ES2136782T3 - Procedimiento para producir compuestos de acido quinolin-2-il-benzoico. - Google Patents

Procedimiento para producir compuestos de acido quinolin-2-il-benzoico.

Info

Publication number
ES2136782T3
ES2136782T3 ES95116957T ES95116957T ES2136782T3 ES 2136782 T3 ES2136782 T3 ES 2136782T3 ES 95116957 T ES95116957 T ES 95116957T ES 95116957 T ES95116957 T ES 95116957T ES 2136782 T3 ES2136782 T3 ES 2136782T3
Authority
ES
Spain
Prior art keywords
benzoic acid
procedure
acid compounds
quinolin
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95116957T
Other languages
English (en)
Inventor
Shuzhong Wang
Tomoko Ito
Takashi Okazoe
Yoshitomi Morizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP26412294A external-priority patent/JPH08119942A/ja
Priority claimed from JP26412194A external-priority patent/JPH08119941A/ja
Application filed by Asahi Glass Co Ltd, Welfide Corp filed Critical Asahi Glass Co Ltd
Application granted granted Critical
Publication of ES2136782T3 publication Critical patent/ES2136782T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN COMPUESTO DE ACIDO QUINOLIN-2-IL BENZOICO UTIL COMO INTERMEDIO DE LOS ANTAGONISTAS DE LA ANGIOTENSINA II QUE SON EFECTIVOS PARA EL TRATAMIENTO DE LA HIPERTENSION Y SE PUEDEN PRODUCIR DESCARBOXILANDO UN COMPUESTO DE ACIDO 2-CARBOXIFENIL-4QUINOLINCARBOXILICO EN DONDE LOS DOS GRUPOS CARBOXILOS NO ESTAN SUSTITUIDOS Y UN ANILLO DE BENCENO Y UN ANILLO DE QUINOLINA PUEDEN TENER SUSTITUYENTES INERTES A DICHA REACCION DE DESCARBOXILACION.
ES95116957T 1994-10-27 1995-10-27 Procedimiento para producir compuestos de acido quinolin-2-il-benzoico. Expired - Lifetime ES2136782T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26412294A JPH08119942A (ja) 1994-10-27 1994-10-27 キノリン−２−イル安息香酸誘導体の製造方法
JP26412194A JPH08119941A (ja) 1994-10-27 1994-10-27 キノリン−２−イル安息香酸類の製造方法

Publications (1)

Publication Number Publication Date
ES2136782T3 true ES2136782T3 (es) 1999-12-01

Family

ID=26546362

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95116957T Expired - Lifetime ES2136782T3 (es) 1994-10-27 1995-10-27 Procedimiento para producir compuestos de acido quinolin-2-il-benzoico.

Country Status (3)

Country Link
EP (1) EP0709377B1 (es)
DE (1) DE69512495T2 (es)
ES (1) ES2136782T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0959277A (ja) * 1995-08-17 1997-03-04 Green Cross Corp:The ６−アミノメチル置換キノリン安息香酸類の製造方法
KR20000035869A (ko) * 1996-08-30 2000-06-26 가마쿠라 아키오 근조직 변성의 예방 또는 치료제
PL344977A1 (en) * 1997-10-17 2001-11-19 Aventis Pharm Prod Inc Therapeutic uses of quinoline derivatives
SG11201502935VA (en) 2012-10-16 2015-09-29 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror-gamma-t
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
BR112015008308A2 (pt) 2012-10-16 2017-12-05 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por metileno do ror-gama-t
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0602246A4 (en) 1992-03-25 1995-07-05 Green Cross Corp ISOINDAZOLE COMPOUND.
JPH0616641A (ja) 1992-05-08 1994-01-25 Asahi Glass Co Ltd キノリン−２−イル安息香酸誘導体およびその製造方法
US5478832A (en) * 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
JP2641686B2 (ja) 1992-06-10 1997-08-20 旭硝子株式会社 新規キノリン誘導体

Also Published As

Publication number Publication date
DE69512495T2 (de) 2000-02-03
EP0709377B1 (en) 1999-09-29
DE69512495D1 (de) 1999-11-04
EP0709377A1 (en) 1996-05-01

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