YU19099A - Supstituisani tricikli - Google Patents
Supstituisani tricikliInfo
- Publication number
- YU19099A YU19099A YU19099A YU19099A YU19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- nitrogen
- sulfur
- hydrogen
- carbon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na nova supstituisana triciklicna jedinjenja koja su pogodna za inhibiranje sPLA2 posredno oslobodjenog iz masnih kiselina u uslovima kao sto je septicni sok, i koja se mogu predstaviti opstom formulom I: A je fenil ili piridin, gde je azot u polozaju 5-, 6-, 7- ili 8; jedan od B ili D je azot i drugi je ugljenik; Z-cikloheksenil ili fenil, piridil, pri cemu azot je u polozaju 1-, 2- ili 3-, ili 6-clani heterociklicni prsten sa jednim heteroatomom izabranim iz grupe koju cine sumpor ili kiseonik u polozaju 1-, 2-, ili 3- i azot u polozaju 1-, 2-, 3-, ili 4-; ---- je dvostruka ili jednostruka veza; R20 se bira iz grupa (a), (b) i (c) gde je: (a) -(C5-C20) alkil, -(C5-C20) alkenil, -(C5-C20) alkinil, karbociklicni radikali, ili heterociklicni radikali, ili (b) clan od (a) supstituisan sa jednim ili vise nezavisno izabranih ne-interreagujucih substituenata; ili (c) je grupa -(L)-R80; gde, (L)-je dvovalentna vezujuca grupa od 1 ili 12 atoma izabranih od ugljenika, vodonika, kiseonika, azota, ili sumpora; gde je kombinacija atoma u -(L) izabrana iz grupe koja se sastoji od (i) ugljenika i vodonika jedino, (ii) samo jednog sumpora, (iii) samo jednog kiseonika, (iv) jedino od jednog ili dva azota i vodonika, (v) samo od ugljenika, vodonika, i jednog sumpora, i (vi) samo od ugljenika, vodonika i kiseonika; i gde je R80 je grupa izabrana iz (a) ili (b); R21 je ne-interreagujucih substituenata gde je f od 1-3; R1 je -NHNH2, -NH2, ili -CONH2; R2 se bira iz grupa koje sadrze -OH, i -O(CH2)tR5 gde R5 je H, -CH, -NH2, -CONH2, -CONR9R10 - NHSO2R15, -CONHSO2R15 gde R15 cini -(C1-C6) alkil ili -CF3; fenil ili fenil supstituisan sa -CO2H ili -CO2(C1-C4) alkil; i-(La)-kisela grupa, gde je -(La)- je kiseli veznik koji ima duzinu kiselog veznog dela od 1 do 7 i t je 1-5. R3 se bira od ne-interagujucih substituenata, karbociklicnih radikala, i heterociklicnih radikala substituisanih sa ne-interagujucim substituentima; ili farmaceutski prihvatljivih racemata, solvata, tautomera, optickih izomera, prolekovitih derivata ili njihovih soli; pod uslovom da jedan od A ili Z je heterociklicni prsten i kada D je azot, hetero atom u Z se bira iz grupe koju cine sumpor ili kiseonik u polozaju 1-, 2-, ili 3-, i azot u polozaju 1-, 2-, 3-, ili 4-.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6216598A | 1998-04-17 | 1998-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU19099A true YU19099A (sh) | 2001-09-28 |
Family
ID=22040624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU19099A YU19099A (sh) | 1998-04-17 | 1999-04-16 | Supstituisani tricikli |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP1156050B1 (sh) |
| JP (1) | JP4435325B2 (sh) |
| KR (1) | KR19990083234A (sh) |
| CN (1) | CN1235968A (sh) |
| AR (1) | AR018185A1 (sh) |
| AT (2) | ATE259818T1 (sh) |
| AU (1) | AU757454B2 (sh) |
| BR (1) | BR9901275A (sh) |
| CA (1) | CA2269256A1 (sh) |
| CO (1) | CO5080728A1 (sh) |
| CZ (1) | CZ137199A3 (sh) |
| DE (2) | DE69914951T2 (sh) |
| EA (1) | EA003129B1 (sh) |
| ES (2) | ES2213668T3 (sh) |
| HU (1) | HUP9901219A1 (sh) |
| ID (1) | ID23219A (sh) |
| IL (1) | IL129484A0 (sh) |
| NO (1) | NO991823L (sh) |
| NZ (1) | NZ335252A (sh) |
| PE (1) | PE20000472A1 (sh) |
| PL (1) | PL332564A1 (sh) |
| SG (1) | SG106035A1 (sh) |
| SV (1) | SV1999000052A (sh) |
| TR (1) | TR199900842A2 (sh) |
| TW (1) | TW555760B (sh) |
| YU (1) | YU19099A (sh) |
| ZA (1) | ZA992773B (sh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009978A1 (en) * | 1997-08-28 | 1999-03-04 | Eli Lilly And Company | Method for treatment of non-rheumatoid athritis |
| WO2001074817A1 (fr) * | 2000-03-30 | 2001-10-11 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'hydrazide |
| CA2413582A1 (en) * | 2000-07-14 | 2002-01-24 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
| DE60120758T2 (de) * | 2000-12-18 | 2007-05-16 | Eli Lilly And Co., Indianapolis | Tetracyclische derivate als spla2 inhibitoren |
| US6933313B2 (en) | 2001-03-28 | 2005-08-23 | Eli Lilly And Company | Substituted carbazoles as inhibitors of sPLA2 |
| JP2005527464A (ja) * | 2001-08-09 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体 |
| ATE312817T1 (de) | 2001-08-09 | 2005-12-15 | Lilly Co Eli | Cyclohept'bö indolderivate als spla2-inhibitoren |
| US6992100B2 (en) | 2001-12-06 | 2006-01-31 | Eli Lilly And Company | sPLA2 inhibitors |
| WO2006050007A2 (en) | 2004-11-01 | 2006-05-11 | Wyeth | Substituted indolizines and derivatives as cns agents |
| ES2523580T3 (es) | 2008-01-11 | 2014-11-27 | Albany Molecular Research, Inc. | Piridoindoles substituidos con (1-Azinona) |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| MX338516B (es) * | 2011-04-14 | 2016-04-20 | Actelion Pharmaceuticals Ltd | Derivados de acido 7- (heteroaril-amino) -6, 7, 8, 9- tetrahidropirido[1,2-a] indol acetico y sus usos como modulador del receptor de prostaglandina. |
| PL2825541T3 (pl) | 2012-03-16 | 2016-12-30 | Modulatory receptora x wątroby | |
| SI2825542T1 (sl) | 2012-03-16 | 2017-01-31 | Vitae Pharmaceutical Inc., | Modulatorji jetrnega receptorja X |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| US6645976B1 (en) * | 1994-07-21 | 2003-11-11 | Eli Lilly And Company | Indolizine SPLA2inhibitors |
| CA2240395A1 (en) * | 1995-12-13 | 1997-06-19 | David Kent Herron | Naphthyl acetamides as spla2 inhibitors |
| IL129481A0 (en) * | 1996-10-30 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| WO1999016453A1 (en) * | 1997-09-26 | 1999-04-08 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
| JP2001522884A (ja) * | 1997-11-14 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | アルツハイマー病の処置方法 |
-
1999
- 1999-04-15 ID IDP990342D patent/ID23219A/id unknown
- 1999-04-15 IL IL12948499A patent/IL129484A0/xx unknown
- 1999-04-16 PL PL99332564A patent/PL332564A1/xx not_active Application Discontinuation
- 1999-04-16 AT AT01203116T patent/ATE259818T1/de not_active IP Right Cessation
- 1999-04-16 DE DE69914951T patent/DE69914951T2/de not_active Expired - Fee Related
- 1999-04-16 PE PE1999000321A patent/PE20000472A1/es not_active Application Discontinuation
- 1999-04-16 CO CO99022891A patent/CO5080728A1/es unknown
- 1999-04-16 EA EA199900304A patent/EA003129B1/ru not_active IP Right Cessation
- 1999-04-16 AU AU23818/99A patent/AU757454B2/en not_active Ceased
- 1999-04-16 ES ES01203116T patent/ES2213668T3/es not_active Expired - Lifetime
- 1999-04-16 TW TW088106131A patent/TW555760B/zh not_active IP Right Cessation
- 1999-04-16 SG SG9901844A patent/SG106035A1/en unknown
- 1999-04-16 KR KR1019990013439A patent/KR19990083234A/ko not_active Application Discontinuation
- 1999-04-16 TR TR1999/00842A patent/TR199900842A2/xx unknown
- 1999-04-16 HU HU9901219A patent/HUP9901219A1/hu unknown
- 1999-04-16 DE DE69912670T patent/DE69912670T2/de not_active Expired - Fee Related
- 1999-04-16 NO NO991823A patent/NO991823L/no not_active Application Discontinuation
- 1999-04-16 SV SV1999000052A patent/SV1999000052A/es not_active Application Discontinuation
- 1999-04-16 AT AT99302969T patent/ATE254128T1/de not_active IP Right Cessation
- 1999-04-16 NZ NZ335252A patent/NZ335252A/xx unknown
- 1999-04-16 ES ES99302969T patent/ES2210979T3/es not_active Expired - Lifetime
- 1999-04-16 EP EP01203116A patent/EP1156050B1/en not_active Expired - Lifetime
- 1999-04-16 CA CA002269256A patent/CA2269256A1/en not_active Abandoned
- 1999-04-16 BR BR9901275-8A patent/BR9901275A/pt not_active IP Right Cessation
- 1999-04-16 AR ARP990101769A patent/AR018185A1/es not_active Application Discontinuation
- 1999-04-16 EP EP99302969A patent/EP0950661B1/en not_active Expired - Lifetime
- 1999-04-16 JP JP10965699A patent/JP4435325B2/ja not_active Expired - Fee Related
- 1999-04-16 CN CN99108097A patent/CN1235968A/zh active Pending
- 1999-04-16 YU YU19099A patent/YU19099A/sh unknown
- 1999-04-16 CZ CZ991371A patent/CZ137199A3/cs unknown
- 1999-04-16 ZA ZA9902773A patent/ZA992773B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU19099A (sh) | Supstituisani tricikli | |
| YU19199A (sh) | Supstituisani tricikli | |
| RU95108387A (ru) | Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина | |
| BR9911048A (pt) | Inibidor de spla2 de pirrolo[1,2-b]piridazina | |
| CO4920250A1 (es) | Compuestos heterociclicos utiles en la inhibicion de la spla2 | |
| ES2046202T3 (es) | Un procedimiento para preparar un analogo de distamicina a. | |
| FI931763A (fi) | 4,1-bensoxazepinderivat och deras anvaendning | |
| DK1026147T3 (da) | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater | |
| ZA877518B (en) | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressandihydropyridine derivatives,their preparation and their usts e | |
| NO20004881L (no) | Pyrrolo[1,2-a]pyrazin sPLA2 inhibitor | |
| AU3415599A (en) | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents | |
| HU9300197D0 (en) | 4-aryl-3(heteroaryl-ureido)-1,2-dihydro-2-oxo-quinoline derivatives and method for producing them | |
| GR3021084T3 (en) | Isochromane derivatives | |
| KR960022438A (ko) | 나프틸옥시아세트산 유도체 | |
| ECSP972301A (es) | Triciclicos sustituidos |