HUP0400253A2 - Szilárd fázisú nukleofil fluorozás - Google Patents

Szilárd fázisú nukleofil fluorozás

Info

Publication number
HUP0400253A2
HUP0400253A2 HU0400253A HUP0400253A HUP0400253A2 HU P0400253 A2 HUP0400253 A2 HU P0400253A2 HU 0400253 A HU0400253 A HU 0400253A HU P0400253 A HUP0400253 A HU P0400253A HU P0400253 A2 HUP0400253 A2 HU P0400253A2
Authority
HU
Hungary
Prior art keywords
solid
radioactive
nucleophilic fluorination
phase nucleophilic
indicators
Prior art date
Application number
HU0400253A
Other languages
English (en)
Inventor
Frank Brady
Alexander Mark Gibson
Matthias Eberhard Glaser
Sajinder Kaur Luthra
Harry John Wadsworth
Original Assignee
Amersham Plc
Hammersmith Imanet Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc, Hammersmith Imanet Limited filed Critical Amersham Plc
Publication of HUP0400253A2 publication Critical patent/HUP0400253A2/hu
Publication of HUP0400253A3 publication Critical patent/HUP0400253A3/hu
Publication of HU228974B1 publication Critical patent/HU228974B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)

Abstract

A találmány tárgyát új, szilárd fázisú eljárások képezik radioaktívizotóppal jelzett indikátorok, különösen 18F izotóppal jelzettvegyületek előállítására. A vegyületek alkalmasak lehetnek radioaktívindikátorokként a pozitronemissziós tomográfiában (PET) történőfelhasználásra. A találmány az ezeket az új eljárásokat felhasználóradioaktív gyógyászati reagenskészletekre is kiterjed. Ó
HU0400253A 2001-06-29 2002-06-18 Solid-phase nucleophilic fluorination HU228974B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115927.6A GB0115927D0 (en) 2001-06-29 2001-06-29 Solid-phase nucleophilic fluorination
PCT/GB2002/002505 WO2003002157A1 (en) 2001-06-29 2002-06-18 Solid-phase nucleophilic fluorination

Publications (3)

Publication Number Publication Date
HUP0400253A2 true HUP0400253A2 (hu) 2004-08-30
HUP0400253A3 HUP0400253A3 (en) 2005-11-28
HU228974B1 HU228974B1 (en) 2013-07-29

Family

ID=9917609

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400253A HU228974B1 (en) 2001-06-29 2002-06-18 Solid-phase nucleophilic fluorination

Country Status (27)

Country Link
US (1) US20040236085A1 (hu)
EP (1) EP1418950B1 (hu)
JP (1) JP4370162B2 (hu)
KR (1) KR100893461B1 (hu)
CN (1) CN1246041C (hu)
AR (1) AR036120A1 (hu)
AT (1) ATE387221T1 (hu)
AU (1) AU2002314298B2 (hu)
BG (1) BG108497A (hu)
BR (1) BR0210713A (hu)
CA (1) CA2450637C (hu)
CZ (1) CZ20033464A3 (hu)
DE (1) DE60225299T2 (hu)
EE (1) EE200400008A (hu)
ES (1) ES2301653T3 (hu)
GB (1) GB0115927D0 (hu)
HK (1) HK1065945A1 (hu)
HU (1) HU228974B1 (hu)
IL (2) IL159260A0 (hu)
MX (1) MXPA03011743A (hu)
NO (1) NO330809B1 (hu)
NZ (1) NZ530159A (hu)
PL (1) PL204305B1 (hu)
RU (1) RU2315769C9 (hu)
SK (1) SK15772003A3 (hu)
WO (1) WO2003002157A1 (hu)
ZA (1) ZA200309558B (hu)

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US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
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Also Published As

Publication number Publication date
PL367772A1 (en) 2005-03-07
EP1418950B1 (en) 2008-02-27
IL159260A (en) 2009-09-22
ZA200309558B (en) 2004-09-27
BR0210713A (pt) 2004-07-20
AR036120A1 (es) 2004-08-11
DE60225299T2 (de) 2009-03-12
ATE387221T1 (de) 2008-03-15
SK15772003A3 (sk) 2005-01-03
GB0115927D0 (en) 2001-08-22
JP2005512952A (ja) 2005-05-12
KR20040022434A (ko) 2004-03-12
NZ530159A (en) 2005-08-26
CA2450637A1 (en) 2003-01-09
EE200400008A (et) 2004-02-16
RU2315769C9 (ru) 2008-05-27
PL204305B1 (pl) 2009-12-31
IL159260A0 (en) 2004-06-01
DE60225299D1 (de) 2008-04-10
ES2301653T3 (es) 2008-07-01
HK1065945A1 (en) 2005-03-11
CN1246041C (zh) 2006-03-22
WO2003002157A1 (en) 2003-01-09
NO330809B1 (no) 2011-07-25
CN1520315A (zh) 2004-08-11
MXPA03011743A (es) 2004-07-01
AU2002314298B2 (en) 2005-07-07
US20040236085A1 (en) 2004-11-25
HUP0400253A3 (en) 2005-11-28
RU2003137589A (ru) 2005-05-20
CA2450637C (en) 2010-08-17
HU228974B1 (en) 2013-07-29
KR100893461B1 (ko) 2009-04-17
CZ20033464A3 (cs) 2004-12-15
RU2315769C2 (ru) 2008-01-27
JP4370162B2 (ja) 2009-11-25
EP1418950A1 (en) 2004-05-19
NO20035545D0 (no) 2003-12-12
BG108497A (en) 2005-03-31

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