SK15772003A3 - Nukleofilná fluorácia na pevnej fáze - Google Patents

Nukleofilná fluorácia na pevnej fáze Download PDF

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Publication number
SK15772003A3
SK15772003A3 SK1577-2003A SK15772003A SK15772003A3 SK 15772003 A3 SK15772003 A3 SK 15772003A3 SK 15772003 A SK15772003 A SK 15772003A SK 15772003 A3 SK15772003 A3 SK 15772003A3
Authority
SK
Slovakia
Prior art keywords
formula
indicator
protecting group
linker
labeled
Prior art date
Application number
SK1577-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Sajinder Kaur Luthra
Frank Brady
Harry John Wadsworth
Alexander Mark Gibson
Matthias Eberhard Glaser
Original Assignee
Amersham Plc
Hammersmith Imanet Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc, Hammersmith Imanet Limited filed Critical Amersham Plc
Publication of SK15772003A3 publication Critical patent/SK15772003A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)
SK1577-2003A 2001-06-29 2002-06-18 Nukleofilná fluorácia na pevnej fáze SK15772003A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination
PCT/GB2002/002505 WO2003002157A1 (en) 2001-06-29 2002-06-18 Solid-phase nucleophilic fluorination

Publications (1)

Publication Number Publication Date
SK15772003A3 true SK15772003A3 (sk) 2005-01-03

Family

ID=9917609

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1577-2003A SK15772003A3 (sk) 2001-06-29 2002-06-18 Nukleofilná fluorácia na pevnej fáze

Country Status (27)

Country Link
US (1) US20040236085A1 (no)
EP (1) EP1418950B1 (no)
JP (1) JP4370162B2 (no)
KR (1) KR100893461B1 (no)
CN (1) CN1246041C (no)
AR (1) AR036120A1 (no)
AT (1) ATE387221T1 (no)
AU (1) AU2002314298B2 (no)
BG (1) BG108497A (no)
BR (1) BR0210713A (no)
CA (1) CA2450637C (no)
CZ (1) CZ20033464A3 (no)
DE (1) DE60225299T2 (no)
EE (1) EE200400008A (no)
ES (1) ES2301653T3 (no)
GB (1) GB0115927D0 (no)
HK (1) HK1065945A1 (no)
HU (1) HU228974B1 (no)
IL (2) IL159260A0 (no)
MX (1) MXPA03011743A (no)
NO (1) NO330809B1 (no)
NZ (1) NZ530159A (no)
PL (1) PL204305B1 (no)
RU (1) RU2315769C9 (no)
SK (1) SK15772003A3 (no)
WO (1) WO2003002157A1 (no)
ZA (1) ZA200309558B (no)

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GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0229688D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
GB0317920D0 (en) * 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren
WO2005030677A1 (ja) * 2003-09-30 2005-04-07 Nihon Medi-Physics Co., Ltd. 放射性フッ素化合物の製造方法
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GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
US20050175534A1 (en) * 2004-02-06 2005-08-11 Adam Michael J. Method of synthesizing compounds having a phosphorus-fluorine-18 bond
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
JP4730760B2 (ja) * 2004-05-25 2011-07-20 住友重機械工業株式会社 Ｒｉ標識化合物合成システム
GB0425501D0 (en) * 2004-11-19 2004-12-22 Amersham Plc Fluoridation process
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
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GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
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US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
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GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
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GB0229688D0 (en) * 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes

Also Published As

Publication number Publication date
NZ530159A (en) 2005-08-26
CA2450637C (en) 2010-08-17
BR0210713A (pt) 2004-07-20
HK1065945A1 (en) 2005-03-11
ATE387221T1 (de) 2008-03-15
DE60225299T2 (de) 2009-03-12
ZA200309558B (en) 2004-09-27
IL159260A (en) 2009-09-22
WO2003002157A1 (en) 2003-01-09
EE200400008A (et) 2004-02-16
ES2301653T3 (es) 2008-07-01
EP1418950B1 (en) 2008-02-27
AR036120A1 (es) 2004-08-11
NO20035545D0 (no) 2003-12-12
BG108497A (en) 2005-03-31
HU228974B1 (en) 2013-07-29
RU2315769C9 (ru) 2008-05-27
CN1246041C (zh) 2006-03-22
CZ20033464A3 (cs) 2004-12-15
KR100893461B1 (ko) 2009-04-17
JP4370162B2 (ja) 2009-11-25
MXPA03011743A (es) 2004-07-01
US20040236085A1 (en) 2004-11-25
EP1418950A1 (en) 2004-05-19
NO330809B1 (no) 2011-07-25
JP2005512952A (ja) 2005-05-12
HUP0400253A2 (hu) 2004-08-30
RU2003137589A (ru) 2005-05-20
PL367772A1 (en) 2005-03-07
RU2315769C2 (ru) 2008-01-27
GB0115927D0 (en) 2001-08-22
PL204305B1 (pl) 2009-12-31
CA2450637A1 (en) 2003-01-09
IL159260A0 (en) 2004-06-01
DE60225299D1 (de) 2008-04-10
HUP0400253A3 (en) 2005-11-28
KR20040022434A (ko) 2004-03-12
CN1520315A (zh) 2004-08-11
AU2002314298B2 (en) 2005-07-07

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