TNSN96107A1 - Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant - Google Patents

Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant

Info

Publication number
TNSN96107A1
TNSN96107A1 TNTNSN96107A TNSN96107A TNSN96107A1 TN SN96107 A1 TNSN96107 A1 TN SN96107A1 TN TNSN96107 A TNTNSN96107 A TN TNSN96107A TN SN96107 A TNSN96107 A TN SN96107A TN SN96107 A1 TNSN96107 A1 TN SN96107A1
Authority
TN
Tunisia
Prior art keywords
benzylaminopiperidines
substituted
compositions containing
pharmaceutical compositions
compounds
Prior art date
Application number
TNTNSN96107A
Other languages
English (en)
Inventor
Satake Kunio
Shishido Yuji
Wakabayashi Hiroaki
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96107A1 publication Critical patent/TNSN96107A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES BENZYLAMINOPIPERIDINES SUBSTITUES UTILES EN CHIMIE MEDICALE ET THERAPEUTIQUE. CES COMPOSES REPONDENT A LA FORMULE : DANS LAQUELLE R, R1, et X CHOISIS ENTRE L’HYDROGENE ET DIVERS SUBSTITUANTS ORGANIQUES. APPLICATION : UTILISATION DE COMPOSITIONS RENFERMANT CES COMPOSES POUR LE TRAITEMENT DE DIVERSES MALADIES ET AFFECTIONS, NOTAMMENT DU TRACTUS GASTRO-INTESTINAL ET DU SYSTEME NERVEUX CENTRAL, CHEZ UN MAMMIFERE, EN PARTICULIER L'HOMME.
TNTNSN96107A 1995-08-24 1996-06-10 Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant TNSN96107A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (1)

Publication Number Publication Date
TNSN96107A1 true TNSN96107A1 (fr) 2005-03-15

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96107A TNSN96107A1 (fr) 1995-08-24 1996-06-10 Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant

Country Status (42)

Country Link
US (1) US6506775B1 (fr)
EP (2) EP0861235B1 (fr)
JP (1) JP3084069B2 (fr)
KR (1) KR100288673B1 (fr)
CN (1) CN1153764C (fr)
AP (1) AP643A (fr)
AR (1) AR006305A1 (fr)
AT (2) ATE208377T1 (fr)
AU (1) AU702698B2 (fr)
BG (1) BG64126B1 (fr)
BR (1) BR9609989A (fr)
CA (1) CA2227814C (fr)
CO (1) CO4480738A1 (fr)
CZ (1) CZ297543B6 (fr)
DE (2) DE69631390T2 (fr)
DK (2) DK1114817T3 (fr)
DZ (1) DZ2086A1 (fr)
ES (2) ES2211684T3 (fr)
HK (1) HK1014935A1 (fr)
HR (1) HRP960386B1 (fr)
HU (1) HU225480B1 (fr)
IL (1) IL119078A (fr)
IS (1) IS1947B (fr)
MA (1) MA23961A1 (fr)
MX (1) MX9801467A (fr)
MY (1) MY114800A (fr)
NO (1) NO310720B1 (fr)
NZ (1) NZ308207A (fr)
OA (1) OA10666A (fr)
PE (2) PE20010700A1 (fr)
PL (1) PL186773B1 (fr)
PT (2) PT861235E (fr)
RO (1) RO119299B1 (fr)
RU (1) RU2152930C2 (fr)
SI (2) SI1114817T1 (fr)
SK (1) SK282925B6 (fr)
TN (1) TNSN96107A1 (fr)
TR (1) TR199800300T1 (fr)
TW (1) TW340842B (fr)
UA (1) UA48981C2 (fr)
WO (1) WO1997008144A1 (fr)
YU (1) YU49122B (fr)

Families Citing this family (51)

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MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
GEP20043224B (en) * 1999-05-06 2004-04-26 Pfizer Prod Inc Substituted Benzolactam Compounds
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
EP1178984B1 (fr) * 1999-05-21 2003-03-19 Pfizer Products Inc. Derives 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchromane
CA2324116A1 (fr) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Antagonistes du recepteur nk-1 et eletriptan pour le traitement de la migraine
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (fr) * 2000-09-28 2003-03-26 Pfizer Products Inc. Composition pour le traitement de la dépression et de l'anxieté contenant un antagoniste du recepteur NK-3 et un antagoniste du récepteur NK-1
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
MXPA05011223A (es) 2003-04-18 2006-01-26 Lilly Co Eli Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas 5-htif.
WO2005113503A2 (fr) * 2004-05-21 2005-12-01 Pfizer Products Inc. Metabolites de (+)-(2s, 3s)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenyl-piperidine
KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
JP5258561B2 (ja) 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ, インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2083831B1 (fr) 2006-09-22 2013-12-25 Merck Sharp & Dohme Corp. Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EA016079B1 (ru) 2007-01-10 2012-01-30 Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа Амидзамещенные индазолы в качестве ингибиторов поли(adp-рибоза)полимеразы (parp)
JP5319518B2 (ja) 2007-04-02 2013-10-16 Msd株式会社 インドールジオン誘導体
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての4−カルボキシベンジルアミノ誘導体
WO2009111354A2 (fr) 2008-03-03 2009-09-11 Tiger Pharmatech Inhibiteurs de la tyrosine kinase
JP5511080B2 (ja) 2008-03-31 2014-06-04 興和株式会社 1,3−ジヒドロイソベンゾフラン誘導体
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
ES2528404T3 (es) 2009-05-12 2015-02-10 Bristol-Myers Squibb Company Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos
AU2010247763B2 (en) 2009-05-12 2015-12-24 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
AU2010247849B2 (en) 2009-05-12 2015-11-19 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
PE20121172A1 (es) 2009-10-14 2012-09-05 Merck Sharp & Dohme Piperidinas sustituidas con actividad en la hdm2
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
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US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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WO2012145471A1 (fr) 2011-04-21 2012-10-26 Merck Sharp & Dohme Corp. Inhibiteurs du récepteur du facteur de croissance 1 analogue à l'insuline
WO2013063214A1 (fr) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Nouveaux composés qui sont des inhibiteurs d'erk
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RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
WO2014120748A1 (fr) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
WO2015034925A1 (fr) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Polynucléotides circulaires
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EP3706742B1 (fr) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
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Also Published As

Publication number Publication date
HUP9901159A3 (en) 2000-05-29
DZ2086A1 (fr) 2002-07-22
IL119078A (en) 2003-11-23
MA23961A1 (fr) 1997-04-01
ES2163017T3 (es) 2002-01-16
DK0861235T3 (da) 2001-12-27
KR100288673B1 (ko) 2001-05-02
US6506775B1 (en) 2003-01-14
EP0861235B1 (fr) 2001-11-07
CN1193961A (zh) 1998-09-23
SI1114817T1 (en) 2004-06-30
YU49122B (sh) 2004-03-12
DE69616817T2 (de) 2002-04-04
PT861235E (pt) 2002-03-28
ATE208377T1 (de) 2001-11-15
AP643A (en) 1998-04-24
NO980751D0 (no) 1998-02-23
MX9801467A (es) 1998-05-31
HUP9901159A2 (hu) 1999-07-28
CO4480738A1 (es) 1997-07-09
CZ52198A3 (cs) 1999-01-13
TW340842B (en) 1998-09-21
BG64126B1 (bg) 2004-01-30
BG102288A (en) 1998-09-30
CZ297543B6 (cs) 2007-02-07
DE69616817D1 (de) 2001-12-13
SI0861235T1 (en) 2002-04-30
YU47896A (sh) 1998-12-23
HRP960386B1 (en) 2002-04-30
WO1997008144A1 (fr) 1997-03-06
DE69631390T2 (de) 2004-11-25
KR19990044077A (ko) 1999-06-25
NO310720B1 (no) 2001-08-20
IS4644A (is) 1997-12-30
CA2227814C (fr) 2002-12-31
NZ308207A (en) 1998-07-28
HRP960386A2 (en) 1998-04-30
PE1398A1 (es) 1998-02-27
EP1114817B1 (fr) 2004-01-21
RU2152930C2 (ru) 2000-07-20
AR006305A1 (es) 1999-08-25
EP0861235A1 (fr) 1998-09-02
ATE258166T1 (de) 2004-02-15
RO119299B1 (ro) 2004-07-30
PE20010700A1 (es) 2001-07-09
PL325332A1 (en) 1998-07-20
BR9609989A (pt) 1999-07-06
CA2227814A1 (fr) 1997-03-06
HK1014935A1 (en) 1999-10-08
EP1114817A1 (fr) 2001-07-11
ES2211684T3 (es) 2004-07-16
SK20798A3 (en) 1999-03-12
SK282925B6 (sk) 2003-01-09
PL186773B1 (pl) 2004-02-27
MY114800A (en) 2003-01-31
IS1947B (is) 2004-10-13
JP3084069B2 (ja) 2000-09-04
DK1114817T3 (da) 2004-04-26
AU5776996A (en) 1997-03-19
UA48981C2 (uk) 2002-09-16
CN1153764C (zh) 2004-06-16
IL119078A0 (en) 1996-11-14
JPH10510554A (ja) 1998-10-13
PT1114817E (pt) 2004-05-31
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
OA10666A (en) 2002-11-25
NO980751L (no) 1998-02-23
AP9600850A0 (en) 1996-10-31
TR199800300T1 (xx) 1998-06-22
AU702698B2 (en) 1999-03-04

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