EA199900303A2 - Замещенные трициклические соединения - Google Patents

Замещенные трициклические соединения

Info

Publication number
EA199900303A2
EA199900303A2 EA199900303A EA199900303A EA199900303A2 EA 199900303 A2 EA199900303 A2 EA 199900303A2 EA 199900303 A EA199900303 A EA 199900303A EA 199900303 A EA199900303 A EA 199900303A EA 199900303 A2 EA199900303 A2 EA 199900303A2
Authority
EA
Eurasian Patent Office
Prior art keywords
carbazol derivatives
compounds
carbazol
derivatives
sfla
Prior art date
Application number
EA199900303A
Other languages
English (en)
Other versions
EA199900303A3 (ru
EA002816B1 (ru
Inventor
Бенджамин Алан Андерсон
Николас Джеймс Бах
Жоли Анн Бастиан
Нэнси Кей Харн
Ричард Вальтц Харпер
Гари Алан Хайт
Майкл Дин Кинник
Хо-Шен Лин
Ричард Джеймс Лончарик
Джон МакНейлл МакДжилл III
Эдвард Дэвид Михелик
Джон Майкл мл. Морин
Майкл ЛеРой Филлипс
Майкл Энрико Ричетт
Дэниел Джон Солл
Джейсон Скотт Сойер
Ричард Вальтер Шевитц
Роберт Теодор Василефф
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900303A2 publication Critical patent/EA199900303A2/ru
Publication of EA199900303A3 publication Critical patent/EA199900303A3/ru
Publication of EA002816B1 publication Critical patent/EA002816B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Заявлены новые трициклические соединения и применение таких соединений для ингибирования опосредованного сФЛАвысвобождения жирных кислот для лечения болезненных состояний, таких как септический шок.
EA199900303A 1998-04-17 1999-04-16 Производные карбазола EA002816B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (3)

Publication Number Publication Date
EA199900303A2 true EA199900303A2 (ru) 1999-10-28
EA199900303A3 EA199900303A3 (ru) 2000-04-24
EA002816B1 EA002816B1 (ru) 2002-10-31

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199900301A EA002347B1 (ru) 1998-04-17 1999-04-16 Замещенные трициклические соединения
EA199900303A EA002816B1 (ru) 1998-04-17 1999-04-16 Производные карбазола

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199900301A EA002347B1 (ru) 1998-04-17 1999-04-16 Замещенные трициклические соединения

Country Status (30)

Country Link
EP (2) EP0950657B1 (ru)
JP (2) JP4435330B2 (ru)
KR (2) KR100586761B1 (ru)
CN (1) CN1149193C (ru)
AR (2) AR018593A1 (ru)
AT (2) ATE271037T1 (ru)
AU (2) AU753436B2 (ru)
BR (2) BR9901279A (ru)
CA (2) CA2269246C (ru)
CO (2) CO5031247A1 (ru)
CZ (2) CZ137099A3 (ru)
DE (2) DE69917833T2 (ru)
DK (1) DK0950657T3 (ru)
DZ (1) DZ2769A1 (ru)
EA (2) EA002347B1 (ru)
ES (2) ES2222663T3 (ru)
HU (2) HUP9901221A3 (ru)
ID (2) ID23287A (ru)
IL (2) IL129483A0 (ru)
NO (2) NO314400B1 (ru)
NZ (3) NZ507564A (ru)
PE (2) PE20000476A1 (ru)
PL (2) PL332565A1 (ru)
PT (1) PT950657E (ru)
SG (2) SG81977A1 (ru)
SI (1) SI0950657T1 (ru)
TR (2) TR199900843A2 (ru)
TW (1) TWI238160B (ru)
YU (2) YU19199A (ru)
ZA (2) ZA992772B (ru)

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WO1999009978A1 (en) * 1997-08-28 1999-03-04 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2002542148A (ja) * 1998-12-21 2002-12-10 イーライ・リリー・アンド・カンパニー 敗血症の処置のための組み合わせ療法
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
EP1202963B1 (en) * 1999-07-19 2007-01-03 Eli Lilly And Company Spla2 inhibitors
AU2001267825A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
WO2002000257A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes a la maladie d'alzheimer
WO2002000255A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes contre le cancer
EP1303262A2 (en) * 2000-07-14 2003-04-23 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
EP1345898A2 (en) * 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
EP1395554B1 (en) 2001-03-28 2007-02-14 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
RU2474575C2 (ru) 2008-03-26 2013-02-10 Дайити Санкио Компани, Лимитед Новое производное тетрагидроизохинолина, фармацевтическая композиция на его основе, применение его и способ лечения и/или предотвращения заболевания
JP5637982B2 (ja) 2008-04-09 2014-12-10 インフィニティー ファーマシューティカルズ， インコーポレイテッド 脂肪酸アミド加水分解酵素の阻害剤
EP2379538A4 (en) * 2009-01-22 2013-01-02 Orchid Res Lab Ltd HETEROCYCLIC COMPOUNDS AS A PHOSOPHODIESTERASE HEMMER
US8546564B2 (en) 2009-04-07 2013-10-01 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US9034849B2 (en) 2010-02-03 2015-05-19 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
KR20150088803A (ko) * 2012-11-30 2015-08-03 지이 헬쓰케어 리미티드 트리시클릭 인돌을 생성하는 아연 할라이드 매개 고리화 방법
IN2015DN03978A (ru) 2012-11-30 2015-10-02 Ge Healthcare Ltd
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

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US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
ES2151993T3 (es) * 1995-06-23 2001-01-16 Lilly Co Eli 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
AU1289797A (en) * 1995-12-13 1997-07-03 Eli Lilly And Company Naphthyl acetamides as spla2 inhibitors
CZ136899A3 (cs) * 1996-10-30 1999-09-15 Eli Lilly And Company Substituované tricyklické sloučeniny
CA2304482A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
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DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
AU753547B2 (en) 2002-10-24
TWI238160B (en) 2005-08-21
SG81976A1 (en) 2001-07-24
JP2000026416A (ja) 2000-01-25
EA199900303A3 (ru) 2000-04-24
HU9901221A (hu) 2000-04-28
PE20000432A1 (es) 2000-05-23
CO5031247A1 (es) 2001-04-27
DE69917833D1 (de) 2004-07-15
NZ335251A (en) 2000-11-24
HU9901221D0 (en) 1999-06-28
ZA992771B (en) 2002-04-18
NZ335253A (en) 2000-11-24
AR018593A1 (es) 2001-11-28
KR19990083233A (ko) 1999-11-25
EP0950657A2 (en) 1999-10-20
IL129485A0 (en) 2000-02-29
NO991822D0 (no) 1999-04-16
HUP9901220A3 (en) 2001-11-28
ATE268756T1 (de) 2004-06-15
ZA992772B (en) 2002-07-16
SI0950657T1 (en) 2005-02-28
DK0950657T3 (da) 2004-11-22
ID23761A (id) 2000-05-11
ES2222663T3 (es) 2005-02-01
IL129483A0 (en) 2000-02-29
DE69917833T2 (de) 2005-07-14
AR018186A1 (es) 2001-10-31
EP0950657B1 (en) 2004-07-14
EP0952149B1 (en) 2004-06-09
NZ507564A (en) 2002-10-25
KR100586761B1 (ko) 2006-06-08
JPH11322713A (ja) 1999-11-24
AU2381999A (en) 1999-10-28
DE69918590T2 (de) 2005-07-21
EP0950657A3 (en) 2001-08-16
TR199900843A2 (xx) 2000-02-21
SG81977A1 (en) 2001-07-24
ID23287A (id) 2000-04-05
CA2269246A1 (en) 1999-10-17
CZ137099A3 (cs) 1999-11-17
DE69918590D1 (de) 2004-08-19
NO991821D0 (no) 1999-04-16
CN1253948A (zh) 2000-05-24
YU19199A (sh) 2002-08-12
AU753436B2 (en) 2002-10-17
TR199900853A3 (tr) 1999-11-22
CA2269246C (en) 2009-08-25
CO5011054A1 (es) 2001-02-28
CZ136999A3 (cs) 1999-11-17
BR9901279A (pt) 2000-05-02
PE20000476A1 (es) 2000-06-02
EA002347B1 (ru) 2002-04-25
ES2226286T3 (es) 2005-03-16
TR199900853A2 (xx) 1999-11-22
CN1149193C (zh) 2004-05-12
AU2381799A (en) 1999-10-28
HU9901220D0 (en) 1999-06-28
PL332565A1 (en) 1999-10-25
EA199900301A2 (ru) 1999-10-28
HUP9901221A3 (en) 2001-11-28
HU9901220A (hu) 2000-04-28
NO991821L (no) 1999-10-18
EP0952149A2 (en) 1999-10-27
ATE271037T1 (de) 2004-07-15
EP0952149A3 (en) 2001-08-16
EA199900301A3 (ru) 2000-04-24
NO312240B1 (no) 2002-04-15
NO991822L (no) 1999-10-18
JP4435330B2 (ja) 2010-03-17
PL332566A1 (en) 1999-10-25
PT950657E (pt) 2004-11-30
DZ2769A1 (fr) 2003-12-01
EA002816B1 (ru) 2002-10-31
KR19990083232A (ko) 1999-11-25
CA2269262A1 (en) 1999-10-17
YU18999A (sh) 2002-08-12
NO314400B1 (no) 2003-03-17
BR9902365A (pt) 2001-04-24

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Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU