DZ2769A1 - Composés tricycliques substitués. - Google Patents

Composés tricycliques substitués.

Info

Publication number
DZ2769A1
DZ2769A1 DZ990069A DZ990069A DZ2769A1 DZ 2769 A1 DZ2769 A1 DZ 2769A1 DZ 990069 A DZ990069 A DZ 990069A DZ 990069 A DZ990069 A DZ 990069A DZ 2769 A1 DZ2769 A1 DZ 2769A1
Authority
DZ
Algeria
Prior art keywords
substituted tricyclics
tricyclics
substituted
Prior art date
Application number
DZ990069A
Other languages
English (en)
French (fr)
Inventor
Anderson Benjamin Alan
Bach Nicholas James
Bastian Jolie Anne
Ham Nancy Kay
Harper Richard Waltz
Hite Gary Alan
Kinnick Michael Dean
Lin Ho-Shen
Richard James Loncharich
John Mcneil Mcgill
Edward David Mihelich
John Michael Morin Jr
Michael Leroy Philips
Michael Enrico Richett
Daniel Jon Sall
Jason Scott Sawyer
Richard Walter Schevitz
Robert Theodore Vasileif
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DZ2769A1 publication Critical patent/DZ2769A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DZ990069A 1998-04-17 1999-04-14 Composés tricycliques substitués. DZ2769A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
DZ2769A1 true DZ2769A1 (fr) 2003-12-01

Family

ID=22041763

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ990069A DZ2769A1 (fr) 1998-04-17 1999-04-14 Composés tricycliques substitués.

Country Status (30)

Country Link
EP (2) EP0950657B1 (xx)
JP (2) JPH11322713A (xx)
KR (2) KR100586761B1 (xx)
CN (1) CN1149193C (xx)
AR (2) AR018593A1 (xx)
AT (2) ATE271037T1 (xx)
AU (2) AU753436B2 (xx)
BR (2) BR9902365A (xx)
CA (2) CA2269246C (xx)
CO (2) CO5011054A1 (xx)
CZ (2) CZ137099A3 (xx)
DE (2) DE69918590T2 (xx)
DK (1) DK0950657T3 (xx)
DZ (1) DZ2769A1 (xx)
EA (2) EA002816B1 (xx)
ES (2) ES2226286T3 (xx)
HU (2) HUP9901220A3 (xx)
ID (2) ID23761A (xx)
IL (2) IL129485A0 (xx)
NO (2) NO314400B1 (xx)
NZ (3) NZ335253A (xx)
PE (2) PE20000476A1 (xx)
PL (2) PL332565A1 (xx)
PT (1) PT950657E (xx)
SG (2) SG81976A1 (xx)
SI (1) SI0950657T1 (xx)
TR (2) TR199900843A2 (xx)
TW (1) TWI238160B (xx)
YU (2) YU19199A (xx)
ZA (2) ZA992771B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009978A1 (en) * 1997-08-28 1999-03-04 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2002542148A (ja) * 1998-12-21 2002-12-10 イーライ・リリー・アンド・カンパニー 敗血症の処置のための組み合わせ療法
EP1202963B1 (en) * 1999-07-19 2007-01-03 Eli Lilly And Company Spla2 inhibitors
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
ATE375171T1 (de) * 2000-06-29 2007-10-15 Anthera Pharmaceuticals Inc Heilmittel für krebs
WO2002000256A1 (en) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedies for cirrhosis
US20040102442A1 (en) * 2000-06-29 2004-05-27 Kohji Hanasaki Remedies for alzheimer's disease
AU2001272915A1 (en) * 2000-07-14 2002-01-30 Eli Lilly And Company Method for treating sepsis
AU2002239263A1 (en) * 2000-12-18 2002-07-01 Eli Lilly And Company Tetracyclic carbazole derivates and their use as spla2 inhibitors
US6933313B2 (en) 2001-03-28 2005-08-23 Eli Lilly And Company Substituted carbazoles as inhibitors of sPLA2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
KR20100124771A (ko) 2008-03-26 2010-11-29 다이이찌 산쿄 가부시키가이샤 신규 테트라하이드로이소퀴놀린 유도체
EP2282742A1 (en) 2008-04-09 2011-02-16 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
EP2379538A4 (en) * 2009-01-22 2013-01-02 Orchid Res Lab Ltd HETEROCYCLIC COMPOUNDS AS A PHOSOPHODIESTERASE HEMMER
JP2012523424A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
MX336742B (es) 2010-02-03 2016-01-29 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso.
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
AU2013351126B2 (en) * 2012-11-30 2017-12-14 Ge Healthcare Limited Zinc halide mediated cyclization process leading to tricyclic indoles
CN104837489A (zh) 2012-11-30 2015-08-12 通用电气健康护理有限公司 三环吲哚衍生物的结晶方法
EP3248230B1 (de) * 2015-01-20 2020-05-06 cynora GmbH Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
JPH06509087A (ja) * 1991-07-05 1994-10-13 メルク　シヤープ　エンド　ドーム　リミテツド 芳香族化合物、それらを含む医薬組成物、及び治療におけるそれらの使用
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles
IL124866A (en) * 1995-12-13 2002-08-14 Lilly Co Eli Naphthalide acetamides as sPLA2 inhibitors
WO1998018464A1 (en) * 1996-10-30 1998-05-07 Eli Lilly And Company Substituted tricyclics
WO1999016453A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
EA199900303A3 (ru) 2000-04-24
CO5011054A1 (es) 2001-02-28
BR9902365A (pt) 2001-04-24
SG81976A1 (en) 2001-07-24
DE69918590T2 (de) 2005-07-21
DE69917833D1 (de) 2004-07-15
AU753436B2 (en) 2002-10-17
JP2000026416A (ja) 2000-01-25
PL332566A1 (en) 1999-10-25
NO312240B1 (no) 2002-04-15
YU19199A (sh) 2002-08-12
CN1149193C (zh) 2004-05-12
TWI238160B (en) 2005-08-21
HUP9901221A3 (en) 2001-11-28
CA2269262A1 (en) 1999-10-17
EA199900303A2 (ru) 1999-10-28
CZ137099A3 (cs) 1999-11-17
TR199900853A3 (tr) 1999-11-22
HU9901221D0 (en) 1999-06-28
ZA992772B (en) 2002-07-16
EP0952149A2 (en) 1999-10-27
HU9901220A (hu) 2000-04-28
ES2222663T3 (es) 2005-02-01
DE69917833T2 (de) 2005-07-14
NO991821D0 (no) 1999-04-16
CO5031247A1 (es) 2001-04-27
YU18999A (sh) 2002-08-12
KR19990083232A (ko) 1999-11-25
AU2381999A (en) 1999-10-28
ATE271037T1 (de) 2004-07-15
ATE268756T1 (de) 2004-06-15
EP0950657B1 (en) 2004-07-14
SI0950657T1 (en) 2005-02-28
NZ335251A (en) 2000-11-24
TR199900853A2 (xx) 1999-11-22
NO314400B1 (no) 2003-03-17
EP0950657A2 (en) 1999-10-20
CN1253948A (zh) 2000-05-24
EP0950657A3 (en) 2001-08-16
AR018186A1 (es) 2001-10-31
PE20000432A1 (es) 2000-05-23
TR199900843A2 (xx) 2000-02-21
HU9901221A (hu) 2000-04-28
SG81977A1 (en) 2001-07-24
EP0952149A3 (en) 2001-08-16
BR9901279A (pt) 2000-05-02
EP0952149B1 (en) 2004-06-09
CA2269246A1 (en) 1999-10-17
CZ136999A3 (cs) 1999-11-17
PT950657E (pt) 2004-11-30
KR19990083233A (ko) 1999-11-25
EA199900301A2 (ru) 1999-10-28
AR018593A1 (es) 2001-11-28
EA199900301A3 (ru) 2000-04-24
CA2269246C (en) 2009-08-25
PE20000476A1 (es) 2000-06-02
IL129483A0 (en) 2000-02-29
NO991822L (no) 1999-10-18
JP4435330B2 (ja) 2010-03-17
AU2381799A (en) 1999-10-28
HU9901220D0 (en) 1999-06-28
PL332565A1 (en) 1999-10-25
DK0950657T3 (da) 2004-11-22
NO991822D0 (no) 1999-04-16
IL129485A0 (en) 2000-02-29
ZA992771B (en) 2002-04-18
NO991821L (no) 1999-10-18
JPH11322713A (ja) 1999-11-24
HUP9901220A3 (en) 2001-11-28
ID23287A (id) 2000-04-05
NZ335253A (en) 2000-11-24
ID23761A (id) 2000-05-11
ES2226286T3 (es) 2005-03-16
KR100586761B1 (ko) 2006-06-08
EA002816B1 (ru) 2002-10-31
DE69918590D1 (de) 2004-08-19
NZ507564A (en) 2002-10-25
EA002347B1 (ru) 2002-04-25
AU753547B2 (en) 2002-10-24

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