SK6032003A3 - Organic compounds, method for the preparation thereof, their use and a pharmaceutical composition - Google Patents
Organic compounds, method for the preparation thereof, their use and a pharmaceutical composition Download PDFInfo
- Publication number
- SK6032003A3 SK6032003A3 SK603-2003A SK6032003A SK6032003A3 SK 6032003 A3 SK6032003 A3 SK 6032003A3 SK 6032003 A SK6032003 A SK 6032003A SK 6032003 A3 SK6032003 A3 SK 6032003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- alkyl
- formula
- compounds
- carbon atoms
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- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title description 17
- 150000002894 organic compounds Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 116
- 150000003839 salts Chemical group 0.000 claims abstract description 35
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
- 239000001257 hydrogen Substances 0.000 claims abstract description 27
- -1 cyano, hydroxy Chemical group 0.000 claims abstract description 25
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 25
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 20
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 17
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 16
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract description 9
- 125000002252 acyl group Chemical group 0.000 claims abstract description 9
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 9
- 125000001424 substituent group Chemical group 0.000 claims abstract description 9
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims abstract description 7
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 7
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 61
- 125000000217 alkyl group Chemical group 0.000 claims description 47
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
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- 125000005843 halogen group Chemical group 0.000 claims description 20
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- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 9
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028383.8A GB0028383D0 (en) | 2000-11-21 | 2000-11-21 | Organic compounds |
| PCT/EP2001/013378 WO2002042298A1 (en) | 2000-11-21 | 2001-11-19 | Aminothiazoles and their use as adenosine receptor antagonists |
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| SK6032003A3 true SK6032003A3 (en) | 2004-01-08 |
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| SK603-2003A SK6032003A3 (en) | 2000-11-21 | 2001-11-19 | Organic compounds, method for the preparation thereof, their use and a pharmaceutical composition |
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| EP (1) | EP1339711B1 (es) |
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| CN (1) | CN1244580C (es) |
| AR (1) | AR035371A1 (es) |
| AT (1) | ATE300536T1 (es) |
| AU (1) | AU2002237221A1 (es) |
| BR (1) | BR0115478A (es) |
| CA (1) | CA2429442A1 (es) |
| CZ (1) | CZ20031393A3 (es) |
| DE (1) | DE60112322T2 (es) |
| EC (1) | ECSP034611A (es) |
| ES (1) | ES2246346T3 (es) |
| GB (1) | GB0028383D0 (es) |
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| PE (1) | PE20020580A1 (es) |
| PL (1) | PL361842A1 (es) |
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| SK (1) | SK6032003A3 (es) |
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| US20200383960A1 (en) | 2019-06-10 | 2020-12-10 | Novartis Ag | Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis |
| CN114008050A (zh) | 2019-06-18 | 2022-02-01 | 豪夫迈·罗氏有限公司 | Jak激酶的吡唑并嘧啶芳基醚抑制剂及其用途 |
| TW202115069A (zh) | 2019-06-18 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | Ｊａｋ激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途 |
| WO2020257145A1 (en) | 2019-06-18 | 2020-12-24 | Genentech, Inc. | Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof |
| US20220306617A1 (en) | 2019-08-28 | 2022-09-29 | Novartis Ag | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
| WO2023139132A1 (en) * | 2022-01-19 | 2023-07-27 | Leadxpro Ag | Functionalized aminothiazoles |
| GB2615307A (en) * | 2022-01-28 | 2023-08-09 | Adorx Therapeutics Ltd | Antagonist compounds |
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| GB8917849D0 (en) * | 1989-08-04 | 1989-09-20 | Shell Int Research | Thiazole derivatives,their preparation and their use as fungicides |
| JPH04118648A (ja) | 1990-07-13 | 1992-04-20 | Konica Corp | 写真用カプラー |
| FR2677356B1 (fr) | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| JPH07128824A (ja) | 1993-11-05 | 1995-05-19 | Konica Corp | 写真用カプラー |
| US5530000A (en) | 1993-12-22 | 1996-06-25 | Ortho Pharmaceutical Corporation | Substituted pyrimidinylaminothiazole derivatives useful as platelet aggreggation inhibitors |
| EP0772606A1 (en) | 1994-07-27 | 1997-05-14 | G.D. SEARLE & CO. | Substituted thiazoles for the treatment of inflammation |
| US5880140A (en) | 1996-04-03 | 1999-03-09 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| US5883105A (en) | 1996-04-03 | 1999-03-16 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5872136A (en) | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
| US5874452A (en) | 1996-04-03 | 1999-02-23 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| US6063930A (en) | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US6080870A (en) | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US5854265A (en) | 1996-04-03 | 1998-12-29 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| US5859035A (en) | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
| US5939557A (en) | 1996-04-03 | 1999-08-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0914322A1 (en) | 1996-05-27 | 1999-05-12 | Fujisawa Pharmaceutical Co., Ltd. | New indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production |
| US6436966B1 (en) | 1997-10-27 | 2002-08-20 | Takeda Chemical Ind., Ltd. | Adenosine A3 receptor antagonists |
| AU4506399A (en) | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
| AU2039800A (en) | 1998-12-04 | 2000-06-26 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulatorsof selectins |
| JP2000302680A (ja) | 1999-04-23 | 2000-10-31 | Takeda Chem Ind Ltd | 脳保護剤 |
| AU4315100A (en) | 1999-04-28 | 2000-11-17 | Sankyo Company Limited | Preventive or inhibitory agents for hepatopathy |
| AU2001239754A1 (en) | 2000-02-25 | 2001-09-03 | Avon Products Inc. | Topical compositions containing thiazolium compounds and methods of using same |
| AU2001237401B2 (en) | 2000-03-01 | 2006-11-09 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
-
2000
- 2000-11-21 GB GBGB0028383.8A patent/GB0028383D0/en not_active Ceased
-
2001
- 2001-11-19 SK SK603-2003A patent/SK6032003A3/sk unknown
- 2001-11-19 MX MXPA03004439A patent/MXPA03004439A/es unknown
- 2001-11-19 IL IL15571201A patent/IL155712A0/xx unknown
- 2001-11-19 AU AU2002237221A patent/AU2002237221A1/en not_active Abandoned
- 2001-11-19 BR BR0115478-8A patent/BR0115478A/pt not_active Application Discontinuation
- 2001-11-19 ES ES01986395T patent/ES2246346T3/es not_active Expired - Lifetime
- 2001-11-19 CN CNB018192882A patent/CN1244580C/zh not_active Expired - Fee Related
- 2001-11-19 WO PCT/EP2001/013378 patent/WO2002042298A1/en active IP Right Grant
- 2001-11-19 AT AT01986395T patent/ATE300536T1/de not_active IP Right Cessation
- 2001-11-19 HU HU0302079A patent/HUP0302079A2/hu unknown
- 2001-11-19 KR KR10-2003-7006156A patent/KR20040007412A/ko not_active Application Discontinuation
- 2001-11-19 NZ NZ525875A patent/NZ525875A/en unknown
- 2001-11-19 CZ CZ20031393A patent/CZ20031393A3/cs unknown
- 2001-11-19 RU RU2003117476/04A patent/RU2003117476A/ru not_active Application Discontinuation
- 2001-11-19 JP JP2002544432A patent/JP3973556B2/ja not_active Expired - Fee Related
- 2001-11-19 PL PL01361842A patent/PL361842A1/xx not_active Application Discontinuation
- 2001-11-19 CA CA002429442A patent/CA2429442A1/en not_active Abandoned
- 2001-11-19 US US10/432,302 patent/US7109202B2/en not_active Expired - Fee Related
- 2001-11-19 DE DE60112322T patent/DE60112322T2/de not_active Expired - Lifetime
- 2001-11-19 AR ARP010105397A patent/AR035371A1/es unknown
- 2001-11-19 EP EP01986395A patent/EP1339711B1/en not_active Expired - Lifetime
- 2001-11-20 PE PE2001001159A patent/PE20020580A1/es not_active Application Discontinuation
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2003
- 2003-05-14 ZA ZA200303721A patent/ZA200303721B/en unknown
- 2003-05-16 EC EC2003004611A patent/ECSP034611A/es unknown
- 2003-05-20 NO NO20032277A patent/NO20032277L/no not_active Application Discontinuation
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| ECSP034611A (es) | 2003-06-25 |
| ES2246346T3 (es) | 2006-02-16 |
| CN1476447A (zh) | 2004-02-18 |
| WO2002042298A1 (en) | 2002-05-30 |
| GB0028383D0 (en) | 2001-01-03 |
| CZ20031393A3 (cs) | 2003-08-13 |
| ZA200303721B (en) | 2004-05-10 |
| DE60112322D1 (de) | 2005-09-01 |
| AR035371A1 (es) | 2004-05-12 |
| NZ525875A (en) | 2004-11-26 |
| EP1339711B1 (en) | 2005-07-27 |
| BR0115478A (pt) | 2004-02-17 |
| EP1339711A1 (en) | 2003-09-03 |
| PL361842A1 (en) | 2004-10-04 |
| NO20032277D0 (no) | 2003-05-20 |
| NO20032277L (no) | 2003-07-21 |
| KR20040007412A (ko) | 2004-01-24 |
| RU2003117476A (ru) | 2005-02-10 |
| AU2002237221A1 (en) | 2002-06-03 |
| IL155712A0 (en) | 2003-11-23 |
| JP3973556B2 (ja) | 2007-09-12 |
| MXPA03004439A (es) | 2003-08-19 |
| US20040053982A1 (en) | 2004-03-18 |
| DE60112322T2 (de) | 2006-05-24 |
| ATE300536T1 (de) | 2005-08-15 |
| HUP0302079A2 (hu) | 2003-09-29 |
| CN1244580C (zh) | 2006-03-08 |
| PE20020580A1 (es) | 2002-08-13 |
| US7109202B2 (en) | 2006-09-19 |
| CA2429442A1 (en) | 2002-05-30 |
| JP2004521871A (ja) | 2004-07-22 |
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