SU1251808A3 - Способ получени гидройодидов производных пирроло(1,2- @ )тиазола - Google Patents
Способ получени гидройодидов производных пирроло(1,2- @ )тиазола Download PDFInfo
- Publication number
- SU1251808A3 SU1251808A3 SU843821204A SU3821204A SU1251808A3 SU 1251808 A3 SU1251808 A3 SU 1251808A3 SU 843821204 A SU843821204 A SU 843821204A SU 3821204 A SU3821204 A SU 3821204A SU 1251808 A3 SU1251808 A3 SU 1251808A3
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- USSR - Soviet Union
- Prior art keywords
- pyrrolo
- producing
- hydroiodides
- thiazole derivatives
- acetone
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Silicon Polymers (AREA)
- Earth Drilling (AREA)
- Peptides Or Proteins (AREA)
- Instructional Devices (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
см
Изобретение относитс к способу получени новых химических соединений а именно гидройодилов производных пирроло 1,2,-с тиазола, вл ющихс полупродуктами в синтезе веществ с биологической актгтностью.
Целью изобретени вл етс получе ние новых соединений в качестве полупродуктов в синтезе производных пирроло 1,2,-с тиазола, про вл ющих новьпЧ вид биологического действи .
Пример 1. Суспензию 7 г 3-(3-пиридил)-1Н, ЗН-пирроло (1,2-с)- 7-тиазол-карботиоамида и 4,2 г ме- ти.пйодида в 250 см ацетона перемешивают при 20°С в течение 16ч. Затем прибавл ют к суспензии 50 см диметилформамида и продолжают пере- ме1аивание в теченеи 3 дн. Затем кристаллы отдел ют фильтрованием, после чего промывают их 3 раза в 90 см ацетона и сутат при пони; сенном давлении (20 мм рт.ст.; 2,7 кПа) при
-20 С в присутствии гидроокиси
кали в форме таблеток. Таким образом , получают 9,5 г гидройодида З-(З-пиридил)-1Н, ЗН-пирроло (1, 2-е)-7-тиазолтиокарбоксимидат-8-метнла в виде желтоватых кристаллов, плав щихс при 193-194 С.
П р и м е р 2. Суспензию 81,3 г 5-(3-пиркдил)-1Н, ЗН-пирроло (1, 2-е)-7-тиазолкарботиоамнаа и 49 г
метилйодида в смеси 3110 см ацетона и 1550 см диметилформамида перемащивают при 20 с в течение 3 дн. По вившиес кристаллы отдел ют фильтрованием , промывают 3 раза в
1500 см ацетона, затем 2 раза в 500 см простого диэтилового эфира и сушат при пониженном давлении (20 мм рт.ст.; 2,7 кПа) при 20°С в присутствии гидроокиси кали в виде теблеток. Таким образом, получают 113 г гидройодида 5-(3-пиридил)-1Н, ЗН-пирроло(1,2-с)-7-тиазолтиокарбок- симидат-5-метила в виде желтых кристаллов , плав щихс при 262 С.
Claims (1)
- СПОСОБ ПОЛУЧЕНИЯ ГИДРОЙОДИДОВ ПРОИЗВОДНЫХ ПИРРОЛО (1,2-с) ТИАЗОЛА общей формулы где Rt низший алкил;один из радикалов Rf и R3 - 3пиридил, а другой - водород, о т л и ч ающийс я тем, что соединение общей Формулы где R? и R3 - имеют указанные значения , е подвергают взаимодействию с соединением общей ФормулыV’’ где R, - имеет указанное значение, в среде ацетона или смеси ацетона и диметилформамида при температуре порядка 20°C.SU ..„1251808 А 51251;
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8300454A FR2539417A1 (fr) | 1983-01-13 | 1983-01-13 | Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1251808A3 true SU1251808A3 (ru) | 1986-08-15 |
Family
ID=9284899
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU843692010A SU1251805A3 (ru) | 1983-01-13 | 1984-01-12 | Способ получени гетероциклических амидов |
| SU843692003A SU1297730A3 (ru) | 1983-01-13 | 1984-01-12 | Способ получени гетероциклических нитрилов |
| SU843821204A SU1251808A3 (ru) | 1983-01-13 | 1984-12-07 | Способ получени гидройодидов производных пирроло(1,2- @ )тиазола |
| SU843823559A SU1282819A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени ортоконденсированных производных пиррола |
| SU843822790A SU1277900A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени 5-/3-пиридил/-1 @ ,3 @ -пиррол /1,2- @ /-7-тиазолкарбоксальдегида |
| SU843823253A SU1282818A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени ортоконденсированных производных пиррола |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU843692010A SU1251805A3 (ru) | 1983-01-13 | 1984-01-12 | Способ получени гетероциклических амидов |
| SU843692003A SU1297730A3 (ru) | 1983-01-13 | 1984-01-12 | Способ получени гетероциклических нитрилов |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU843823559A SU1282819A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени ортоконденсированных производных пиррола |
| SU843822790A SU1277900A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени 5-/3-пиридил/-1 @ ,3 @ -пиррол /1,2- @ /-7-тиазолкарбоксальдегида |
| SU843823253A SU1282818A3 (ru) | 1983-01-13 | 1984-12-14 | Способ получени ортоконденсированных производных пиррола |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US4546100A (ru) |
| EP (1) | EP0118321B1 (ru) |
| JP (1) | JPS59134797A (ru) |
| KR (1) | KR910001284B1 (ru) |
| AT (1) | ATE24321T1 (ru) |
| AU (1) | AU562832B2 (ru) |
| BG (4) | BG40968A3 (ru) |
| CA (1) | CA1222514A (ru) |
| CS (1) | CS259516B2 (ru) |
| DD (1) | DD216022A5 (ru) |
| DE (1) | DE3461713D1 (ru) |
| DK (1) | DK13884A (ru) |
| ES (3) | ES8502122A1 (ru) |
| FI (1) | FI76578C (ru) |
| FR (1) | FR2539417A1 (ru) |
| GR (1) | GR81680B (ru) |
| HU (1) | HU194224B (ru) |
| IE (1) | IE56838B1 (ru) |
| IL (1) | IL70663A (ru) |
| MA (1) | MA20002A1 (ru) |
| NO (1) | NO167032C (ru) |
| NZ (1) | NZ206809A (ru) |
| PL (4) | PL144351B1 (ru) |
| PT (1) | PT77951B (ru) |
| SU (6) | SU1251805A3 (ru) |
| ZA (1) | ZA84234B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557111B1 (fr) * | 1983-12-21 | 1986-04-11 | Rhone Poulenc Sante | Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent |
| GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
| US5260451A (en) * | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
| DE3915450A1 (de) * | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
| JP3061631B2 (ja) * | 1989-10-11 | 2000-07-10 | 山之内製薬株式会社 | 新規なヘテロ環化合物およびその製造法 |
| DE4419247A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
| DE4419246A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| FR2735476B1 (fr) * | 1995-06-14 | 1997-07-18 | Rhone Poulenc Rorer Sa | Nouvelle application de derives du pyrrole |
| WO2001005792A1 (de) | 1999-11-23 | 2001-01-25 | Merckle Gmbh | Antiinflammatorische oxo- und hydroxyderivate von pyrrolizinen und deren anwendung in der pharmazie |
| DE10004157A1 (de) | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie |
| US8424704B2 (en) * | 2004-06-02 | 2013-04-23 | X-Pert Paint Mixing Systems, Inc. | Self-cleaning lid for a paint container fluid pour spout |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1401707A (fr) * | 1963-07-03 | 1965-06-04 | Kodak Pathe | Nouveaux colorants, nouveaux composés intermédiaires servant à les préparer et produits photographiques les contenant |
| BE649903A (ru) * | 1963-07-03 | |||
| US3642807A (en) * | 1970-06-18 | 1972-02-15 | Schering Corp | Certain 1-/dilower-alkyl amino-loweralkyl/-2-phenyl indolizines and quaternary salts thereof |
-
1983
- 1983-01-13 FR FR8300454A patent/FR2539417A1/fr active Granted
-
1984
- 1984-01-10 CS CS84198A patent/CS259516B2/cs unknown
- 1984-01-11 NZ NZ206809A patent/NZ206809A/en unknown
- 1984-01-11 GR GR73492A patent/GR81680B/el unknown
- 1984-01-11 US US06/569,907 patent/US4546100A/en not_active Expired - Lifetime
- 1984-01-11 MA MA20223A patent/MA20002A1/fr unknown
- 1984-01-11 ZA ZA84234A patent/ZA84234B/xx unknown
- 1984-01-11 DD DD84259352A patent/DD216022A5/de unknown
- 1984-01-11 AU AU23201/84A patent/AU562832B2/en not_active Ceased
- 1984-01-11 IL IL70663A patent/IL70663A/xx unknown
- 1984-01-12 DK DK13884A patent/DK13884A/da not_active Application Discontinuation
- 1984-01-12 AT AT84400058T patent/ATE24321T1/de not_active IP Right Cessation
- 1984-01-12 HU HU8481A patent/HU194224B/hu unknown
- 1984-01-12 FI FI840107A patent/FI76578C/fi not_active IP Right Cessation
- 1984-01-12 BG BG8463860A patent/BG40968A3/xx unknown
- 1984-01-12 IE IE63/84A patent/IE56838B1/en not_active IP Right Cessation
- 1984-01-12 DE DE8484400058T patent/DE3461713D1/de not_active Expired
- 1984-01-12 BG BG8466791A patent/BG40148A3/xx unknown
- 1984-01-12 EP EP84400058A patent/EP0118321B1/fr not_active Expired
- 1984-01-12 PT PT77951A patent/PT77951B/pt not_active IP Right Cessation
- 1984-01-12 CA CA000445144A patent/CA1222514A/fr not_active Expired
- 1984-01-12 BG BG8466790A patent/BG40147A3/xx unknown
- 1984-01-12 NO NO840107A patent/NO167032C/no unknown
- 1984-01-12 KR KR1019840000094A patent/KR910001284B1/ko not_active IP Right Cessation
- 1984-01-12 BG BG8466789A patent/BG40146A3/xx unknown
- 1984-01-12 SU SU843692010A patent/SU1251805A3/ru active
- 1984-01-12 SU SU843692003A patent/SU1297730A3/ru active
- 1984-01-13 PL PL1984251479A patent/PL144351B1/pl unknown
- 1984-01-13 PL PL1984251478A patent/PL144350B1/pl unknown
- 1984-01-13 PL PL1984245704A patent/PL142322B1/pl unknown
- 1984-01-13 PL PL1984245702A patent/PL144341B1/pl unknown
- 1984-01-13 JP JP59003685A patent/JPS59134797A/ja active Granted
- 1984-01-13 ES ES528874A patent/ES8502122A1/es not_active Expired
- 1984-03-28 ES ES531063A patent/ES8501771A1/es not_active Expired
- 1984-03-28 ES ES531062A patent/ES531062A0/es active Granted
- 1984-12-07 SU SU843821204A patent/SU1251808A3/ru active
- 1984-12-14 SU SU843823559A patent/SU1282819A3/ru active
- 1984-12-14 SU SU843822790A patent/SU1277900A3/ru active
- 1984-12-14 SU SU843823253A patent/SU1282818A3/ru active
-
1985
- 1985-04-10 US US06/721,773 patent/US4584297A/en not_active Expired - Fee Related
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