MXPA05010575A - Peptacuerpo para el tratamiento del cancer. - Google Patents
Peptacuerpo para el tratamiento del cancer.Info
- Publication number
- MXPA05010575A MXPA05010575A MXPA05010575A MXPA05010575A MXPA05010575A MX PA05010575 A MXPA05010575 A MX PA05010575A MX PA05010575 A MXPA05010575 A MX PA05010575A MX PA05010575 A MXPA05010575 A MX PA05010575A MX PA05010575 A MXPA05010575 A MX PA05010575A
- Authority
- MX
- Mexico
- Prior art keywords
- isolated
- recombinant fusion
- peptabody
- fusion peptabody
- cancer treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 abstract 4
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
La presente invencion se refiere a un peptacuerpo de fusion aislado y recombinante, que se enlaza a un miembro de la familia de receptores del factor de crecimiento epidermico, util en la inhibicion del crecimiento de ciertas celulas tumorales. Se describen tambien los acidos nucleicos que codifican para el peptacuerpo de fusion aislado y recombinante, los equipos y las composiciones farmaceuticas que comprenden el peptacuerpo de fusion aislado y recombinante, como una sustancia activa. Finalmente, se proporciona un metodo para la fabricacion del peptacuerpo de fusion aislado y recombinante, y su uso para la preparacion de un medicamento para el tratamiento o prevencion del cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46049003P | 2003-04-04 | 2003-04-04 | |
PCT/IB2004/001049 WO2004087766A2 (en) | 2003-04-04 | 2004-04-05 | Peptabody for cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05010575A true MXPA05010575A (es) | 2006-03-09 |
Family
ID=33131924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05010575A MXPA05010575A (es) | 2003-04-04 | 2004-04-05 | Peptacuerpo para el tratamiento del cancer. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060233808A1 (es) |
EP (1) | EP1613661B1 (es) |
JP (1) | JP2007527206A (es) |
KR (1) | KR20060017585A (es) |
CN (1) | CN1798770B (es) |
AT (1) | ATE514718T1 (es) |
AU (1) | AU2004226162A1 (es) |
BR (1) | BRPI0409554A (es) |
CA (1) | CA2521393A1 (es) |
MX (1) | MXPA05010575A (es) |
NO (1) | NO20055209L (es) |
WO (1) | WO2004087766A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2643478C (en) * | 2006-02-23 | 2019-06-18 | Novocell, Inc. | Compositions and methods useful for culturing differentiable cells |
WO2009103072A2 (en) * | 2008-02-14 | 2009-08-20 | The Trustees Of The University Of Pennsylvania | Erbb4 inhibitors and uses thereof in treatment of neuropsychiatric disorders |
WO2010033249A2 (en) * | 2008-09-22 | 2010-03-25 | Massachusetts Institute Of Technology | Compositions of and methods using ligand dimers |
AU2009314534B2 (en) | 2008-11-12 | 2014-06-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of ERBB4 as a prognostic and therapeutic marker for melanoma |
CA2753282C (en) | 2009-03-10 | 2017-11-28 | Med Discovery Sa | Use of serine protease inhibitors in the treatment of neutropenia |
WO2011119836A1 (en) | 2010-03-24 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions for cardioprotection and cardioregeneration |
US9168297B2 (en) | 2010-06-23 | 2015-10-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Regulation of skin pigmentation by neuregulin-1 (NRG-1) |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
JP2013540125A (ja) * | 2010-09-30 | 2013-10-31 | ゴラブ,エミール | 水中細菌抽出物−濃縮物からの乾燥粉末の調製方法 |
KR101633159B1 (ko) * | 2013-11-28 | 2016-06-23 | 부경대학교 산학협력단 | 클라미도모나스 유래 활성 펩타이드를 유효성분으로 포함하는 위장 질환 치료 및 예방용 조성물 |
KR101587622B1 (ko) | 2014-05-23 | 2016-01-22 | 한국과학기술원 | 상피세포 성장인자 수용체의 세포외 도메인과 결합하는 신규 폴리펩타이드 |
WO2019086394A1 (en) * | 2017-11-01 | 2019-05-09 | F. Hoffmann-La Roche Ag | The compbody - a multivalent target binder |
CA3091423A1 (en) * | 2018-02-15 | 2019-08-22 | Children's National Medical Center | Heptamethine cyanines for use as fluorescent markers of the biliary and renal systems |
US12014835B2 (en) | 2020-02-19 | 2024-06-18 | Vanderbilt University | Methods for evaluating therapeutic benefit of combination therapies |
CN116370335A (zh) * | 2021-12-31 | 2023-07-04 | 康码(上海)生物科技有限公司 | 用于擦拭的病毒防护溶液以及病毒防护擦拭产品 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571507A (en) * | 1992-02-25 | 1996-11-05 | Seragen, Inc. | Methods of treating diabetes |
WO1994018345A1 (en) * | 1993-02-05 | 1994-08-18 | Affymax Technologies N.V. | Receptor-binding antiproliferative peptides |
WO1998018943A1 (en) * | 1996-10-28 | 1998-05-07 | Novartis Ag | Method for the oligomerisation of peptides |
CA2297692A1 (en) * | 1997-08-18 | 1999-02-25 | Innogenetics N.V. | Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders |
US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
US6656906B1 (en) * | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
WO2001005433A2 (en) * | 1999-07-14 | 2001-01-25 | Board Of Regents, The University Of Texas System | Delivery and retention of activity agents to lymph nodes |
EP2267026A1 (en) * | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1301612A2 (en) * | 2000-05-31 | 2003-04-16 | Genvec, Inc. | Method and composition for targeting an adenoviral vector |
AU2001273559A1 (en) * | 2000-07-18 | 2002-01-30 | Enchira Biotechnology Corporation | Methods of ligation mediated chimeragenesis utilizing populations of scaffold and donor nucleic acids |
DE10108100A1 (de) * | 2001-02-20 | 2002-08-29 | Aventis Pharma Gmbh | Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse |
PL363322A1 (en) * | 2001-05-08 | 2004-11-15 | Merck Patent Gmbh | Combination therapy using anti-egfr antibodies and anti-hormonal agents |
US7081443B2 (en) * | 2002-05-21 | 2006-07-25 | Korea Advanced Institutes Of Science And Technology (Kaist) | Chimeric comp-ang1 molecule |
-
2004
- 2004-04-05 US US10/551,977 patent/US20060233808A1/en not_active Abandoned
- 2004-04-05 WO PCT/IB2004/001049 patent/WO2004087766A2/en active Search and Examination
- 2004-04-05 AU AU2004226162A patent/AU2004226162A1/en not_active Abandoned
- 2004-04-05 CA CA002521393A patent/CA2521393A1/en not_active Abandoned
- 2004-04-05 EP EP04725746A patent/EP1613661B1/en not_active Expired - Lifetime
- 2004-04-05 CN CN2004800152672A patent/CN1798770B/zh not_active Expired - Fee Related
- 2004-04-05 KR KR1020057018924A patent/KR20060017585A/ko not_active Application Discontinuation
- 2004-04-05 JP JP2006506445A patent/JP2007527206A/ja active Pending
- 2004-04-05 AT AT04725746T patent/ATE514718T1/de not_active IP Right Cessation
- 2004-04-05 BR BRPI0409554-5A patent/BRPI0409554A/pt not_active IP Right Cessation
- 2004-04-05 MX MXPA05010575A patent/MXPA05010575A/es unknown
-
2005
- 2005-11-04 NO NO20055209A patent/NO20055209L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004087766A2 (en) | 2004-10-14 |
EP1613661B1 (en) | 2011-06-29 |
CN1798770B (zh) | 2010-06-09 |
KR20060017585A (ko) | 2006-02-24 |
ATE514718T1 (de) | 2011-07-15 |
BRPI0409554A (pt) | 2006-04-25 |
WO2004087766A3 (en) | 2004-12-16 |
AU2004226162A1 (en) | 2004-10-14 |
NO20055209D0 (no) | 2005-11-04 |
NO20055209L (no) | 2006-01-02 |
CN1798770A (zh) | 2006-07-05 |
JP2007527206A (ja) | 2007-09-27 |
EP1613661A2 (en) | 2006-01-11 |
US20060233808A1 (en) | 2006-10-19 |
CA2521393A1 (en) | 2004-10-14 |
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