CO5011054A1 - Compuestos triciclicos sustituidos - Google Patents

Compuestos triciclicos sustituidos

Info

Publication number
CO5011054A1
CO5011054A1 CO99022897A CO99022897A CO5011054A1 CO 5011054 A1 CO5011054 A1 CO 5011054A1 CO 99022897 A CO99022897 A CO 99022897A CO 99022897 A CO99022897 A CO 99022897A CO 5011054 A1 CO5011054 A1 CO 5011054A1
Authority
CO
Colombia
Prior art keywords
group
substituted
hydrogen
carbon
sulfur
Prior art date
Application number
CO99022897A
Other languages
English (en)
Inventor
Benjamin Alan Anderson
James Bach Nicholas
Jolie Anne Bastian
Nancy Kay Harn
Richard Waltz Harper
Gary Alan Hite
Michael Dean Kinnick
Lin Ho-Shen
Richard James Loncharich
Edward David Mihelich
Junior John Michael Morin
Michael Leroy Phillips
Michael Enrico Richett
Sall Daniel Jon
Sawyer Jason Scott
Richard Walter Schevitz
Robert Theodore Vasileff
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5011054A1 publication Critical patent/CO5011054A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Un compuesto de la fórmula (I)en la que;Z es ciclohexenilo o fenilo, R20 se selecciona entre grupos (a), (b) y (c), donde; (a) es -alquilo (C5 -C20 ), -alquenilo(C5 -C20 ), -alquinilo(C5 -C20 ), radicales carbocíclicos o radicales heterocíclicos, o (b) es un miembro de (a) sustituido con uno o más sustituyentes no interferentes, seleccionados independientemente; o (c) es el grupo -(L)-R80 ; donde (L) - es un grupo de unión divalente de 1 a 12 átomos, seleccionado entre carbono, hidrógeno, oxígeno, nitrógeno y azufre; donde la combinación de átomos en - (L) - se selecciona entre el grupo compuesto por (i) sólo carbono e hidrógeno, (ii) sólo un azufre, (iii) sólo un oxígeno, (iv) solo uno o dos nitrógenos e hidrógeno, (v) carbono, hidrógeno y solo un azufre, y (vi) un carbono, hidrógeno y sólo oxígeno; y donde R80 es un grupo seleccionado entre (a) o (b); R21 es un sustituyente no interferente en el que f es 1-3; R1 es -NHNH2 , -NH2 o -CONH2 ; R2´ se selecciona entre el grupo compuesto por -OH y -O(CH2 )t R5´ donde R5´ es H, -CN, -NH2 , -CONH2 , -CONR9 R10 , -NHSO2 R15 ; -CONHSO2 R15 , donde R15 es -alquilo(C1 -C6 ) o CF3 ; fenilo o fenilo sustituido con -CO2 H o -CO2 -alquilo (C1 -C4 ); y - (La ) - (grupo ácido), donde- (La ) - es un conector ácido que tiene una longitud de conector ácido de 1 a 7, y t es 1-5; R3´ se selecciona entre sustituyentes no interferentes, radicales carbocíclicos, radicales carbocíclicos sustituidos con sustituyentes no interferentes, radicales heterocíclicos y radicales heterocíclicos sustituidos con sustituyentes no interferentes; o un racemato, solvato, tautómero, isómero óptico, derivado profármaco o sal farmacéuticamente aceptables del mismo.
CO99022897A 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos CO5011054A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
CO5011054A1 true CO5011054A1 (es) 2001-02-28

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
CO99022897A CO5011054A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos
CO99022884A CO5031247A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CO99022884A CO5031247A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Country Status (30)

Country Link
EP (2) EP0952149B1 (es)
JP (2) JPH11322713A (es)
KR (2) KR100586761B1 (es)
CN (1) CN1149193C (es)
AR (2) AR018593A1 (es)
AT (2) ATE271037T1 (es)
AU (2) AU753436B2 (es)
BR (2) BR9901279A (es)
CA (2) CA2269262A1 (es)
CO (2) CO5011054A1 (es)
CZ (2) CZ137099A3 (es)
DE (2) DE69917833T2 (es)
DK (1) DK0950657T3 (es)
DZ (1) DZ2769A1 (es)
EA (2) EA002816B1 (es)
ES (2) ES2226286T3 (es)
HU (2) HUP9901221A3 (es)
ID (2) ID23761A (es)
IL (2) IL129485A0 (es)
NO (2) NO314400B1 (es)
NZ (3) NZ335251A (es)
PE (2) PE20000476A1 (es)
PL (2) PL332565A1 (es)
PT (1) PT950657E (es)
SG (2) SG81976A1 (es)
SI (1) SI0950657T1 (es)
TR (2) TR199900853A3 (es)
TW (1) TWI238160B (es)
YU (2) YU19199A (es)
ZA (2) ZA992771B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009978A1 (en) * 1997-08-28 1999-03-04 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
CA2358492A1 (en) * 1998-12-21 2000-06-29 Eli Lilly And Company Combination therapy for the treatment of sepsis
ATE350367T1 (de) * 1999-07-19 2007-01-15 Lilly Co Eli Spla2 inhibitoren
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
ATE375171T1 (de) * 2000-06-29 2007-10-15 Anthera Pharmaceuticals Inc Heilmittel für krebs
AU2001267826A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for alzheimer's disease
AU2001267825A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
CN1450893A (zh) * 2000-07-14 2003-10-22 伊莱利利公司 治疗脓毒症的方法
EP1345898A2 (en) 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
DE60218155D1 (de) * 2001-03-28 2007-03-29 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
AU2009230127B2 (en) 2008-03-26 2011-12-22 Daiichi Sankyo Company, Limited Novel tetrahydroisoquinoline derivative
JP5637982B2 (ja) 2008-04-09 2014-12-10 インフィニティー ファーマシューティカルズ， インコーポレイテッド 脂肪酸アミド加水分解酵素の阻害剤
WO2010084402A2 (en) * 2009-01-22 2010-07-29 Orchid Research Laboratories Ltd. Heterocyclic compounds as phosphodiesterase inhibitors
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8546564B2 (en) 2009-04-07 2013-10-01 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
EP2531511A1 (en) 2010-02-03 2012-12-12 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
BR112015012401A2 (pt) 2012-11-30 2019-10-01 Ge Healthcare Ltd método para a produção de um composto da fórmula z
IN2015DN03978A (es) 2012-11-30 2015-10-02 Ge Healthcare Ltd
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
CA2179678A1 (en) * 1995-06-23 1996-12-24 Michael Edward Flaugh 6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b| indoles
IL124866A (en) * 1995-12-13 2002-08-14 Lilly Co Eli Naphthalide acetamides as sPLA2 inhibitors
NZ335246A (en) * 1996-10-30 2001-09-28 Lilly Co Eli Substituted carbazole or hydrogenated carbazole derivatives; useful for inhibiting sPLA2 (human non-pancreatic secretory phospholipase A2) mediated release of fatty acids for conditions such as septic shock
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
DZ2769A1 (fr) 2003-12-01
EP0950657A2 (en) 1999-10-20
HU9901221A (hu) 2000-04-28
ID23761A (id) 2000-05-11
ES2226286T3 (es) 2005-03-16
DE69918590D1 (de) 2004-08-19
EA002347B1 (ru) 2002-04-25
JPH11322713A (ja) 1999-11-24
JP4435330B2 (ja) 2010-03-17
NO991821D0 (no) 1999-04-16
EA002816B1 (ru) 2002-10-31
KR19990083233A (ko) 1999-11-25
AU753436B2 (en) 2002-10-17
HUP9901221A3 (en) 2001-11-28
CA2269246C (en) 2009-08-25
EA199900301A2 (ru) 1999-10-28
EA199900301A3 (ru) 2000-04-24
NO991822L (no) 1999-10-18
YU18999A (sh) 2002-08-12
YU19199A (sh) 2002-08-12
CA2269262A1 (en) 1999-10-17
EP0950657B1 (en) 2004-07-14
EP0950657A3 (en) 2001-08-16
DE69917833D1 (de) 2004-07-15
PL332566A1 (en) 1999-10-25
EP0952149A2 (en) 1999-10-27
HU9901220A (hu) 2000-04-28
CN1149193C (zh) 2004-05-12
BR9901279A (pt) 2000-05-02
ATE271037T1 (de) 2004-07-15
NO312240B1 (no) 2002-04-15
ES2222663T3 (es) 2005-02-01
KR19990083232A (ko) 1999-11-25
ATE268756T1 (de) 2004-06-15
JP2000026416A (ja) 2000-01-25
DK0950657T3 (da) 2004-11-22
NZ335253A (en) 2000-11-24
IL129485A0 (en) 2000-02-29
TR199900853A2 (xx) 1999-11-22
AR018593A1 (es) 2001-11-28
PT950657E (pt) 2004-11-30
KR100586761B1 (ko) 2006-06-08
PE20000476A1 (es) 2000-06-02
AR018186A1 (es) 2001-10-31
TR199900843A2 (xx) 2000-02-21
PL332565A1 (en) 1999-10-25
AU753547B2 (en) 2002-10-24
ZA992771B (en) 2002-04-18
NZ507564A (en) 2002-10-25
DE69917833T2 (de) 2005-07-14
AU2381999A (en) 1999-10-28
NO314400B1 (no) 2003-03-17
TR199900853A3 (tr) 1999-11-22
EA199900303A3 (ru) 2000-04-24
EP0952149B1 (en) 2004-06-09
CA2269246A1 (en) 1999-10-17
CO5031247A1 (es) 2001-04-27
CZ136999A3 (cs) 1999-11-17
CN1253948A (zh) 2000-05-24
NO991822D0 (no) 1999-04-16
SG81977A1 (en) 2001-07-24
ZA992772B (en) 2002-07-16
NZ335251A (en) 2000-11-24
DE69918590T2 (de) 2005-07-21
IL129483A0 (en) 2000-02-29
NO991821L (no) 1999-10-18
AU2381799A (en) 1999-10-28
EP0952149A3 (en) 2001-08-16
HU9901220D0 (en) 1999-06-28
PE20000432A1 (es) 2000-05-23
HU9901221D0 (en) 1999-06-28
TWI238160B (en) 2005-08-21
CZ137099A3 (cs) 1999-11-17
BR9902365A (pt) 2001-04-24
EA199900303A2 (ru) 1999-10-28
HUP9901220A3 (en) 2001-11-28
SG81976A1 (en) 2001-07-24
ID23287A (id) 2000-04-05
SI0950657T1 (en) 2005-02-28

Similar Documents

Publication Publication Date Title
CO5011054A1 (es) Compuestos triciclicos sustituidos
CO4920250A1 (es) Compuestos heterociclicos utiles en la inhibicion de la spla2
CO5080728A1 (es) Compuestos triciclicos sustituidos
KR870000288A (ko) (메트)-아크릴산 에스테르의 제조방법
DE3781716T2 (de) Mittel zur ortsspezifischen alkylierung.
NO20013379L (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
AR009212A1 (es) Un derivado de 3-piperidil-4-oxoquinazolina; una composicion farmaceutica, un inhibidor de la proteina de transferencia de los trigliceridos microsomal(mtp) y un agente terapeutico o preventivo para la hiperlipemia o la arteriosclerosis que lo contienen
EA200100428A1 (ru) Производные тетрагидробензазепина, полезные в качестве модуляторов допаминовых d3 рецепторов (антипсихотические агенты)
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
HUP9903836A2 (hu) Új eljárás Cox-2 inhibítor hatású fenil-szubsztituált 2(5H)-furanonok előállítására
EA200100310A1 (ru) Кислородсодержащие гетероциклические соединения
ES8302783A1 (es) "un procedimiento para preparar un compuesto de inclusion de ciclodextrina".
DE69326302T2 (de) Pleuromutilin-derivate
FI885036A0 (fi) Hiilivetykoostumus, kuten polttoaineöljy, ja sen lisäaineet
FI890520A0 (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 2- (piperidin-4-ylmetyl) -1,2,3,4 -tetrahydroisokinolinderivat.
DK0471266T3 (da) Anvendelse af cooligomerer af (meth)acrylsyreestere og alfa-olefiner som synteseolier inden for smøring
ES2190222T3 (es) Derivados de 3-(2-oxo-(1,3')bipirrolindinil-3-iliden-metil)-cefem.
ES2087103T3 (es) Procedimiento para la determinacion especifica de la alfa-amilasa del pancreas.
KR930702269A (ko) 포스포리파제 a2저해 물질
ES456400A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
FI853685A0 (fi) Nya n-alk(en)yl-n-(o,o-disubstituerade -tiofosforyl)-n'n'-disubstituerade glycinamider, foerfarande foer framstaellning av dessa samt kvalstergifter, insektgifter och svampgifter vilka innehaoller dessa som aktiv bestaondsdel.
YU72392A (sh) Postupak za proizvodnju antihipertenzionog kombinacionog preparata
DK82583A (da) Furyloxazolyleddikesyrederivater og fremgangsmaader til fremstilling deraf
FI933468A (fi) Tetrahydronaftalenderivat, framstaellning av dessa och terapeutisk anvaendning av dessa
KR910000619A (ko) γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법