IL119078A - Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them - Google Patents

Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them

Info

Publication number
IL119078A
IL119078A IL11907896A IL11907896A IL119078A IL 119078 A IL119078 A IL 119078A IL 11907896 A IL11907896 A IL 11907896A IL 11907896 A IL11907896 A IL 11907896A IL 119078 A IL119078 A IL 119078A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
substituted
compounds
substituted benzylaminopiperidine
benzylaminopiperidine compounds
Prior art date
Application number
IL11907896A
Other languages
English (en)
Other versions
IL119078A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL119078A0 publication Critical patent/IL119078A0/xx
Publication of IL119078A publication Critical patent/IL119078A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11907896A 1995-08-24 1996-08-15 Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them IL119078A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (2)

Publication Number Publication Date
IL119078A0 IL119078A0 (en) 1996-11-14
IL119078A true IL119078A (en) 2003-11-23

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11907896A IL119078A (en) 1995-08-24 1996-08-15 Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them

Country Status (42)

Country Link
US (1) US6506775B1 (sh)
EP (2) EP0861235B1 (sh)
JP (1) JP3084069B2 (sh)
KR (1) KR100288673B1 (sh)
CN (1) CN1153764C (sh)
AP (1) AP643A (sh)
AR (1) AR006305A1 (sh)
AT (2) ATE208377T1 (sh)
AU (1) AU702698B2 (sh)
BG (1) BG64126B1 (sh)
BR (1) BR9609989A (sh)
CA (1) CA2227814C (sh)
CO (1) CO4480738A1 (sh)
CZ (1) CZ297543B6 (sh)
DE (2) DE69616817T2 (sh)
DK (2) DK1114817T3 (sh)
DZ (1) DZ2086A1 (sh)
ES (2) ES2163017T3 (sh)
HK (1) HK1014935A1 (sh)
HR (1) HRP960386B1 (sh)
HU (1) HU225480B1 (sh)
IL (1) IL119078A (sh)
IS (1) IS1947B (sh)
MA (1) MA23961A1 (sh)
MX (1) MX9801467A (sh)
MY (1) MY114800A (sh)
NO (1) NO310720B1 (sh)
NZ (1) NZ308207A (sh)
OA (1) OA10666A (sh)
PE (2) PE1398A1 (sh)
PL (1) PL186773B1 (sh)
PT (2) PT861235E (sh)
RO (1) RO119299B1 (sh)
RU (1) RU2152930C2 (sh)
SI (2) SI1114817T1 (sh)
SK (1) SK282925B6 (sh)
TN (1) TNSN96107A1 (sh)
TR (1) TR199800300T1 (sh)
TW (1) TW340842B (sh)
UA (1) UA48981C2 (sh)
WO (1) WO1997008144A1 (sh)
YU (1) YU49122B (sh)

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MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
TR200103222T2 (tr) * 1999-05-06 2002-03-21 Pfizer Products Inc. íkame edilmiç benzolaktam bileçikleri.
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
GEP20043225B (en) * 1999-05-21 2004-04-26 Pfizer Prod Inc 1-Trifluoromethyl-4-Hydroxy-7- Piperidinyl-Aminomethylchroman Derivatives
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
MXPA05011223A (es) 2003-04-18 2006-01-26 Lilly Co Eli Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas 5-htif.
EP1753722A2 (en) * 2004-05-21 2007-02-21 Pfizer Products Inc. Metabolites of (+)-(2s, 3s)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenyl-piperidine
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
EP1888050B1 (en) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
AU2006270071B2 (en) 2005-07-15 2012-02-02 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
RU2008116844A (ru) 2005-09-29 2009-11-10 Мерк энд Ко., Инк. (US) Ацилированные производные спиропиперидина как модуляторы рецептора меланокортина-4
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2083831B1 (en) 2006-09-22 2013-12-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2008204380B2 (en) 2007-01-10 2013-08-15 Msd Italia S.R.L. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5319518B2 (ja) 2007-04-02 2013-10-16 Msd株式会社 インドールジオン誘導体
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AU2009222122A1 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
US7951822B2 (en) 2008-03-31 2011-05-31 Kowa Company, Ltd. 1,3-dihydroisobenzofuran derivatives
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
EA020553B1 (ru) 2009-05-12 2014-12-30 Олбани Молекьюлар Рисерч, Инк. 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ
CN102458123A (zh) 2009-05-12 2012-05-16 阿尔巴尼分子研究公司 芳基、杂芳基和杂环取代的四氢异喹啉及其用途
US8815894B2 (en) 2009-05-12 2014-08-26 Bristol-Myers Squibb Company Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
CN104945382B (zh) 2009-10-14 2020-02-07 默沙东公司 提高p53活性的取代的哌啶和其用途
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
JP6043285B2 (ja) 2010-08-02 2016-12-14 サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害
LT2606134T (lt) 2010-08-17 2019-07-25 Sirna Therapeutics, Inc. Hepatito b viruso (hbv) geno raiškos slopinimas, tarpininkaujant rnr interferencijai naudojant mažą interferuojančią nukleorūgštį (sina)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
CN103732592A (zh) 2011-04-21 2014-04-16 默沙东公司 胰岛素样生长因子-1受体抑制剂
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
EP2900241B1 (en) 2012-09-28 2018-08-08 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
PT2925888T (pt) 2012-11-28 2017-12-13 Merck Sharp & Dohme Composições e métodos para tratamento do cancro
AU2013361694B2 (en) 2012-12-20 2017-10-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
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US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
RU2105001C1 (ru) * 1991-03-26 1998-02-20 Пфайзер Инк. Способ получения замещенных 3-аминопиперидинов
ATE142199T1 (de) * 1991-06-20 1996-09-15 Pfizer Fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0653208A3 (en) * 1993-11-17 1995-10-11 Pfizer Substance P antagonists for the treatment or prevention of sunburn.
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US5990125A (en) 1996-01-19 1999-11-23 Pfizer Inc. NK-1 receptor antagonists for the treatment of cancer

Also Published As

Publication number Publication date
TR199800300T1 (xx) 1998-06-22
IS1947B (is) 2004-10-13
PT1114817E (pt) 2004-05-31
ATE258166T1 (de) 2004-02-15
CZ297543B6 (cs) 2007-02-07
CN1193961A (zh) 1998-09-23
TNSN96107A1 (fr) 2005-03-15
AP643A (en) 1998-04-24
PE20010700A1 (es) 2001-07-09
NO310720B1 (no) 2001-08-20
JP3084069B2 (ja) 2000-09-04
RU2152930C2 (ru) 2000-07-20
DK0861235T3 (da) 2001-12-27
CA2227814A1 (en) 1997-03-06
NZ308207A (en) 1998-07-28
BR9609989A (pt) 1999-07-06
BG64126B1 (bg) 2004-01-30
EP0861235B1 (en) 2001-11-07
JPH10510554A (ja) 1998-10-13
DE69616817D1 (de) 2001-12-13
US6506775B1 (en) 2003-01-14
MY114800A (en) 2003-01-31
HK1014935A1 (en) 1999-10-08
WO1997008144A1 (en) 1997-03-06
AU702698B2 (en) 1999-03-04
DE69631390D1 (de) 2004-02-26
OA10666A (en) 2002-11-25
CZ52198A3 (cs) 1999-01-13
HUP9901159A2 (hu) 1999-07-28
AP9600850A0 (en) 1996-10-31
HRP960386B1 (en) 2002-04-30
IS4644A (is) 1997-12-30
ES2211684T3 (es) 2004-07-16
AR006305A1 (es) 1999-08-25
HRP960386A2 (en) 1998-04-30
DK1114817T3 (da) 2004-04-26
CN1153764C (zh) 2004-06-16
PL186773B1 (pl) 2004-02-27
AU5776996A (en) 1997-03-19
CO4480738A1 (es) 1997-07-09
KR100288673B1 (ko) 2001-05-02
MA23961A1 (fr) 1997-04-01
BG102288A (en) 1998-09-30
DE69616817T2 (de) 2002-04-04
NO980751L (no) 1998-02-23
KR19990044077A (ko) 1999-06-25
EP1114817A1 (en) 2001-07-11
TW340842B (en) 1998-09-21
EP0861235A1 (en) 1998-09-02
NO980751D0 (no) 1998-02-23
CA2227814C (en) 2002-12-31
HU225480B1 (en) 2006-12-28
PT861235E (pt) 2002-03-28
YU47896A (sh) 1998-12-23
SK20798A3 (en) 1999-03-12
DE69631390T2 (de) 2004-11-25
PE1398A1 (es) 1998-02-27
RO119299B1 (ro) 2004-07-30
PL325332A1 (en) 1998-07-20
MX9801467A (es) 1998-05-31
SK282925B6 (sk) 2003-01-09
SI1114817T1 (en) 2004-06-30
EP1114817B1 (en) 2004-01-21
ATE208377T1 (de) 2001-11-15
HUP9901159A3 (en) 2000-05-29
UA48981C2 (uk) 2002-09-16
SI0861235T1 (en) 2002-04-30
IL119078A0 (en) 1996-11-14
ES2163017T3 (es) 2002-01-16
DZ2086A1 (fr) 2002-07-22
YU49122B (sh) 2004-03-12

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