DK0874057T3 - Vektor og pattedyrcellelinie med forbedret produktionsevne - Google Patents
Vektor og pattedyrcellelinie med forbedret produktionsevneInfo
- Publication number
- DK0874057T3 DK0874057T3 DK98108577T DK98108577T DK0874057T3 DK 0874057 T3 DK0874057 T3 DK 0874057T3 DK 98108577 T DK98108577 T DK 98108577T DK 98108577 T DK98108577 T DK 98108577T DK 0874057 T3 DK0874057 T3 DK 0874057T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell line
- vector
- promoter
- mammalian cell
- improved production
- Prior art date
Links
- 210000004962 mammalian cell Anatomy 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000001690 Factor VIII Human genes 0.000 abstract 1
- 108010054218 Factor VIII Proteins 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 229960000301 factor viii Drugs 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7520993A | 1993-06-10 | 1993-06-10 | |
| EP94108283A EP0629700A3 (en) | 1993-06-10 | 1994-05-30 | Vector and mammalian cell line having improved productivity. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0874057T3 true DK0874057T3 (da) | 2004-11-22 |
Family
ID=22124251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98108577T DK0874057T3 (da) | 1993-06-10 | 1994-05-30 | Vektor og pattedyrcellelinie med forbedret produktionsevne |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5612213A (da) |
| EP (2) | EP0629700A3 (da) |
| JP (1) | JPH06343476A (da) |
| AT (1) | ATE272122T1 (da) |
| CA (1) | CA2125449C (da) |
| DE (1) | DE69433925T2 (da) |
| DK (1) | DK0874057T3 (da) |
| ES (1) | ES2226029T3 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2226945A1 (en) * | 1996-06-12 | 1997-12-18 | Japan Tobacco Inc. | Method for expressing foreign genes and vectors therefor |
| US5854021A (en) * | 1997-02-28 | 1998-12-29 | Bayer Corporation | Enhance protein production method |
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| US6051401A (en) * | 1998-07-28 | 2000-04-18 | Bayer Corporation | Methods and constructs for protein expression |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| US6358703B1 (en) * | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| US20040235715A1 (en) * | 1999-11-12 | 2004-11-25 | Bayer Corporation | Method of producing glycosylated bikunin |
| IL153601A0 (en) | 2000-06-27 | 2003-07-06 | Basf Ag | Cyanobacterial nucleic acid fragments encoding proteins useful for controlling plant traits via nuclear or plastome transformation |
| US7723102B2 (en) | 2000-09-28 | 2010-05-25 | Bayer Corporation | Enhanced transfection system |
| EP2298926A1 (en) | 2003-09-30 | 2011-03-23 | The Trustees of The University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| ATE417066T1 (de) * | 2003-10-16 | 2008-12-15 | Claude Negrier | Modifizierte cdna für hohe expressionsniveaus von faktor viii und dessen derivaten |
| EP3409296A1 (en) | 2005-04-07 | 2018-12-05 | The Trustees of the University of Pennsylvania | Method of increasing the function of an aav vector |
| US20070214041A1 (en) * | 2006-03-10 | 2007-09-13 | Cisco Technologies, Inc. | System and method for location-based mapping of soft-keys on a mobile communication device |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| SG10201908848RA (en) | 2010-03-29 | 2019-10-30 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
| PL2675902T3 (pl) | 2011-02-17 | 2019-08-30 | The Trustees Of The University Of Pennsylvania | Kompozycje i sposoby do zmieniania specyficzności względem tkanki i poprawy transferu genu z udziałem aav9 |
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| US10058624B2 (en) | 2015-04-16 | 2018-08-28 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
| US20240043494A1 (en) | 2020-08-07 | 2024-02-08 | Amicus Therapeutics, Inc. | Vesicle Targeting Proteins And Uses Of Same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US5079159A (en) * | 1983-12-27 | 1992-01-07 | Genetics Institute, Inc. | Method for making tissue plasminogen activator |
| US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| GB2197321B (en) * | 1986-09-12 | 1990-10-03 | Genentech Inc | Method and vectors for obtaining continuous production of heterologous protein in a eukaryotic host cell line |
-
1994
- 1994-05-30 EP EP94108283A patent/EP0629700A3/en not_active Withdrawn
- 1994-05-30 EP EP98108577A patent/EP0874057B1/en not_active Expired - Lifetime
- 1994-05-30 ES ES98108577T patent/ES2226029T3/es not_active Expired - Lifetime
- 1994-05-30 DE DE69433925T patent/DE69433925T2/de not_active Expired - Lifetime
- 1994-05-30 AT AT98108577T patent/ATE272122T1/de active
- 1994-05-30 DK DK98108577T patent/DK0874057T3/da active
- 1994-06-07 JP JP6147027A patent/JPH06343476A/ja active Pending
- 1994-06-08 CA CA2125449A patent/CA2125449C/en not_active Expired - Lifetime
- 1994-11-03 US US08/333,706 patent/US5612213A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0874057A2 (en) | 1998-10-28 |
| EP0629700A2 (en) | 1994-12-21 |
| EP0874057B1 (en) | 2004-07-28 |
| JPH06343476A (ja) | 1994-12-20 |
| DE69433925D1 (de) | 2004-09-02 |
| EP0874057A3 (en) | 1999-01-07 |
| ES2226029T3 (es) | 2005-03-16 |
| EP0629700A3 (en) | 1995-02-15 |
| DE69433925T2 (de) | 2005-07-28 |
| CA2125449A1 (en) | 1994-12-11 |
| CA2125449C (en) | 2010-02-23 |
| ATE272122T1 (de) | 2004-08-15 |
| US5612213A (en) | 1997-03-18 |
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