EA199900305A1 - Замещенные трициклические соединения - Google Patents

Замещенные трициклические соединения

Info

Publication number
EA199900305A1
EA199900305A1 EA199900305A EA199900305A EA199900305A1 EA 199900305 A1 EA199900305 A1 EA 199900305A1 EA 199900305 A EA199900305 A EA 199900305A EA 199900305 A EA199900305 A EA 199900305A EA 199900305 A1 EA199900305 A1 EA 199900305A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tricyclic compounds
substituted tricyclic
compounds
spla
mediated
Prior art date
Application number
EA199900305A
Other languages
English (en)
Other versions
EA003992B1 (ru
Inventor
Николас Дж. Бах
Робер Д. Дийяр
Сьюзн Е. Драхейм
Джон М. мл. Морин
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900305A1 publication Critical patent/EA199900305A1/ru
Publication of EA003992B1 publication Critical patent/EA003992B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описывается класс новых трициклических соединений и применение таких соединений для ингибирования опосредуемого сФЛАвысвобождения жирных кислот с целью лечения таких состояний, как септический шок.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900305A 1996-10-30 1997-10-23 Замещенные трициклические соединения EA003992B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2984996P 1996-10-30 1996-10-30
PCT/US1997/019183 WO1998018464A1 (en) 1996-10-30 1997-10-23 Substituted tricyclics

Publications (2)

Publication Number Publication Date
EA199900305A1 true EA199900305A1 (ru) 1999-12-29
EA003992B1 EA003992B1 (ru) 2003-12-25

Family

ID=21851210

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900305A EA003992B1 (ru) 1996-10-30 1997-10-23 Замещенные трициклические соединения

Country Status (26)

Country Link
EP (1) EP0839806B1 (ru)
JP (1) JP2001503055A (ru)
KR (1) KR20000049210A (ru)
CN (1) CN1233176A (ru)
AR (1) AR010050A1 (ru)
AT (1) ATE244703T1 (ru)
AU (1) AU734096B2 (ru)
BR (1) BR9713261A (ru)
CA (1) CA2269203A1 (ru)
CO (1) CO4920250A1 (ru)
CZ (1) CZ136899A3 (ru)
DE (1) DE69723393T2 (ru)
DK (1) DK0839806T3 (ru)
EA (1) EA003992B1 (ru)
ES (1) ES2202560T3 (ru)
ID (1) ID18685A (ru)
IL (1) IL129481A0 (ru)
NO (1) NO314899B1 (ru)
NZ (1) NZ335246A (ru)
PE (1) PE10999A1 (ru)
PL (1) PL332896A1 (ru)
PT (1) PT839806E (ru)
TR (1) TR199900956T2 (ru)
TW (1) TW513428B (ru)
WO (1) WO1998018464A1 (ru)
YU (1) YU19299A (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
HUP0102981A3 (en) 1998-03-31 2002-10-28 Shionogi & Co Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof
ID23219A (id) * 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
PL343708A1 (en) 1998-05-01 2001-08-27 Lilly Co Eli Spla2
AU748787B2 (en) 1998-05-21 2002-06-13 Shionogi & Co., Ltd. Pyrrolo(1,2-b)pyridazine derivatives having sPLA2 inhibitory effect
EP1157704B1 (en) 1998-10-14 2006-06-14 Shionogi & Co., Ltd. Spla2 inhibitors for the treatment of ischaemic reperfusion injury
WO2000037472A2 (en) * 1998-12-22 2000-06-29 Eli Lilly And Company Substituted pirroloindoles
US6703385B1 (en) 1999-07-19 2004-03-09 Shionogi & Co., Ltd. Tricyclic compounds having sPLA2-inhibitory activities
US6673781B1 (en) 1999-08-02 2004-01-06 Shionogi & Co., Ltd. Tricyclic compounds having sPLA2-inhibitory activities
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
MY125942A (en) 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
AU1304801A (en) 1999-11-15 2001-05-30 Shionogi & Co., Ltd. Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
EP1259260A1 (en) * 2000-01-06 2002-11-27 Eli Lilly And Company Combination therapy for the treatment of inflammatory and respiratory diseases
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
AU2001267823A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
CA2431028A1 (en) 2000-12-18 2002-06-27 Ho-Shen Lin Tetracyclic carbazole derivates and their use as spla2 inhibitors
TWI314457B (ru) * 2001-03-19 2009-09-11 Shionogi & Co
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
JP3997491B2 (ja) 2004-10-29 2007-10-24 ゼリア新薬工業株式会社 カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩
EP3307323B1 (en) 2015-06-15 2022-07-13 Raziel Therapeutics Ltd. Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof
CN112409493B (zh) * 2020-08-12 2022-09-30 浙江工业大学 一种重组融合酶及其在乙醛酸甲酯合成中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479391A (en) * 1966-10-03 1969-11-18 Squibb & Sons Inc Delta**3,14-17alpha-hydroxy-norprogesterone and esters
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AR010050A1 (es) 2000-05-17
PL332896A1 (en) 1999-10-25
ATE244703T1 (de) 2003-07-15
CZ136899A3 (cs) 1999-09-15
PT839806E (pt) 2003-11-28
JP2001503055A (ja) 2001-03-06
ES2202560T3 (es) 2004-04-01
EA003992B1 (ru) 2003-12-25
DK0839806T3 (da) 2003-10-27
BR9713261A (pt) 2000-03-28
IL129481A0 (en) 2000-02-29
NO991831L (no) 1999-06-21
AU5149498A (en) 1998-05-22
AU734096B2 (en) 2001-06-07
CA2269203A1 (en) 1998-05-07
NZ335246A (en) 2001-09-28
EP0839806B1 (en) 2003-07-09
DE69723393T2 (de) 2004-06-09
NO991831D0 (no) 1999-04-16
TW513428B (en) 2002-12-11
WO1998018464A1 (en) 1998-05-07
PE10999A1 (es) 1999-02-10
DE69723393D1 (de) 2003-08-14
EP0839806A1 (en) 1998-05-06
YU19299A (sh) 2000-03-21
NO314899B1 (no) 2003-06-10
CN1233176A (zh) 1999-10-27
KR20000049210A (ko) 2000-07-25
ID18685A (id) 1998-04-30
TR199900956T2 (xx) 1999-07-21
CO4920250A1 (es) 2000-05-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU