-03 Med Institute, Inc Medical Device Including an Anesthetic and Method of Preparation Thereof
FR2921060B1 (fr) 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
AU2010295269B2 (en) 2009-09-21 2014-06-05 Pfizer Anti-Infectives Ab Compositions and methods for treating bacterial infections using ceftaroline
WO2011163330A1 (en) * 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
PL2657234T3 (pl) * 2010-12-22 2017-06-30 Meiji Seika Pharma Co., Ltd. Optycznie czynna pochodna diazabicyklooktanowa i sposób jej wytwarzania
SG191831A1 (en) * 2011-03-31 2013-08-30 Kaneka Corp Process for preparing cyclic amine compounds
MX361020B (es) * 2011-06-17 2018-11-26 Pfizer Anti Infectives Ab Procesos para preparar compuestos heterociclicos, incluida trans-7-oxo-6-(sulfooxi)-1,6-diazabiciclo [3,2,1]octano-2-carboxam ida y sales de la misma.
US10158850B2 (en) * 2011-08-25 2018-12-18 Telefonaktiebolaget Lm Ericsson (Publ) Depth map encoding and decoding
CA2845108C (en) * 2011-08-30 2015-06-16 Wockhardt Limited 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020572A1 (en) * 2002-01-28 2005-01-27 Aventis Pharma S.A. Heterocyclic compounds as inhibitors of beta-lactamases
CN101918407A (zh) * 2008-01-18 2010-12-15 默沙东公司 β-内酰胺酶抑制剂
WO2011042560A1 (en) * 2009-10-09 2011-04-14 Novexel Sa Polymorphic and pseudopolymorphic forms of a pharmaceutical compound

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