TWI354666B - Heterocyclic aspartyl protease inhibitors - Google Patents
Heterocyclic aspartyl protease inhibitors Download PDFInfo
- Publication number
- TWI354666B TWI354666B TW093138776A TW93138776A TWI354666B TW I354666 B TWI354666 B TW I354666B TW 093138776 A TW093138776 A TW 093138776A TW 93138776 A TW93138776 A TW 93138776A TW I354666 B TWI354666 B TW I354666B
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- Prior art keywords
- alkyl
- group
- aryl
- cycloalkyl
- heteroaryl
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- 0 *CN(C([C@@](CCC1CCCCC1)(C[C@@](CCC1)CC1NCc1cnccc1)N1)=O)C1=N Chemical compound *CN(C([C@@](CCC1CCCCC1)(C[C@@](CCC1)CC1NCc1cnccc1)N1)=O)C1=N 0.000 description 8
- UTINZRXRTSRTHP-UHFFFAOYSA-N CC(C(N1C)=O)(c2cc(-c3cccc(OC)c3)ccc2)NC1=N Chemical compound CC(C(N1C)=O)(c2cc(-c3cccc(OC)c3)ccc2)NC1=N UTINZRXRTSRTHP-UHFFFAOYSA-N 0.000 description 1
- FDNOXQMGIQFQRJ-SXNCYPNXSA-N CC(C)CC(C)(C(N1Cc(cc2)ccc2NC(N[C@H](C2)[C@@H]2c2ccccc2)=O)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc(cc2)ccc2NC(N[C@H](C2)[C@@H]2c2ccccc2)=O)=O)NC1=N FDNOXQMGIQFQRJ-SXNCYPNXSA-N 0.000 description 1
- ZQNPAEUBTOSHPH-UHFFFAOYSA-N CC(C)CC(C)(C(N1Cc2cc(CNC(c(cc3)ccc3Oc3ccccc3)=O)ccc2)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc2cc(CNC(c(cc3)ccc3Oc3ccccc3)=O)ccc2)=O)NC1=N ZQNPAEUBTOSHPH-UHFFFAOYSA-N 0.000 description 1
- LGUVDKIEYBSHPT-UHFFFAOYSA-N CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc(cc(C(F)(F)F)cc3)c3F)=O)cc2)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc(cc(C(F)(F)F)cc3)c3F)=O)cc2)=O)NC1=N LGUVDKIEYBSHPT-UHFFFAOYSA-N 0.000 description 1
- YYKAUWKPMNZCNP-UHFFFAOYSA-N CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc(cc3C(F)(F)F)ccc3F)=O)cc2)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc(cc3C(F)(F)F)ccc3F)=O)cc2)=O)NC1=N YYKAUWKPMNZCNP-UHFFFAOYSA-N 0.000 description 1
- MMCRQXIEMIRMDP-UHFFFAOYSA-N CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc3cccc(C#N)c3)=O)cc2)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc2ccc(CNC(Nc3cccc(C#N)c3)=O)cc2)=O)NC1=N MMCRQXIEMIRMDP-UHFFFAOYSA-N 0.000 description 1
- GMZQKLXGIXLCET-UHFFFAOYSA-N CC(C)CC(C)(C(N1Cc2ccc(CNC(c(cc3)ccc3Oc3ccccc3)=O)cc2)=O)NC1=N Chemical compound CC(C)CC(C)(C(N1Cc2ccc(CNC(c(cc3)ccc3Oc3ccccc3)=O)cc2)=O)NC1=N GMZQKLXGIXLCET-UHFFFAOYSA-N 0.000 description 1
- DAPAWHZCRYDKKN-UHFFFAOYSA-N CCC(CC)C(NCc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O Chemical compound CCC(CC)C(NCc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O DAPAWHZCRYDKKN-UHFFFAOYSA-N 0.000 description 1
- JYJCGTGDHJPOKE-UHFFFAOYSA-N CCCCCCC(NCc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O Chemical compound CCCCCCC(NCc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O JYJCGTGDHJPOKE-UHFFFAOYSA-N 0.000 description 1
- VBHVLBWNBZVCKO-UHFFFAOYSA-N CCCCCCC(Nc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O Chemical compound CCCCCCC(Nc1ccc(CN(C(C(C)(CC(C)C)N2)=O)C2=N)cc1)=O VBHVLBWNBZVCKO-UHFFFAOYSA-N 0.000 description 1
- SBLUJWAOHMWLEE-HHHXNRCGSA-N C[C@@](Cc1cc(F)cc(F)c1)(C(N1Cc2ccc(CNC(NCc3ccccc3)=O)cc2)=O)NC1=N Chemical compound C[C@@](Cc1cc(F)cc(F)c1)(C(N1Cc2ccc(CNC(NCc3ccccc3)=O)cc2)=O)NC1=N SBLUJWAOHMWLEE-HHHXNRCGSA-N 0.000 description 1
- INJAVJBNNQYSMJ-AWRGLXIESA-N N=C(N[C@](CCC1CCCCC1)(C[C@@H](CCC1)C[C@H]1NCc1ccncc1)C1=O)N1[ClH]I Chemical compound N=C(N[C@](CCC1CCCCC1)(C[C@@H](CCC1)C[C@H]1NCc1ccncc1)C1=O)N1[ClH]I INJAVJBNNQYSMJ-AWRGLXIESA-N 0.000 description 1
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
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EP0882022A1 (en) * | 1996-01-26 | 1998-12-09 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
AU2012199A (en) * | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
PT1159278E (pt) * | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inibidores de aspartil-protease |
JP2002543126A (ja) * | 1999-05-03 | 2002-12-17 | スミスクライン・ビーチャム・コーポレイション | Cxcr−4受容体アンタゴニスト−トロンボポエチン模倣物 |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
AU2002306734A1 (en) | 2001-03-15 | 2002-10-03 | The Johns Hopkins University | Inhibitors of plasmepsins |
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