DK1114817T3 - Substituerede benzylaminopiperidinforbindelser - Google Patents

Substituerede benzylaminopiperidinforbindelser

Info

Publication number
DK1114817T3
DK1114817T3 DK01108350T DK01108350T DK1114817T3 DK 1114817 T3 DK1114817 T3 DK 1114817T3 DK 01108350 T DK01108350 T DK 01108350T DK 01108350 T DK01108350 T DK 01108350T DK 1114817 T3 DK1114817 T3 DK 1114817T3
Authority
DK
Denmark
Prior art keywords
compounds
substituted
substituted benzylaminopiperidine
benzylaminopiperidine compounds
benzylaminopiperidine
Prior art date
Application number
DK01108350T
Other languages
English (en)
Inventor
Kunio Satake
Yuji Shishido
Hiroaki Wakabayashi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK1114817T3 publication Critical patent/DK1114817T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01108350T 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser DK1114817T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24
EP96914375A EP0861235B1 (en) 1995-08-24 1996-06-10 Substituted benzylaminopiperidine compounds

Publications (1)

Publication Number Publication Date
DK1114817T3 true DK1114817T3 (da) 2004-04-26

Family

ID=11004362

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01108350T DK1114817T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser
DK96914375T DK0861235T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96914375T DK0861235T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Country Status (42)

Country Link
US (1) US6506775B1 (da)
EP (2) EP0861235B1 (da)
JP (1) JP3084069B2 (da)
KR (1) KR100288673B1 (da)
CN (1) CN1153764C (da)
AP (1) AP643A (da)
AR (1) AR006305A1 (da)
AT (2) ATE258166T1 (da)
AU (1) AU702698B2 (da)
BG (1) BG64126B1 (da)
BR (1) BR9609989A (da)
CA (1) CA2227814C (da)
CO (1) CO4480738A1 (da)
CZ (1) CZ297543B6 (da)
DE (2) DE69616817T2 (da)
DK (2) DK1114817T3 (da)
DZ (1) DZ2086A1 (da)
ES (2) ES2211684T3 (da)
HK (1) HK1014935A1 (da)
HR (1) HRP960386B1 (da)
HU (1) HU225480B1 (da)
IL (1) IL119078A (da)
IS (1) IS1947B (da)
MA (1) MA23961A1 (da)
MX (1) MX9801467A (da)
MY (1) MY114800A (da)
NO (1) NO310720B1 (da)
NZ (1) NZ308207A (da)
OA (1) OA10666A (da)
PE (2) PE1398A1 (da)
PL (1) PL186773B1 (da)
PT (2) PT861235E (da)
RO (1) RO119299B1 (da)
RU (1) RU2152930C2 (da)
SI (2) SI0861235T1 (da)
SK (1) SK282925B6 (da)
TN (1) TNSN96107A1 (da)
TR (1) TR199800300T1 (da)
TW (1) TW340842B (da)
UA (1) UA48981C2 (da)
WO (1) WO1997008144A1 (da)
YU (1) YU49122B (da)

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MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
HUP0201135A3 (en) * 1999-05-06 2003-05-28 Pfizer Prod Inc Substituted benzolactam compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
TR200103332T2 (tr) * 1999-05-21 2002-04-22 Pfizer Products Inc. 1-Triflorometil-4-hidroksi-7-piperidinil-aminometilkroman türevleri.
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
CN1777584A (zh) 2003-04-18 2006-05-24 伊莱利利公司 作为5-ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物
JP2008500382A (ja) * 2004-05-21 2008-01-10 ファイザー・プロダクツ・インク (+)−(2s,3s)−3−(2−メトキシ−5−トリフルオロメトキシベンジルアミノ)−2−フェニル−ピペリジンの代謝産物
NZ552397A (en) 2004-07-15 2011-04-29 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
KR101589551B1 (ko) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
BRPI0616463A2 (pt) 2005-09-29 2011-06-21 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2109608T3 (pl) 2007-01-10 2011-08-31 Msd Italia Srl Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
CA2682727C (en) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Indoledione derivative
CA2690191C (en) 2007-06-27 2015-07-28 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
KR20100126467A (ko) 2008-03-03 2010-12-01 타이거 파마테크 티로신 키나아제 억제제
WO2009122707A1 (ja) 2008-03-31 2009-10-08 興和株式会社 1,3-ジヒドロイソベンゾフラン誘導体
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
BR112012008849A2 (pt) 2009-10-14 2015-09-22 Schering Corp composto, composição farmacêutica, e, uso de um composto
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
SI2606134T1 (sl) 2010-08-17 2019-08-30 Sirna Therapeutics, Inc. RNA-INTERFERENČNO POSREDOVANO ZAVIRANJE IZRAŽANJA GENA VIRUSA HEPATITISA B (HBV) Z UPORABO KRATKE INTERFERENČNE NUKLEINSKE KISLINE (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
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EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
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WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
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EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
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PL2925888T3 (pl) 2012-11-28 2018-03-30 Merck Sharp & Dohme Corp. Kompozycje i sposoby do stosowania w leczeniu nowotworów
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US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
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US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
BR9205807A (pt) * 1991-03-26 1994-06-28 Pfizer Preparação estéreo-seletiva de piperidinas substituidas
UA39168C2 (uk) * 1991-06-20 2001-06-15 Пфайзер, Інк. Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
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Also Published As

Publication number Publication date
JP3084069B2 (ja) 2000-09-04
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
RU2152930C2 (ru) 2000-07-20
ES2211684T3 (es) 2004-07-16
OA10666A (en) 2002-11-25
HUP9901159A3 (en) 2000-05-29
DZ2086A1 (fr) 2002-07-22
CZ52198A3 (cs) 1999-01-13
PE1398A1 (es) 1998-02-27
MY114800A (en) 2003-01-31
YU47896A (sh) 1998-12-23
AP643A (en) 1998-04-24
NZ308207A (en) 1998-07-28
JPH10510554A (ja) 1998-10-13
RO119299B1 (ro) 2004-07-30
DE69616817T2 (de) 2002-04-04
CN1193961A (zh) 1998-09-23
AU702698B2 (en) 1999-03-04
YU49122B (sh) 2004-03-12
EP0861235A1 (en) 1998-09-02
DE69616817D1 (de) 2001-12-13
CZ297543B6 (cs) 2007-02-07
PL325332A1 (en) 1998-07-20
BG64126B1 (bg) 2004-01-30
AR006305A1 (es) 1999-08-25
ATE208377T1 (de) 2001-11-15
SI1114817T1 (en) 2004-06-30
NO980751D0 (no) 1998-02-23
HUP9901159A2 (hu) 1999-07-28
HRP960386B1 (en) 2002-04-30
ATE258166T1 (de) 2004-02-15
BR9609989A (pt) 1999-07-06
PE20010700A1 (es) 2001-07-09
MX9801467A (es) 1998-05-31
CA2227814A1 (en) 1997-03-06
HRP960386A2 (en) 1998-04-30
SK20798A3 (en) 1999-03-12
US6506775B1 (en) 2003-01-14
KR100288673B1 (ko) 2001-05-02
EP1114817B1 (en) 2004-01-21
CO4480738A1 (es) 1997-07-09
IL119078A (en) 2003-11-23
BG102288A (en) 1998-09-30
EP1114817A1 (en) 2001-07-11
MA23961A1 (fr) 1997-04-01
IS4644A (is) 1997-12-30
HK1014935A1 (en) 1999-10-08
CA2227814C (en) 2002-12-31
NO980751L (no) 1998-02-23
PT1114817E (pt) 2004-05-31
IL119078A0 (en) 1996-11-14
CN1153764C (zh) 2004-06-16
SI0861235T1 (en) 2002-04-30
DE69631390T2 (de) 2004-11-25
ES2163017T3 (es) 2002-01-16
PL186773B1 (pl) 2004-02-27
NO310720B1 (no) 2001-08-20
EP0861235B1 (en) 2001-11-07
WO1997008144A1 (en) 1997-03-06
PT861235E (pt) 2002-03-28
AU5776996A (en) 1997-03-19
SK282925B6 (sk) 2003-01-09
AP9600850A0 (en) 1996-10-31
TW340842B (en) 1998-09-21
DK0861235T3 (da) 2001-12-27
IS1947B (is) 2004-10-13
KR19990044077A (ko) 1999-06-25
TR199800300T1 (xx) 1998-06-22
TNSN96107A1 (fr) 2005-03-15
UA48981C2 (uk) 2002-09-16

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