YU72392A - Postupak za proizvodnju antihipertenzionog kombinacionog preparata - Google Patents
Postupak za proizvodnju antihipertenzionog kombinacionog preparataInfo
- Publication number
- YU72392A YU72392A YU72392A YU72392A YU72392A YU 72392 A YU72392 A YU 72392A YU 72392 A YU72392 A YU 72392A YU 72392 A YU72392 A YU 72392A YU 72392 A YU72392 A YU 72392A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- atoms
- phenyl
- alkyl
- radical
- halogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Plant Substances (AREA)
- External Artificial Organs (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Postupak za proizvodnju antihipertenzionog kombinacionog preparata, koji sadrži smešu derivata tetrahidronaftalina opšte formule u kojoj R1 označava halogen, R2 označava niži alkoksi-niži alkilkarboniloksi, X označava C2-C8-alkilen i A označava benzimidazolil koji je na N-atomu supstituisan alkilom sa 1-12 C-atoma, i piridazodiazepina opšte formule u kojoj R4 označava aralkil sa 1-6 C-atoma u alkil-ostatku i fenil u aril-ostatku, pri čemu je ovaj fenil-ostatak u datom slučaju jednostruko supstituisan halogenom, alkoksi-grupom sa 1-6 C-atoma ili fenilom, R3 i R6 nezavisno jedan od drugog svaki pojedinačno označavaju vodonik ili alkil sa 1-6 C-atoma i R7 i R označavaju vodonik ili zajedno označavaju okso-grupu, u obliku svojih slobodnih baza, njihovih hidrata ili njihovih farmaceutski primenljivih soli za istovremenu, odvojenu ili vremenski stupnjevitu primenu.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH219191 | 1991-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU72392A true YU72392A (sh) | 1997-05-28 |
Family
ID=4228024
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU72392A YU49198B (sh) | 1991-07-23 | 1992-07-23 | Postupak za dobijanje antihipertenzionog kombinovanog preparata |
| YU72392A YU72392A (sh) | 1991-07-23 | 1992-07-23 | Postupak za proizvodnju antihipertenzionog kombinacionog preparata |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU72392A YU49198B (sh) | 1991-07-23 | 1992-07-23 | Postupak za dobijanje antihipertenzionog kombinovanog preparata |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5620975A (sh) |
| EP (1) | EP0524512B1 (sh) |
| JP (1) | JPH0680009B2 (sh) |
| KR (1) | KR100260479B1 (sh) |
| CN (1) | CN1040505C (sh) |
| AT (1) | ATE260661T1 (sh) |
| AU (1) | AU656207B2 (sh) |
| BG (1) | BG60949B1 (sh) |
| BR (1) | BR9202830A (sh) |
| CA (1) | CA2074039C (sh) |
| CZ (1) | CZ281691B6 (sh) |
| DE (1) | DE59209993D1 (sh) |
| DK (1) | DK0524512T3 (sh) |
| ES (1) | ES2215160T3 (sh) |
| HR (1) | HRP930953B1 (sh) |
| HU (1) | HU214029B (sh) |
| IE (1) | IE922378A1 (sh) |
| IL (1) | IL102541A (sh) |
| IS (1) | IS3887A (sh) |
| MX (1) | MX9204212A (sh) |
| MY (1) | MY118064A (sh) |
| NO (1) | NO301047B1 (sh) |
| NZ (1) | NZ243577A (sh) |
| PT (1) | PT524512E (sh) |
| RO (1) | RO110905B (sh) |
| RU (1) | RU2084225C1 (sh) |
| SK (1) | SK278918B6 (sh) |
| TW (1) | TW216770B (sh) |
| UY (1) | UY23449A1 (sh) |
| YU (2) | YU49198B (sh) |
| ZA (1) | ZA925322B (sh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0634175B1 (de) * | 1993-07-15 | 2001-01-10 | F. Hoffmann-La Roche Ag | Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält |
| IL131816A (en) | 1997-04-04 | 2003-06-24 | Exxon Res & Engineering Compan | Composite structures having high containment strength |
| EP1438297A1 (en) | 2001-10-10 | 2004-07-21 | Aryx Therapeutics | Mibefradil-based compounds as calcium channel blockers useful in the treatment of hypertension and angina |
| US7687086B1 (en) | 2003-02-28 | 2010-03-30 | University Of Portland | Method for obtaining taxanes |
| EP2537534B1 (en) | 2011-06-22 | 2014-12-17 | Hexal AG | Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| DE3542794A1 (de) * | 1985-12-04 | 1987-06-11 | Bayer Ag | Antihypertensives kombinationspraeparat |
| DK171349B1 (da) * | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
| FR2607004B1 (fr) * | 1986-11-20 | 1990-06-01 | Synthelabo | Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine |
| US5110813A (en) * | 1987-09-15 | 1992-05-05 | Alcoholism And Drug Addiction Research Foundation | Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors |
| US4871731A (en) * | 1987-10-07 | 1989-10-03 | Marion Laboratories, Inc. | Captopril and diltiazem composition and the like |
| KR940005408B1 (ko) * | 1990-12-03 | 1994-06-18 | 만도기계 주식회사 | 파워 윈도우 모우터 회전자의 선단부 흔들림 측정장치 |
-
1992
- 1992-07-04 TW TW081105301A patent/TW216770B/zh active
- 1992-07-11 EP EP92111847A patent/EP0524512B1/de not_active Expired - Lifetime
- 1992-07-11 ES ES92111847T patent/ES2215160T3/es not_active Expired - Lifetime
- 1992-07-11 AT AT92111847T patent/ATE260661T1/de not_active IP Right Cessation
- 1992-07-11 DE DE59209993T patent/DE59209993D1/de not_active Expired - Fee Related
- 1992-07-11 PT PT92111847T patent/PT524512E/pt unknown
- 1992-07-11 DK DK92111847T patent/DK0524512T3/da active
- 1992-07-16 ZA ZA925322A patent/ZA925322B/xx unknown
- 1992-07-16 CA CA002074039A patent/CA2074039C/en not_active Expired - Fee Related
- 1992-07-16 NZ NZ243577A patent/NZ243577A/en unknown
- 1992-07-17 MX MX9204212A patent/MX9204212A/es active IP Right Grant
- 1992-07-17 IL IL10254192A patent/IL102541A/en not_active IP Right Cessation
- 1992-07-20 AU AU20416/92A patent/AU656207B2/en not_active Ceased
- 1992-07-20 RU SU925052378A patent/RU2084225C1/ru not_active IP Right Cessation
- 1992-07-20 HU HU9202367A patent/HU214029B/hu not_active IP Right Cessation
- 1992-07-21 MY MYPI92001289A patent/MY118064A/en unknown
- 1992-07-21 KR KR1019920012932A patent/KR100260479B1/ko not_active IP Right Cessation
- 1992-07-21 CZ CS922270A patent/CZ281691B6/cs not_active IP Right Cessation
- 1992-07-21 BG BG96664A patent/BG60949B1/bg unknown
- 1992-07-21 RO RO92-0990A patent/RO110905B/ro unknown
- 1992-07-21 SK SK2270-92A patent/SK278918B6/sk unknown
- 1992-07-22 NO NO922903A patent/NO301047B1/no not_active IP Right Cessation
- 1992-07-22 UY UY23449A patent/UY23449A1/es not_active IP Right Cessation
- 1992-07-22 CN CN92108668A patent/CN1040505C/zh not_active Expired - Fee Related
- 1992-07-22 IE IE237892A patent/IE922378A1/en not_active Application Discontinuation
- 1992-07-23 YU YU72392A patent/YU49198B/sh unknown
- 1992-07-23 IS IS3887A patent/IS3887A/is unknown
- 1992-07-23 JP JP4216629A patent/JPH0680009B2/ja not_active Expired - Fee Related
- 1992-07-23 YU YU72392A patent/YU72392A/sh unknown
- 1992-07-23 BR BR929202830A patent/BR9202830A/pt not_active Application Discontinuation
-
1993
- 1993-06-07 HR HR930953A patent/HRP930953B1/xx not_active IP Right Cessation
-
1994
- 1994-11-02 US US08/333,171 patent/US5620975A/en not_active Expired - Fee Related
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