TR199900842A2 - S�bstit�e edilmi� trisiklik bile�ikler. - Google Patents

S�bstit�e edilmi� trisiklik bile�ikler.

Info

Publication number
TR199900842A2
TR199900842A2 TR1999/00842A TR9900842A TR199900842A2 TR 199900842 A2 TR199900842 A2 TR 199900842A2 TR 1999/00842 A TR1999/00842 A TR 1999/00842A TR 9900842 A TR9900842 A TR 9900842A TR 199900842 A2 TR199900842 A2 TR 199900842A2
Authority
TR
Turkey
Prior art keywords
ikler
edilmi
bstit
tricyclic
bile
Prior art date
Application number
TR1999/00842A
Other languages
English (en)
Turkish (tr)
Inventor
James Bach Nicholas
Anne Bastian Jolie
Wade Beight Douglas
Dean Kinnick Michael
John Martinelli Michael
David Mihelich Edward
Michael Morin John
Jon Sall Daniel
Scott Sawyer Jason
C.R. Smith Edward
Suarez Tulio
Wang Qiuping
Michael Wilson Thomas
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR199900842A2 publication Critical patent/TR199900842A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
TR1999/00842A 1998-04-17 1999-04-16 S�bstit�e edilmi� trisiklik bile�ikler. TR199900842A2 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
TR199900842A2 true TR199900842A2 (xx) 2000-09-21

Family

ID=22040624

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00842A TR199900842A2 (xx) 1998-04-17 1999-04-16 S�bstit�e edilmi� trisiklik bile�ikler.

Country Status (27)

Country Link
EP (2) EP1156050B1 (xx)
JP (1) JP4435325B2 (xx)
KR (1) KR19990083234A (xx)
CN (1) CN1235968A (xx)
AR (1) AR018185A1 (xx)
AT (2) ATE259818T1 (xx)
AU (1) AU757454B2 (xx)
BR (1) BR9901275A (xx)
CA (1) CA2269256A1 (xx)
CO (1) CO5080728A1 (xx)
CZ (1) CZ137199A3 (xx)
DE (2) DE69914951T2 (xx)
EA (1) EA003129B1 (xx)
ES (2) ES2213668T3 (xx)
HU (1) HUP9901219A1 (xx)
ID (1) ID23219A (xx)
IL (1) IL129484A0 (xx)
NO (1) NO991823L (xx)
NZ (1) NZ335252A (xx)
PE (1) PE20000472A1 (xx)
PL (1) PL332564A1 (xx)
SG (1) SG106035A1 (xx)
SV (1) SV1999000052A (xx)
TR (1) TR199900842A2 (xx)
TW (1) TW555760B (xx)
YU (1) YU19099A (xx)
ZA (1) ZA992773B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
CN1450893A (zh) * 2000-07-14 2003-10-22 伊莱利利公司 治疗脓毒症的方法
WO2002050029A2 (en) * 2000-12-18 2002-06-27 Eli Lilly And Company Tetracyclic derivatives as spla2 inhibitors
EP1395554B1 (en) * 2001-03-28 2007-02-14 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
US7160909B2 (en) 2001-08-09 2007-01-09 Eli Lilly And Company Cyclopenta[b]indole derivatives as sPLA2 inhibitors
JP2005527466A (ja) * 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプトＢインドール誘導体
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
BRPI0517955A (pt) 2004-11-01 2008-10-21 Wyeth Corp indolizinas substituìdas e derivados como agentes de snc
CA2727055C (en) 2008-01-11 2016-12-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
DK2697223T3 (en) * 2011-04-14 2016-09-05 Actelion Pharmaceuticals Ltd 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor
WO2013138565A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
JP6114815B2 (ja) 2012-03-16 2017-04-12 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 肝臓ｘレセプターモジュレーター

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
WO1996003383A1 (en) * 1994-07-21 1996-02-08 Eli Lilly And Company INDOLIZINE sPLA2 INHIBITORS
HUP9901984A3 (en) * 1995-12-13 2001-01-29 Lilly Co Eli Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds
CZ136899A3 (cs) * 1996-10-30 1999-09-15 Eli Lilly And Company Substituované tricyklické sloučeniny
WO1999016453A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
JP2001522884A (ja) * 1997-11-14 2001-11-20 イーライ・リリー・アンド・カンパニー アルツハイマー病の処置方法

Also Published As

Publication number Publication date
ATE259818T1 (de) 2004-03-15
DE69912670D1 (de) 2003-12-18
NO991823D0 (no) 1999-04-16
SG106035A1 (en) 2004-09-30
SV1999000052A (es) 2000-03-14
EA003129B1 (ru) 2003-02-27
EP1156050B1 (en) 2004-02-18
TW555760B (en) 2003-10-01
AR018185A1 (es) 2001-10-31
DE69914951T2 (de) 2004-12-23
DE69914951D1 (de) 2004-03-25
JP4435325B2 (ja) 2010-03-17
EP1156050A2 (en) 2001-11-21
NZ335252A (en) 2000-11-24
JPH11322745A (ja) 1999-11-24
ATE254128T1 (de) 2003-11-15
BR9901275A (pt) 2000-05-02
AU757454B2 (en) 2003-02-20
HUP9901219A1 (hu) 2000-08-28
CN1235968A (zh) 1999-11-24
ES2210979T3 (es) 2004-07-01
YU19099A (sh) 2001-09-28
PL332564A1 (en) 1999-10-25
ID23219A (id) 2000-03-30
EP0950661B1 (en) 2003-11-12
EP0950661A1 (en) 1999-10-20
ZA992773B (en) 2002-07-16
HU9901219D0 (en) 1999-06-28
NO991823L (no) 1999-10-18
AU2381899A (en) 1999-10-28
DE69912670T2 (de) 2004-08-12
IL129484A0 (en) 2000-02-29
EA199900304A3 (ru) 2000-04-24
EP1156050A3 (en) 2001-11-28
CZ137199A3 (cs) 1999-11-17
EA199900304A2 (ru) 1999-10-28
ES2213668T3 (es) 2004-09-01
CA2269256A1 (en) 1999-10-17
KR19990083234A (ko) 1999-11-25
PE20000472A1 (es) 2000-06-02
CO5080728A1 (es) 2001-09-25

Similar Documents

Publication Publication Date Title
TR199900843A2 (xx) S�bstit�e edilmi� trisiklik bile�ikler.
TR199900956T2 (xx) S�bstit�e edilmi� trisiklik bile�imler.
TR199900842A2 (xx) S�bstit�e edilmi� trisiklik bile�ikler.
GT199900056A (es) Nuevas dihidropirimidinas
BR9917179B1 (pt) processo para gerar um composto de bromo oxidante estÁvel.
DK1075260T3 (da) Hidtil ukendte fedtsyreanaloger til behandling af sekundær restenose
SE9903594L (sv) Katjoniska polymerer för slamavvattning
DK1485359T3 (da) Natriumkanalblokkere
TR200000906T2 (tr) Serin/treonin protein kinaz fonksiyonunun 5-azakuinoksalin-bazlı bileşikler ile modüle edilmesi için yöntemler.
ATE457970T1 (de) Zusammensetzungen zur beseitigung von unangenehmen gerüchen
DE69928655D1 (de) Substituierte porphyrine
BR9914380A (pt) Processos para prevenir ou tratar condição prurìtica vaginal em um mamìfero, e, para prevenir ou tratar condição prurìtica nas áreas procto-uro-genital de um mamìfero
GT199900011A (es) Nuevos derivados del acido dihidroxihexanoico
ES2183340T3 (es) Procedimiento para la preparcion de compuestos de 4-bromometil-bifenilo.
TR199801866A1 (xx) Yeni piperazin ve piperidin bile�ikleri
ES2210733T5 (es) Compuesto detergente.
ES2159347T3 (es) Naftil-acetamidas como inhibidores de spla2.
FR2379581A1 (fr) Colorants fluorescents derives de la coumarine
PT1067966E (pt) Composicao oftalmica compreendendo um bloqueador beta
TR200102742T2 (tr) Rezorsinol türevleri
ES2136782T3 (es) Procedimiento para producir compuestos de acido quinolin-2-il-benzoico.
CO5160271A1 (es) Composicion de alta pureza que comprende (7 alfa, 17 alfa)- 17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona
ES2174034T3 (es) Naftilglioxamidas como inhibidores de spla2
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
AR051991A1 (es) Procedimiento para la preparacion de anilinas