CO5080728A1 - Compuestos triciclicos sustituidos - Google Patents

Compuestos triciclicos sustituidos

Info

Publication number
CO5080728A1
CO5080728A1 CO99022891A CO99022891A CO5080728A1 CO 5080728 A1 CO5080728 A1 CO 5080728A1 CO 99022891 A CO99022891 A CO 99022891A CO 99022891 A CO99022891 A CO 99022891A CO 5080728 A1 CO5080728 A1 CO 5080728A1
Authority
CO
Colombia
Prior art keywords
nitrogen
group
hydrogen
sulfur
alkyl
Prior art date
Application number
CO99022891A
Other languages
English (en)
Inventor
James Bach Nicholas
Jolie Ann Bastian
Beight Douglas Wade
Michael Dean Kinnick
Michael John Martinelli
Edward Daavid Mihelich
Junior John Michael Morin
Sall Daniel Jon
Sawyer Jason Scott
Edward C R Smith
Suarez Tulio
Wang Qiuping
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5080728A1 publication Critical patent/CO5080728A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Un compuesto de la fórmula (I)<EMI FILE="99022891_1" ID="1" IMF=JPEG >En la que; A es fenilo o piridilo, donde el nitrógeno está en la posición 5, 6, 7 u 8;Uno de B o D es nitrógeno y el otro es carbono;Z es ciclohexenilo, fenilo, piridilo, donde el nitrógeno está en la posición 1, 2 ó 3, o un anillo heterocíclico de 6 eslabones que tiene un heteroátomo seleccionado entre el grupo compuesto por azufre u oxígeno en la posición 1, 2 ó 3, y nitrógeno en la posición 1, 2, 3, ó 4;------ es un enlace sencillo o doble;R20 se selecciona entre grupos (a), (b) y (c), donde;(a) es -alquilo (C5-20), -alquenilo (C5-C20), -alquinilo (C5-C20), radicales carbocíclicos o radicales heterocíclicos, o (b) es un miembro de (a) sustituido con uno o más sustituyentes no interferentes, seleccionados independientemente; o (c) es el grupo -(L)-R80 ; donde (L) - es un grupo de unión divalente de 1 a 12 átomos, seleccionado entre carbono, hidrógeno, oxígeno, nitrógeno y azufre; donde la combinación de átomos en -(L)- se selecciona entre el grupo compuesto por (i) sólo carbono e hidrógeno, (ii) sólo azufre, (iii) sólo un oxígeno, (iv) sólo uno o dos nitrógenos e hidrógeno, (v) carbono, hidrógeno y sólo un azufre, y (vi) carbono, hidrógeno y sólo oxígeno; y donde R80 es un grupo seleccionado entre (a) o (b);R21 es un sustituyente no interferente;R1 es -NHNH2 , -NH2 o -CONH2 ;R2´ se selecciona entre el grupo compuesto por -OH y -O(CH2 )t R5' dondeR5' es H, -CN, -NH2, -CONH2, -CONH2, -CONR9R10 , -NHSO2 R15 ;-CONHSO2 R15, donde R15 es -alquilo(C1 -C6 ) o CF3 ; fenilo o fenilo sustituido con -CO2 H o -CO2 -alquilo(C1-C4 ); y-(La) - (grupo ácido), donde -(La) - es un conector ácido que tiene una longitud de conector ácido de 1 a 7, t es 1-5;R9 y R10 son independientemente hidrógeno, -CF3 , fenilo, -alquilo(C1 -C4 ), alquilfenilo(C1 -C4 ) o -fenilalquilo(C1-C4 );R3' se selecciona entre sustituyentes no interferentes, radicales carbocíclicos, radicales carbocíclicos sustituidos con sustituyentes no interferentes, radicales heterocíclicos y radicales heterocíclicos sustituidos con sustituyentes no interferentes; o un racemato, solvato, tautómero, isómero óptico, derivado profármaco o sal farmacéuticamente aceptables de los mismos.Con la condición de que uno de A o Z es un anillo heterocíclico; y cuando D es nitrógeno, el heteroátomo de Z se selecciona entre el grupo compuesto por azufre u oxígeno en la posición 1, 2 ó 3 y el nitrógeno en la posición 1, 2, 3 ó 4.
CO99022891A 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos CO5080728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
CO5080728A1 true CO5080728A1 (es) 2001-09-25

Family

ID=22040624

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99022891A CO5080728A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Country Status (27)

Country Link
EP (2) EP1156050B1 (es)
JP (1) JP4435325B2 (es)
KR (1) KR19990083234A (es)
CN (1) CN1235968A (es)
AR (1) AR018185A1 (es)
AT (2) ATE254128T1 (es)
AU (1) AU757454B2 (es)
BR (1) BR9901275A (es)
CA (1) CA2269256A1 (es)
CO (1) CO5080728A1 (es)
CZ (1) CZ137199A3 (es)
DE (2) DE69912670T2 (es)
EA (1) EA003129B1 (es)
ES (2) ES2210979T3 (es)
HU (1) HUP9901219A1 (es)
ID (1) ID23219A (es)
IL (1) IL129484A0 (es)
NO (1) NO991823L (es)
NZ (1) NZ335252A (es)
PE (1) PE20000472A1 (es)
PL (1) PL332564A1 (es)
SG (1) SG106035A1 (es)
SV (1) SV1999000052A (es)
TR (1) TR199900842A2 (es)
TW (1) TW555760B (es)
YU (1) YU19099A (es)
ZA (1) ZA992773B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
JP2004503586A (ja) * 2000-07-14 2004-02-05 イーライ・リリー・アンド・カンパニー 敗血症の治療方法
ES2264708T3 (es) * 2000-12-18 2007-01-16 Eli Lilly And Company Derivados tetraciclicos como inhibidores de la spla2.
US6933313B2 (en) 2001-03-28 2005-08-23 Eli Lilly And Company Substituted carbazoles as inhibitors of sPLA2
JP2005527464A (ja) * 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
ES2252497T3 (es) * 2001-08-09 2006-05-16 Eli Lilly And Company Derivados ciclohept(b)indol como inhibidores de spla2.
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
WO2006050007A2 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as cns agents
MX2010007430A (es) 2008-01-11 2010-12-21 Albany Molecular Res Inc Piridoindoles (1-azinona)-sustituidos como antagonistas de la hormona de concentracion melanina humana.
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US9096595B2 (en) * 2011-04-14 2015-08-04 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators
RS55166B1 (sr) 2012-03-16 2017-01-31 Vitae Pharmaceuticals Inc Modulatori x receptora iz jetre
BR112014022780A8 (pt) 2012-03-16 2021-06-15 Vitae Pharmaceuticals Inc composto modulador de receptor de fígado x, composição farmacêutica que o compreende e seu uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
CN1158121A (zh) * 1994-07-21 1997-08-27 伊莱利利公司 吲哚嗪sPLA2抑制剂
IL124866A (en) * 1995-12-13 2002-08-14 Lilly Co Eli Naphthalide acetamides as sPLA2 inhibitors
CA2269203A1 (en) * 1996-10-30 1998-05-07 Nicholas James Bach Substituted tricyclics
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
JP2001522884A (ja) * 1997-11-14 2001-11-20 イーライ・リリー・アンド・カンパニー アルツハイマー病の処置方法

Also Published As

Publication number Publication date
EP0950661A1 (en) 1999-10-20
DE69912670T2 (de) 2004-08-12
EA003129B1 (ru) 2003-02-27
BR9901275A (pt) 2000-05-02
ATE259818T1 (de) 2004-03-15
DE69914951D1 (de) 2004-03-25
PE20000472A1 (es) 2000-06-02
CN1235968A (zh) 1999-11-24
DE69912670D1 (de) 2003-12-18
EA199900304A2 (ru) 1999-10-28
TW555760B (en) 2003-10-01
CA2269256A1 (en) 1999-10-17
EP0950661B1 (en) 2003-11-12
AU757454B2 (en) 2003-02-20
ID23219A (id) 2000-03-30
JP4435325B2 (ja) 2010-03-17
DE69914951T2 (de) 2004-12-23
AU2381899A (en) 1999-10-28
ES2213668T3 (es) 2004-09-01
EP1156050A3 (en) 2001-11-28
HUP9901219A1 (hu) 2000-08-28
NO991823D0 (no) 1999-04-16
ATE254128T1 (de) 2003-11-15
KR19990083234A (ko) 1999-11-25
EP1156050A2 (en) 2001-11-21
SG106035A1 (en) 2004-09-30
AR018185A1 (es) 2001-10-31
NZ335252A (en) 2000-11-24
PL332564A1 (en) 1999-10-25
NO991823L (no) 1999-10-18
EP1156050B1 (en) 2004-02-18
JPH11322745A (ja) 1999-11-24
EA199900304A3 (ru) 2000-04-24
CZ137199A3 (cs) 1999-11-17
YU19099A (sh) 2001-09-28
ZA992773B (en) 2002-07-16
TR199900842A2 (xx) 2000-09-21
ES2210979T3 (es) 2004-07-01
IL129484A0 (en) 2000-02-29
HU9901219D0 (en) 1999-06-28
SV1999000052A (es) 2000-03-14

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