MA34555B1 - Nouvelles protéines de liaison à un antigène - Google Patents

Nouvelles protéines de liaison à un antigène

Info

Publication number
MA34555B1
MA34555B1 MA35784A MA35784A MA34555B1 MA 34555 B1 MA34555 B1 MA 34555B1 MA 35784 A MA35784 A MA 35784A MA 35784 A MA35784 A MA 35784A MA 34555 B1 MA34555 B1 MA 34555B1
Authority
MA
Morocco
Prior art keywords
binding proteins
antigen
cancer
novel antigen
her3
Prior art date
Application number
MA35784A
Other languages
English (en)
Inventor
Neil James Clarke
Kyung Oh Johanson
Zdenka Ludmila Jonak
Alexander H Taylor
Christopher B Hopson
Stephen H Trulli
Zdenka Haskova
Judithann M Lee
John R White
Yu Xue
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45773540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34555(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MA34555B1 publication Critical patent/MA34555B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des protéines de liaison à un antigène, tels que des anticorps, qui se lient à HER3, des polynucléotides codant pour de telles protéines de liaison à un antigène, des compositions pharmaceutiques comprenant lesdites protéines de liaison à un antigène et des procédés de fabrication. L'invention concerne aussi l'utilisation de telles protéines de liaison à un antigène dans le traitement thérapeutique ou prophylactique de maladies associées au cancer du sein, au cancer de l'ovaire, au cancer de la prostate, au cancer de la vessie, au cancer du pancréas, au cancer de l'estomac, au mélanome ou à d'autres cancers surexprimant HER3.
MA35784A 2010-09-03 2011-09-02 Nouvelles protéines de liaison à un antigène MA34555B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37984010P 2010-09-03 2010-09-03
US201161440460P 2011-02-08 2011-02-08
PCT/US2011/050322 WO2012031198A2 (fr) 2010-09-03 2011-09-02 Nouvelles protéines de liaison à un antigène

Publications (1)

Publication Number Publication Date
MA34555B1 true MA34555B1 (fr) 2013-09-02

Family

ID=45773540

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35784A MA34555B1 (fr) 2010-09-03 2011-09-02 Nouvelles protéines de liaison à un antigène

Country Status (20)

Country Link
US (1) US9085622B2 (fr)
EP (1) EP2611829A4 (fr)
JP (1) JP2013544492A (fr)
KR (1) KR20130101047A (fr)
CN (1) CN103189391A (fr)
AU (1) AU2011295726B2 (fr)
BR (1) BR112013005242A2 (fr)
CA (1) CA2809443A1 (fr)
CL (1) CL2013000566A1 (fr)
CO (1) CO6690769A2 (fr)
CR (1) CR20130128A (fr)
EA (1) EA201390328A1 (fr)
MA (1) MA34555B1 (fr)
MX (1) MX2013002535A (fr)
NZ (1) NZ607680A (fr)
PE (1) PE20140133A1 (fr)
SG (2) SG187930A1 (fr)
TW (1) TW201302793A (fr)
UY (1) UY33591A (fr)
WO (1) WO2012031198A2 (fr)

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BR112014012539B1 (pt) 2011-11-23 2022-12-20 Medimmune, Llc Anticorpo que se liga especificamente a her3, composição compreendendo o mesmo, e usos do anticorpo
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CN108341873B (zh) 2011-12-05 2022-03-25 诺华股份有限公司 表皮生长因子受体3(her3)的抗体
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PE20150955A1 (es) 2012-11-08 2015-06-20 Hoffmann La Roche Proteinas ligantes de antigeno anti-her3/her4 de union a la horquilla beta de her3 y a la horquilla beta de her4
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
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CN106459212B (zh) * 2014-02-28 2021-07-13 美勒斯公司 结合erbb-2和erbb-3的抗体
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US20130156779A1 (en) 2013-06-20
KR20130101047A (ko) 2013-09-12
BR112013005242A2 (pt) 2016-06-28
AU2011295726A1 (en) 2013-03-21
CN103189391A (zh) 2013-07-03
CA2809443A1 (fr) 2012-03-08
SG10201401681PA (en) 2014-07-30
EP2611829A4 (fr) 2014-05-07
NZ607680A (en) 2015-02-27
CR20130128A (es) 2013-06-28
PE20140133A1 (es) 2014-02-09
US9085622B2 (en) 2015-07-21
UY33591A (es) 2012-03-30
SG187930A1 (en) 2013-03-28
AU2011295726B2 (en) 2014-11-06
CL2013000566A1 (es) 2014-01-24
WO2012031198A3 (fr) 2012-05-18
WO2012031198A2 (fr) 2012-03-08
EA201390328A1 (ru) 2013-08-30
EP2611829A2 (fr) 2013-07-10
MX2013002535A (es) 2013-06-03
TW201302793A (zh) 2013-01-16
JP2013544492A (ja) 2013-12-19

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