TW201302793A - 新穎之抗原結合蛋白 - Google Patents
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| EP3608340A1 (en) | 2011-11-23 | 2020-02-12 | Medlmmune, LLC | Binding molecules specific for her3 and uses thereof |
| CA2857939A1 (en) * | 2011-12-05 | 2013-06-13 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) directed to domain iii and domain iv of her3 |
| WO2013084147A2 (en) * | 2011-12-05 | 2013-06-13 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| EP2807272A1 (en) * | 2012-01-27 | 2014-12-03 | Ventana Medical Systems, Inc. | Devices and methods for detecting bio-analytes using optically decipherable patterns |
| KR20150064205A (ko) * | 2012-11-08 | 2015-06-10 | 에프. 호프만-라 로슈 아게 | Her3의 베타-헤어핀에 결합하는 her3 항원 결합 단백질 |
| EP2917242B1 (en) | 2012-11-08 | 2018-05-16 | F.Hoffmann-La Roche Ag | Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and the beta-hairpin of her4 |
| AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| WO2015048008A2 (en) | 2013-09-24 | 2015-04-02 | Medimmune, Llc | Binding molecules specific for her3 and uses thereof |
| WO2015049355A1 (en) * | 2013-10-04 | 2015-04-09 | Roche Diagnostics Gmbh | Antibodies specifically binding to her3 |
| JP6967853B2 (ja) * | 2014-02-28 | 2021-11-17 | メルス ナムローゼ フェンノートシャップ | ＥｒｂＢ−２およびＥｒｂＢ−３に結合する抗体 |
| WO2015130172A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibodies that bind egfr and erbb3 |
| WO2015157634A1 (en) | 2014-04-11 | 2015-10-15 | Kolltan Pharmaceuticals, Inc. | Anti-erbb antibodies and methods of use thereof |
| US10780182B2 (en) | 2014-04-25 | 2020-09-22 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| JP6433511B2 (ja) | 2014-05-14 | 2018-12-05 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｈｅｒ３のベータヘアピンに結合する抗ｈｅｒ３抗体 |
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| ES3047792T3 (en) * | 2014-07-14 | 2025-12-04 | Univ California | Crispr/cas transcriptional modulation |
| WO2016038610A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki) |
| US10526416B2 (en) | 2014-09-08 | 2020-01-07 | Yeda Research And Development Co. Ltd. | Anti-HER3 antibodies and uses of same |
| WO2016059602A2 (en) * | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
| SG11201803359VA (en) | 2015-10-23 | 2018-05-30 | Merus Nv | Binding molecules that inhibit cancer growth |
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-
2011
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- 2011-09-02 SG SG10201401681PA patent/SG10201401681PA/en unknown
- 2011-09-02 JP JP2013527341A patent/JP2013544492A/ja active Pending
- 2011-09-02 NZ NZ607680A patent/NZ607680A/en not_active IP Right Cessation
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- 2011-09-02 CN CN2011800533015A patent/CN103189391A/zh active Pending
- 2011-09-02 BR BR112013005242A patent/BR112013005242A2/pt not_active IP Right Cessation
- 2011-09-02 PE PE2013000314A patent/PE20140133A1/es not_active Application Discontinuation
- 2011-09-02 EP EP11822713.1A patent/EP2611829A4/en not_active Withdrawn
- 2011-09-02 MA MA35784A patent/MA34555B1/fr unknown
- 2011-09-02 EA EA201390328A patent/EA201390328A1/ru unknown
- 2011-09-02 PH PH1/2013/500353A patent/PH12013500353A1/en unknown
- 2011-09-02 MX MX2013002535A patent/MX2013002535A/es unknown
- 2011-09-02 KR KR1020137008415A patent/KR20130101047A/ko not_active Withdrawn
- 2011-09-02 US US13/639,918 patent/US9085622B2/en active Active
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| AU2011295726B2 (en) | 2014-11-06 |
| EP2611829A2 (en) | 2013-07-10 |
| KR20130101047A (ko) | 2013-09-12 |
| MX2013002535A (es) | 2013-06-03 |
| WO2012031198A3 (en) | 2012-05-18 |
| CL2013000566A1 (es) | 2014-01-24 |
| EP2611829A4 (en) | 2014-05-07 |
| SG10201401681PA (en) | 2014-07-30 |
| PH12013500353A1 (en) | 2013-03-25 |
| BR112013005242A2 (pt) | 2016-06-28 |
| CA2809443A1 (en) | 2012-03-08 |
| MA34555B1 (fr) | 2013-09-02 |
| CN103189391A (zh) | 2013-07-03 |
| WO2012031198A2 (en) | 2012-03-08 |
| EA201390328A1 (ru) | 2013-08-30 |
| SG187930A1 (en) | 2013-03-28 |
| CR20130128A (es) | 2013-06-28 |
| PE20140133A1 (es) | 2014-02-09 |
| AU2011295726A1 (en) | 2013-03-21 |
| CO6690769A2 (es) | 2013-06-17 |
| US20130156779A1 (en) | 2013-06-20 |
| NZ607680A (en) | 2015-02-27 |
| US9085622B2 (en) | 2015-07-21 |
| UY33591A (es) | 2012-03-30 |
| JP2013544492A (ja) | 2013-12-19 |
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