SK287012B6 - Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom - Google Patents

Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom Download PDF

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Publication number
SK287012B6
SK287012B6 SK337-2001A SK3372001A SK287012B6 SK 287012 B6 SK287012 B6 SK 287012B6 SK 3372001 A SK3372001 A SK 3372001A SK 287012 B6 SK287012 B6 SK 287012B6
Authority
SK
Slovakia
Prior art keywords
physiologically acceptable
acceptable salt
cyclo
phe
gly
Prior art date
Application number
SK337-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK3372001A3 (en
Inventor
Alfred Jonczyk
Astrid Perschl
Simon Goodman
Sigrid R�SENER
Jutta Haunschild
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK3372001A3 publication Critical patent/SK3372001A3/sk
Publication of SK287012B6 publication Critical patent/SK287012B6/sk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK337-2001A 1998-09-16 1999-09-09 Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom SK287012B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19842415A DE19842415A1 (de) 1998-09-16 1998-09-16 Pharmazeutische Zubereitung
PCT/EP1999/006654 WO2000015244A2 (de) 1998-09-16 1999-09-09 Pharmazeutische zubereitung enthaltend ein cyclo-peptide und ein chemotherapeutikum oder einen angiogeneseinhibitor

Publications (2)

Publication Number Publication Date
SK3372001A3 SK3372001A3 (en) 2001-11-06
SK287012B6 true SK287012B6 (sk) 2009-09-07

Family

ID=7881169

Family Applications (1)

Application Number Title Priority Date Filing Date
SK337-2001A SK287012B6 (sk) 1998-09-16 1999-09-09 Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom

Country Status (31)

Country Link
US (1) US6683051B1 (hu)
EP (2) EP1466615B1 (hu)
JP (2) JP2002524526A (hu)
KR (1) KR100703253B1 (hu)
CN (2) CN1201812C (hu)
AR (2) AR022382A1 (hu)
AT (2) ATE292470T1 (hu)
AU (1) AU765073B2 (hu)
BR (1) BR9913737A (hu)
CA (1) CA2344151A1 (hu)
CO (1) CO5140070A1 (hu)
CZ (1) CZ302908B6 (hu)
DE (3) DE19842415A1 (hu)
DK (2) DK1113809T3 (hu)
ES (2) ES2327331T3 (hu)
HU (1) HUP0103521A3 (hu)
ID (1) ID29226A (hu)
IL (2) IL141516A0 (hu)
MY (1) MY129572A (hu)
NO (1) NO331734B1 (hu)
NZ (1) NZ510040A (hu)
PE (1) PE20001046A1 (hu)
PL (1) PL201902B1 (hu)
PT (2) PT1113809E (hu)
RU (1) RU2227041C2 (hu)
SI (1) SI1113809T1 (hu)
SK (1) SK287012B6 (hu)
TR (1) TR200100765T2 (hu)
TW (1) TW576744B (hu)
WO (1) WO2000015244A2 (hu)
ZA (1) ZA200103073B (hu)

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US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
KR100983997B1 (ko) * 2001-01-09 2010-09-28 메르크 파텐트 게엠베하 수용체 타이로신 키나아제 저해제 및 혈관형성 저해제를 사용하는 병용 요법
AU2003211594A1 (en) * 2002-03-05 2003-09-16 Eisai Co., Ltd. Antitumor agent comprising combination of sulfonamide-containing heterocyclic compound with angiogenesis inhibitor
JP5223072B2 (ja) 2004-04-02 2013-06-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア avβ5インテグリンに関連のある疾患を治療および予防するための方法および組成物
NZ567837A (en) * 2005-11-02 2011-11-25 Univ Texas Concurrent chemotherapy and immunotherapy with EGFRvIII peptide and temozolomide
WO2007084670A2 (en) * 2006-01-18 2007-07-26 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
US20110165150A1 (en) * 2006-01-18 2011-07-07 Merck Patent Gmbh Isolated organ perfusion combination therapy of cancer
DK2101805T3 (da) 2007-01-18 2013-01-21 Merck Patent Gmbh Integrinligander til anvendelse i behandling af cancer
PL2167128T3 (pl) 2007-07-17 2013-03-29 Merck Patent Gmbh Skonstruowane metodami inżynierii hybrydowe przeciwciała skierowane przeciwko integrynie alfa-v
WO2010051667A1 (zh) * 2008-11-10 2010-05-14 复旦大学 一种环肽纳米管药物组合物及其应用
WO2010057596A2 (en) * 2008-11-20 2010-05-27 Merck Patent Gmbh New therapy and medicament using integrin ligands for treating cancer
US20120130146A1 (en) 2009-05-25 2012-05-24 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
EP2456460A4 (en) 2009-07-24 2013-02-20 Univ California METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING INEGRINE V ASSOCIATED DISEASES
EA022700B1 (ru) 2009-12-10 2016-02-29 Мерк Патент Гмбх Фармацевтическая композиция, содержащая олигопептиды
CN103153328A (zh) 2010-07-16 2013-06-12 默克专利股份有限公司 肽在乳腺癌和/或骨转移灶的治疗中的用途
WO2012069149A1 (en) 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
SI2672994T1 (sl) 2011-02-11 2018-09-28 Merck Patent Gmbh Protitelo proti alfa-v integrinu za zdravljenje raka prostate
WO2012110200A1 (en) * 2011-02-18 2012-08-23 Merck Patent Gmbh Cyclic peptide cyclo (l -arginyl - glycyl - l -aspartyl - d - phenylalanyl - n-methyl - l -valyl), compositions thereof, and use thereof in methods for treating graft -versus - host disease
JP2014516996A (ja) * 2011-06-09 2014-07-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング キャリア中のシレンギチドの懸濁液による癌および転移の処置
US20130230485A1 (en) * 2012-03-01 2013-09-05 Kathleen E. Rodgers Methods for Treating Patients Undergoing Multi-Cycle Chemotherapy
CN103333227B (zh) * 2013-06-07 2015-10-07 东南大学 转移肿瘤缺失蛋白小分子环肽抑制剂及其制备方法与应用
EP3510407A1 (en) 2016-09-08 2019-07-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating nephrotic syndrome
JP2019208422A (ja) * 2018-06-04 2019-12-12 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー ヒアルロニダーゼを含む新規な組換えエキソソーム及びその用途
GB201911816D0 (en) * 2019-08-16 2019-10-02 Univ London Queen Mary Treatment
GB202103122D0 (en) * 2021-03-05 2021-04-21 Univ London Queen Mary Treatment

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JPH04367367A (ja) 1991-06-11 1992-12-18 Nkk Corp ロータリノズル
CA2144762A1 (en) 1992-10-14 1994-04-28 George D. Hartman Fibrinogen receptor antagonists
EP0673247A4 (en) 1992-12-01 1996-05-01 Merck & Co Inc FIBRINOGEN RECEPTOR ANTAGONISTS.
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JPH10504808A (ja) 1994-06-29 1998-05-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗物質
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DK0710657T3 (da) 1994-11-02 1999-05-25 Merck Patent Gmbh Adhæsionsreceptor-antagonister
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JPH09208571A (ja) * 1996-02-02 1997-08-12 Takeda Chem Ind Ltd アルキリデンシクロヘキサン誘導体
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DK0951295T3 (da) * 1996-05-31 2010-09-13 Scripps Research Inst Sammensætninger til anvendelse ved inhibering af alfa-v-beta3-medieret angiogenese
JPH1081631A (ja) * 1996-07-17 1998-03-31 Takeda Chem Ind Ltd 癌転移または再発抑制剤
DE19629817A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629816A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
EP1007026A4 (en) * 1997-01-17 2002-08-07 Merck & Co Inc INTEGRIN ANTAGONISTS
DE19850131A1 (de) 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate

Also Published As

Publication number Publication date
NO20011308D0 (no) 2001-03-15
AU5975899A (en) 2000-04-03
DE19842415A1 (de) 2000-03-23
CO5140070A1 (es) 2002-03-22
WO2000015244A3 (de) 2000-06-22
TW576744B (en) 2004-02-21
DK1466615T3 (da) 2009-08-31
DE59915033D1 (de) 2009-07-16
ID29226A (id) 2001-08-16
CN1636590A (zh) 2005-07-13
EP1113809B1 (de) 2005-04-06
US6683051B1 (en) 2004-01-27
PL348026A1 (en) 2002-05-06
NZ510040A (en) 2003-12-19
WO2000015244A2 (de) 2000-03-23
JP2011252012A (ja) 2011-12-15
HUP0103521A2 (hu) 2002-02-28
EP1466615A1 (de) 2004-10-13
CZ302908B6 (cs) 2012-01-18
CA2344151A1 (en) 2000-03-23
AR078175A2 (es) 2011-10-19
AR022382A1 (es) 2002-09-04
CZ2001932A3 (cs) 2001-09-12
TR200100765T2 (tr) 2001-08-21
KR20010073155A (ko) 2001-07-31
PT1113809E (pt) 2005-08-31
EP1466615B1 (de) 2009-06-03
ATE292470T1 (de) 2005-04-15
PL201902B1 (pl) 2009-05-29
PT1466615E (pt) 2009-09-07
CN1329499A (zh) 2002-01-02
NO331734B1 (no) 2012-03-12
ES2327331T3 (es) 2009-10-28
SK3372001A3 (en) 2001-11-06
ZA200103073B (en) 2002-08-21
NO20011308L (no) 2001-03-15
RU2227041C2 (ru) 2004-04-20
EP1113809A2 (de) 2001-07-11
BR9913737A (pt) 2001-06-05
DE59911881D1 (de) 2005-05-12
IL141516A (en) 2009-09-22
IL141516A0 (en) 2002-03-10
SI1113809T1 (en) 2005-10-31
JP2002524526A (ja) 2002-08-06
HUP0103521A3 (en) 2002-05-28
DK1113809T3 (da) 2005-08-08
KR100703253B1 (ko) 2007-04-03
AU765073B2 (en) 2003-09-11
ATE432707T1 (de) 2009-06-15
CN1201812C (zh) 2005-05-18
CN100352494C (zh) 2007-12-05
ES2241363T3 (es) 2005-10-16
PE20001046A1 (es) 2000-10-14
MY129572A (en) 2007-04-30

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20130909