HUP0103521A3 - Pharmaceutical preparations containing a cyclopeptide and a chemotherapeutic agent or an angiogenesis inhibitor - Google Patents

Pharmaceutical preparations containing a cyclopeptide and a chemotherapeutic agent or an angiogenesis inhibitor

Info

Publication number
HUP0103521A3
HUP0103521A3 HU0103521A HUP0103521A HUP0103521A3 HU P0103521 A3 HUP0103521 A3 HU P0103521A3 HU 0103521 A HU0103521 A HU 0103521A HU P0103521 A HUP0103521 A HU P0103521A HU P0103521 A3 HUP0103521 A3 HU P0103521A3
Authority
HU
Hungary
Prior art keywords
cyclopeptide
chemotherapeutic agent
pharmaceutical preparations
preparations containing
angiogenesis inhibitor
Prior art date
Application number
HU0103521A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0103521A2 publication Critical patent/HUP0103521A2/hu
Publication of HUP0103521A3 publication Critical patent/HUP0103521A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU0103521A 1998-09-16 1999-09-09 Pharmaceutical preparations containing a cyclopeptide and a chemotherapeutic agent or an angiogenesis inhibitor HUP0103521A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19842415A DE19842415A1 (de) 1998-09-16 1998-09-16 Pharmazeutische Zubereitung
PCT/EP1999/006654 WO2000015244A2 (de) 1998-09-16 1999-09-09 Pharmazeutische zubereitung enthaltend ein cyclo-peptide und ein chemotherapeutikum oder einen angiogeneseinhibitor

Publications (2)

Publication Number Publication Date
HUP0103521A2 HUP0103521A2 (hu) 2002-02-28
HUP0103521A3 true HUP0103521A3 (en) 2002-05-28

Family

ID=7881169

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103521A HUP0103521A3 (en) 1998-09-16 1999-09-09 Pharmaceutical preparations containing a cyclopeptide and a chemotherapeutic agent or an angiogenesis inhibitor

Country Status (31)

Country Link
US (1) US6683051B1 (hu)
EP (2) EP1113809B1 (hu)
JP (2) JP2002524526A (hu)
KR (1) KR100703253B1 (hu)
CN (2) CN1201812C (hu)
AR (2) AR022382A1 (hu)
AT (2) ATE292470T1 (hu)
AU (1) AU765073B2 (hu)
BR (1) BR9913737A (hu)
CA (1) CA2344151A1 (hu)
CO (1) CO5140070A1 (hu)
CZ (1) CZ302908B6 (hu)
DE (3) DE19842415A1 (hu)
DK (2) DK1466615T3 (hu)
ES (2) ES2241363T3 (hu)
HU (1) HUP0103521A3 (hu)
ID (1) ID29226A (hu)
IL (2) IL141516A0 (hu)
MY (1) MY129572A (hu)
NO (1) NO331734B1 (hu)
NZ (1) NZ510040A (hu)
PE (1) PE20001046A1 (hu)
PL (1) PL201902B1 (hu)
PT (2) PT1466615E (hu)
RU (1) RU2227041C2 (hu)
SI (1) SI1113809T1 (hu)
SK (1) SK287012B6 (hu)
TR (1) TR200100765T2 (hu)
TW (1) TW576744B (hu)
WO (1) WO2000015244A2 (hu)
ZA (1) ZA200103073B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
HUP0302544A3 (en) * 2001-01-09 2012-09-28 Merck Patent Gmbh Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
JP4542783B2 (ja) * 2002-03-05 2010-09-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有複素環化合物及び血管新生抑制剤とを組み合わせてなる抗腫瘍剤
ES2671522T3 (es) * 2004-04-02 2018-06-06 The Regents Of The University Of California Métodos y composiciones para tratar y prevenir una enfermedad asociada con la integrina alfa V beta 5
US9399662B2 (en) * 2005-11-02 2016-07-26 Duke University Concurrent chemotherapy and immunotherapy
US20110165150A1 (en) * 2006-01-18 2011-07-07 Merck Patent Gmbh Isolated organ perfusion combination therapy of cancer
US20090130098A1 (en) * 2006-01-18 2009-05-21 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
EP2101805B1 (en) 2007-01-18 2012-11-07 Merck Patent GmbH Integrin ligands for use in treating cancer
EP2526967A1 (en) 2007-07-17 2012-11-28 Merck Patent GmbH Engineered anti-alpha v-integrin hybrid antibodies
WO2010051667A1 (zh) * 2008-11-10 2010-05-14 复旦大学 一种环肽纳米管药物组合物及其应用
KR20110086757A (ko) * 2008-11-20 2011-07-29 메르크 파텐트 게엠베하 암을 치료하기 위해 인테그린 리간드를 사용하는 신규한 치료요법 및 약제
CA2763275A1 (en) 2009-05-25 2010-12-02 Merck Patent Gmbh Continuous administration of integrin ligands for treating cancer
IN2012DN00303A (hu) 2009-07-24 2015-05-08 Univ California
PE20121359A1 (es) 2009-12-10 2012-10-15 Merck Patent Gmbh Composicion farmaceutica que comprende oligopeptidos
AU2011278700A1 (en) 2010-07-16 2013-02-28 Merck Patent Gmbh Peptide for use in the treatment of breast cancer and/or bone metastases
WO2012069149A1 (en) 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
SI2672994T1 (sl) 2011-02-11 2018-09-28 Merck Patent Gmbh Protitelo proti alfa-v integrinu za zdravljenje raka prostate
WO2012110200A1 (en) * 2011-02-18 2012-08-23 Merck Patent Gmbh Cyclic peptide cyclo (l -arginyl - glycyl - l -aspartyl - d - phenylalanyl - n-methyl - l -valyl), compositions thereof, and use thereof in methods for treating graft -versus - host disease
ES2720477T3 (es) * 2011-06-09 2019-07-22 Merck Patent Gmbh Tratamiento de cánceres y metástasis con suspensiones de Cilengitide en portador
WO2013130775A1 (en) * 2012-03-01 2013-09-06 Dizerega, Gere, S. Methods for treating patients undergoing multi-cycle chemotherapy
CN103333227B (zh) * 2013-06-07 2015-10-07 东南大学 转移肿瘤缺失蛋白小分子环肽抑制剂及其制备方法与应用
WO2018046610A1 (en) 2016-09-08 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating nephrotic syndrome
JP2019208422A (ja) * 2018-06-04 2019-12-12 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー ヒアルロニダーゼを含む新規な組換えエキソソーム及びその用途
GB201911816D0 (en) * 2019-08-16 2019-10-02 Univ London Queen Mary Treatment
GB202103122D0 (en) * 2021-03-05 2021-04-21 Univ London Queen Mary Treatment

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04367367A (ja) 1991-06-11 1992-12-18 Nkk Corp ロータリノズル
EP0667773A4 (en) 1992-10-14 1996-09-25 Merck & Co Inc FIBRINOGEN RECEPTOR ANTAGONISTS.
CA2150550A1 (en) 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
JPH10501222A (ja) 1994-05-27 1998-02-03 メルク エンド カンパニー インコーポレーテッド 破骨細胞仲介骨吸収を抑制するための化合物
EP0767792A4 (en) 1994-06-29 2002-11-20 Smithkline Beecham Corp VITRONECTIN RECEPTOR ANTAGONISTS
EP0762882A4 (en) 1994-06-29 2002-09-11 Smithkline Beecham Corp Vibronectin Receptor Antagonists
DK0710657T3 (da) 1994-11-02 1999-05-25 Merck Patent Gmbh Adhæsionsreceptor-antagonister
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19548709A1 (de) * 1995-12-23 1997-07-03 Merck Patent Gmbh Tyrosinderivate
JPH09208571A (ja) * 1996-02-02 1997-08-12 Takeda Chem Ind Ltd アルキリデンシクロヘキサン誘導体
AU2438297A (en) * 1996-05-09 1997-11-26 Alcon Laboratories, Inc. Combinations of angiostatic compounds
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
ATE470450T1 (de) * 1996-05-31 2010-06-15 Scripps Research Inst Zusammenstellungen zur verwendung als alpha-v- beta3 vermittelter angiogenesis hemmers
JPH1081631A (ja) * 1996-07-17 1998-03-31 Takeda Chem Ind Ltd 癌転移または再発抑制剤
DE19629816A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629817A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
WO1998031359A1 (en) * 1997-01-17 1998-07-23 Merck & Co., Inc. Integrin antagonists
DE19850131A1 (de) 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate

Also Published As

Publication number Publication date
CO5140070A1 (es) 2002-03-22
NZ510040A (en) 2003-12-19
TW576744B (en) 2004-02-21
PE20001046A1 (es) 2000-10-14
ZA200103073B (en) 2002-08-21
CZ2001932A3 (cs) 2001-09-12
SK287012B6 (sk) 2009-09-07
DK1113809T3 (da) 2005-08-08
TR200100765T2 (tr) 2001-08-21
CN1201812C (zh) 2005-05-18
SK3372001A3 (en) 2001-11-06
CA2344151A1 (en) 2000-03-23
IL141516A (en) 2009-09-22
KR20010073155A (ko) 2001-07-31
IL141516A0 (en) 2002-03-10
MY129572A (en) 2007-04-30
WO2000015244A2 (de) 2000-03-23
ATE432707T1 (de) 2009-06-15
PT1466615E (pt) 2009-09-07
PL348026A1 (en) 2002-05-06
AU765073B2 (en) 2003-09-11
PT1113809E (pt) 2005-08-31
ES2241363T3 (es) 2005-10-16
EP1113809B1 (de) 2005-04-06
DE59911881D1 (de) 2005-05-12
JP2002524526A (ja) 2002-08-06
NO331734B1 (no) 2012-03-12
RU2227041C2 (ru) 2004-04-20
DK1466615T3 (da) 2009-08-31
ES2327331T3 (es) 2009-10-28
CZ302908B6 (cs) 2012-01-18
EP1466615A1 (de) 2004-10-13
AR078175A2 (es) 2011-10-19
NO20011308D0 (no) 2001-03-15
US6683051B1 (en) 2004-01-27
SI1113809T1 (en) 2005-10-31
PL201902B1 (pl) 2009-05-29
HUP0103521A2 (hu) 2002-02-28
KR100703253B1 (ko) 2007-04-03
ID29226A (id) 2001-08-16
CN100352494C (zh) 2007-12-05
BR9913737A (pt) 2001-06-05
JP2011252012A (ja) 2011-12-15
AU5975899A (en) 2000-04-03
ATE292470T1 (de) 2005-04-15
NO20011308L (no) 2001-03-15
EP1466615B1 (de) 2009-06-03
DE59915033D1 (de) 2009-07-16
WO2000015244A3 (de) 2000-06-22
DE19842415A1 (de) 2000-03-23
EP1113809A2 (de) 2001-07-11
CN1329499A (zh) 2002-01-02
CN1636590A (zh) 2005-07-13
AR022382A1 (es) 2002-09-04

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees