SK280905B6 - 3-metylamino-6-karboxamido-1,2,3,4-tetrahydrokarbazol, spôsob jeho prípravy, farmaceutický prípravok s jeho obsahom a jeho použitie - Google Patents

3-metylamino-6-karboxamido-1,2,3,4-tetrahydrokarbazol, spôsob jeho prípravy, farmaceutický prípravok s jeho obsahom a jeho použitie Download PDF

Info

Publication number
SK280905B6
SK280905B6 SK1319-93A SK131993A SK280905B6 SK 280905 B6 SK280905 B6 SK 280905B6 SK 131993 A SK131993 A SK 131993A SK 280905 B6 SK280905 B6 SK 280905B6
Authority
SK
Slovakia
Prior art keywords
formula
compound
physiologically acceptable
tetrahydrocarbazole
methylamino
Prior art date
Application number
SK1319-93A
Other languages
English (en)
Slovak (sk)
Other versions
SK131993A3 (en
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK280905(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SK131993A3 publication Critical patent/SK131993A3/sk
Publication of SK280905B6 publication Critical patent/SK280905B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1319-93A 1991-06-26 1992-06-17 3-metylamino-6-karboxamido-1,2,3,4-tetrahydrokarbazol, spôsob jeho prípravy, farmaceutický prípravok s jeho obsahom a jeho použitie SK280905B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (2)

Publication Number Publication Date
SK131993A3 SK131993A3 (en) 1994-06-08
SK280905B6 true SK280905B6 (sk) 2000-09-12

Family

ID=10697363

Family Applications (3)

Application Number Title Priority Date Filing Date
SK1319-93A SK280905B6 (sk) 1991-06-26 1992-06-17 3-metylamino-6-karboxamido-1,2,3,4-tetrahydrokarbazol, spôsob jeho prípravy, farmaceutický prípravok s jeho obsahom a jeho použitie
SK1054-98A SK280906B6 (sk) 1991-06-26 1992-06-17 Použitie tetrahydrokarbazolových derivátov
SK1685-98A SK280907B6 (sk) 1991-06-26 1992-06-17 Deriváty tetrahydrokarbazolu, spôsob ich prípravy a farmaceutický prípravok s ich obsahom

Family Applications After (2)

Application Number Title Priority Date Filing Date
SK1054-98A SK280906B6 (sk) 1991-06-26 1992-06-17 Použitie tetrahydrokarbazolových derivátov
SK1685-98A SK280907B6 (sk) 1991-06-26 1992-06-17 Deriváty tetrahydrokarbazolu, spôsob ich prípravy a farmaceutický prípravok s ich obsahom

Country Status (34)

Country Link
US (2) US5464864A (cs)
EP (1) EP0591280B1 (cs)
JP (1) JP3261502B2 (cs)
KR (1) KR100251571B1 (cs)
CN (1) CN1034072C (cs)
AP (1) AP344A (cs)
AT (1) ATE170746T1 (cs)
BR (2) BR9206237A (cs)
CA (1) CA2113726C (cs)
CZ (3) CZ282083B6 (cs)
DE (2) DE69226953T2 (cs)
DK (1) DK0591280T3 (cs)
FI (1) FI103967B (cs)
GB (1) GB9113802D0 (cs)
HU (1) HU218907B (cs)
IE (1) IE922062A1 (cs)
IL (4) IL117105A (cs)
LU (1) LU90939I2 (cs)
MA (1) MA22563A1 (cs)
MX (1) MX9203444A (cs)
NL (1) NL300103I2 (cs)
NO (2) NO304774B1 (cs)
NZ (1) NZ243288A (cs)
PL (3) PL169392B1 (cs)
PT (1) PT100620B (cs)
RU (1) RU2137474C1 (cs)
SA (1) SA92130141B1 (cs)
SG (1) SG47877A1 (cs)
SI (1) SI9200125B (cs)
SK (3) SK280905B6 (cs)
TW (1) TW214544B (cs)
UA (1) UA41254C2 (cs)
WO (1) WO1993000086A1 (cs)
ZA (1) ZA924658B (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
DE60221683T2 (de) * 2001-09-28 2008-04-30 F. Hoffmann-La Roche Ag Pseudopolymorphe formen von carvedilol
DK1537113T5 (da) 2002-06-21 2011-01-10 Suven Life Sciences Ltd Arylalkylindoler med serotoninreceptoraffinitet anvendelige som terapeutiske midler, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
DE60317333T2 (de) 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
EA009193B1 (ru) 2002-11-28 2007-12-28 Сувен Лайф Сайенсиз Лимитед N-арилсульфонил-3-аминоалкоксииндолы
US7781476B2 (en) 2002-12-18 2010-08-24 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
DK2051962T3 (da) * 2006-08-07 2012-01-02 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-eddikesyrederivater
US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
MX2009008582A (es) 2007-02-11 2009-10-30 Map Pharmaceuticals Inc Metodo para la administracion terapeutica de dihidroergotamina para permitir un rapido alivio de la migraña mientras se minimiza el perfil de efectos secundarios.
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP3311667A1 (en) 2009-07-08 2018-04-25 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
US9399053B2 (en) 2011-07-22 2016-07-26 The University Of Chicago Treatments for migraine and related disorders
WO2014100351A2 (en) 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
WO2017152130A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
BR1100460A (pt) 2000-07-18
SK131993A3 (en) 1994-06-08
CZ286193A3 (en) 1994-07-13
CN1034072C (zh) 1997-02-19
ZA924658B (en) 1993-12-24
DE69226953D1 (de) 1998-10-15
NZ243288A (en) 1994-09-27
PL171034B1 (en) 1997-02-28
CN1069726A (zh) 1993-03-10
EP0591280B1 (en) 1998-09-09
AU1977592A (en) 1993-01-25
PL169392B1 (pl) 1996-07-31
AU652842B2 (en) 1994-09-08
SK280907B6 (sk) 2000-09-12
LU90939I2 (fr) 2002-09-24
JPH06508827A (ja) 1994-10-06
HK1014669A1 (en) 1999-09-30
IL117105A0 (en) 1996-06-18
IL102322A0 (en) 1993-01-14
GB9113802D0 (en) 1991-08-14
NO2005011I2 (no) 2008-02-11
WO1993000086A1 (en) 1993-01-07
HUT68961A (en) 1995-08-28
FI935842A0 (fi) 1993-12-23
BR9206237A (pt) 1995-04-11
FI103967B1 (fi) 1999-10-29
FI935842A7 (fi) 1993-12-23
IL117105A (en) 1998-01-04
PT100620B (pt) 1999-01-29
SA92130141B1 (ar) 2005-12-18
NL300103I1 (nl) 2002-12-02
DE69226953T2 (de) 1999-05-12
MX9203444A (es) 1993-12-01
US5464864A (en) 1995-11-07
CZ150596A3 (en) 1997-05-14
NO2005011I1 (no) 2005-05-18
TW214544B (cs) 1993-10-11
IE922062A1 (en) 1992-12-30
KR100251571B1 (ko) 2000-07-01
EP0591280A1 (en) 1994-04-13
MA22563A1 (fr) 1992-12-31
NO934800D0 (no) 1993-12-23
CA2113726A1 (en) 1993-01-07
SG47877A1 (en) 1998-04-17
IL102322A (en) 1997-09-30
CZ282327B6 (cs) 1997-06-11
HU218907B (hu) 2000-12-28
AP9200403A0 (en) 1992-07-31
US5637611A (en) 1997-06-10
CZ150696A3 (en) 1997-06-11
DK0591280T3 (da) 1999-02-15
IL117104A (en) 1997-09-30
SI9200125B (en) 2001-12-31
AP344A (en) 1994-07-05
NL300103I2 (nl) 2003-02-03
DE10299042I2 (de) 2005-02-03
CA2113726C (en) 2008-02-19
NO934800L (no) 1993-12-23
FI103967B (fi) 1999-10-29
IL117104A0 (en) 1996-06-18
NO304774B1 (no) 1999-02-15
SI9200125A (en) 1992-12-31
JP3261502B2 (ja) 2002-03-04
ATE170746T1 (de) 1998-09-15
CZ282061B6 (cs) 1997-05-14
DE10299042I1 (de) 2003-02-20
PL169410B1 (pl) 1996-07-31
SK280906B6 (sk) 2000-09-12
RU2137474C1 (ru) 1999-09-20
CZ282083B6 (cs) 1997-05-14
UA41254C2 (uk) 2001-09-17
PT100620A (pt) 1993-09-30

Similar Documents

Publication Publication Date Title
SK280905B6 (sk) 3-metylamino-6-karboxamido-1,2,3,4-tetrahydrokarbazol, spôsob jeho prípravy, farmaceutický prípravok s jeho obsahom a jeho použitie
KR19990014907A (ko) 디아릴디아민 유도체 및 델타 오피오이드 작용 (또는 길항) 물질로서의 그의 용도
AU688748B2 (en) Enantiomers of carbazole derivatives as 5-HT1-like agonists
CZ298413B6 (cs) Beta-Alaninový derivát, farmaceutická kompozice tento derivát obsahující a použití tohoto derivátu pro prípravu léciva
US8802734B2 (en) Method of treating or preventing pain
JPH09506885A (ja) ５ｈｔ▲下１ｄ▼（抗うつ作用）活性を有するインドール、インドリンおよびキノリン誘導体
US5827871A (en) Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
SI9300217A (sl) Farmacevtiki, ki vsebujejo ariloksialkilamino in ariltioalkilamino derivate
EP0603432B1 (en) Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated
CA2756876A1 (en) A process for the preparation of frovatriptan and frovatriptan succinate and their synthetic intermediates
JP2000007671A (ja) ２，３−ジヒドロベンゾフラン誘導体
JP2931190B2 (ja) ２，３−ジヒドロベンゾフラン誘導体
AU652842C (en) Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
HK1014669B (en) Use of tetrahydrocarbazole derivatives as 5ht1-receptor agonists
NZ299232A (en) (+)-6-carboxamido-3-n-ethylamino-1,2,3,4- tetrahydrocarbazoles; medicaments thereof

Legal Events

Date Code Title Description
MK4A Patent expired

Expiry date: 20120617

SPCE Expiry of an spc

Free format text: PRODUCT NAME: 3-METYLAMINO-6-KARBOXAMIDO-1,2,3,4-TETRAHYDROKARBAZOL, SPOSOB JEHO PRIPRAVY, FARMACEUTICKY PRIPRAVOK S JEHO OBSAHOM A JEHO POUZITIE; NAT. REGISTRATION NO/DATE: 07/0034/05-S, 20050218, FIRST REGISTRATION: NL24548 20051212

Spc suppl protection certif: DO 38; 4-2005

Expiry date: 20151212