PE20000472A1 - Compuestos triciclicos sustituidos - Google Patents
Compuestos triciclicos sustituidosInfo
- Publication number
- PE20000472A1 PE20000472A1 PE1999000321A PE00032199A PE20000472A1 PE 20000472 A1 PE20000472 A1 PE 20000472A1 PE 1999000321 A PE1999000321 A PE 1999000321A PE 00032199 A PE00032199 A PE 00032199A PE 20000472 A1 PE20000472 A1 PE 20000472A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- conh2
- pyridyl
- interfering
- substitute
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS TRICICLICOS I, DONDE A ES FENILO, PIRIDILO, EL N ESTA EN POSICION 5, 6, 7 o 8; B o D ES N Y EL OTRO ES C; Z ES CICLOHEXENILO, FENILO, PIRIDILO, EL N ESTA EN POSICION 1, 2 o 3; ANILLO HETEROCICLICO DE 6 MIEMBROS CON UN O, S EN LA POSICION 1, 2 o 3 Y EL N ESTA EN LA POSICION 1, 2, 3 o 4; R20 ES 1)-ALQUILO C5-C20, -ALQUENILO C5-C20, -ALQUINILO C5-C20, RADICALES CARBOCICLICOS O HETEROCICLICOS OPCIONALMENTE SUSTITUIDOS; 2)-(L)-R80; L ES UN GRUPO DE UNION DIVALENTE SELECCIONADO ENTRE i)C, H; ii)S; iii)O; iv)1-2 N, H; v)C, H, S; vi)C, H, O; R80 ES 1) DE R20; R21 ES UN SUSTITUYENTE NO INTERFERENTE; R1` ES -NHNH2, -NH2, -CONH2, R2' ES -OH, -O(CH2)tR5'; R5' ES H, -CN, -NH2, -CONH2, -CONR9R10, -NHSO2R15, -CONHSO2R15; R15 ES -ALQUILO C1-C6, -CF3, FENILO OPCIONALMENTE SUSTITUIDO; R3' ES UN SUSTITUYENTE NO INTERFERENTE, CARBOCICLOS, HETEROCICLOS; SOLO UNO DE A o Z ES UN ANILLO HETEROCICLICO; CUANDO D ES N, Z ES S, O EN LA POSICION 1-3; Y EL N EN LA POSICION 1-4. UN COMPUESTO PREFERIDO ES ACIDO (R,S)-(9-BENCIL-4-CARBAMOIL-1-OXO-3-TIA-1,2,3,4-TETRAHIDROCARBAZOL-5-IL)OXIACETICO, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE LA LIBERACION DE ACIDOS GRASOS MEDIADA POR sPLA2 O INHIBIENDO LA CASCADA DE ACIDO ARAQUIDONICO POR LO QUE PUEDE SER UTIL EN EL TRATAMIENTO DE SEPSIS, CHOQUE SEPTICO, ARTRITIS REUMATOIDE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6216598A | 1998-04-17 | 1998-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000472A1 true PE20000472A1 (es) | 2000-06-02 |
Family
ID=22040624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000321A PE20000472A1 (es) | 1998-04-17 | 1999-04-16 | Compuestos triciclicos sustituidos |
Country Status (27)
Country | Link |
---|---|
EP (2) | EP0950661B1 (es) |
JP (1) | JP4435325B2 (es) |
KR (1) | KR19990083234A (es) |
CN (1) | CN1235968A (es) |
AR (1) | AR018185A1 (es) |
AT (2) | ATE254128T1 (es) |
AU (1) | AU757454B2 (es) |
BR (1) | BR9901275A (es) |
CA (1) | CA2269256A1 (es) |
CO (1) | CO5080728A1 (es) |
CZ (1) | CZ137199A3 (es) |
DE (2) | DE69914951T2 (es) |
EA (1) | EA003129B1 (es) |
ES (2) | ES2210979T3 (es) |
HU (1) | HUP9901219A1 (es) |
ID (1) | ID23219A (es) |
IL (1) | IL129484A0 (es) |
NO (1) | NO991823L (es) |
NZ (1) | NZ335252A (es) |
PE (1) | PE20000472A1 (es) |
PL (1) | PL332564A1 (es) |
SG (1) | SG106035A1 (es) |
SV (1) | SV1999000052A (es) |
TR (1) | TR199900842A2 (es) |
TW (1) | TW555760B (es) |
YU (1) | YU19099A (es) |
ZA (1) | ZA992773B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1011670A4 (en) * | 1997-08-28 | 2004-10-27 | Lilly Co Eli | PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS |
AU2001244635A1 (en) * | 2000-03-30 | 2001-10-15 | Yamanouchi Pharmaceutical Co..Ltd. | Hydrazide derivatives |
AU2001272915A1 (en) * | 2000-07-14 | 2002-01-30 | Eli Lilly And Company | Method for treating sepsis |
DE60120758T2 (de) * | 2000-12-18 | 2007-05-16 | Eli Lilly And Co., Indianapolis | Tetracyclische derivate als spla2 inhibitoren |
EP1395554B1 (en) | 2001-03-28 | 2007-02-14 | Eli Lilly And Company | Substituted carbazoles as inhibitors of spla2 |
DE60208065T2 (de) * | 2001-08-09 | 2006-07-13 | Eli Lilly And Co., Indianapolis | Cyclohept'b! indolderivate als spla2-inhibitoren |
JP2005527464A (ja) * | 2001-08-09 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | sPLA2インヒビターとしてのシクロヘプタBインドール誘導体 |
US6992100B2 (en) | 2001-12-06 | 2006-01-31 | Eli Lilly And Company | sPLA2 inhibitors |
MX2007005199A (es) | 2004-11-01 | 2007-05-11 | Wyeth Corp | Indolizinas sustituidas y derivados como agentes del sistema nervioso central. |
JP5501251B2 (ja) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ, インコーポレイテッド | Mch拮抗薬としての(1−アジノン)置換ピリドインドール類 |
US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
EP2697223B1 (en) * | 2011-04-14 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
SG11201405328SA (en) | 2012-03-16 | 2014-11-27 | Vitae Pharmaceuticals Inc | Liver x receptor modulators |
US9073931B2 (en) | 2012-03-16 | 2015-07-07 | Vitae Pharmaceuticals, Inc. | Liver X receptor modulators |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
ES2208685T3 (es) * | 1994-07-21 | 2004-06-16 | Eli Lilly And Company | Inhibidores de indolizina spla2. |
KR19990072110A (ko) * | 1995-12-13 | 1999-09-27 | 피터 지. 스트링거 | Spla2 억제제인 나프틸 아세트아미드 |
BR9713261A (pt) * | 1996-10-30 | 2000-03-28 | Lilly Co Eli | Tricìclicos substituìdos |
WO1999016453A1 (en) * | 1997-09-26 | 1999-04-08 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
CA2310250A1 (en) * | 1997-11-14 | 1999-05-27 | August Masaru Watanabe | Treatment for alzheimer's disease |
-
1999
- 1999-04-15 ID IDP990342D patent/ID23219A/id unknown
- 1999-04-15 IL IL12948499A patent/IL129484A0/xx unknown
- 1999-04-16 BR BR9901275-8A patent/BR9901275A/pt not_active IP Right Cessation
- 1999-04-16 EA EA199900304A patent/EA003129B1/ru not_active IP Right Cessation
- 1999-04-16 ES ES99302969T patent/ES2210979T3/es not_active Expired - Lifetime
- 1999-04-16 CN CN99108097A patent/CN1235968A/zh active Pending
- 1999-04-16 CA CA002269256A patent/CA2269256A1/en not_active Abandoned
- 1999-04-16 EP EP99302969A patent/EP0950661B1/en not_active Expired - Lifetime
- 1999-04-16 YU YU19099A patent/YU19099A/sh unknown
- 1999-04-16 TW TW088106131A patent/TW555760B/zh not_active IP Right Cessation
- 1999-04-16 JP JP10965699A patent/JP4435325B2/ja not_active Expired - Fee Related
- 1999-04-16 PE PE1999000321A patent/PE20000472A1/es not_active Application Discontinuation
- 1999-04-16 NZ NZ335252A patent/NZ335252A/xx unknown
- 1999-04-16 DE DE69914951T patent/DE69914951T2/de not_active Expired - Fee Related
- 1999-04-16 CZ CZ991371A patent/CZ137199A3/cs unknown
- 1999-04-16 AT AT99302969T patent/ATE254128T1/de not_active IP Right Cessation
- 1999-04-16 ZA ZA9902773A patent/ZA992773B/xx unknown
- 1999-04-16 TR TR1999/00842A patent/TR199900842A2/xx unknown
- 1999-04-16 ES ES01203116T patent/ES2213668T3/es not_active Expired - Lifetime
- 1999-04-16 SV SV1999000052A patent/SV1999000052A/es not_active Application Discontinuation
- 1999-04-16 DE DE69912670T patent/DE69912670T2/de not_active Expired - Fee Related
- 1999-04-16 KR KR1019990013439A patent/KR19990083234A/ko not_active Application Discontinuation
- 1999-04-16 AU AU23818/99A patent/AU757454B2/en not_active Ceased
- 1999-04-16 EP EP01203116A patent/EP1156050B1/en not_active Expired - Lifetime
- 1999-04-16 PL PL99332564A patent/PL332564A1/xx not_active Application Discontinuation
- 1999-04-16 CO CO99022891A patent/CO5080728A1/es unknown
- 1999-04-16 AR ARP990101769A patent/AR018185A1/es not_active Application Discontinuation
- 1999-04-16 AT AT01203116T patent/ATE259818T1/de not_active IP Right Cessation
- 1999-04-16 HU HU9901219A patent/HUP9901219A1/hu unknown
- 1999-04-16 SG SG9901844A patent/SG106035A1/en unknown
- 1999-04-16 NO NO991823A patent/NO991823L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |