SK286314B6 - 4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors - Google Patents

4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors Download PDF

Info

Publication number
SK286314B6
SK286314B6 SK1451-2001A SK14512001A SK286314B6 SK 286314 B6 SK286314 B6 SK 286314B6 SK 14512001 A SK14512001 A SK 14512001A SK 286314 B6 SK286314 B6 SK 286314B6
Authority
SK
Slovakia
Prior art keywords
phenyl
furanone
dimethyl
methylsulfonyl
aminosulfonyl
Prior art date
Application number
SK1451-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK14512001A3 (sk
Inventor
Song Seok Shin
Min-Soo Noh
Young Joo Byun
Jin Kyu Choi
Jin Kwan Kim
Kyung Min Lim
Ji Young Kim
Young Hoon Choi
Jun-Young Ha
Ki-Wha Lee
Joo Hyun Moh
Yeon Su Jeong
Shin Chung
Yung Hyup Joo
Chang Hoon Lee
Seon Hwa Kang
Young Ho Park
Jung Bum Yi
Original Assignee
Pacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019990013170A external-priority patent/KR20000066223A/ko
Priority claimed from KR1019990029779A external-priority patent/KR20010010728A/ko
Priority claimed from KR1019990039043A external-priority patent/KR20010027342A/ko
Priority claimed from KR1020000016866A external-priority patent/KR20010094519A/ko
Priority claimed from KR1020000017647A external-priority patent/KR20010094161A/ko
Application filed by Pacific Corp filed Critical Pacific Corp
Publication of SK14512001A3 publication Critical patent/SK14512001A3/sk
Publication of SK286314B6 publication Critical patent/SK286314B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK1451-2001A 1999-04-14 2000-04-12 4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors SK286314B6 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1019990013170A KR20000066223A (ko) 1999-04-14 1999-04-14 디아릴-3(2ｈ)퓨라논 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1019990029779A KR20010010728A (ko) 1999-07-22 1999-07-22 2,2-디알킬-4,5-디아릴-3(2ｈ)퓨라논의 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1019990039043A KR20010027342A (ko) 1999-09-13 1999-09-13 2,2-디알킬-4,5-디아릴-3(2ｈ)퓨라논의 술폰아마이드 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1020000016866A KR20010094519A (ko) 2000-03-31 2000-03-31 2,2,4,5-사중 치환된 3(2ｈ)-퓨라논 유도체의 제조 방법
KR1020000017647A KR20010094161A (ko) 2000-04-04 2000-04-04 2,2-디메틸-4,5-디아릴-3(2ｈ)퓨라논의 유도체 및 이를함유하는 선택적인 시클로옥시게네이즈-2 저해제로서약제학적 조성물
PCT/KR2000/000339 WO2000061571A1 (fr) 1999-04-14 2000-04-12 Derives de 4,5-diaryl-3(2h)-furanone comme inhibiteurs de cyclo-oxygenase-2

Publications (2)

Publication Number Publication Date
SK14512001A3 SK14512001A3 (sk) 2002-04-04
SK286314B6 true SK286314B6 (en) 2008-07-07

Family

ID=27532305

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1451-2001A SK286314B6 (en) 1999-04-14 2000-04-12 4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

Country Status (26)

Country Link
US (1) US6492416B1 (fr)
EP (1) EP1109799B1 (fr)
JP (1) JP3844657B2 (fr)
KR (1) KR20010111584A (fr)
CN (1) CN1166658C (fr)
AT (1) ATE256672T1 (fr)
AU (1) AU767811B2 (fr)
BR (1) BRPI0011172B8 (fr)
CA (1) CA2369979C (fr)
CZ (1) CZ300766B6 (fr)
DE (1) DE60007267T2 (fr)
DZ (1) DZ3265A1 (fr)
EA (1) EA004432B1 (fr)
ES (1) ES2213007T3 (fr)
HK (1) HK1046413B (fr)
HU (1) HU227863B1 (fr)
IL (2) IL145305A0 (fr)
MA (1) MA25406A1 (fr)
MX (1) MXPA01010312A (fr)
NO (1) NO327814B1 (fr)
NZ (1) NZ514101A (fr)
PL (1) PL204249B1 (fr)
PT (1) PT1109799E (fr)
SK (1) SK286314B6 (fr)
TR (1) TR200102958T2 (fr)
WO (1) WO2000061571A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010010728A (ko) * 1999-07-22 2001-02-15 서경배 2,2-디알킬-4,5-디아릴-3(2ｈ)퓨라논의 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR20010094161A (ko) * 2000-04-04 2001-10-31 서경배 2,2-디메틸-4,5-디아릴-3(2ｈ)퓨라논의 유도체 및 이를함유하는 선택적인 시클로옥시게네이즈-2 저해제로서약제학적 조성물
KR20000066223A (ko) * 1999-04-14 2000-11-15 서경배 디아릴-3(2ｈ)퓨라논 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
US6686390B2 (en) * 2000-05-22 2004-02-03 Dr. Reddy's Laboratories Limited Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
CA2411960C (fr) 2000-06-13 2010-10-12 Wyeth Compositions analgesiques et anti-inflammatoires contenant des inhibiteurs de cox-2
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
WO2003018575A1 (fr) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation Furanones 5-substituees-3(2h)- utiles pour inhiber la farnesyl-proteine transferase
US6667330B2 (en) * 2002-01-31 2003-12-23 Galileo Pharmaceuticals, Inc. Furanone derivatives
ES2214129B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 3-fenilfuran-2-onas.
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
ES2214130B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 2-3'-bipiridinas.
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
WO2005009342A2 (fr) * 2003-07-16 2005-02-03 Pharmacia Corporation Methode de traitement ou de prevention de troubles dermatologiques a l'aide d'un seul inhibiteur de la cyclooxygenase-2 ou en combinaison avec un agent de traitement dermatologique, et compositions contenant ceux-ci
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
WO2005023189A2 (fr) * 2003-09-03 2005-03-17 Pharmacia Corporation Procede de prevention ou de traitement de la douleur, de l'inflammation, et de troubles lies a l'inflammation avec un inhibiteur selectif de cox-2 en combinaison avec un agent donneur de monoxyde d'azote et compositions en contenant
JP4641772B2 (ja) * 2003-10-23 2011-03-02 長谷川香料株式会社 フラノンの製造方法
WO2005094815A1 (fr) * 2004-03-30 2005-10-13 Amorepacific Corporation Double inhibition de la cyclooxygenase 2 et de l'anhydrase carbonique
US20080306146A1 (en) * 2005-11-02 2008-12-11 Amorepacific Corporation Dosing Regimens for Cox-2 Inhibitor
NZ573111A (en) * 2006-04-28 2012-02-24 Cambridge Scient Pty Ltd Cox-2 inhibitor
WO2008094574A2 (fr) * 2007-01-30 2008-08-07 Biogen Idec Ma Inc. Composés de furanone et procédés de fabrication et d'utilisation de ceux-ci
TWI634114B (zh) * 2013-05-08 2018-09-01 永恒生物科技公司 作為激酶抑制劑之呋喃酮化合物
WO2015080435A1 (fr) * 2013-11-26 2015-06-04 화일약품주식회사 Procédé de préparation de 4-(3-(3-fluorophényl)-5,5-diméthyl-4-oxo-4,5-dihydrofuran-2-yl)benzènesulfonamide
KR101446601B1 (ko) * 2014-01-29 2014-10-07 크리스탈지노믹스(주) 5-(4-(아미노설포닐)페닐)-2,2-디메틸-4-(3-플루오로페닐)-3(2h)-퓨라논을 포함하는 약학적 조성물 및 캡슐 제형
US10413520B2 (en) 2014-01-29 2019-09-17 Crystalgenomics, Inc. Oral pharmacological composition including 5-{4-(amino sulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone having crystalline structure with excellent stability
CN104926797B (zh) * 2014-06-10 2019-04-16 北京元博方医药科技有限公司 呋喃酮衍生物、制备方法及用途
CN104098535A (zh) * 2014-07-25 2014-10-15 南通市华峰化工有限责任公司 一种4-(3-氟苯基)-2,2-二甲基-5-(4-(甲硫基)苯基)呋喃-3(2h)-酮的制备方法
RU2563876C1 (ru) * 2014-11-11 2015-09-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) Способ получения 2,2-диалкил-4,5-диарилфуран-3(2н)-онов
CN106866558B (zh) * 2015-08-21 2019-07-30 宁波百思佳医药科技有限公司 酰基三氮唑类化合物及其制备方法和应用
RU2631317C1 (ru) * 2016-05-13 2017-09-21 Общество с ограниченной ответственностью "Органик Эмиттерс" Селективные ингибиторы циклооксигеназы и способ их получения
CN111303085B (zh) * 2020-03-13 2022-04-01 西安瑞联新材料股份有限公司 5-溴-2,2-二甲基-5-(4-甲磺酰基苯基)呋喃-3(2h)-酮的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63313719A (ja) * 1987-06-15 1988-12-21 T Hasegawa Co Ltd 香料組成物
JPH0745483B2 (ja) * 1987-09-26 1995-05-17 長谷川香料株式会社 フラノン類の製造方法
JPH0825864B2 (ja) * 1988-12-16 1996-03-13 長谷川香料株式会社 柴外線吸収剤
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
ES2191069T3 (es) * 1994-12-21 2003-09-01 Merck Frosst Canada Inc Diaril-2-(5h)-furanonas como inhibidores de cox-2.
US5698585A (en) * 1995-04-13 1997-12-16 Kikkoman Corporation Pharmaceutical preparation for prevention and/or treatment for cataract
UA57002C2 (uk) * 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування

Also Published As

Publication number Publication date
WO2000061571A1 (fr) 2000-10-19
US6492416B1 (en) 2002-12-10
TR200102958T2 (tr) 2002-05-21
DE60007267D1 (de) 2004-01-29
CZ20013662A3 (cs) 2002-02-13
CA2369979A1 (fr) 2000-10-19
JP3844657B2 (ja) 2006-11-15
IL145305A (en) 2006-10-31
ES2213007T3 (es) 2004-08-16
NO20014986L (no) 2001-11-01
NZ514101A (en) 2001-09-28
CZ300766B6 (cs) 2009-08-05
AU767811B2 (en) 2003-11-27
DE60007267T2 (de) 2004-09-16
EP1109799A1 (fr) 2001-06-27
KR20010111584A (ko) 2001-12-19
AU4148000A (en) 2000-11-14
IL145305A0 (en) 2002-06-30
CN1348447A (zh) 2002-05-08
BR0011172A (pt) 2002-02-19
HK1046413B (zh) 2005-05-27
EP1109799B1 (fr) 2003-12-17
HUP0200623A3 (en) 2002-10-28
PL204249B1 (pl) 2009-12-31
DZ3265A1 (fr) 2000-10-19
MA25406A1 (fr) 2002-04-01
JP2002541251A (ja) 2002-12-03
HU0200623D0 (en) 2002-03-28
EA200100958A1 (ru) 2002-06-27
MXPA01010312A (es) 2005-07-25
SK14512001A3 (sk) 2002-04-04
CA2369979C (fr) 2009-12-08
BRPI0011172B1 (pt) 2017-05-16
NO327814B1 (no) 2009-09-28
BRPI0011172B8 (pt) 2021-05-25
PL351125A1 (en) 2003-03-24
HK1046413A1 (en) 2003-01-10
HU227863B1 (en) 2012-05-29
ATE256672T1 (de) 2004-01-15
HUP0200623A2 (hu) 2002-07-29
NO20014986D0 (no) 2001-10-12
PT1109799E (pt) 2004-05-31
EA004432B1 (ru) 2004-04-29
CN1166658C (zh) 2004-09-15

Similar Documents

Publication Publication Date Title
SK286314B6 (en) 4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors
US6180651B1 (en) Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
AU2005266890B9 (en) Pyrrole derivatives as pharmaceutical agents
JP2977137B2 (ja) シクロオキシゲナーゼ−２阻害剤としてのフェニルヘテロ環
EP0794942B1 (fr) Composes diphenyle substitues pour le traitement des inflammations
FI108792B (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten furanonijohdannaisten valmistamiseksi
JP5775519B2 (ja) Ｓ−ニトロソグルタチオンレダクターゼ阻害薬としての新規ジヒドロピリミジン−２（１ｈ）−オン化合物
WO2008113255A1 (fr) Dérivés de benzamide avec activité antiproliférative, leurs préparations pharmaceutiques
TW200521108A (en) Compounds having lysophosphatidic acid receptor(LPA)-antagonizing effect and their use
JPH09505043A (ja) 置換フェニル化合物
HUT75225A (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
JP2002517496A (ja) 抗炎症薬／鎮痛薬としてのスルホニルベンゼン化合物
AU706518B2 (en) Bisarylcyclobutene derivates as cyclooxygenase inhibitors
JP4717211B2 (ja) ２−フェニルピラン−４−オン誘導体
AU717146B2 (en) Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof
KR100495389B1 (ko) 시클로옥시게네이즈-2 저해제로서의4,5-디아릴-3(2ｈ)-퓨라논 유도체
KR100975995B1 (ko) Ａｍｐａ 수용체 증강제
CA2550187C (fr) Inhibiteurs de la transcriptase inverse non nucleosidiques
JP3490406B2 (ja) シクロオキシゲナーゼ−２阻害剤としてのフェニルヘテロ環
US20040158074A1 (en) Substituted biphenyl compounds for the treatment of inflammation
HU228070B1 (hu) 4,5-Diaril-3(2H9-furanonszármazékok, mint a ciklooxigenáz-2 inhibitorai, diaril-oxaspiro-biciklusos származékok

Legal Events

Date Code Title Description
MK4A Expiry of patent

Expiry date: 20200412