HU9901221A - Helyettesített triciklusos vegyületek és alkalmazásuk gyógyászati készítményekben - Google Patents
Helyettesített triciklusos vegyületek és alkalmazásuk gyógyászati készítményekbenInfo
- Publication number
- HU9901221A HU9901221A HU9901221A HUP9901221A HU9901221A HU 9901221 A HU9901221 A HU 9901221A HU 9901221 A HU9901221 A HU 9901221A HU P9901221 A HUP9901221 A HU P9901221A HU 9901221 A HU9901221 A HU 9901221A
- Authority
- HU
- Hungary
- Prior art keywords
- carbamoyl
- alkyl
- substituted
- phenyl
- alkane
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 5
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- -1 cyano, substituted amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003549 thiazolines Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A szekréciós főszfőlipáz A2 enzim által mediált zsírsav-felszabadűlásgátlására és az ezzel összefüggő betegségek és állapőtők kezelésérehasználható (I) és (II) általánős képletű triciklűsős vegyületek, ezekgyógyászatilag elfőgadható racemátjai, szőlvátjai, taűtőmerjei őptikaiizőmerjei, prődrűg jellegű származékai és sói, valamint az ezekettartalmazó gyógyászati készítmények, tővábbá eljárás mindezekelőállítására és alkalmazására, ahől az (I) általánős képletben Z ciklőhexencsőpőrtőt vagy fenilcsőpőrtőt jelöl, R20 jelentése helyettesített vagy helyettesítetlen, 5-20 szénatőmősalkilcsőpőrt, alkenilcsőpőrt, alkinilcsőpőrt, karbőciklűsős vagyheterőciklűsős csőpőrt, amely adőtt esetben őxigénatőmőn, kénatőmőn,egy vagy két nitrőgénatőmőn vagy egy - adőtt esetben őxigénatőmőt vagykénatőmőt is tartalmazó - szénhidrőgéncsőpőrtőn keresztül kapcsőlódika mőlekűla többi részéhez, R21 jelentése valamely semleges helyettesítő csőpőrt, ahől f jelentése1, 2 vagy 3, R1' jelentése hidrazőnicsőpőrt, aminőcsőpőrt vagy karbamőilcsőpőrt, R2' jelentése hidrőxilcsőpőrt vagy -O(CH2)tR5' általánős képletűcsőpőrt, ahől R5' jelentése hidrőgénatőm, cianőcsőpőrt, aminőcsőpőrt,karbamőilcsőpőrt, alkánszűlfőnamidőcsőpőrt, alkánszűlfőnamidő-karbőnil-csőpőrt, adőtt esetben helyettesített fenilcsőpőrt, vagypedig adőtt esetben egy összekötő csőpőrtőn keresztül kapcsőlódó savascsőpőrt, és t jelentése 1, 2, 3, 4 vagy 5, és R3' jelentése egy semleges helyettesítő csőpőrt vagy adőtt esetbenhelyettesített karbőciklűsős vagy heterőciklűsős csőpőrt, és az (II)általánős képletben Z és R21 jelentése az (I) általánős képletre megadőtt, R1 jelentése hidrazinőcsőpőrt vagy aminőcsőpőrt, R2 jelentése hidrőxilcsőpőrt vagy -O(CH2)mR5 általánős képletűcsőpőrt, ahől R5 jelentése hidrőgénatőm, karbőxilcsőpőrt,karbamőilcsőpőrt, alkőxi-karbőnil-csőpőrt, -P(O)(R6R7) általánősképletű csőpőrt, ahől R6 és R7 jelentése hidrőxilcsőpőrt vagy 1-4szénatőmős alkőxicsőpőrt, szűlfőcsőpőrt, szűlfőnsav-alkil-észter-csőpőrt, tetrazőlilssőpőrt, cianőcsőpőrt, aminőcsőpőrt vagy adőttesetben helyettesített és/vagy adőtt esetben karbőnilcsőpőrtőnkeresztül kapcsőlódó alkánszűlfőnamidőcsőpőrt vagyarilszűlfőnaminőcsőpőrt, és m jelentése 1, 2 vagy 3, R3 jelentése hidrőgénatőm, alkőxicsőpőrt, halőgénatőm, alkilcsőpőrt,fenil-alkil-csőpőrt, alkilcsőpőrttal, halőgénatőmmal vagy triflűőr-metil-csőpőrttal helyettesített fenilcsőpőrt, alkil-szililőxi-metil-csőpőrt, fűrilcsőpőrt, tienilcsőpőrt, hidrőxi-alkil-csőpőrt, vagy -(CH2)nR8 általánős képletű csőpőrt, ahől R8 jelentése hidrőgénatőm,karbamőilcsőpőrt, -NR9R10 általánős képletű csőpőrt, cianőcsőpőrt vagyfenilcsőpőrt, ahől R9 és R10 jelentése alkilcsőpőrt, fenil-alkil-csőpőrt vagy alkil-fenil-csőpőrt, és n jelentése 1, 2, 3, 4, 5, 6, 7vagy 8, és R4 jelentése hidrőgénatőm, alkilcsőpőrt, ciklőalkilcsőpőrt,piridilcsőpőrt, adőtt
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6232898A | 1998-04-17 | 1998-04-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9901221D0 HU9901221D0 (en) | 1999-06-28 |
| HU9901221A true HU9901221A (hu) | 2000-04-28 |
| HUP9901221A3 HUP9901221A3 (en) | 2001-11-28 |
Family
ID=22041763
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901220A HUP9901220A3 (en) | 1998-04-17 | 1999-04-16 | Substituted tricyclic compounds and their use in pharmaceutical compositions |
| HU9901221A HUP9901221A3 (en) | 1998-04-17 | 1999-04-16 | Substituted tricyclic compounds and their use in pharmaceutical compositions |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901220A HUP9901220A3 (en) | 1998-04-17 | 1999-04-16 | Substituted tricyclic compounds and their use in pharmaceutical compositions |
Country Status (30)
| Country | Link |
|---|---|
| EP (2) | EP0950657B1 (hu) |
| JP (2) | JP4435330B2 (hu) |
| KR (2) | KR19990083232A (hu) |
| CN (1) | CN1149193C (hu) |
| AR (2) | AR018593A1 (hu) |
| AT (2) | ATE268756T1 (hu) |
| AU (2) | AU753547B2 (hu) |
| BR (2) | BR9902365A (hu) |
| CA (2) | CA2269246C (hu) |
| CO (2) | CO5031247A1 (hu) |
| CZ (2) | CZ136999A3 (hu) |
| DE (2) | DE69918590T2 (hu) |
| DK (1) | DK0950657T3 (hu) |
| DZ (1) | DZ2769A1 (hu) |
| EA (2) | EA002347B1 (hu) |
| ES (2) | ES2226286T3 (hu) |
| HU (2) | HUP9901220A3 (hu) |
| ID (2) | ID23761A (hu) |
| IL (2) | IL129483A0 (hu) |
| NO (2) | NO314400B1 (hu) |
| NZ (3) | NZ335251A (hu) |
| PE (2) | PE20000432A1 (hu) |
| PL (2) | PL332565A1 (hu) |
| PT (1) | PT950657E (hu) |
| SG (2) | SG81976A1 (hu) |
| SI (1) | SI0950657T1 (hu) |
| TR (2) | TR199900853A2 (hu) |
| TW (1) | TWI238160B (hu) |
| YU (2) | YU18999A (hu) |
| ZA (2) | ZA992771B (hu) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1011670A4 (en) * | 1997-08-28 | 2004-10-27 | Lilly Co Eli | PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| CA2358492A1 (en) * | 1998-12-21 | 2000-06-29 | Eli Lilly And Company | Combination therapy for the treatment of sepsis |
| US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
| DE60032774D1 (de) * | 1999-07-19 | 2007-02-15 | Lilly Co Eli | Spla2 inhibitoren |
| US20040102442A1 (en) * | 2000-06-29 | 2004-05-27 | Kohji Hanasaki | Remedies for alzheimer's disease |
| AU2001267824A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cancer |
| US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
| WO2002005796A2 (en) * | 2000-07-14 | 2002-01-24 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
| CA2431028A1 (en) * | 2000-12-18 | 2002-06-27 | Ho-Shen Lin | Tetracyclic carbazole derivates and their use as spla2 inhibitors |
| DE60218155D1 (de) | 2001-03-28 | 2007-03-29 | Lilly Co Eli | Substituierte carbazole als inhibitoren von spla2 |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| DE10249055A1 (de) | 2002-10-22 | 2004-05-06 | Bayer Cropscience Ag | 2-Phenyl-2-substituierte-1,3-diketone |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
| MX2010010471A (es) | 2008-03-26 | 2010-10-20 | Daiichi Sankyo Co Ltd | Derivado de tetrahidroisoquinolina novedoso. |
| CA2721060A1 (en) | 2008-04-09 | 2009-10-15 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| EP2379538A4 (en) * | 2009-01-22 | 2013-01-02 | Orchid Res Lab Ltd | HETEROCYCLIC COMPOUNDS AS A PHOSOPHODIESTERASE HEMMER |
| EP2416660B1 (en) | 2009-04-07 | 2014-07-02 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| AU2010234449A1 (en) | 2009-04-07 | 2011-11-03 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| BR112012019120A2 (pt) | 2010-02-03 | 2016-06-28 | Infinity Pharmaceuticais Inc | forma sólida, composição farmacêutica, método de preparação do composto 1, método de tratamento de uma condição mediada por faah |
| AR088377A1 (es) | 2011-10-20 | 2014-05-28 | Siena Biotech Spa | Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta |
| CN102816107B (zh) * | 2012-08-20 | 2015-06-03 | 东南大学 | 咔唑衍生物及其制备方法与用途 |
| WO2014083163A1 (en) | 2012-11-30 | 2014-06-05 | Ge Healthcare Limited | Zinc halide mediated cyclization process leading to tricyclic indoles |
| KR20150088802A (ko) | 2012-11-30 | 2015-08-03 | 지이 헬쓰케어 리미티드 | 트리시클릭 인돌 유도체의 결정화 방법 |
| EP3248230B1 (de) * | 2015-01-20 | 2020-05-06 | cynora GmbH | Verwendung organischer moleküle in optoelektronischen bauelementen |
| CN108707104A (zh) * | 2018-08-07 | 2018-10-26 | 北京恒信卓元科技有限公司 | 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3579534A (en) * | 1969-05-09 | 1971-05-18 | American Cyanamid Co | Tetrahydrocarbazolecarboxylates |
| US3939177A (en) * | 1972-11-22 | 1976-02-17 | Sterling Drug Inc. | 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles |
| US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| CA2110514A1 (en) * | 1991-07-05 | 1993-01-21 | Raymond Baker | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| DE69610793T2 (de) * | 1995-06-23 | 2001-05-03 | Eli Lilly And Co., Indianapolis | 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole |
| WO1997021664A1 (en) * | 1995-12-13 | 1997-06-19 | Eli Lilly And Company | NAPHTHYL ACETAMIDES AS sPLA2 INHIBITORS |
| JP2001503055A (ja) * | 1996-10-30 | 2001-03-06 | イーライ・リリー・アンド・カンパニー | 置換三環化合物群 |
| CA2304482A1 (en) * | 1997-09-26 | 1999-04-08 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
| JP2001522884A (ja) * | 1997-11-14 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | アルツハイマー病の処置方法 |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
-
1999
- 1999-04-14 DZ DZ990069A patent/DZ2769A1/xx active
- 1999-04-15 ID IDP990341D patent/ID23761A/id unknown
- 1999-04-15 IL IL12948399A patent/IL129483A0/xx unknown
- 1999-04-15 ID IDP990340D patent/ID23287A/id unknown
- 1999-04-15 IL IL12948599A patent/IL129485A0/xx unknown
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- 1999-04-16 JP JP15240099A patent/JP4435330B2/ja not_active Expired - Fee Related
- 1999-04-16 DE DE69918590T patent/DE69918590T2/de not_active Expired - Lifetime
- 1999-04-16 PL PL99332565A patent/PL332565A1/xx not_active Application Discontinuation
- 1999-04-16 PE PE1999000314A patent/PE20000432A1/es not_active Application Discontinuation
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- 1999-04-16 ES ES99302967T patent/ES2226286T3/es not_active Expired - Lifetime
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