SK286945B6 - Expresný systém faktora VIII - Google Patents

Expresný systém faktora VIII Download PDF

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Publication number
SK286945B6
SK286945B6 SK792-2001A SK7922001A SK286945B6 SK 286945 B6 SK286945 B6 SK 286945B6 SK 7922001 A SK7922001 A SK 7922001A SK 286945 B6 SK286945 B6 SK 286945B6
Authority
SK
Slovakia
Prior art keywords
leu
ser
protein
factor viii
glu
Prior art date
Application number
SK792-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK7922001A3 (en
Inventor
Myung-Sam Cho
Sham-Yuen Chan
William Kelsey
Helena Yee
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of SK7922001A3 publication Critical patent/SK7922001A3/sk
Publication of SK286945B6 publication Critical patent/SK286945B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
SK792-2001A 1998-12-10 1999-12-08 Expresný systém faktora VIII SK286945B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/209,916 US6358703B1 (en) 1998-12-10 1998-12-10 Expression system for factor VIII
PCT/US1999/029169 WO2000034505A1 (en) 1998-12-10 1999-12-08 Expression system for factor viii

Publications (2)

Publication Number Publication Date
SK7922001A3 SK7922001A3 (en) 2002-01-07
SK286945B6 true SK286945B6 (sk) 2009-08-06

Family

ID=22780858

Family Applications (1)

Application Number Title Priority Date Filing Date
SK792-2001A SK286945B6 (sk) 1998-12-10 1999-12-08 Expresný systém faktora VIII

Country Status (26)

Country Link
US (10) US6358703B1 (ja)
EP (1) EP1137797B1 (ja)
JP (1) JP4240818B2 (ja)
KR (1) KR100616028B1 (ja)
AT (1) ATE412765T1 (ja)
AU (1) AU761801B2 (ja)
BG (1) BG65431B1 (ja)
BR (1) BRPI9916069B8 (ja)
CA (1) CA2354845C (ja)
CZ (1) CZ302330B6 (ja)
DE (1) DE69939839D1 (ja)
DK (1) DK1137797T3 (ja)
ES (1) ES2315026T3 (ja)
HU (1) HU228489B1 (ja)
IL (2) IL143353A0 (ja)
NO (1) NO329544B1 (ja)
NZ (1) NZ512234A (ja)
PL (1) PL200676B1 (ja)
PT (1) PT1137797E (ja)
RO (1) RO121604B1 (ja)
RU (1) RU2249041C2 (ja)
SI (1) SI20644B (ja)
SK (1) SK286945B6 (ja)
TR (1) TR200101592T2 (ja)
UA (1) UA77383C2 (ja)
WO (1) WO2000034505A1 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus
DE60115613T2 (de) * 2000-03-22 2006-08-24 Octagene Gmbh Herstellung von rekombinanten muteine des blutgerinnungsfaktors viii in humanen zellinien
ES2331909T3 (es) * 2001-06-14 2010-01-20 The Scripps Research Institute Factor viii estabilizado con enlaces disulfuro modificados geneticamente.
CN1767857A (zh) * 2003-02-26 2006-05-03 尼克塔治疗亚拉巴马公司 聚合物－因子ⅷ部分共轭物
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US7709224B2 (en) * 2003-06-03 2010-05-04 Biosante Pharmaceuticals, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
AU2005302516A1 (en) * 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
WO2006053299A2 (en) 2004-11-12 2006-05-18 Bayer Healthcare Llc Site-directed modification of fviii
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
KR101398713B1 (ko) 2005-12-20 2014-06-12 브리스톨-마이어스 스큅 컴퍼니 조성물 및 조성물의 제조 방법
EP3255152A1 (en) * 2007-12-27 2017-12-13 Baxalta GmbH Cell culture processes
KR101005967B1 (ko) * 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
CN102137935A (zh) * 2008-06-25 2011-07-27 拜耳医药保健有限公司 具有降低的免疫原性的因子viii突变蛋白
RU2011110459A (ru) 2008-08-21 2012-09-27 Октафарма АГ (CH) Рекомбинантно полученный человеческий фактор viii и ix
MX2011002316A (es) * 2008-09-03 2011-05-10 Octapharma Ag Nuevas composiciones protectoras para el factor viii producido de manera recombinante.
MX362028B (es) 2009-02-03 2019-01-04 Amunix Pharmaceuticals Inc Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
CN102427823A (zh) * 2009-03-24 2012-04-25 拜耳医药保健有限公司 因子viii变体及使用方法
AU2010290077C1 (en) 2009-08-24 2015-12-03 Bioverativ Therapeutics Inc. Coagulation factor IX compositions and methods of making and using same
US20110150843A1 (en) * 2009-10-30 2011-06-23 National Institute Of Immunology Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
US20130017997A1 (en) * 2010-08-19 2013-01-17 Amunix Operating Inc. Factor VIII Compositions and Methods of Making and Using Same
BR112013028006A2 (pt) * 2011-05-13 2016-09-06 Octapharma Ag método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii
BR112014017165B1 (pt) 2012-01-12 2023-05-02 Bioverativ Therapeutics Inc Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos
ES2771208T3 (es) * 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
EP3549953A1 (en) 2012-02-15 2019-10-09 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
WO2017180807A1 (en) 2016-04-15 2017-10-19 Baxalta Incorporated Method and apparatus for providing a pharmacokinetic drug dosing regiment
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
CN106456718A (zh) 2014-01-10 2017-02-22 比奥根Ma公司 因子viii嵌合蛋白及其用途
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
EP3487538A1 (en) 2016-07-22 2019-05-29 Nektar Therapeutics Conjugates of a factor viii moiety having an oxime-containing linkage
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
WO2019055717A1 (en) * 2017-09-13 2019-03-21 Evolve Biosystems, Inc. OLIGOSACCHARIDE COMPOSITIONS AND THEIR USE DURING THE TRANSIENT PHASES OF INTESTINAL MICROBIOMA OF A MAMMALIAN
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
AU2019366942A1 (en) * 2018-10-23 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045849B2 (ja) 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR890002004B1 (ko) * 1984-01-11 1989-06-07 가부시끼 가이샤 도오시바 지폐류 판별장치
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
US4868112A (en) 1985-04-12 1989-09-19 Genetics Institute, Inc. Novel procoagulant proteins
US5198349A (en) 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
ATE63335T1 (de) * 1986-07-11 1991-05-15 Miles Inc Herstellung von rekombinantem protein.
DK175363B1 (da) 1986-09-12 2004-09-13 Genentech Inc Fremgangsmåde til kontinuert produktion af et önsket heterologt protein i en eukaryotisk værtcelle, vektor, som tilförer denne evne, og celler transformeret med vektoren
US5171844A (en) * 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5859204A (en) 1992-04-07 1999-01-12 Emory University Modified factor VIII
DK0874057T3 (da) * 1993-06-10 2004-11-22 Bayer Ag Vektor og pattedyrcellelinie med forbedret produktionsevne
US5952198A (en) * 1995-05-04 1999-09-14 Bayer Corporation Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition
DE19517194A1 (de) * 1995-05-11 1996-11-14 Giesecke & Devrient Gmbh Vorrichtung und Verfahren zur Prüfung von Blattgut, wie z.B. Banknoten oder Wertpapiere
MX9504215A (es) 1995-10-05 1997-04-30 Inst Politecnico Nacional Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.
US5922959A (en) * 1996-10-15 1999-07-13 Currency Systems International Methods of measuring currency limpness
US5923413A (en) * 1996-11-15 1999-07-13 Interbold Universal bank note denominator and validator
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
CA2312291A1 (en) * 1997-12-05 1999-06-17 The Immune Response Corporation Novel vectors and genes exhibiting increased expression
US6040584A (en) * 1998-05-22 2000-03-21 Mti Corporation Method and for system for detecting damaged bills
US6528286B1 (en) 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
US6136599A (en) * 1998-12-10 2000-10-24 Bayer Corporation Human hybrid host cell for mammalian gene expression
US6180108B1 (en) 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus

Also Published As

Publication number Publication date
US20170267745A1 (en) 2017-09-21
HUP0200558A3 (en) 2004-11-29
BG105567A (en) 2002-03-29
KR20020013481A (ko) 2002-02-20
RU2249041C2 (ru) 2005-03-27
US20160115219A1 (en) 2016-04-28
US20130267468A1 (en) 2013-10-10
US8945869B2 (en) 2015-02-03
US20030077752A1 (en) 2003-04-24
EP1137797A4 (en) 2005-06-22
AU761801B2 (en) 2003-06-12
US9650431B2 (en) 2017-05-16
SI20644B (sl) 2009-04-30
IL143353A0 (en) 2002-04-21
WO2000034505A1 (en) 2000-06-15
TR200101592T2 (tr) 2001-11-21
SI20644A (sl) 2002-02-28
IL143353A (en) 2010-12-30
CA2354845A1 (en) 2000-06-15
EP1137797A1 (en) 2001-10-04
US7459525B2 (en) 2008-12-02
US20110144025A1 (en) 2011-06-16
KR100616028B1 (ko) 2006-08-28
CA2354845C (en) 2008-08-12
BR9916069A (pt) 2001-09-04
US20090036358A1 (en) 2009-02-05
US6358703B1 (en) 2002-03-19
HUP0200558A2 (en) 2002-06-28
RO121604B1 (ro) 2007-12-28
ATE412765T1 (de) 2008-11-15
CZ20012024A3 (cs) 2001-10-17
SK7922001A3 (en) 2002-01-07
US20130143818A1 (en) 2013-06-06
JP4240818B2 (ja) 2009-03-18
PL200676B1 (pl) 2009-01-30
US20020102730A1 (en) 2002-08-01
BRPI9916069B8 (pt) 2021-05-25
EP1137797B1 (en) 2008-10-29
AU2170100A (en) 2000-06-26
US8207117B2 (en) 2012-06-26
US9249209B2 (en) 2016-02-02
NZ512234A (en) 2002-12-20
CZ302330B6 (cs) 2011-03-16
PL349284A1 (en) 2002-07-15
PT1137797E (pt) 2008-12-26
NO20012718L (no) 2001-06-01
DK1137797T3 (da) 2009-02-23
NO329544B1 (no) 2010-11-08
ES2315026T3 (es) 2009-03-16
JP2002531137A (ja) 2002-09-24
UA77383C2 (uk) 2006-12-15
NO20012718D0 (no) 2001-06-01
DE69939839D1 (de) 2008-12-11
US20020115152A1 (en) 2002-08-22
BG65431B1 (bg) 2008-07-31
BRPI9916069B1 (pt) 2016-08-02
HU228489B1 (en) 2013-03-28

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MK4A Expiry of patent

Expiry date: 20191208