NO327814B1 - 4,5-diaryl-3(2H)-furanonderivater, fremgangsmate for fremstilling derav, farmasoytiske preparater samt anvendelse av slike derivater - Google Patents

4,5-diaryl-3(2H)-furanonderivater, fremgangsmate for fremstilling derav, farmasoytiske preparater samt anvendelse av slike derivater Download PDF

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Publication number
NO327814B1
NO327814B1 NO20014986A NO20014986A NO327814B1 NO 327814 B1 NO327814 B1 NO 327814B1 NO 20014986 A NO20014986 A NO 20014986A NO 20014986 A NO20014986 A NO 20014986A NO 327814 B1 NO327814 B1 NO 327814B1
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NO
Norway
Prior art keywords
phenyl
dimethyl
methylsulfonyl
furanone
aminosulfonyl
Prior art date
Application number
NO20014986A
Other languages
English (en)
Norwegian (no)
Other versions
NO20014986D0 (no
NO20014986L (no
Inventor
Song Seok Shin
Min-Soo Noh
Young Joo Byun
Jin Kyu Choi
Jin Kwan Kim
Kyung Min Lim
Ji Young Kim
Young Hoon Choi
Jun-Yong Ha
Ki-Wha Lee
Joo Hyun Moh
Yeon Su Jeong
Shin Chung
Yung Hyup Joo
Chang Hoon Lee
Seon Hwa Kang
Young-Ho Park
Jung Bum Yl
Original Assignee
Pacific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019990013170A external-priority patent/KR20000066223A/ko
Priority claimed from KR1019990029779A external-priority patent/KR20010010728A/ko
Priority claimed from KR1019990039043A external-priority patent/KR20010027342A/ko
Priority claimed from KR1020000016866A external-priority patent/KR20010094519A/ko
Priority claimed from KR1020000017647A external-priority patent/KR20010094161A/ko
Application filed by Pacific Corp filed Critical Pacific Corp
Publication of NO20014986D0 publication Critical patent/NO20014986D0/no
Publication of NO20014986L publication Critical patent/NO20014986L/no
Publication of NO327814B1 publication Critical patent/NO327814B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58One oxygen atom, e.g. butenolide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20014986A 1999-04-14 2001-10-12 4,5-diaryl-3(2H)-furanonderivater, fremgangsmate for fremstilling derav, farmasoytiske preparater samt anvendelse av slike derivater NO327814B1 (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1019990013170A KR20000066223A (ko) 1999-04-14 1999-04-14 디아릴-3(2h)퓨라논 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1019990029779A KR20010010728A (ko) 1999-07-22 1999-07-22 2,2-디알킬-4,5-디아릴-3(2h)퓨라논의 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1019990039043A KR20010027342A (ko) 1999-09-13 1999-09-13 2,2-디알킬-4,5-디아릴-3(2h)퓨라논의 술폰아마이드 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR1020000016866A KR20010094519A (ko) 2000-03-31 2000-03-31 2,2,4,5-사중 치환된 3(2h)-퓨라논 유도체의 제조 방법
KR1020000017647A KR20010094161A (ko) 2000-04-04 2000-04-04 2,2-디메틸-4,5-디아릴-3(2h)퓨라논의 유도체 및 이를함유하는 선택적인 시클로옥시게네이즈-2 저해제로서약제학적 조성물
PCT/KR2000/000339 WO2000061571A1 (fr) 1999-04-14 2000-04-12 Derives de 4,5-diaryl-3(2h)-furanone comme inhibiteurs de cyclo-oxygenase-2

Publications (3)

Publication Number Publication Date
NO20014986D0 NO20014986D0 (no) 2001-10-12
NO20014986L NO20014986L (no) 2001-11-01
NO327814B1 true NO327814B1 (no) 2009-09-28

Family

ID=27532305

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NO20014986A NO327814B1 (no) 1999-04-14 2001-10-12 4,5-diaryl-3(2H)-furanonderivater, fremgangsmate for fremstilling derav, farmasoytiske preparater samt anvendelse av slike derivater

Country Status (26)

Country Link
US (1) US6492416B1 (fr)
EP (1) EP1109799B1 (fr)
JP (1) JP3844657B2 (fr)
KR (1) KR20010111584A (fr)
CN (1) CN1166658C (fr)
AT (1) ATE256672T1 (fr)
AU (1) AU767811B2 (fr)
BR (1) BRPI0011172B8 (fr)
CA (1) CA2369979C (fr)
CZ (1) CZ300766B6 (fr)
DE (1) DE60007267T2 (fr)
DZ (1) DZ3265A1 (fr)
EA (1) EA004432B1 (fr)
ES (1) ES2213007T3 (fr)
HK (1) HK1046413B (fr)
HU (1) HU227863B1 (fr)
IL (2) IL145305A0 (fr)
MA (1) MA25406A1 (fr)
MX (1) MXPA01010312A (fr)
NO (1) NO327814B1 (fr)
NZ (1) NZ514101A (fr)
PL (1) PL204249B1 (fr)
PT (1) PT1109799E (fr)
SK (1) SK286314B6 (fr)
TR (1) TR200102958T2 (fr)
WO (1) WO2000061571A1 (fr)

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KR20010094161A (ko) * 2000-04-04 2001-10-31 서경배 2,2-디메틸-4,5-디아릴-3(2h)퓨라논의 유도체 및 이를함유하는 선택적인 시클로옥시게네이즈-2 저해제로서약제학적 조성물
KR20010010728A (ko) * 1999-07-22 2001-02-15 서경배 2,2-디알킬-4,5-디아릴-3(2h)퓨라논의 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
KR20000066223A (ko) * 1999-04-14 2000-11-15 서경배 디아릴-3(2h)퓨라논 유도체 및 이를 함유하는 시클로옥시게네이즈-2 저해제 조성물
CA2412651A1 (fr) * 2000-05-22 2001-11-29 Dr. Reddy's Research Foundation Nouveaux composes possedant une activite anti-inflammatoire, procede de preparation de ceux-ci et compositions pharmaceutiques les contenant
US6924303B2 (en) 2000-06-13 2005-08-02 Wyeth Analgesic and anti-inflammatory compositions containing COX-2 inhibitors
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
WO2003018575A1 (fr) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation Furanones 5-substituees-3(2h)- utiles pour inhiber la farnesyl-proteine transferase
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WO2005009342A2 (fr) * 2003-07-16 2005-02-03 Pharmacia Corporation Methode de traitement ou de prevention de troubles dermatologiques a l'aide d'un seul inhibiteur de la cyclooxygenase-2 ou en combinaison avec un agent de traitement dermatologique, et compositions contenant ceux-ci
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
WO2005023189A2 (fr) * 2003-09-03 2005-03-17 Pharmacia Corporation Procede de prevention ou de traitement de la douleur, de l'inflammation, et de troubles lies a l'inflammation avec un inhibiteur selectif de cox-2 en combinaison avec un agent donneur de monoxyde d'azote et compositions en contenant
JP4641772B2 (ja) * 2003-10-23 2011-03-02 長谷川香料株式会社 フラノンの製造方法
WO2005094815A1 (fr) * 2004-03-30 2005-10-13 Amorepacific Corporation Double inhibition de la cyclooxygenase 2 et de l'anhydrase carbonique
US20080306146A1 (en) * 2005-11-02 2008-12-11 Amorepacific Corporation Dosing Regimens for Cox-2 Inhibitor
EP2032147A4 (fr) * 2006-04-28 2011-02-02 Cambridge Scient Pty Ltd Inhibiteur de l'enzyme cox-2
US20100105714A1 (en) * 2007-01-30 2010-04-29 Biogen Idec Ma Inc. Furanone Compounds and Methods of Making and Using The Same
TWI634114B (zh) * 2013-05-08 2018-09-01 永恒生物科技公司 作為激酶抑制劑之呋喃酮化合物
WO2015080435A1 (fr) * 2013-11-26 2015-06-04 화일약품주식회사 Procédé de préparation de 4-(3-(3-fluorophényl)-5,5-diméthyl-4-oxo-4,5-dihydrofuran-2-yl)benzènesulfonamide
KR101446601B1 (ko) * 2014-01-29 2014-10-07 크리스탈지노믹스(주) 5-(4-(아미노설포닐)페닐)-2,2-디메틸-4-(3-플루오로페닐)-3(2h)-퓨라논을 포함하는 약학적 조성물 및 캡슐 제형
US10413520B2 (en) 2014-01-29 2019-09-17 Crystalgenomics, Inc. Oral pharmacological composition including 5-{4-(amino sulfonyl)phenyl}-2,2-dimethyl-4-(3-fluorophenyl)-3(2H)-furanone having crystalline structure with excellent stability
CN104926797B (zh) * 2014-06-10 2019-04-16 北京元博方医药科技有限公司 呋喃酮衍生物、制备方法及用途
CN104098535A (zh) * 2014-07-25 2014-10-15 南通市华峰化工有限责任公司 一种4-(3-氟苯基)-2,2-二甲基-5-(4-(甲硫基)苯基)呋喃-3(2h)-酮的制备方法
RU2563876C1 (ru) * 2014-11-11 2015-09-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) Способ получения 2,2-диалкил-4,5-диарилфуран-3(2н)-онов
CN105061341B (zh) * 2015-08-21 2017-09-01 宁波百思佳医药科技有限公司 酰基三氮唑类化合物、苯乙酮取代的苯基甲基亚砜类化合物及其制备方法和应用
RU2631317C1 (ru) * 2016-05-13 2017-09-21 Общество с ограниченной ответственностью "Органик Эмиттерс" Селективные ингибиторы циклооксигеназы и способ их получения
CN111303085B (zh) * 2020-03-13 2022-04-01 西安瑞联新材料股份有限公司 5-溴-2,2-二甲基-5-(4-甲磺酰基苯基)呋喃-3(2h)-酮的合成方法

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Publication number Publication date
HU227863B1 (en) 2012-05-29
EA004432B1 (ru) 2004-04-29
EP1109799B1 (fr) 2003-12-17
JP2002541251A (ja) 2002-12-03
HUP0200623A3 (en) 2002-10-28
NO20014986D0 (no) 2001-10-12
EA200100958A1 (ru) 2002-06-27
EP1109799A1 (fr) 2001-06-27
MXPA01010312A (es) 2005-07-25
TR200102958T2 (tr) 2002-05-21
PL204249B1 (pl) 2009-12-31
PL351125A1 (en) 2003-03-24
SK286314B6 (en) 2008-07-07
HK1046413B (zh) 2005-05-27
CN1166658C (zh) 2004-09-15
CA2369979C (fr) 2009-12-08
PT1109799E (pt) 2004-05-31
AU767811B2 (en) 2003-11-27
BRPI0011172B1 (pt) 2017-05-16
DZ3265A1 (fr) 2000-10-19
HUP0200623A2 (hu) 2002-07-29
ATE256672T1 (de) 2004-01-15
HU0200623D0 (en) 2002-03-28
NO20014986L (no) 2001-11-01
CZ300766B6 (cs) 2009-08-05
JP3844657B2 (ja) 2006-11-15
ES2213007T3 (es) 2004-08-16
US6492416B1 (en) 2002-12-10
SK14512001A3 (sk) 2002-04-04
CN1348447A (zh) 2002-05-08
NZ514101A (en) 2001-09-28
AU4148000A (en) 2000-11-14
CA2369979A1 (fr) 2000-10-19
KR20010111584A (ko) 2001-12-19
MA25406A1 (fr) 2002-04-01
IL145305A (en) 2006-10-31
BRPI0011172B8 (pt) 2021-05-25
BR0011172A (pt) 2002-02-19
DE60007267T2 (de) 2004-09-16
HK1046413A1 (en) 2003-01-10
IL145305A0 (en) 2002-06-30
DE60007267D1 (de) 2004-01-29
CZ20013662A3 (cs) 2002-02-13
WO2000061571A1 (fr) 2000-10-19

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