IL159260A0 - Solid-phase-nucleophilic fluorination - Google Patents

Solid-phase-nucleophilic fluorination

Info

Publication number
IL159260A0
IL159260A0 IL15926002A IL15926002A IL159260A0 IL 159260 A0 IL159260 A0 IL 159260A0 IL 15926002 A IL15926002 A IL 15926002A IL 15926002 A IL15926002 A IL 15926002A IL 159260 A0 IL159260 A0 IL 159260A0
Authority
IL
Israel
Prior art keywords
solid
phase
nucleophilic fluorination
fluorination
nucleophilic
Prior art date
Application number
IL15926002A
Other languages
English (en)
Original Assignee
Amersham Plc
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc, Hammersmith Imanet Ltd filed Critical Amersham Plc
Publication of IL159260A0 publication Critical patent/IL159260A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)
IL15926002A 2001-06-29 2002-06-18 Solid-phase-nucleophilic fluorination IL159260A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination
PCT/GB2002/002505 WO2003002157A1 (en) 2001-06-29 2002-06-18 Solid-phase nucleophilic fluorination

Publications (1)

Publication Number Publication Date
IL159260A0 true IL159260A0 (en) 2004-06-01

Family

ID=9917609

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15926002A IL159260A0 (en) 2001-06-29 2002-06-18 Solid-phase-nucleophilic fluorination
IL159260A IL159260A (en) 2001-06-29 2003-12-09 Processes, compounds, kits and cartridges for markers marked with fluorine isotope 18 and their use in positron emission tomography

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159260A IL159260A (en) 2001-06-29 2003-12-09 Processes, compounds, kits and cartridges for markers marked with fluorine isotope 18 and their use in positron emission tomography

Country Status (27)

Country Link
US (1) US20040236085A1 (no)
EP (1) EP1418950B1 (no)
JP (1) JP4370162B2 (no)
KR (1) KR100893461B1 (no)
CN (1) CN1246041C (no)
AR (1) AR036120A1 (no)
AT (1) ATE387221T1 (no)
AU (1) AU2002314298B2 (no)
BG (1) BG108497A (no)
BR (1) BR0210713A (no)
CA (1) CA2450637C (no)
CZ (1) CZ20033464A3 (no)
DE (1) DE60225299T2 (no)
EE (1) EE200400008A (no)
ES (1) ES2301653T3 (no)
GB (1) GB0115927D0 (no)
HK (1) HK1065945A1 (no)
HU (1) HU228974B1 (no)
IL (2) IL159260A0 (no)
MX (1) MXPA03011743A (no)
NO (1) NO330809B1 (no)
NZ (1) NZ530159A (no)
PL (1) PL204305B1 (no)
RU (1) RU2315769C9 (no)
SK (1) SK15772003A3 (no)
WO (1) WO2003002157A1 (no)
ZA (1) ZA200309558B (no)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
GB0206117D0 (en) 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
JP2006505610A (ja) * 2002-11-05 2006-02-16 イヨン ベアム アプリカスィヨン エッス．アー． １８−ｆ標識放射性製剤の安定化
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
GB0229688D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0317920D0 (en) 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren
US20070036258A1 (en) * 2003-09-30 2007-02-15 Osamu Ito Process for producing radioactive fluorine compound
GB0329812D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Romp polymer synthesis
GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
US20050175534A1 (en) * 2004-02-06 2005-08-11 Adam Michael J. Method of synthesizing compounds having a phosphorus-fluorine-18 bond
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
JP4730760B2 (ja) * 2004-05-25 2011-07-20 住友重機械工業株式会社 Ｒｉ標識化合物合成システム
GB0425501D0 (en) * 2004-11-19 2004-12-22 Amersham Plc Fluoridation process
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
GB0428012D0 (en) * 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
JP2007031647A (ja) * 2005-07-29 2007-02-08 Japan Health Science Foundation 固相合成を利用した超短半減期核種を含む化合物の製造方法およびそれに用いる化合物
US7824659B2 (en) * 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
CN100563812C (zh) * 2006-03-22 2009-12-02 上海化工研究院 一种可制备多种氟标试剂的化学合成装置
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
RU2009112716A (ru) 2006-09-08 2010-10-20 Байер Шеринг Фарма Акциенгезельшафт (DE) Соединения и способы для агентов, меченых 18f
EP1985624A3 (en) * 2007-04-23 2008-12-24 Bayer Schering Pharma Aktiengesellschaft Single step method of radiofluorination of biologically active compounds or biomolecules
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
NO345488B1 (no) * 2006-12-27 2021-03-01 Nihon Mediphysics Co Ltd Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
GB0709561D0 (en) * 2007-05-18 2007-06-27 Siemens Medical Solutions Assessment of vascular compartment volume PET modeling
RU2475448C2 (ru) * 2008-01-03 2013-02-20 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ обработки фторида
ES2767973T3 (es) 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
KR100973724B1 (ko) * 2008-03-14 2010-08-04 류현욱 신발창용 쿠션부재
EP2110367A1 (en) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures
EP2318332A1 (en) * 2008-07-07 2011-05-11 Bayer Schering Pharma Aktiengesellschaft Process for production of radiopharmaceuticals
EP2349977A4 (en) 2008-10-21 2012-03-28 Nutech Ventures FLUORATION OF AROMATIC RING SYSTEMS
US9302990B2 (en) 2008-10-21 2016-04-05 Nutech Ventures Fluorination of aromatic ring systems
KR101155403B1 (ko) * 2008-11-06 2013-12-20 서울대학교산학협력단 플루오린이 도입된 벤조타이아졸 유도체, 이의 제조방법 및 이를 이용한 알츠하이머 질환 진단용 영상화제
GB0904715D0 (en) 2009-03-19 2009-05-06 Ge Healthcare Ltd Aryloxyanilide derivataives
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
US9687571B2 (en) 2009-04-15 2017-06-27 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
JP5237880B2 (ja) * 2009-04-30 2013-07-17 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置
CA2767470A1 (en) 2009-07-11 2011-01-20 Bayer Pharma Aktiengesellschaft Non-polar and polar leaving groups
US8377704B2 (en) 2009-10-20 2013-02-19 Nutech Ventures Detection and quantification of anions
GB0921967D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
US8546578B2 (en) 2010-02-04 2013-10-01 Nutech Ventures Iodonium Cyclophanes for SECURE arene functionalization
DK2534136T3 (en) 2010-02-08 2017-12-04 Lantheus Medical Imaging Inc METHODS OF SYNTHETIZING CONTRAST AGENTS AND INTERMEDIATES THEREOF
CN102753561B (zh) 2010-02-12 2015-10-21 国立大学法人东京工业大学 18f标记化合物的制造方法和该方法中使用的高分子化合物
EP2556372A1 (en) 2010-04-08 2013-02-13 Siemens Medical Solutions USA, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
KR101351878B1 (ko) 2010-12-14 2014-02-06 서강대학교산학협력단 １８ｆ 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용
WO2013176522A1 (ko) 2012-05-24 2013-11-28 서강대학교산학협력단 카트리지를 이용한 방사성의약품 제조방법
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN103755679A (zh) * 2014-02-14 2014-04-30 宁德新能源科技有限公司 一种亚烷基二磺酸酐的制备方法
CN109988085B (zh) * 2017-12-29 2021-11-09 张家港市国泰华荣化工新材料有限公司 金属离子含量低的1,3-丙二烷基磺酸的制备方法
US20220072163A1 (en) * 2018-07-03 2022-03-10 The Regents Of The University Of California Mild and site-selective 18f-labeling of small molecules and/or biomolecules via a thiol-reactive synthon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510522A (en) * 1995-02-22 1996-04-23 Regents Of The University Of California Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa
EP1027365B1 (en) * 1997-10-30 2005-01-19 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Antitumour uridine analogues
WO2000010614A1 (en) * 1998-08-20 2000-03-02 Regents Of The University Of California METHODS FOR LABELING β-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
GB0229683D0 (en) * 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
GB0229688D0 (en) * 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Solid-phase preparation of [18F] Fluorohaloalkanes

Also Published As

Publication number Publication date
PL367772A1 (en) 2005-03-07
BG108497A (en) 2005-03-31
MXPA03011743A (es) 2004-07-01
HUP0400253A3 (en) 2005-11-28
ATE387221T1 (de) 2008-03-15
ES2301653T3 (es) 2008-07-01
GB0115927D0 (en) 2001-08-22
EP1418950B1 (en) 2008-02-27
NZ530159A (en) 2005-08-26
CA2450637C (en) 2010-08-17
DE60225299D1 (de) 2008-04-10
CZ20033464A3 (cs) 2004-12-15
IL159260A (en) 2009-09-22
RU2003137589A (ru) 2005-05-20
HUP0400253A2 (hu) 2004-08-30
EP1418950A1 (en) 2004-05-19
JP2005512952A (ja) 2005-05-12
AR036120A1 (es) 2004-08-11
CA2450637A1 (en) 2003-01-09
JP4370162B2 (ja) 2009-11-25
CN1520315A (zh) 2004-08-11
WO2003002157A1 (en) 2003-01-09
ZA200309558B (en) 2004-09-27
BR0210713A (pt) 2004-07-20
NO330809B1 (no) 2011-07-25
EE200400008A (et) 2004-02-16
NO20035545D0 (no) 2003-12-12
SK15772003A3 (sk) 2005-01-03
PL204305B1 (pl) 2009-12-31
KR100893461B1 (ko) 2009-04-17
HK1065945A1 (en) 2005-03-11
CN1246041C (zh) 2006-03-22
KR20040022434A (ko) 2004-03-12
RU2315769C9 (ru) 2008-05-27
RU2315769C2 (ru) 2008-01-27
AU2002314298B2 (en) 2005-07-07
HU228974B1 (en) 2013-07-29
US20040236085A1 (en) 2004-11-25
DE60225299T2 (de) 2009-03-12

Similar Documents

Publication Publication Date Title
IL159260A0 (en) Solid-phase-nucleophilic fluorination
DE50202400D1 (en) Baw-resonator
DE50201180D1 (en) Organopolysiloxan/polyharnstoff/polyurethan-blockcopolymere
DE50209614D1 (en) 2-heteroarylcarbonsäureamide
DE50211022D1 (en) Heteroarylcarbonsäureamide
DE60141364D1 (en) Polyphenylensulfidharzzusammensetzung
DE60141362D1 (en) Ösophagus-stoma-knopf
DE50202633D1 (en) Ophthalmoskop
AU2002360430A8 (en) 14-methyl-epothilones
DE60107296D1 (en) Kabelverstärkerverbindungsanordnung
DE50203686D1 (en) Substituierte c-furan-2-yl-methylamin- und c-thiophen-2-yl-methylamin-derivate
DE50206483D1 (en) Displaymodul
DE50201028D1 (en) Diarylgelbpigmentpraeparationen
DE50214962D1 (en) Heterocyclylarylsulfonamide
AU2002313943A8 (en) Electromobile
GB0106031D0 (en) Use
AU2001100134A4 (en) Enviro-trap
GB0111831D0 (en) Former
CA92665S (en) Bedboard
AU2288P (en) Prime322 xTriticosecale
CA93126S (en) Titlt-latch
CA93125S (en) Tilt-latch
CA93075S (en) Travelbag
CA92978S (en) Photo-changer
CA93646S (en) Fauteuil