BRPI0517955A - indolizinas substituìdas e derivados como agentes de snc - Google Patents
indolizinas substituìdas e derivados como agentes de sncInfo
- Publication number
- BRPI0517955A BRPI0517955A BRPI0517955-6A BRPI0517955A BRPI0517955A BR PI0517955 A BRPI0517955 A BR PI0517955A BR PI0517955 A BRPI0517955 A BR PI0517955A BR PI0517955 A BRPI0517955 A BR PI0517955A
- Authority
- BR
- Brazil
- Prior art keywords
- agents
- snc
- derivatives
- compounds
- indolizines
- Prior art date
Links
- 150000002478 indolizines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000004556 brain Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000000952 serotonin receptor agonist Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
INDOLIZINAS SUBSTITUìDAS E DERIVADOS COMO AGENTES DE SNC. A presente invenção refere-se aos compostos de fórmula (I) ou sais farmaceuticamente aceitáveis dos mesmos que são agonistas ou agonistas parciais dos receptores de serotonina de cérebro do subtipo 2C. Os compostos, e composições contendo os compostos, podem ser usados para tratar uma variedade de distúrbios do sistema nervoso central tais como esquizofrenia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62442304P | 2004-11-01 | 2004-11-01 | |
PCT/US2005/038702 WO2006050007A2 (en) | 2004-11-01 | 2005-10-27 | Substituted indolizines and derivatives as cns agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517955A true BRPI0517955A (pt) | 2008-10-21 |
Family
ID=36177318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517955-6A BRPI0517955A (pt) | 2004-11-01 | 2005-10-27 | indolizinas substituìdas e derivados como agentes de snc |
Country Status (9)
Country | Link |
---|---|
US (1) | US7608626B2 (pt) |
EP (1) | EP1807427A2 (pt) |
JP (1) | JP2008518917A (pt) |
CN (1) | CN101094852A (pt) |
AU (1) | AU2005302559A1 (pt) |
BR (1) | BRPI0517955A (pt) |
CA (1) | CA2585967A1 (pt) |
MX (1) | MX2007005199A (pt) |
WO (1) | WO2006050007A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2742936A1 (en) | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
WO2011031086A2 (ko) * | 2009-09-10 | 2011-03-17 | 주식회사 엘지화학 | 신규한 헤테로고리 유도체 및 이를 이용한 유기 발광 소자 |
FR2953716B1 (fr) * | 2009-12-16 | 2015-03-27 | Oreal | Kit de formulation d'un produit cosmetique |
FR2961097B1 (fr) * | 2010-06-09 | 2012-07-13 | Oreal | Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine |
FR2961095B1 (fr) * | 2010-06-09 | 2012-06-15 | Oreal | Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine |
US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
CN102295644B (zh) * | 2011-05-25 | 2012-12-05 | 同济大学 | 一种合成1-卤-2-芳基中氮茚类化合物的方法 |
CN102603735B (zh) * | 2012-02-06 | 2014-07-16 | 浙江新和成股份有限公司 | 一种c-2芳基化吲哚嗪化合物的制备方法 |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE |
CN112010777B (zh) * | 2020-08-20 | 2022-10-11 | 浙江大学衢州研究院 | 于管道化反应器内进行的酰胺连续化制备腈的方法 |
WO2023081306A1 (en) * | 2021-11-03 | 2023-05-11 | Tactogen Inc | Indolizine compounds for the treatment of mental disorders or mental enhancement |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8416724D0 (en) | 1984-06-30 | 1984-08-01 | Sorbio Sa Lab | Active compounds |
EP0213696B1 (en) | 1985-06-28 | 1991-01-23 | Beecham Wuelfing GmbH & Co KG | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
EP0252643A1 (en) | 1986-07-01 | 1988-01-13 | BEECHAM - WUELFING GmbH & Co. KG | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them |
CA1329597C (en) | 1986-12-22 | 1994-05-17 | Dagmar Hoeltje | Derivatives of tetrahydropyrido[1,2-a]indole |
AU2235592A (en) | 1991-06-07 | 1993-01-08 | Smithkline Beecham Corporation | Lipoxygenase inhibiting pyrrolo (1,2a)indole compounds |
GB9316195D0 (en) | 1993-08-05 | 1993-09-22 | Smithkline Beecham Plc | Pharmaceuticals |
GB9318790D0 (en) | 1993-09-10 | 1993-10-27 | Fujisawa Pharmaceutical Co | Heterocyclic derivatives |
EP0974592A4 (en) | 1995-09-22 | 2001-09-19 | Fujisawa Pharmaceutical Co | NEW PROCESS FOR PRODUCING PYRIDOINDOL DERIVATIVES |
ID23219A (id) | 1998-04-17 | 2000-03-30 | Lilly Co Eli | Trisiklik tersubstitusi |
WO2000006564A1 (fr) | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Composes de maleimide disubstitues et utilisation en medecine de ces derniers |
GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
MXPA01005905A (es) | 1998-12-11 | 2002-09-18 | Univ Virginia Commonwealth | Ligandos selectivos de receptores de 5-ht6. |
DE19907701A1 (de) | 1999-02-23 | 2000-08-24 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
JP4636521B2 (ja) | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環系化合物 |
DE50112961D1 (de) | 2000-02-01 | 2007-10-18 | Abbott Gmbh & Co Kg | Heterozyklische verbindungen und deren anwendung als parp-inhibitoren |
FR2805539B1 (fr) * | 2000-02-25 | 2005-06-10 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives d'indolizine et procede de teinture |
PT1268479E (pt) | 2000-03-31 | 2004-06-30 | Ortho Mcneil Pharm Inc | Derivados de indolizina fenil-substituidos e sua utilizacao como ligandos h3 de histamina |
CA2432085C (en) | 2000-12-27 | 2009-02-24 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
-
2005
- 2005-10-27 WO PCT/US2005/038702 patent/WO2006050007A2/en active Application Filing
- 2005-10-27 AU AU2005302559A patent/AU2005302559A1/en not_active Abandoned
- 2005-10-27 JP JP2007539092A patent/JP2008518917A/ja active Pending
- 2005-10-27 CN CNA2005800454342A patent/CN101094852A/zh active Pending
- 2005-10-27 BR BRPI0517955-6A patent/BRPI0517955A/pt not_active Application Discontinuation
- 2005-10-27 CA CA002585967A patent/CA2585967A1/en not_active Abandoned
- 2005-10-27 US US11/260,716 patent/US7608626B2/en not_active Expired - Fee Related
- 2005-10-27 EP EP05822693A patent/EP1807427A2/en not_active Withdrawn
- 2005-10-27 MX MX2007005199A patent/MX2007005199A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1807427A2 (en) | 2007-07-18 |
US20060094752A1 (en) | 2006-05-04 |
WO2006050007A3 (en) | 2006-08-03 |
JP2008518917A (ja) | 2008-06-05 |
AU2005302559A1 (en) | 2006-05-11 |
US7608626B2 (en) | 2009-10-27 |
CN101094852A (zh) | 2007-12-26 |
CA2585967A1 (en) | 2006-05-11 |
WO2006050007A2 (en) | 2006-05-11 |
MX2007005199A (es) | 2007-05-11 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |