SK286945B6 - Expresný systém faktora VIII - Google Patents

Expresný systém faktora VIII Download PDF

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Publication number
SK286945B6
SK286945B6 SK792-2001A SK7922001A SK286945B6 SK 286945 B6 SK286945 B6 SK 286945B6 SK 7922001 A SK7922001 A SK 7922001A SK 286945 B6 SK286945 B6 SK 286945B6
Authority
SK
Slovakia
Prior art keywords
leu
ser
protein
factor viii
glu
Prior art date
Application number
SK792-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK7922001A3 (en
Inventor
Myung-Sam Cho
Sham-Yuen Chan
William Kelsey
Helena Yee
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of SK7922001A3 publication Critical patent/SK7922001A3/sk
Publication of SK286945B6 publication Critical patent/SK286945B6/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
SK792-2001A 1998-12-10 1999-12-08 Expresný systém faktora VIII SK286945B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/209,916 US6358703B1 (en) 1998-12-10 1998-12-10 Expression system for factor VIII
PCT/US1999/029169 WO2000034505A1 (en) 1998-12-10 1999-12-08 Expression system for factor viii

Publications (2)

Publication Number Publication Date
SK7922001A3 SK7922001A3 (en) 2002-01-07
SK286945B6 true SK286945B6 (sk) 2009-08-06

Family

ID=22780858

Family Applications (1)

Application Number Title Priority Date Filing Date
SK792-2001A SK286945B6 (sk) 1998-12-10 1999-12-08 Expresný systém faktora VIII

Country Status (26)

Country Link
US (10) US6358703B1 (ja)
EP (1) EP1137797B1 (ja)
JP (1) JP4240818B2 (ja)
KR (1) KR100616028B1 (ja)
AT (1) ATE412765T1 (ja)
AU (1) AU761801B2 (ja)
BG (1) BG65431B1 (ja)
BR (1) BRPI9916069B8 (ja)
CA (1) CA2354845C (ja)
CZ (1) CZ302330B6 (ja)
DE (1) DE69939839D1 (ja)
DK (1) DK1137797T3 (ja)
ES (1) ES2315026T3 (ja)
HU (1) HU228489B1 (ja)
IL (2) IL143353A0 (ja)
NO (1) NO329544B1 (ja)
NZ (1) NZ512234A (ja)
PL (1) PL200676B1 (ja)
PT (1) PT1137797E (ja)
RO (1) RO121604B1 (ja)
RU (1) RU2249041C2 (ja)
SI (1) SI20644B (ja)
SK (1) SK286945B6 (ja)
TR (1) TR200101592T2 (ja)
UA (1) UA77383C2 (ja)
WO (1) WO2000034505A1 (ja)

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US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus
DE60115613T2 (de) * 2000-03-22 2006-08-24 Octagene Gmbh Herstellung von rekombinanten muteine des blutgerinnungsfaktors viii in humanen zellinien
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US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US7709224B2 (en) * 2003-06-03 2010-05-04 Biosante Pharmaceuticals, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
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WO2006053299A2 (en) 2004-11-12 2006-05-18 Bayer Healthcare Llc Site-directed modification of fviii
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
KR101398713B1 (ko) 2005-12-20 2014-06-12 브리스톨-마이어스 스큅 컴퍼니 조성물 및 조성물의 제조 방법
EP3255152A1 (en) * 2007-12-27 2017-12-13 Baxalta GmbH Cell culture processes
KR101005967B1 (ko) * 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
CN102137935A (zh) * 2008-06-25 2011-07-27 拜耳医药保健有限公司 具有降低的免疫原性的因子viii突变蛋白
RU2011110459A (ru) 2008-08-21 2012-09-27 Октафарма АГ (CH) Рекомбинантно полученный человеческий фактор viii и ix
MX2011002316A (es) * 2008-09-03 2011-05-10 Octapharma Ag Nuevas composiciones protectoras para el factor viii producido de manera recombinante.
MX362028B (es) 2009-02-03 2019-01-04 Amunix Pharmaceuticals Inc Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
CN102427823A (zh) * 2009-03-24 2012-04-25 拜耳医药保健有限公司 因子viii变体及使用方法
AU2010290077C1 (en) 2009-08-24 2015-12-03 Bioverativ Therapeutics Inc. Coagulation factor IX compositions and methods of making and using same
US20110150843A1 (en) * 2009-10-30 2011-06-23 National Institute Of Immunology Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
US20130017997A1 (en) * 2010-08-19 2013-01-17 Amunix Operating Inc. Factor VIII Compositions and Methods of Making and Using Same
BR112013028006A2 (pt) * 2011-05-13 2016-09-06 Octapharma Ag método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii
BR112014017165B1 (pt) 2012-01-12 2023-05-02 Bioverativ Therapeutics Inc Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos
ES2771208T3 (es) * 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
EP3549953A1 (en) 2012-02-15 2019-10-09 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
WO2017180807A1 (en) 2016-04-15 2017-10-19 Baxalta Incorporated Method and apparatus for providing a pharmacokinetic drug dosing regiment
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
CN106456718A (zh) 2014-01-10 2017-02-22 比奥根Ma公司 因子viii嵌合蛋白及其用途
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
EP3487538A1 (en) 2016-07-22 2019-05-29 Nektar Therapeutics Conjugates of a factor viii moiety having an oxime-containing linkage
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
WO2019055717A1 (en) * 2017-09-13 2019-03-21 Evolve Biosystems, Inc. OLIGOSACCHARIDE COMPOSITIONS AND THEIR USE DURING THE TRANSIENT PHASES OF INTESTINAL MICROBIOMA OF A MAMMALIAN
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
AU2019366942A1 (en) * 2018-10-23 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function

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Also Published As

Publication number Publication date
US20170267745A1 (en) 2017-09-21
HUP0200558A3 (en) 2004-11-29
BG105567A (en) 2002-03-29
KR20020013481A (ko) 2002-02-20
RU2249041C2 (ru) 2005-03-27
US20160115219A1 (en) 2016-04-28
US20130267468A1 (en) 2013-10-10
US8945869B2 (en) 2015-02-03
US20030077752A1 (en) 2003-04-24
EP1137797A4 (en) 2005-06-22
AU761801B2 (en) 2003-06-12
US9650431B2 (en) 2017-05-16
SI20644B (sl) 2009-04-30
IL143353A0 (en) 2002-04-21
WO2000034505A1 (en) 2000-06-15
TR200101592T2 (tr) 2001-11-21
SI20644A (sl) 2002-02-28
IL143353A (en) 2010-12-30
CA2354845A1 (en) 2000-06-15
EP1137797A1 (en) 2001-10-04
US7459525B2 (en) 2008-12-02
US20110144025A1 (en) 2011-06-16
KR100616028B1 (ko) 2006-08-28
CA2354845C (en) 2008-08-12
BR9916069A (pt) 2001-09-04
US20090036358A1 (en) 2009-02-05
US6358703B1 (en) 2002-03-19
HUP0200558A2 (en) 2002-06-28
RO121604B1 (ro) 2007-12-28
ATE412765T1 (de) 2008-11-15
CZ20012024A3 (cs) 2001-10-17
SK7922001A3 (en) 2002-01-07
US20130143818A1 (en) 2013-06-06
JP4240818B2 (ja) 2009-03-18
PL200676B1 (pl) 2009-01-30
US20020102730A1 (en) 2002-08-01
BRPI9916069B8 (pt) 2021-05-25
EP1137797B1 (en) 2008-10-29
AU2170100A (en) 2000-06-26
US8207117B2 (en) 2012-06-26
US9249209B2 (en) 2016-02-02
NZ512234A (en) 2002-12-20
CZ302330B6 (cs) 2011-03-16
PL349284A1 (en) 2002-07-15
PT1137797E (pt) 2008-12-26
NO20012718L (no) 2001-06-01
DK1137797T3 (da) 2009-02-23
NO329544B1 (no) 2010-11-08
ES2315026T3 (es) 2009-03-16
JP2002531137A (ja) 2002-09-24
UA77383C2 (uk) 2006-12-15
NO20012718D0 (no) 2001-06-01
DE69939839D1 (de) 2008-12-11
US20020115152A1 (en) 2002-08-22
BG65431B1 (bg) 2008-07-31
BRPI9916069B1 (pt) 2016-08-02
HU228489B1 (en) 2013-03-28

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Expiry date: 20191208