|
SI0828740T1
(en)
*
|
1995-05-30 |
2001-12-31 |
Aventis Pharma Sa |
2-azabicyclo(2.2.1)heptane derivatives, preparation and application thereof
|
|
TW528755B
(en)
|
1996-12-24 |
2003-04-21 |
Glaxo Group Ltd |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
|
|
JP3861413B2
(ja)
*
|
1997-11-05 |
2006-12-20 |
ソニー株式会社 |
情報配信システム、情報処理端末装置、携帯端末装置
|
|
YU44900A
(sh)
|
1998-01-31 |
2003-01-31 |
Glaxo Group Limited |
Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
|
|
US6413974B1
(en)
|
1998-02-26 |
2002-07-02 |
Aventis Pharmaceuticals Inc. |
6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
|
|
WO1999043676A2
(en)
*
|
1998-02-26 |
1999-09-02 |
Aventis Pharmaceuticals Inc. |
6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines
|
|
US6479487B1
(en)
|
1998-02-26 |
2002-11-12 |
Aventis Pharmaceuticals Inc. |
6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
|
|
US6878716B1
(en)
|
1998-06-02 |
2005-04-12 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A1 receptor and uses thereof
|
|
PL204628B1
(pl)
|
1998-06-02 |
2010-01-29 |
Osi Pharmaceuticals |
Pochodna pirolo[2,3d]pirymidyny, jej zastosowanie i sposoby wytwarzania tej pochodnej i preparaty farmaceutyczne
|
|
US6686366B1
(en)
|
1998-06-02 |
2004-02-03 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A3 receptor and uses thereof
|
|
GB9813540D0
(en)
*
|
1998-06-23 |
1998-08-19 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB9813554D0
(en)
*
|
1998-06-23 |
1998-08-19 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB9813535D0
(en)
*
|
1998-06-23 |
1998-08-19 |
Glaxo Group Ltd |
Chemical compounds
|
|
HRP20000894A2
(en)
|
1998-06-23 |
2001-12-31 |
Glaxo Group Ltd |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
|
|
GB9813565D0
(en)
*
|
1998-06-23 |
1998-08-19 |
Glaxo Group Ltd |
Chemical compounds
|
|
RU2258071C2
(ru)
*
|
1999-05-24 |
2005-08-10 |
Юниверсити Оф Вирджиния Пэйтент Фаундейшн |
Производные 2-алкиниладенозина для борьбы с воспалительной реакцией
|
|
US6664252B2
(en)
|
1999-12-02 |
2003-12-16 |
Osi Pharmaceuticals, Inc. |
4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
|
|
US7160890B2
(en)
|
1999-12-02 |
2007-01-09 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A3 receptor and uses thereof
|
|
US6680322B2
(en)
|
1999-12-02 |
2004-01-20 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A1 receptors and uses thereof
|
|
CA2394654A1
(en)
|
1999-12-17 |
2001-06-21 |
Manfred Weigele |
Proton pump inhibitors
|
|
CN1440408B
(zh)
*
|
2000-04-25 |
2012-07-18 |
艾科斯有限公司 |
人磷脂酰肌醇3-激酶δ的抑制剂
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
EP1939203B1
(en)
*
|
2000-04-25 |
2014-11-19 |
ICOS Corporation |
Inhibitors of human phosphatidyl-inositol 3-kinase delta isoform
|
|
US6861524B2
(en)
|
2000-10-31 |
2005-03-01 |
Aventis Pharmaceuticals Inc. |
Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
|
|
US6673802B2
(en)
|
2000-12-01 |
2004-01-06 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A3 receptor and uses thereof
|
|
US6680324B2
(en)
|
2000-12-01 |
2004-01-20 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A1 receptors and uses thereof
|
|
WO2002088079A2
(en)
*
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
PE20030008A1
(es)
*
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
ES2301659T3
(es)
*
|
2001-07-06 |
2008-07-01 |
Topigen Pharmaceuticals Inc. |
Metodos para aumentar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos.
|
|
US6825349B2
(en)
*
|
2001-11-09 |
2004-11-30 |
Cv Therapeutics Inc. |
A2B adenosine receptor antagonists
|
|
US7321033B2
(en)
|
2001-11-27 |
2008-01-22 |
Anadys Pharmaceuticals, Inc. |
3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
|
|
US6924271B2
(en)
|
2001-11-27 |
2005-08-02 |
Anadys Pharmaceuticals, Inc. |
3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
|
|
ATE446298T1
(de)
|
2001-11-30 |
2009-11-15 |
Osi Pharm Inc |
Verbindungen, die für adenosin a1 und a3 rezeptoren spezifisch sind, und deren anwendungen
|
|
US20030229067A1
(en)
|
2001-12-20 |
2003-12-11 |
Arlindo Castelhano |
Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
|
|
US6916804B2
(en)
|
2001-12-20 |
2005-07-12 |
Osi Pharmaceuticals, Inc. |
Pyrimidine A2b selective antagonist compounds, their synthesis and use
|
|
ES2237234B1
(es)
*
|
2002-08-02 |
2006-11-01 |
Universidad De Oviedo |
Preparacion de (+) y (-)-trans-ciclopentano-1,2-diamina.
|
|
AU2003263846B2
(en)
*
|
2002-08-15 |
2009-12-17 |
Gilead Palo Alto, Inc. |
Partial and full agonists of A1 adenosine receptors
|
|
TW200519106A
(en)
|
2003-05-02 |
2005-06-16 |
Novartis Ag |
Organic compounds
|
|
GB0328319D0
(en)
*
|
2003-12-05 |
2004-01-07 |
Cambridge Biotechnology Ltd |
Improved synthesis of 2-substituted adenosines
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
DK2612862T3
(en)
|
2004-05-13 |
2016-12-05 |
Icos Corp |
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
PE20060272A1
(es)
|
2004-05-24 |
2006-05-22 |
Glaxo Group Ltd |
(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
|
|
DK1758596T3
(da)
*
|
2004-05-26 |
2010-07-26 |
Inotek Pharmaceuticals Corp |
Purinderivater som adenosin-A1-receptoragonister og fremgangsmåder til anvendelse deraf
|
|
FR2874014B1
(fr)
*
|
2004-08-03 |
2010-05-14 |
Univ Paris Descartes |
Analogues d'aminoglycosides, leur utilisation et leur synthese
|
|
ES2450929T3
(es)
|
2004-10-29 |
2014-03-25 |
Topigen Pharmaceuticals Inc. |
Oligonucleótidos antisentido para tratar la alergia y la proliferación de las células neoplásicas
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
DK2561872T3
(en)
|
2004-12-17 |
2014-12-08 |
Anadys Pharmaceuticals Inc |
3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED 3H-OXAZOLO- [4,5-d] PYRIMIDIN-2-ON COMPOUNDS AND PRODRUGS THEREOF
|
|
GB0500785D0
(en)
*
|
2005-01-14 |
2005-02-23 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
GB0514809D0
(en)
|
2005-07-19 |
2005-08-24 |
Glaxo Group Ltd |
Compounds
|
|
AR058104A1
(es)
|
2005-10-21 |
2008-01-23 |
Novartis Ag |
Compuestos organicos
|
|
DE602006015700D1
(de)
|
2005-11-21 |
2010-09-02 |
Anadys Pharmaceuticals Inc |
Neues verfahren zur herstellung von 5-amino-3h-thiazoloä4,5-düpyrimidin-2-on
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
KR101461604B1
(ko)
|
2006-06-22 |
2014-11-18 |
애나디스 파마슈티칼스, 인코포레이티드 |
5-아미노-3-(3''-데옥시-β-D-리보퓨라노실)-티아졸로[4,5-d]파이리미딘-2,7-다이온의 프로드럭
|
|
US7528115B2
(en)
|
2006-07-18 |
2009-05-05 |
Anadys Pharmaceuticals, Inc. |
Carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidines
|
|
EP2081933B1
(en)
|
2006-09-29 |
2011-03-23 |
Novartis AG |
Pyrazolopyrimidines as pi3k lipid kinase inhibitors
|
|
MX2009004715A
(es)
|
2006-10-30 |
2009-05-20 |
Novartis Ag |
Compuestos heterociclicos como agentes antiinflamatorios.
|
|
US8796241B2
(en)
|
2007-08-29 |
2014-08-05 |
Adam Lubin |
Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase
|
|
EP2231642B1
(en)
|
2008-01-11 |
2013-10-23 |
Novartis AG |
Pyrimidines as kinase inhibitors
|
|
ES2331867B1
(es)
*
|
2008-07-17 |
2010-10-27 |
Entrechem, S.L. |
Sintesis enzimatica de derivados enantiomericamente enriquecidos de trans-ciclopentano- 1,2-diaminas.
|
|
US9492449B2
(en)
|
2008-11-13 |
2016-11-15 |
Gilead Calistoga Llc |
Therapies for hematologic malignancies
|
|
EP3427739A1
(en)
|
2008-11-13 |
2019-01-16 |
Gilead Calistoga LLC |
Therapies for hematologic malignancies
|
|
ES2396023T3
(es)
|
2009-01-29 |
2013-02-18 |
Novartis Ag |
Bencimidazoles sustituidos para el tratamiento de astrocitomas
|
|
EP2411391A1
(en)
|
2009-03-24 |
2012-02-01 |
Gilead Calistoga LLC |
Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
|
|
AU2010239312A1
(en)
|
2009-04-20 |
2011-11-10 |
Gilead Calistoga Llc |
Methods of treatment for solid tumors
|
|
WO2011011550A1
(en)
|
2009-07-21 |
2011-01-27 |
Calistoga Pharmaceuticals Inc. |
Treatment of liver disorders with pi3k inhibitors
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
AU2010283806A1
(en)
|
2009-08-12 |
2012-03-01 |
Novartis Ag |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
|
BR112012003709B1
(pt)
|
2009-08-17 |
2021-05-18 |
Intellikine Llc |
compostos heterocíclicos e usos dos mesmos
|
|
JP5775871B2
(ja)
|
2009-08-20 |
2015-09-09 |
ノバルティス アーゲー |
ヘテロ環式オキシム化合物
|
|
RU2012132278A
(ru)
|
2010-01-12 |
2014-02-20 |
Ф. Хоффманн-Ля Рош Аг |
Трициклические гетероциклические соединения, содержащие их композиции и способы их применения
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
WO2012107500A1
(en)
|
2011-02-10 |
2012-08-16 |
Novartis Ag |
[1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
PE20140378A1
(es)
|
2011-02-25 |
2014-03-28 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
|
MX339302B
(es)
|
2011-09-15 |
2016-05-19 |
Novartis Ag |
3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
|
|
JP6130391B2
(ja)
|
2011-11-23 |
2017-05-17 |
インテリカイン, エルエルシー |
Mtor阻害剤を使用する強化された治療レジメン
|
|
CA2864305C
(en)
|
2012-03-05 |
2021-02-16 |
Gilead Calistoga Llc |
Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one
|
|
CA2868202C
(en)
|
2012-04-03 |
2021-08-10 |
Novartis Ag |
Combination products with tyrosine kinase inhibitors and their use
|
|
PL2822954T3
(pl)
|
2012-12-21 |
2016-09-30 |
|
Policykliczne związki karbamoilopirydonu i ich farmaceutyczne zastosowanie
|
|
CN105246482A
(zh)
|
2013-03-15 |
2016-01-13 |
因特利凯有限责任公司 |
激酶抑制剂的组合及其用途
|
|
NO2865735T3
(OSRAM)
|
2013-07-12 |
2018-07-21 |
|
|
|
AU2014286993B2
(en)
|
2013-07-12 |
2018-10-25 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
|
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Mdm2抑制劑與BRAF抑制劑之組合及其用途
|
|
PL3083630T3
(pl)
|
2013-12-20 |
2020-02-28 |
Gilead Calistoga Llc |
Sposoby otrzymywania inhibitorów 3-kinazy fosfatydyloinozytolu
|
|
US9708327B2
(en)
|
2013-12-20 |
2017-07-18 |
Gilead Calistoga Llc |
Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
|
|
US11021467B2
(en)
|
2014-06-13 |
2021-06-01 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
TW201613936A
(en)
|
2014-06-20 |
2016-04-16 |
Gilead Sciences Inc |
Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
|
|
NO2717902T3
(OSRAM)
|
2014-06-20 |
2018-06-23 |
|
|
|
TWI677489B
(zh)
|
2014-06-20 |
2019-11-21 |
美商基利科學股份有限公司 |
多環型胺甲醯基吡啶酮化合物之合成
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
CA2954862A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
|
CN109563238B
(zh)
*
|
2016-08-10 |
2021-08-27 |
三键有限公司 |
环氧树脂组合物以及含有其的导电性胶粘剂
|
|
CN106632339B
(zh)
*
|
2016-12-16 |
2018-11-27 |
温州医科大学 |
一种6-取代-9h-嘌呤类衍生物及其制备方法和应用
|
|
WO2019152977A2
(en)
|
2018-02-05 |
2019-08-08 |
Bio-Rad Laboratories, Inc. |
Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
|
|
TW202140550A
(zh)
|
2020-01-29 |
2021-11-01 |
瑞士商諾華公司 |
使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法
|
|
CN119798352B
(zh)
*
|
2024-01-15 |
2025-11-11 |
中国医学科学院药物研究所 |
化合物yzg-331的晶型及其制备方法
|