KR880003909A - 5-클로로메틸피리딘의 제조방법 - Google Patents
5-클로로메틸피리딘의 제조방법 Download PDFInfo
- Publication number
- KR880003909A KR880003909A KR1019870009730A KR870009730A KR880003909A KR 880003909 A KR880003909 A KR 880003909A KR 1019870009730 A KR1019870009730 A KR 1019870009730A KR 870009730 A KR870009730 A KR 870009730A KR 880003909 A KR880003909 A KR 880003909A
- Authority
- KR
- South Korea
- Prior art keywords
- process according
- chlorine
- acid acceptor
- inert diluent
- optionally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식(Ⅱ)의 5-메틸피리딘을 0℃내지 100℃의 온도에서, 경우에 따라서는 산수용체의 존재하에 또한 경우에 따라서는 불활성 희석제의 존재하에 염소와 시킴을 특징으로 하는, 일반식(Ⅰ)의 5-클로로메틸피리딘의 제조방법.상기식에서, R1은 염소 또는 니트로이고, R2는 염소이며, N은 0 또는 1의 수이다.
- 제1항 있어서, 반응을 산수용체 및 불활성 희석제의 존재하에 수행함을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 사용된 불활성 희석제가 임의로 할로겐화된 지방족 탄화수소 또는 에테르임을 특징으로 하는 방법.
- 제1항 내지 제3항중 어느 한 항에 있어서, 사용된 산 수용체가 알칼리 금속 탄산염, 또는 지방족, 방향족 또는 헤테로 사이클릭 아민임을 특징으로 하는 방법.
- 제1항 내지 제4항중 어느 한 항에 있어서, 반응을 40내지 80℃의 온도에서 수행함을 특징으로 하는 방법.
- 제1항 내지 제5항중 어느 한 항에 있어서, 일반식(Ⅱ)의 출발물질, 산수용체 및 희석제의 혼합물에 원소성 염소를 통과시키고, 반응 혼합물을 수시간 동안 교반시킴을 특징으로 하는 방법.
- 제1항 내지 제6항중 어느 한 항에 있어서, 2-클로로-5-클로로 메틸피리딘을 수득하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3630046 | 1986-09-04 | ||
DE19863630046 DE3630046A1 (de) | 1986-09-04 | 1986-09-04 | Verfahren zur herstellung von 5-chlormethylpyridinen |
DE36300462 | 1986-09-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880003909A true KR880003909A (ko) | 1988-06-01 |
KR950009750B1 KR950009750B1 (ko) | 1995-08-28 |
Family
ID=6308855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870009730A KR950009750B1 (ko) | 1986-09-04 | 1987-09-03 | 5-클로로메틸피리딘의 제조방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4778896A (ko) |
EP (1) | EP0260485B1 (ko) |
JP (1) | JPH0794441B2 (ko) |
KR (1) | KR950009750B1 (ko) |
CA (1) | CA1302419C (ko) |
DD (1) | DD263529A5 (ko) |
DE (2) | DE3630046A1 (ko) |
HU (1) | HU202202B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5329011A (en) * | 1989-04-20 | 1994-07-12 | Bayer Aktiengesellschaft | Process for the preparation of 2-chloro-5-chloromethyl-pyridine, and new intermediates |
DE3912964A1 (de) * | 1989-04-20 | 1990-10-25 | Bayer Ag | Verfahren zur herstellung von 2-chlor-5-chlormethyl-pyridin und neue zwischenprodukte |
DE4020053A1 (de) * | 1990-01-31 | 1991-08-01 | Bayer Ag | Verfahren zur herstellung von 2-chlor-5-methyl-pyridin |
DE4016175A1 (de) * | 1990-05-19 | 1991-11-21 | Bayer Ag | Seitenkettenchlorierung von alkylierten stickstoff-heteroaromaten |
JP2823414B2 (ja) * | 1992-02-26 | 1998-11-11 | セントラル硝子株式会社 | 2−クロロ−メチルピリジン類の側鎖塩素化法 |
KR930023342A (ko) * | 1992-05-12 | 1993-12-18 | 비트 라우버, 토마스 케플러 | 2-클로로-5-클로로메틸- 피리딘의 제조방법 |
US5508410A (en) * | 1993-11-30 | 1996-04-16 | Reilly Industries, Inc. | Process for preparing 2-halo-5-substituted pyridines |
US5521316A (en) * | 1994-05-20 | 1996-05-28 | Cytec Technology Corp. | Chloroalkyl pyridinum hydrochloride compounds and processes for their preparation |
DE4446338A1 (de) * | 1994-12-23 | 1996-06-27 | Bayer Ag | Verfahren zur Herstellung von Chlormethylpyridinen |
EP0791583B1 (en) * | 1995-09-08 | 2001-04-18 | Nippon Soda Co., Ltd. | Process for producing 3-(aminomethyl)-6-chloropyridines |
DE19710613A1 (de) * | 1997-03-14 | 1998-09-17 | Bayer Ag | Verfahren zur Herstellung von 5-Aminomethyl-2-chlorpyridinen |
NZ520214A (en) * | 2000-01-19 | 2004-06-25 | Bayer Ag | Process for the preparation of heterocyclic compounds |
DE102006015467A1 (de) | 2006-03-31 | 2007-10-04 | Bayer Cropscience Ag | Substituierte Enaminocarbonylverbindungen |
DE102006033572A1 (de) | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
EP2039678A1 (de) | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zum Herstellen von 4-Aminobut-2-enoliden |
EP2107058A1 (de) | 2008-03-31 | 2009-10-07 | Bayer CropScience AG | Substituierte Enaminothiocarbonylverbindungen |
EP2264008A1 (de) | 2009-06-18 | 2010-12-22 | Bayer CropScience AG | Substituierte Enaminocarbonylverbindungen |
WO2012062740A1 (de) | 2010-11-12 | 2012-05-18 | Bayer Cropscience Ag | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten ausgehend von n-(2,2-difluorethyl)prop-2-en-1-amin |
WO2012152741A1 (de) | 2011-05-10 | 2012-11-15 | Bayer Intellectual Property Gmbh | Bicyclische (thio)carbonylamidine |
CN102796039B (zh) * | 2012-08-16 | 2014-11-12 | 浙江工业大学 | 一种微通道内连续化制备2-氯-5-氯甲基吡啶的方法 |
CN106187869A (zh) * | 2016-07-28 | 2016-12-07 | 南京红太阳生物化学有限责任公司 | 一种合成2‑氯‑5‑氯甲基吡啶的方法 |
CN109574918B (zh) * | 2019-01-17 | 2020-06-05 | 内蒙古元正精细化工有限责任公司 | 利用微通道反应器连续化制备2-氯-5-氯甲基吡啶的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123608A (en) * | 1964-03-03 | Process for chlorination of side chains | ||
US3931200A (en) * | 1974-01-22 | 1976-01-06 | The Dow Chemical Company | Substituted pyridinylalkoxy-, pyridinylalkylsulfonyl- and pyridinylalkylthio- phenylureas |
GB1599783A (en) * | 1978-02-15 | 1981-10-07 | Ici Ltd | Partial chlorination of 3-methyl pyridine |
ZW5085A1 (en) * | 1984-04-13 | 1985-09-18 | Nihon Tokushu Noyaku Seizo Kk | Nitromethylene derivatives,intermediates thereof,processes for production thereof,and insecticides |
-
1986
- 1986-09-04 DE DE19863630046 patent/DE3630046A1/de not_active Withdrawn
-
1987
- 1987-08-17 US US07/086,418 patent/US4778896A/en not_active Expired - Lifetime
- 1987-08-25 DE DE8787112284T patent/DE3763558D1/de not_active Expired - Lifetime
- 1987-08-25 EP EP87112284A patent/EP0260485B1/de not_active Expired - Lifetime
- 1987-09-01 JP JP62216563A patent/JPH0794441B2/ja not_active Expired - Lifetime
- 1987-09-02 DD DD87306588A patent/DD263529A5/de not_active IP Right Cessation
- 1987-09-02 CA CA000545935A patent/CA1302419C/en not_active Expired - Lifetime
- 1987-09-03 KR KR1019870009730A patent/KR950009750B1/ko not_active IP Right Cessation
- 1987-09-04 HU HU873971A patent/HU202202B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DD263529A5 (de) | 1989-01-04 |
CA1302419C (en) | 1992-06-02 |
US4778896A (en) | 1988-10-18 |
DE3763558D1 (de) | 1990-08-09 |
HUT48212A (en) | 1989-05-29 |
DE3630046A1 (de) | 1988-03-17 |
HU202202B (en) | 1991-02-28 |
JPH0794441B2 (ja) | 1995-10-11 |
JPS6368565A (ja) | 1988-03-28 |
KR950009750B1 (ko) | 1995-08-28 |
EP0260485A1 (de) | 1988-03-23 |
EP0260485B1 (de) | 1990-07-04 |
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