SU574156A3 - Способ получени 6-аза-1,2-дигидро-3н1,4-бензодиазепинов или их солей - Google Patents
Способ получени 6-аза-1,2-дигидро-3н1,4-бензодиазепинов или их солейInfo
- Publication number
- SU574156A3 SU574156A3 SU7402067128A SU2067128A SU574156A3 SU 574156 A3 SU574156 A3 SU 574156A3 SU 7402067128 A SU7402067128 A SU 7402067128A SU 2067128 A SU2067128 A SU 2067128A SU 574156 A3 SU574156 A3 SU 574156A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- benzodiazepines
- aza
- salrs
- dihydro
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ,2-ДИГИ.Щ О-ЗН-1,4-БЕНЗОДИАЗЕПИНОВ HJBi ИХ COJTEft
Изобретение касаетс способа получени новых биологически активных производных 6 - азабензодиазепина .
Способ основан на известном приеме дезокси- генировани N - окисей 1 и позвол ет получать соединени , которые обладают ценными фармакологическими свойствами.
Описан способ получени 6 - аза - 1,2 - дигадро- ЗН - 1,4 - бензодиазеринов общей формулы
О
III
.N-C
(1)
где RI - фтор, хлор или бром,
RZ и RS - водород, фтор, хлор или бром R4 - водород или алкил GI - 6, или их солей.
Согласно изобретению способ получени соединений формулы (Г) заключаетс в том, что N - окись формулы
(И)
где RI , RI , Rj и R имеют указанные значени , подвергают взаимодействию с водородом в присутствии металлических катализаторов гидрировани
или треххлористым фосфором, или с диметилсульфоксидом .
Дезоксигерирование соединений формулы (П) осуществл ют предпочтительно в среде расворител , в качестве которых используют, например,
диоксан, бензол или толуол, а в случае применени водорода - низшие спирты. Способ ведут при температурах от 20 до 140° С, предпочтительно от 20 до 100° С. В качестве металлических катализаторов гидрировани примен ют катализаторы из
благородных металлов (палладий, платина или
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1060471A AT333284B (de) | 1971-12-09 | 1971-12-09 | Verfahren zur herstellung von neuen 6-aza-3h-1,4-benzodiazepinen, deren optischen isomeren und deren salzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU574156A3 true SU574156A3 (ru) | 1977-09-25 |
Family
ID=3623479
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1855103A SU468423A3 (ru) | 1971-12-09 | 1972-12-08 | Способ получени 6-аза-3н-1,4-бензодиазепинов |
| SU742041603A SU674675A3 (ru) | 1971-12-09 | 1974-07-08 | Способ получени 6-аза-1,2-дигидро3н-1,4-бензодиазепинов или их солей |
| SU7402042686A SU564809A3 (ru) | 1971-12-09 | 1974-07-08 | Способ получени 6-аза-1,2дигидро-3н-1,4-бензодиазепинов или их солей |
| SU7402067128A SU574156A3 (ru) | 1971-12-09 | 1974-10-15 | Способ получени 6-аза-1,2-дигидро-3н1,4-бензодиазепинов или их солей |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1855103A SU468423A3 (ru) | 1971-12-09 | 1972-12-08 | Способ получени 6-аза-3н-1,4-бензодиазепинов |
| SU742041603A SU674675A3 (ru) | 1971-12-09 | 1974-07-08 | Способ получени 6-аза-1,2-дигидро3н-1,4-бензодиазепинов или их солей |
| SU7402042686A SU564809A3 (ru) | 1971-12-09 | 1974-07-08 | Способ получени 6-аза-1,2дигидро-3н-1,4-бензодиазепинов или их солей |
Country Status (26)
| Country | Link |
|---|---|
| JP (4) | JPS569509B2 (ru) |
| AR (3) | AR201201A1 (ru) |
| AT (4) | AT332877B (ru) |
| AU (1) | AU473253B2 (ru) |
| BE (1) | BE792541A (ru) |
| CH (4) | CH594665A5 (ru) |
| CS (1) | CS212736B2 (ru) |
| DD (1) | DD105448A5 (ru) |
| DE (1) | DE2259471C2 (ru) |
| DK (1) | DK138425B (ru) |
| EG (1) | EG10918A (ru) |
| ES (2) | ES409090A1 (ru) |
| FI (1) | FI54710C (ru) |
| FR (1) | FR2162482B1 (ru) |
| GB (1) | GB1400755A (ru) |
| HU (1) | HU169468B (ru) |
| IL (1) | IL41034A (ru) |
| IT (1) | IT1035053B (ru) |
| NL (1) | NL171986C (ru) |
| NO (1) | NO137094C (ru) |
| PL (3) | PL91876B1 (ru) |
| RO (4) | RO65263A (ru) |
| SE (1) | SE404803B (ru) |
| SU (4) | SU468423A3 (ru) |
| YU (2) | YU305972A (ru) |
| ZA (1) | ZA728497B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2364636C2 (de) * | 1973-12-24 | 1982-11-04 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 2-Benzoyl-6-chlor-3-nitro-pyridinen |
| EP0032516B1 (en) * | 1980-01-16 | 1984-05-02 | Lacer, S.A. | New 2-halo-pyridines, their production and pharmaceutical compositions |
| JPS60132610A (ja) * | 1983-12-20 | 1985-07-15 | Japan Organo Co Ltd | 汚泥脱水装置 |
| JPS6219221A (ja) * | 1985-07-16 | 1987-01-28 | Chiyoda Chem Eng & Constr Co Ltd | 原液中の微細粒子を除去する濾過方法と濾過装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US3523939A (en) * | 1967-07-03 | 1970-08-11 | Hoffmann La Roche | 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation |
-
1971
- 1971-12-09 AT AT902174A patent/AT332877B/de active
- 1971-12-09 AT AT1060471A patent/AT333284B/de not_active IP Right Cessation
- 1971-12-09 AT AT902274A patent/AT332878B/de active
-
1972
- 1972-11-29 ES ES409090A patent/ES409090A1/es not_active Expired
- 1972-11-29 ES ES409089A patent/ES409089A1/es not_active Expired
- 1972-11-30 FI FI3390/72A patent/FI54710C/fi active
- 1972-11-30 ZA ZA728497A patent/ZA728497B/xx unknown
- 1972-12-05 SE SE7215858A patent/SE404803B/xx unknown
- 1972-12-05 DE DE2259471A patent/DE2259471C2/de not_active Expired
- 1972-12-06 EG EG502/72A patent/EG10918A/xx active
- 1972-12-06 FR FR7243359A patent/FR2162482B1/fr not_active Expired
- 1972-12-06 HU HUDE799A patent/HU169468B/hu unknown
- 1972-12-07 RO RO7281196A patent/RO65263A/ro unknown
- 1972-12-07 PL PL1972175581A patent/PL91876B1/pl unknown
- 1972-12-07 RO RO7281197A patent/RO67345A/ro unknown
- 1972-12-07 RO RO7200073075A patent/RO62312A/ro unknown
- 1972-12-07 NL NLAANVRAGE7216621,A patent/NL171986C/xx not_active IP Right Cessation
- 1972-12-07 IT IT7254583Q patent/IT1035053B/it active
- 1972-12-07 PL PL1972175582A patent/PL91828B1/pl unknown
- 1972-12-07 PL PL1972159365A patent/PL89682B1/pl unknown
- 1972-12-07 RO RO7281195A patent/RO65264A/ro unknown
- 1972-12-08 NO NO4536/72A patent/NO137094C/no unknown
- 1972-12-08 BE BE792541A patent/BE792541A/xx not_active IP Right Cessation
- 1972-12-08 GB GB5688372A patent/GB1400755A/en not_active Expired
- 1972-12-08 CS CS728424A patent/CS212736B2/cs unknown
- 1972-12-08 IL IL41034A patent/IL41034A/en unknown
- 1972-12-08 SU SU1855103A patent/SU468423A3/ru active
- 1972-12-08 YU YU03059/72A patent/YU305972A/xx unknown
- 1972-12-08 DK DK615172AA patent/DK138425B/da not_active IP Right Cessation
- 1972-12-09 JP JP12387872A patent/JPS569509B2/ja not_active Expired
- 1972-12-11 CH CH1794972A patent/CH594665A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1506576A patent/CH605946A5/xx not_active IP Right Cessation
- 1972-12-11 DD DD167428A patent/DD105448A5/xx unknown
- 1972-12-11 AU AU49931/72A patent/AU473253B2/en not_active Expired
- 1972-12-11 CH CH1526076A patent/CH603645A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1506676A patent/CH603644A5/xx not_active IP Right Cessation
-
1973
- 1973-09-10 AR AR250008A patent/AR201201A1/es active
-
1974
- 1974-03-20 AR AR252867A patent/AR200309A1/es active
- 1974-07-08 SU SU742041603A patent/SU674675A3/ru active
- 1974-07-08 SU SU7402042686A patent/SU564809A3/ru active
- 1974-10-15 SU SU7402067128A patent/SU574156A3/ru active
- 1974-10-31 AR AR256352A patent/AR203311A1/es active
- 1974-11-11 AT AT902074A patent/AT338798B/de not_active IP Right Cessation
-
1980
- 1980-04-15 JP JP5022180A patent/JPS5625180A/ja active Granted
- 1980-04-15 JP JP5022280A patent/JPS55147282A/ja active Granted
- 1980-04-15 JP JP5022380A patent/JPS5625181A/ja active Granted
-
1981
- 1981-05-07 YU YU01168/81A patent/YU116881A/xx unknown
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