AR036120A1 - Un proceso para la produccion de un trazador rotulado por fluoracion nucleofila en fase solida, compuestos, un kit radiofarmaceutico para la preparacion del trazador, un cartucho para un kit y un metodo para obtener una imagen - Google Patents
Un proceso para la produccion de un trazador rotulado por fluoracion nucleofila en fase solida, compuestos, un kit radiofarmaceutico para la preparacion del trazador, un cartucho para un kit y un metodo para obtener una imagenInfo
- Publication number
- AR036120A1 AR036120A1 ARP020102433A ARP020102433A AR036120A1 AR 036120 A1 AR036120 A1 AR 036120A1 AR P020102433 A ARP020102433 A AR P020102433A AR P020102433 A ARP020102433 A AR P020102433A AR 036120 A1 AR036120 A1 AR 036120A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- production
- kit
- compound
- trazer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Nuclear Medicine (AREA)
Abstract
Un proceso para la producción de un trazador rotulado con 18F el cual comprende tratamiento de un precursor unido a una resina de fórmula (1) SOPORTE SOLIDO-CONECTOR-X-TRAZADOR (1) en la cual X es un grupo que promueve la sustitución nucleófila en un sitio específico en el TRAZADOR adherido; con 18F para producir el trazador rotulado de fórmula (2) 18F-TRAZADOR (2). U n compuesto de la fórmula (3) en donde P1b, P2b, P3b y P4b son cada uno independientemente hidrógeno o un grupo protector . Un compuesto de la fórmula (4) en donde P1c y P2c son cada uno independientemente hidrógeno o un grupo protector. Un compuesto de la fórmula (5), un compuesto de la fórmula (6) en donde P1e, P2e, P3e yP4e son cada uno independientemente hidrógeno o un grupo protector y Y es un anión como ser triflato. Procesos en fase sólida para la producción de trazadores radiorrotulados, en particular para la producción de compuestos rotulados con 18F que puede ser adecuada para utilizar como radioindicadores para Tomografía de Emisión de Positrones (PET). También comprende kits farmacéuticos radiactivos que utilizan estos novedosos procesos y un cartucho para un kit radiofarmacéutico; y un método para obtener una imagen de PET de diagnóstico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115927.6A GB0115927D0 (en) | 2001-06-29 | 2001-06-29 | Solid-phase nucleophilic fluorination |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036120A1 true AR036120A1 (es) | 2004-08-11 |
Family
ID=9917609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102433A AR036120A1 (es) | 2001-06-29 | 2002-06-28 | Un proceso para la produccion de un trazador rotulado por fluoracion nucleofila en fase solida, compuestos, un kit radiofarmaceutico para la preparacion del trazador, un cartucho para un kit y un metodo para obtener una imagen |
Country Status (27)
Country | Link |
---|---|
US (1) | US20040236085A1 (es) |
EP (1) | EP1418950B1 (es) |
JP (1) | JP4370162B2 (es) |
KR (1) | KR100893461B1 (es) |
CN (1) | CN1246041C (es) |
AR (1) | AR036120A1 (es) |
AT (1) | ATE387221T1 (es) |
AU (1) | AU2002314298B2 (es) |
BG (1) | BG108497A (es) |
BR (1) | BR0210713A (es) |
CA (1) | CA2450637C (es) |
CZ (1) | CZ20033464A3 (es) |
DE (1) | DE60225299T2 (es) |
EE (1) | EE200400008A (es) |
ES (1) | ES2301653T3 (es) |
GB (1) | GB0115927D0 (es) |
HK (1) | HK1065945A1 (es) |
HU (1) | HU228974B1 (es) |
IL (2) | IL159260A0 (es) |
MX (1) | MXPA03011743A (es) |
NO (1) | NO330809B1 (es) |
NZ (1) | NZ530159A (es) |
PL (1) | PL204305B1 (es) |
RU (1) | RU2315769C9 (es) |
SK (1) | SK15772003A3 (es) |
WO (1) | WO2003002157A1 (es) |
ZA (1) | ZA200309558B (es) |
Families Citing this family (65)
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GB0115929D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase electrophilic fluorination |
GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
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GB0229683D0 (en) | 2002-12-20 | 2003-01-29 | Imaging Res Solutions Ltd | Preparation of radiopharmaceuticals |
GB0229688D0 (en) * | 2002-12-20 | 2003-01-29 | Imaging Res Solutions Ltd | Solid-phase preparation of [18F] Fluorohaloalkanes |
GB0229695D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase preparation of 18F-labelled amino acids |
GB0229686D0 (en) | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
GB0317920D0 (en) | 2003-07-31 | 2003-09-03 | Amersham Plc | Solid-phase synthesis |
US20050049487A1 (en) * | 2003-08-26 | 2005-03-03 | Johnson Bruce Fletcher | Compounds and kits for preparing imaging agents and methods of imaging |
DE10346228B4 (de) * | 2003-09-25 | 2009-04-09 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren |
US20070036258A1 (en) * | 2003-09-30 | 2007-02-15 | Osamu Ito | Process for producing radioactive fluorine compound |
GB0329812D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Romp polymer synthesis |
GB0329716D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Radical trap |
US20050175534A1 (en) * | 2004-02-06 | 2005-08-11 | Adam Michael J. | Method of synthesizing compounds having a phosphorus-fluorine-18 bond |
GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
JP4730760B2 (ja) * | 2004-05-25 | 2011-07-20 | 住友重機械工業株式会社 | Ri標識化合物合成システム |
GB0425501D0 (en) * | 2004-11-19 | 2004-12-22 | Amersham Plc | Fluoridation process |
KR100789847B1 (ko) * | 2004-12-15 | 2007-12-28 | (주)퓨쳐켐 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
GB0428012D0 (en) | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
JP2007031647A (ja) * | 2005-07-29 | 2007-02-08 | Japan Health Science Foundation | 固相合成を利用した超短半減期核種を含む化合物の製造方法およびそれに用いる化合物 |
US7824659B2 (en) * | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
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US7998418B1 (en) | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
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WO2012081880A2 (ko) * | 2010-12-14 | 2012-06-21 | 서강대학교산학협력단 | 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용 |
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US5510522A (en) | 1995-02-22 | 1996-04-23 | Regents Of The University Of California | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa |
JP2001522034A (ja) * | 1997-10-30 | 2001-11-13 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, リプレゼンテッド バイ ザ セクレタリー オブ ヘルス アンド ヒューマン サービシーズ | 画像化および処置適用のためのヌクレオシド |
US6274119B1 (en) * | 1998-08-20 | 2001-08-14 | The Regents Of The Univ. Of California | Methods for labeling β-amyloid plaques and neurofibrillary tangles |
GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
GB0115929D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase electrophilic fluorination |
GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
GB0229683D0 (en) * | 2002-12-20 | 2003-01-29 | Imaging Res Solutions Ltd | Preparation of radiopharmaceuticals |
GB0229688D0 (en) * | 2002-12-20 | 2003-01-29 | Imaging Res Solutions Ltd | Solid-phase preparation of [18F] Fluorohaloalkanes |
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2001
- 2001-06-29 GB GBGB0115927.6A patent/GB0115927D0/en not_active Ceased
-
2002
- 2002-06-18 WO PCT/GB2002/002505 patent/WO2003002157A1/en active IP Right Grant
- 2002-06-18 IL IL15926002A patent/IL159260A0/xx unknown
- 2002-06-18 RU RU2003137589/04A patent/RU2315769C9/ru not_active IP Right Cessation
- 2002-06-18 HU HU0400253A patent/HU228974B1/hu not_active IP Right Cessation
- 2002-06-18 CN CNB028127536A patent/CN1246041C/zh not_active Expired - Fee Related
- 2002-06-18 US US10/482,540 patent/US20040236085A1/en not_active Abandoned
- 2002-06-18 NZ NZ530159A patent/NZ530159A/en not_active IP Right Cessation
- 2002-06-18 ES ES02740868T patent/ES2301653T3/es not_active Expired - Lifetime
- 2002-06-18 CZ CZ20033464A patent/CZ20033464A3/cs unknown
- 2002-06-18 JP JP2003508395A patent/JP4370162B2/ja not_active Expired - Fee Related
- 2002-06-18 DE DE60225299T patent/DE60225299T2/de not_active Expired - Lifetime
- 2002-06-18 MX MXPA03011743A patent/MXPA03011743A/es active IP Right Grant
- 2002-06-18 AU AU2002314298A patent/AU2002314298B2/en not_active Ceased
- 2002-06-18 SK SK1577-2003A patent/SK15772003A3/sk unknown
- 2002-06-18 CA CA2450637A patent/CA2450637C/en not_active Expired - Fee Related
- 2002-06-18 AT AT02740868T patent/ATE387221T1/de not_active IP Right Cessation
- 2002-06-18 PL PL367772A patent/PL204305B1/pl not_active IP Right Cessation
- 2002-06-18 KR KR1020037016951A patent/KR100893461B1/ko not_active IP Right Cessation
- 2002-06-18 EE EEP200400008A patent/EE200400008A/xx unknown
- 2002-06-18 EP EP02740868A patent/EP1418950B1/en not_active Expired - Lifetime
- 2002-06-18 BR BR0210713-9A patent/BR0210713A/pt not_active IP Right Cessation
- 2002-06-28 AR ARP020102433A patent/AR036120A1/es unknown
-
2003
- 2003-12-09 ZA ZA200309558A patent/ZA200309558B/xx unknown
- 2003-12-09 IL IL159260A patent/IL159260A/en not_active IP Right Cessation
- 2003-12-12 NO NO20035545A patent/NO330809B1/no not_active IP Right Cessation
- 2003-12-22 BG BG108497A patent/BG108497A/xx unknown
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2004
- 2004-11-10 HK HK04108827A patent/HK1065945A1/xx not_active IP Right Cessation
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