YU47896A - Supstituisana benzilaminopiperidinska jedinjenja - Google Patents

Supstituisana benzilaminopiperidinska jedinjenja

Info

Publication number
YU47896A
YU47896A YU47896A YU47896A YU47896A YU 47896 A YU47896 A YU 47896A YU 47896 A YU47896 A YU 47896A YU 47896 A YU47896 A YU 47896A YU 47896 A YU47896 A YU 47896A
Authority
YU
Yugoslavia
Prior art keywords
halo
diseases
alkoxy
alkyl
angiogenesis
Prior art date
Application number
YU47896A
Other languages
English (en)
Other versions
YU49122B (sh
Inventor
Kunio Satake
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU47896A publication Critical patent/YU47896A/sh
Publication of YU49122B publication Critical patent/YU49122B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Ovaj pronalazak obezbeđuje jedinjenje formule: i njegove farmaceutski prihvatljive soli, gde R je halo C1-C8 alkil, halo C1-C8 alkenil, halo C1-C8 alkinil ili halo C1-C8 alkil supstituisan sa hidroksi ili C1-C8 alkoki; R1 je vodonik, halo C1-C6 alkoksi; ili R i R1, zajedno sa dva ugljenikova atoma koja deli između benzenskog prstena i R i R1, zajedno sa spojenim C4-C6 cikloalkil gde je jedan ugljenikov atom opciono zamenjen sa kiseonikom i gde jedan ili dva ugljenikova atoma su opciono supstituisana sa do pet supstituenata odabranih od halo, C1-C6 alkil halo C1-C6 alkil; X je C1-C6 alkoksi, halo C1-C6 alkoksi, fenoksi ili halo; i Ar je fenil opciono supstituisan sa halo. Ova jedinjenja su korisna za tretman ili sperčavanje gastrointestinalnih oboljenja, oboljenja centralnog nervnog sistema (CNS), inflamatorna oboljenja, emeze, urinarne neumerenosti, bolove, migrene, opekotine od sunca, oboljenja angiogeneze, oboljenja i povratna stanja prouzrokovana sa Heliocobacter pylori, ili angiogeneze posebno CNS oboljenja kod pacijenata sisara, posebno ljudi.
YU47896A 1995-08-24 1996-08-23 Supstituisana benzilaminopiperidinska jedinjenja YU49122B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (2)

Publication Number Publication Date
YU47896A true YU47896A (sh) 1998-12-23
YU49122B YU49122B (sh) 2004-03-12

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
YU47896A YU49122B (sh) 1995-08-24 1996-08-23 Supstituisana benzilaminopiperidinska jedinjenja

Country Status (42)

Country Link
US (1) US6506775B1 (sh)
EP (2) EP1114817B1 (sh)
JP (1) JP3084069B2 (sh)
KR (1) KR100288673B1 (sh)
CN (1) CN1153764C (sh)
AP (1) AP643A (sh)
AR (1) AR006305A1 (sh)
AT (2) ATE258166T1 (sh)
AU (1) AU702698B2 (sh)
BG (1) BG64126B1 (sh)
BR (1) BR9609989A (sh)
CA (1) CA2227814C (sh)
CO (1) CO4480738A1 (sh)
CZ (1) CZ297543B6 (sh)
DE (2) DE69616817T2 (sh)
DK (2) DK1114817T3 (sh)
DZ (1) DZ2086A1 (sh)
ES (2) ES2163017T3 (sh)
HK (1) HK1014935A1 (sh)
HR (1) HRP960386B1 (sh)
HU (1) HU225480B1 (sh)
IL (1) IL119078A (sh)
IS (1) IS1947B (sh)
MA (1) MA23961A1 (sh)
MX (1) MX9801467A (sh)
MY (1) MY114800A (sh)
NO (1) NO310720B1 (sh)
NZ (1) NZ308207A (sh)
OA (1) OA10666A (sh)
PE (2) PE20010700A1 (sh)
PL (1) PL186773B1 (sh)
PT (2) PT1114817E (sh)
RO (1) RO119299B1 (sh)
RU (1) RU2152930C2 (sh)
SI (2) SI1114817T1 (sh)
SK (1) SK282925B6 (sh)
TN (1) TNSN96107A1 (sh)
TR (1) TR199800300T1 (sh)
TW (1) TW340842B (sh)
UA (1) UA48981C2 (sh)
WO (1) WO1997008144A1 (sh)
YU (1) YU49122B (sh)

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Also Published As

Publication number Publication date
IL119078A (en) 2003-11-23
DE69631390T2 (de) 2004-11-25
HRP960386B1 (en) 2002-04-30
HUP9901159A3 (en) 2000-05-29
US6506775B1 (en) 2003-01-14
CZ297543B6 (cs) 2007-02-07
EP0861235A1 (en) 1998-09-02
WO1997008144A1 (en) 1997-03-06
CN1193961A (zh) 1998-09-23
CA2227814A1 (en) 1997-03-06
BG64126B1 (bg) 2004-01-30
AU5776996A (en) 1997-03-19
NZ308207A (en) 1998-07-28
AP9600850A0 (en) 1996-10-31
DZ2086A1 (fr) 2002-07-22
HUP9901159A2 (hu) 1999-07-28
SI1114817T1 (en) 2004-06-30
PL186773B1 (pl) 2004-02-27
PE1398A1 (es) 1998-02-27
EP1114817A1 (en) 2001-07-11
ATE208377T1 (de) 2001-11-15
DK1114817T3 (da) 2004-04-26
MY114800A (en) 2003-01-31
SK20798A3 (en) 1999-03-12
MA23961A1 (fr) 1997-04-01
EP1114817B1 (en) 2004-01-21
AR006305A1 (es) 1999-08-25
YU49122B (sh) 2004-03-12
NO310720B1 (no) 2001-08-20
NO980751D0 (no) 1998-02-23
SI0861235T1 (en) 2002-04-30
SK282925B6 (sk) 2003-01-09
AU702698B2 (en) 1999-03-04
JPH10510554A (ja) 1998-10-13
UA48981C2 (uk) 2002-09-16
TNSN96107A1 (fr) 2005-03-15
ES2163017T3 (es) 2002-01-16
DE69616817T2 (de) 2002-04-04
HRP960386A2 (en) 1998-04-30
DE69616817D1 (de) 2001-12-13
NO980751L (no) 1998-02-23
ATE258166T1 (de) 2004-02-15
PL325332A1 (en) 1998-07-20
PT861235E (pt) 2002-03-28
PE20010700A1 (es) 2001-07-09
CA2227814C (en) 2002-12-31
AP643A (en) 1998-04-24
MX9801467A (es) 1998-05-31
RU2152930C2 (ru) 2000-07-20
EP0861235B1 (en) 2001-11-07
ES2211684T3 (es) 2004-07-16
IS4644A (is) 1997-12-30
IS1947B (is) 2004-10-13
KR19990044077A (ko) 1999-06-25
TR199800300T1 (xx) 1998-06-22
CO4480738A1 (es) 1997-07-09
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
TW340842B (en) 1998-09-21
OA10666A (en) 2002-11-25
CZ52198A3 (cs) 1999-01-13
DK0861235T3 (da) 2001-12-27
BR9609989A (pt) 1999-07-06
BG102288A (en) 1998-09-30
CN1153764C (zh) 2004-06-16
PT1114817E (pt) 2004-05-31
JP3084069B2 (ja) 2000-09-04
KR100288673B1 (ko) 2001-05-02
RO119299B1 (ro) 2004-07-30
IL119078A0 (en) 1996-11-14
HK1014935A1 (en) 1999-10-08

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