AR010050A1 - COMPUESTO TRICíCLICO SUSTITUIDO, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE Y USO PARA FABRICAR UN MEDICAMENTO PARA INHIBIR SELECTIVAMENTE SPLA2 - Google Patents

COMPUESTO TRICíCLICO SUSTITUIDO, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE Y USO PARA FABRICAR UN MEDICAMENTO PARA INHIBIR SELECTIVAMENTE SPLA2

Info

Publication number
AR010050A1
AR010050A1 ARP970104997A ARP970104997A AR010050A1 AR 010050 A1 AR010050 A1 AR 010050A1 AR P970104997 A ARP970104997 A AR P970104997A AR P970104997 A ARP970104997 A AR P970104997A AR 010050 A1 AR010050 A1 AR 010050A1
Authority
AR
Argentina
Prior art keywords
understands
drug
manufacture
pharmaceutical composition
nitrogen
Prior art date
Application number
ARP970104997A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR010050A1 publication Critical patent/AR010050A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Abstract

Se trata de una clase de compuestos tricíclicos novedosos que está descripta conjuntamente con el uso de tales compuestos para inhibir laliberacion de ácidos grasos mediada por sPLA2 para el tratamiento de condiciones tales comoe l shock séptico. Dichos compuestos responden a laformula (III), donde A es fenilo o piridilo, donde el nitrogeno está en la posicion 5-,6-, 7- u 8-, uno de B y D es nitrogeno y el otro carbono y Z esciclohexenilo, fenilo o piridilo, con elátomo de nitrogeno en posicion 1-, 2- o 3-; o un anillo heterocíclico de 6 miembros y un heteroátomo como S o O enposicion 2 o 3 nitrogeno en 2-, 3- o 4- y los restantes símbolos tienen los valores indicados en la descripcion.
ARP970104997A 1996-10-30 1997-10-28 COMPUESTO TRICíCLICO SUSTITUIDO, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE Y USO PARA FABRICAR UN MEDICAMENTO PARA INHIBIR SELECTIVAMENTE SPLA2 AR010050A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2984996P 1996-10-30 1996-10-30

Publications (1)

Publication Number Publication Date
AR010050A1 true AR010050A1 (es) 2000-05-17

Family

ID=21851210

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104997A AR010050A1 (es) 1996-10-30 1997-10-28 COMPUESTO TRICíCLICO SUSTITUIDO, COMPOSICIoN FARMACÉUTICA QUE LO COMPRENDE Y USO PARA FABRICAR UN MEDICAMENTO PARA INHIBIR SELECTIVAMENTE SPLA2

Country Status (26)

Country Link
EP (1) EP0839806B1 (es)
JP (1) JP2001503055A (es)
KR (1) KR20000049210A (es)
CN (1) CN1233176A (es)
AR (1) AR010050A1 (es)
AT (1) ATE244703T1 (es)
AU (1) AU734096B2 (es)
BR (1) BR9713261A (es)
CA (1) CA2269203A1 (es)
CO (1) CO4920250A1 (es)
CZ (1) CZ136899A3 (es)
DE (1) DE69723393T2 (es)
DK (1) DK0839806T3 (es)
EA (1) EA003992B1 (es)
ES (1) ES2202560T3 (es)
ID (1) ID18685A (es)
IL (1) IL129481A0 (es)
NO (1) NO314899B1 (es)
NZ (1) NZ335246A (es)
PE (1) PE10999A1 (es)
PL (1) PL332896A1 (es)
PT (1) PT839806E (es)
TR (1) TR199900956T2 (es)
TW (1) TW513428B (es)
WO (1) WO1998018464A1 (es)
YU (1) YU19299A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
HUP0102981A3 (en) 1998-03-31 2002-10-28 Shionogi & Co Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
IL129484A0 (en) * 1998-04-17 2000-02-29 Lilly Co Eli Substituted tricyclics
HUP0102243A2 (hu) 1998-05-01 2001-10-28 Eli Lilly And Co. sPLA2-inhibitor vegyületek betegség kezelésére
JP4544446B2 (ja) 1998-05-21 2010-09-15 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有するピロロ［１，２−ｂ］ピリダジン誘導体
ATE329619T1 (de) 1998-10-14 2006-07-15 Shionogi & Co Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden
DE69910432D1 (de) * 1998-12-22 2003-09-18 Lilly Co Eli Substituierte pyrroloindole
JP4636521B2 (ja) 1999-07-19 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環系化合物
US6673781B1 (en) 1999-08-02 2004-01-06 Shionogi & Co., Ltd. Tricyclic compounds having sPLA2-inhibitory activities
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
MY125942A (en) 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
US6756376B1 (en) 1999-11-15 2004-06-29 Shionogi & Co., Ltd. Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities
EP1259260A1 (en) * 2000-01-06 2002-11-27 Eli Lilly And Company Combination therapy for the treatment of inflammatory and respiratory diseases
AU2001267823A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
EP1345898A2 (en) * 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
TWI314457B (es) 2001-03-19 2009-09-11 Shionogi & Co
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
AU2005297800B2 (en) 2004-10-29 2011-02-03 Zeria Pharmaceutical Co., Ltd. Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof
US10632102B2 (en) 2015-06-15 2020-04-28 Raziel Therapeutics Ltd Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof
CN112409493B (zh) * 2020-08-12 2022-09-30 浙江工业大学 一种重组融合酶及其在乙醛酸甲酯合成中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479391A (en) * 1966-10-03 1969-11-18 Squibb & Sons Inc Delta**3,14-17alpha-hydroxy-norprogesterone and esters
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors

Also Published As

Publication number Publication date
DE69723393T2 (de) 2004-06-09
CO4920250A1 (es) 2000-05-29
ES2202560T3 (es) 2004-04-01
ATE244703T1 (de) 2003-07-15
CN1233176A (zh) 1999-10-27
PT839806E (pt) 2003-11-28
EA003992B1 (ru) 2003-12-25
KR20000049210A (ko) 2000-07-25
EP0839806B1 (en) 2003-07-09
PE10999A1 (es) 1999-02-10
DE69723393D1 (de) 2003-08-14
NO314899B1 (no) 2003-06-10
NZ335246A (en) 2001-09-28
DK0839806T3 (da) 2003-10-27
PL332896A1 (en) 1999-10-25
IL129481A0 (en) 2000-02-29
YU19299A (sh) 2000-03-21
ID18685A (id) 1998-04-30
TW513428B (en) 2002-12-11
BR9713261A (pt) 2000-03-28
NO991831D0 (no) 1999-04-16
EP0839806A1 (en) 1998-05-06
EA199900305A1 (ru) 1999-12-29
TR199900956T2 (xx) 1999-07-21
NO991831L (no) 1999-06-21
AU5149498A (en) 1998-05-22
AU734096B2 (en) 2001-06-07
WO1998018464A1 (en) 1998-05-07
CZ136899A3 (cs) 1999-09-15
CA2269203A1 (en) 1998-05-07
JP2001503055A (ja) 2001-03-06

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