DE69939839D1 - Expressionssystem für faktor viii - Google Patents

Expressionssystem für faktor viii

Info

Publication number
DE69939839D1
DE69939839D1 DE69939839T DE69939839T DE69939839D1 DE 69939839 D1 DE69939839 D1 DE 69939839D1 DE 69939839 T DE69939839 T DE 69939839T DE 69939839 T DE69939839 T DE 69939839T DE 69939839 D1 DE69939839 D1 DE 69939839D1
Authority
DE
Germany
Prior art keywords
factor viii
expression system
glycosylated
linked
oligosaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939839T
Other languages
English (en)
Inventor
Myung-Sam Cho
Sham Yuen Chan
William Kelsey
Helena Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Application granted granted Critical
Publication of DE69939839D1 publication Critical patent/DE69939839D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69939839T 1998-12-10 1999-12-08 Expressionssystem für faktor viii Expired - Lifetime DE69939839D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/209,916 US6358703B1 (en) 1998-12-10 1998-12-10 Expression system for factor VIII
PCT/US1999/029169 WO2000034505A1 (en) 1998-12-10 1999-12-08 Expression system for factor viii

Publications (1)

Publication Number Publication Date
DE69939839D1 true DE69939839D1 (de) 2008-12-11

Family

ID=22780858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939839T Expired - Lifetime DE69939839D1 (de) 1998-12-10 1999-12-08 Expressionssystem für faktor viii

Country Status (26)

Country Link
US (10) US6358703B1 (de)
EP (1) EP1137797B1 (de)
JP (1) JP4240818B2 (de)
KR (1) KR100616028B1 (de)
AT (1) ATE412765T1 (de)
AU (1) AU761801B2 (de)
BG (1) BG65431B1 (de)
BR (1) BRPI9916069B8 (de)
CA (1) CA2354845C (de)
CZ (1) CZ302330B6 (de)
DE (1) DE69939839D1 (de)
DK (1) DK1137797T3 (de)
ES (1) ES2315026T3 (de)
HU (1) HU228489B1 (de)
IL (2) IL143353A0 (de)
NO (1) NO329544B1 (de)
NZ (1) NZ512234A (de)
PL (1) PL200676B1 (de)
PT (1) PT1137797E (de)
RO (1) RO121604B1 (de)
RU (1) RU2249041C2 (de)
SI (1) SI20644B (de)
SK (1) SK286945B6 (de)
TR (1) TR200101592T2 (de)
UA (1) UA77383C2 (de)
WO (1) WO2000034505A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus
CA2404163C (en) * 2000-03-22 2009-09-29 Octagene Gmbh Production of recombinant blood clotting factors in human cell lines
EP2110385A1 (de) 2001-06-14 2009-10-21 The Scripps Research Institute Stabilisierte Faktor VIII mit manipulierten Disulfid-Bindungen
EP1596887B1 (de) * 2003-02-26 2022-03-23 Nektar Therapeutics Polymer-factor viii-konjugate
WO2005017149A1 (en) * 2003-06-03 2005-02-24 Cell Genesys, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
JP2008518597A (ja) * 2004-10-29 2008-06-05 セントカー・インコーポレーテツド 化学的規定培地組成物
EP2371856B1 (de) 2004-11-12 2022-05-18 Bayer HealthCare LLC Ortsgerichtete Modifizierung von FVIII
ES2439641T3 (es) 2005-12-20 2014-01-24 Bristol-Myers Squibb Company Composiciones y procedimientos de producción de una composición
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
DK2235197T3 (en) 2007-12-27 2017-10-09 Baxalta GmbH Methods of cell culture
KR101005967B1 (ko) 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
KR20110033242A (ko) * 2008-06-25 2011-03-30 바이엘 헬스케어 엘엘씨 면역원성이 감소된, 인자 ⅷ 뮤테인
JP2012500250A (ja) 2008-08-21 2012-01-05 オクタファルマ アクチェン ゲゼルシャフト 組換えにより産生したヒト第ｖｉｉｉ及び第ｉｘ因子
CA2735376C (en) * 2008-09-03 2016-11-29 Octapharma Ag New protecting compositions for recombinantly produced factor viii
EP2393828B1 (de) 2009-02-03 2016-10-12 Amunix Operating Inc. Verlängerte rekombinante polypeptide und zusammensetzungen damit
JP5739865B2 (ja) * 2009-03-24 2015-06-24 バイエル・ヘルスケア・エルエルシー 第ｖｉｉｉ因子変異体および使用の方法
WO2011028229A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor ix compositions and methods of making and using same
US20110150843A1 (en) * 2009-10-30 2011-06-23 National Institute Of Immunology Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
US20130017997A1 (en) * 2010-08-19 2013-01-17 Amunix Operating Inc. Factor VIII Compositions and Methods of Making and Using Same
DK3626737T3 (da) * 2011-05-13 2024-02-05 Octapharma Ag Fremgangsmåde til at forøge produktiviteten af eukaryote celler i produktionen af rekombinant fviii
LT2804623T (lt) 2012-01-12 2019-12-10 Bioverativ Therapeutics Inc Chimeriniai viii faktoriaus polipeptidai ir jų panaudojimas
RS63870B1 (sr) 2012-02-15 2023-01-31 Bioverativ Therapeutics Inc Sastavi faktora viii i postupci za pravljenje i upotrebu istih
HUE043537T2 (hu) 2012-02-15 2019-08-28 Bioverativ Therapeutics Inc Rekombináns VIII faktor fehérjék
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
CN116731201A (zh) 2014-01-10 2023-09-12 比奥贝拉蒂治疗公司 因子viii嵌合蛋白及其用途
EP3331608A4 (de) 2015-08-03 2019-05-01 Bioverativ Therapeutics Inc. Faktor-ix-fusionsproteine und verfahren zur herstellung und verwendung davon
HUE065455T2 (hu) 2016-04-15 2024-05-28 Takeda Pharmaceuticals Co Eljárás és berendezés egy farmakokinetikai gyógyszer adagolási rendjének biztosítására
EP3487538A1 (de) 2016-07-22 2019-05-29 Nektar Therapeutics Konjugate eines faktor-viii-elements mit einer oxim-haltigen verbindung
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
US20200245667A1 (en) * 2017-09-13 2020-08-06 Evolve Biosystems, Inc. Oligosaccharide compositions and their use during transitional phases of the mammalian gut microbiome
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
WO2020086686A2 (en) * 2018-10-23 2020-04-30 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045849B2 (ja) 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR890002004B1 (ko) * 1984-01-11 1989-06-07 가부시끼 가이샤 도오시바 지폐류 판별장치
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
EP0218712B1 (de) * 1985-04-12 1992-02-26 Genetics Institute, Inc. Neue prokoagulierungsproteine
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
ATE63335T1 (de) * 1986-07-11 1991-05-15 Miles Inc Herstellung von rekombinantem protein.
GB2197321B (en) 1986-09-12 1990-10-03 Genentech Inc Method and vectors for obtaining continuous production of heterologous protein in a eukaryotic host cell line
IL86693A (en) * 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5859204A (en) 1992-04-07 1999-01-12 Emory University Modified factor VIII
EP0629700A3 (de) * 1993-06-10 1995-02-15 Miles Inc Vektor und Zelllinien von Säugetieren, die eine erhöhte Produktivität aufweisen.
US5952198A (en) * 1995-05-04 1999-09-14 Bayer Corporation Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition
DE19517194A1 (de) * 1995-05-11 1996-11-14 Giesecke & Devrient Gmbh Vorrichtung und Verfahren zur Prüfung von Blattgut, wie z.B. Banknoten oder Wertpapiere
MX9504215A (es) 1995-10-05 1997-04-30 Inst Politecnico Nacional Procedimiento mejorado para la purificacion de oligopeptidos con pesos moleculares de 1000 a 10,000 daltones, a partir de estractos leucocitos y su presentacion farmaceutica.
US5922959A (en) * 1996-10-15 1999-07-13 Currency Systems International Methods of measuring currency limpness
US5923413A (en) * 1996-11-15 1999-07-13 Interbold Universal bank note denominator and validator
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AU735763B2 (en) * 1997-12-05 2001-07-12 Immune Response Corporation, The Novel vectors and genes exhibiting increased expression
US6040584A (en) * 1998-05-22 2000-03-21 Mti Corporation Method and for system for detecting damaged bills
US6528286B1 (en) * 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
US6136599A (en) * 1998-12-10 2000-10-24 Bayer Corporation Human hybrid host cell for mammalian gene expression
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus

Also Published As

Publication number Publication date
US9249209B2 (en) 2016-02-02
US20020102730A1 (en) 2002-08-01
SK286945B6 (sk) 2009-08-06
US6358703B1 (en) 2002-03-19
IL143353A (en) 2010-12-30
CA2354845A1 (en) 2000-06-15
TR200101592T2 (tr) 2001-11-21
HUP0200558A2 (en) 2002-06-28
CA2354845C (en) 2008-08-12
HU228489B1 (en) 2013-03-28
NO329544B1 (no) 2010-11-08
CZ302330B6 (cs) 2011-03-16
WO2000034505A1 (en) 2000-06-15
SI20644A (sl) 2002-02-28
PL349284A1 (en) 2002-07-15
NZ512234A (en) 2002-12-20
IL143353A0 (en) 2002-04-21
AU761801B2 (en) 2003-06-12
EP1137797A4 (de) 2005-06-22
EP1137797B1 (de) 2008-10-29
ES2315026T3 (es) 2009-03-16
US20090036358A1 (en) 2009-02-05
BG65431B1 (bg) 2008-07-31
NO20012718L (no) 2001-06-01
US20130267468A1 (en) 2013-10-10
AU2170100A (en) 2000-06-26
US20130143818A1 (en) 2013-06-06
NO20012718D0 (no) 2001-06-01
RU2249041C2 (ru) 2005-03-27
PL200676B1 (pl) 2009-01-30
KR20020013481A (ko) 2002-02-20
JP4240818B2 (ja) 2009-03-18
RO121604B1 (ro) 2007-12-28
BRPI9916069B8 (pt) 2021-05-25
HUP0200558A3 (en) 2004-11-29
BRPI9916069B1 (pt) 2016-08-02
BR9916069A (pt) 2001-09-04
ATE412765T1 (de) 2008-11-15
JP2002531137A (ja) 2002-09-24
CZ20012024A3 (cs) 2001-10-17
US8207117B2 (en) 2012-06-26
US8945869B2 (en) 2015-02-03
KR100616028B1 (ko) 2006-08-28
US20170267745A1 (en) 2017-09-21
SK7922001A3 (en) 2002-01-07
PT1137797E (pt) 2008-12-26
US20030077752A1 (en) 2003-04-24
UA77383C2 (uk) 2006-12-15
SI20644B (sl) 2009-04-30
US20110144025A1 (en) 2011-06-16
EP1137797A1 (de) 2001-10-04
US7459525B2 (en) 2008-12-02
DK1137797T3 (da) 2009-02-23
US9650431B2 (en) 2017-05-16
US20160115219A1 (en) 2016-04-28
US20020115152A1 (en) 2002-08-22
BG105567A (en) 2002-03-29

Similar Documents

Publication Publication Date Title
ATE412765T1 (de) Expressionssystem für faktor viii
DE3853922D1 (de) Aminosäurederivate als Amphotere.
HK1039355A1 (en) Dna-protein fusions and uses thereof
DK259790D0 (da) Mikrofragmenterede ioniske polysaccharid/protein-kompleksdispersioner
BG104149A (en) Interleukin-18-binding proteins, methods for their preparation and administration
IT1284373B1 (it) Disposizione di fissaggio di guarniture in particolare minuteria per mobili.
ATE329018T1 (de) Verbesserte galactosylierung von rekombinanten proteinen
FI952574A (fi) Glykosyylitransferaasiaktiiviset proteiinit
EE9900297A (et) Piimavalkude selektiivse lagundamise meetod teiste piimavalkude manulusel
TR199600116A2 (tr) Bir delta-5,7 sterol, delta-7 reduktaz aktivitesi, delta 7-red proteinine sahip bir a. talian proteini icin dna sirasi kodlamasi, üretim islemi, dönüstürülmüs maya türü, kullanimlari.
DE69330189D1 (de) Lösung für die Peritonealdialyse
DE69634077D1 (de) Haemophilus adhäsionsproteinen
CA2032167A1 (en) Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
ATE103141T1 (de) Protein-hydrolyse.
DE59811071D1 (de) Präparation umfassend Thiolgruppen-haltige Proteine
FR2720407B1 (fr) Véhicule aqueux pour micro-organismes non autonomes du règne animal à maintenir vivants hors de leur milieu naturel, notamment spermatozoïdes de bovin.
ATE301713T1 (de) Plazentaprotein 13
DE69825646D1 (de) Pufferverstärker für Bussteuerung
ID26903A (id) Metode untuk menghasilkan protein terhidrolisis
MX250271B (es) Expresion de proteinas en hongos geneticamente modificados.
WO2002070564A3 (en) The guinea pig proteinase-activated receptor 4 and its activating peptide
BR9810558B1 (pt) composição quìmica agrìcola em suspensão aquosa.
ATE327324T1 (de) Herstellung von protein c in transgenen tieren
EP1066310A4 (de) Neokin-proteine und nukleinsäuren und ihre anwendung
WO2000008143A3 (de) Gen isoliert auf dem kurzen arm des menschlichen chromosoms 17

Legal Events

Date Code Title Description
8364 No opposition during term of opposition