MA23961A1 - Benzylaminopiperidines substituees et compositions les contenant - Google Patents

Benzylaminopiperidines substituees et compositions les contenant

Info

Publication number
MA23961A1
MA23961A1 MA24339A MA24339A MA23961A1 MA 23961 A1 MA23961 A1 MA 23961A1 MA 24339 A MA24339 A MA 24339A MA 24339 A MA24339 A MA 24339A MA 23961 A1 MA23961 A1 MA 23961A1
Authority
MA
Morocco
Prior art keywords
benzylaminopiperidines
substituted
compositions containing
compositions
substituted benzylaminopiperidines
Prior art date
Application number
MA24339A
Other languages
English (en)
Inventor
Stake Kunio
Shishido Yuji
Wakabayashi Hiroaki
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA23961A1 publication Critical patent/MA23961A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA24339A 1995-08-24 1996-08-23 Benzylaminopiperidines substituees et compositions les contenant MA23961A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (1)

Publication Number Publication Date
MA23961A1 true MA23961A1 (fr) 1997-04-01

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24339A MA23961A1 (fr) 1995-08-24 1996-08-23 Benzylaminopiperidines substituees et compositions les contenant

Country Status (42)

Country Link
US (1) US6506775B1 (fr)
EP (2) EP0861235B1 (fr)
JP (1) JP3084069B2 (fr)
KR (1) KR100288673B1 (fr)
CN (1) CN1153764C (fr)
AP (1) AP643A (fr)
AR (1) AR006305A1 (fr)
AT (2) ATE258166T1 (fr)
AU (1) AU702698B2 (fr)
BG (1) BG64126B1 (fr)
BR (1) BR9609989A (fr)
CA (1) CA2227814C (fr)
CO (1) CO4480738A1 (fr)
CZ (1) CZ297543B6 (fr)
DE (2) DE69616817T2 (fr)
DK (2) DK1114817T3 (fr)
DZ (1) DZ2086A1 (fr)
ES (2) ES2211684T3 (fr)
HK (1) HK1014935A1 (fr)
HR (1) HRP960386B1 (fr)
HU (1) HU225480B1 (fr)
IL (1) IL119078A (fr)
IS (1) IS1947B (fr)
MA (1) MA23961A1 (fr)
MX (1) MX9801467A (fr)
MY (1) MY114800A (fr)
NO (1) NO310720B1 (fr)
NZ (1) NZ308207A (fr)
OA (1) OA10666A (fr)
PE (2) PE1398A1 (fr)
PL (1) PL186773B1 (fr)
PT (2) PT861235E (fr)
RO (1) RO119299B1 (fr)
RU (1) RU2152930C2 (fr)
SI (2) SI0861235T1 (fr)
SK (1) SK282925B6 (fr)
TN (1) TNSN96107A1 (fr)
TR (1) TR199800300T1 (fr)
TW (1) TW340842B (fr)
UA (1) UA48981C2 (fr)
WO (1) WO1997008144A1 (fr)
YU (1) YU49122B (fr)

Families Citing this family (51)

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MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
HUP0201135A3 (en) * 1999-05-06 2003-05-28 Pfizer Prod Inc Substituted benzolactam compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
TR200103332T2 (tr) * 1999-05-21 2002-04-22 Pfizer Products Inc. 1-Triflorometil-4-hidroksi-7-piperidinil-aminometilkroman türevleri.
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (fr) * 2000-09-28 2003-03-26 Pfizer Products Inc. Composition pour le traitement de la dépression et de l'anxieté contenant un antagoniste du recepteur NK-3 et un antagoniste du récepteur NK-1
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
CN1777584A (zh) 2003-04-18 2006-05-24 伊莱利利公司 作为5-ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物
JP2008500382A (ja) * 2004-05-21 2008-01-10 ファイザー・プロダクツ・インク (+)−(2s,3s)−3−(2−メトキシ−5−トリフルオロメトキシベンジルアミノ)−2−フェニル−ピペリジンの代謝産物
NZ552397A (en) 2004-07-15 2011-04-29 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
KR101589551B1 (ko) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
BRPI0616463A2 (pt) 2005-09-29 2011-06-21 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2664113C (fr) 2006-09-22 2013-05-28 Merck & Co., Inc. Utilisation de la platencine et de la platensimycine en tant qu'inhibiteurs de la synthese des acides gras pour traiter l'obesite, lediabete et le cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2109608T3 (pl) 2007-01-10 2011-08-31 Msd Italia Srl Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
CA2682727C (fr) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Derive d'indoledione
CA2690191C (fr) 2007-06-27 2015-07-28 Merck Sharp & Dohme Corp. Derives de 4-carboxybenzylamino utilises en tant qu'inhibiteurs de l'histone desacetylase
KR20100126467A (ko) 2008-03-03 2010-12-01 타이거 파마테크 티로신 키나아제 억제제
WO2009122707A1 (fr) 2008-03-31 2009-10-08 興和株式会社 Dérivé de 1,3-dihydroisobenzofurane
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (fr) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
BR112012008849A2 (pt) 2009-10-14 2015-09-22 Schering Corp composto, composição farmacêutica, e, uso de um composto
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
SI2606134T1 (sl) 2010-08-17 2019-08-30 Sirna Therapeutics, Inc. RNA-INTERFERENČNO POSREDOVANO ZAVIRANJE IZRAŽANJA GENA VIRUSA HEPATITISA B (HBV) Z UPORABO KRATKE INTERFERENČNE NUKLEINSKE KISLINE (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (fr) 2010-09-01 2012-03-08 Schering Corporation Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
EP2615916B1 (fr) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (fr) 2010-12-21 2012-06-28 Schering Corporation Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
IN2013MN02170A (fr) 2011-04-21 2015-06-12 Piramal Entpr Ltd
EP2770987B1 (fr) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Nouveaux composés qui sont des inhibiteurs d'erk
EP3919620A1 (fr) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Compositions d'acide nucléique interférent court (sina)
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Erk阻害剤である新規化合物
EP2919788A4 (fr) 2012-11-14 2016-05-25 Univ Johns Hopkins Méthodes et compositions pour le traitement de la schizophrénie
PL2925888T3 (pl) 2012-11-28 2018-03-30 Merck Sharp & Dohme Corp. Kompozycje i sposoby do stosowania w leczeniu nowotworów
WO2014100065A1 (fr) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Imidazopyridines substituées en tant qu'inhibiteurs de hdm2
WO2014120748A1 (fr) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2020033284A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
BR9205807A (pt) * 1991-03-26 1994-06-28 Pfizer Preparação estéreo-seletiva de piperidinas substituidas
UA39168C2 (uk) * 1991-06-20 2001-06-15 Пфайзер, Інк. Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0653208A3 (fr) * 1993-11-17 1995-10-11 Pfizer Antagonistes de la substance P pour le traitement et la prévention de l'erythème solaire.
EP0655246A1 (fr) * 1993-11-30 1995-05-31 Pfizer Inc. Antagonistes de la substance P pour le traitement des maladies causées par Helicobacter Pylori ou d'autres bacteries spirales, ureare-positives, gram-négatives
DK0780375T3 (da) * 1995-12-21 2002-10-07 Pfizer 3-((5-substitueret benzyl)amino)-2-phenylpiperidiner som substans P-antagonister
US5990125A (en) 1996-01-19 1999-11-23 Pfizer Inc. NK-1 receptor antagonists for the treatment of cancer

Also Published As

Publication number Publication date
JP3084069B2 (ja) 2000-09-04
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
RU2152930C2 (ru) 2000-07-20
ES2211684T3 (es) 2004-07-16
OA10666A (en) 2002-11-25
HUP9901159A3 (en) 2000-05-29
DZ2086A1 (fr) 2002-07-22
CZ52198A3 (cs) 1999-01-13
PE1398A1 (es) 1998-02-27
MY114800A (en) 2003-01-31
YU47896A (sh) 1998-12-23
AP643A (en) 1998-04-24
NZ308207A (en) 1998-07-28
JPH10510554A (ja) 1998-10-13
RO119299B1 (ro) 2004-07-30
DE69616817T2 (de) 2002-04-04
CN1193961A (zh) 1998-09-23
AU702698B2 (en) 1999-03-04
YU49122B (sh) 2004-03-12
EP0861235A1 (fr) 1998-09-02
DE69616817D1 (de) 2001-12-13
CZ297543B6 (cs) 2007-02-07
PL325332A1 (en) 1998-07-20
BG64126B1 (bg) 2004-01-30
AR006305A1 (es) 1999-08-25
ATE208377T1 (de) 2001-11-15
SI1114817T1 (en) 2004-06-30
NO980751D0 (no) 1998-02-23
HUP9901159A2 (hu) 1999-07-28
HRP960386B1 (en) 2002-04-30
ATE258166T1 (de) 2004-02-15
BR9609989A (pt) 1999-07-06
PE20010700A1 (es) 2001-07-09
MX9801467A (es) 1998-05-31
CA2227814A1 (fr) 1997-03-06
HRP960386A2 (en) 1998-04-30
SK20798A3 (en) 1999-03-12
US6506775B1 (en) 2003-01-14
KR100288673B1 (ko) 2001-05-02
EP1114817B1 (fr) 2004-01-21
CO4480738A1 (es) 1997-07-09
IL119078A (en) 2003-11-23
BG102288A (en) 1998-09-30
EP1114817A1 (fr) 2001-07-11
IS4644A (is) 1997-12-30
HK1014935A1 (en) 1999-10-08
CA2227814C (fr) 2002-12-31
NO980751L (no) 1998-02-23
PT1114817E (pt) 2004-05-31
IL119078A0 (en) 1996-11-14
CN1153764C (zh) 2004-06-16
SI0861235T1 (en) 2002-04-30
DE69631390T2 (de) 2004-11-25
ES2163017T3 (es) 2002-01-16
PL186773B1 (pl) 2004-02-27
NO310720B1 (no) 2001-08-20
EP0861235B1 (fr) 2001-11-07
WO1997008144A1 (fr) 1997-03-06
PT861235E (pt) 2002-03-28
AU5776996A (en) 1997-03-19
SK282925B6 (sk) 2003-01-09
AP9600850A0 (en) 1996-10-31
TW340842B (en) 1998-09-21
DK0861235T3 (da) 2001-12-27
IS1947B (is) 2004-10-13
KR19990044077A (ko) 1999-06-25
DK1114817T3 (da) 2004-04-26
TR199800300T1 (xx) 1998-06-22
TNSN96107A1 (fr) 2005-03-15
UA48981C2 (uk) 2002-09-16

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