ATE529423T1 - Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate - Google Patents

Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate

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Publication number
ATE529423T1
ATE529423T1 AT07797473T AT07797473T ATE529423T1 AT E529423 T1 ATE529423 T1 AT E529423T1 AT 07797473 T AT07797473 T AT 07797473T AT 07797473 T AT07797473 T AT 07797473T AT E529423 T1 ATE529423 T1 AT E529423T1
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AT
Austria
Prior art keywords
derivatives
alkande
cns
condensed
activated
Prior art date
Application number
AT07797473T
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English (en)
Inventor
Jianguo Ji
Tao Li
Christopher L Lynch
Murali Gopalakrishnan
Original Assignee
Abbott Lab
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Publication of ATE529423T1 publication Critical patent/ATE529423T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/08—Diarylmethoxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/04—Antibacterial agents
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pregnancy & Childbirth (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07797473T 2006-05-19 2007-05-15 Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate ATE529423T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80219506P 2006-05-19 2006-05-19
PCT/US2007/068930 WO2007137030A2 (en) 2006-05-19 2007-05-15 Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives

Publications (1)

Publication Number Publication Date
ATE529423T1 true ATE529423T1 (de) 2011-11-15

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AT07797473T ATE529423T1 (de) 2006-05-19 2007-05-15 Cns-aktivierte kondensierte bi- und heterocyclisch substituierte azabicyklische alkanderivate

Country Status (30)

Country Link
US (2) US7872017B2 (de)
EP (2) EP2431368B1 (de)
JP (3) JP5420398B2 (de)
KR (1) KR20090018972A (de)
CN (2) CN101448825A (de)
AT (1) ATE529423T1 (de)
AU (1) AU2007253950B2 (de)
BR (1) BRPI0711588A2 (de)
CA (1) CA2647830C (de)
CY (1) CY1112531T1 (de)
DK (1) DK2018380T3 (de)
EC (1) ECSP088918A (de)
ES (2) ES2373792T3 (de)
GT (1) GT200800248A (de)
HK (1) HK1122569A1 (de)
HR (1) HRP20110917T1 (de)
IL (1) IL195234A0 (de)
MX (1) MX2008014672A (de)
MY (1) MY147661A (de)
NO (1) NO20085153L (de)
NZ (2) NZ589784A (de)
PL (1) PL2018380T3 (de)
PT (1) PT2018380E (de)
RS (1) RS52062B (de)
RU (2) RU2437884C2 (de)
SI (1) SI2018380T1 (de)
TW (1) TWI343385B (de)
UA (1) UA92083C2 (de)
WO (1) WO2007137030A2 (de)
ZA (2) ZA200810687B (de)

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