PT2534136T - Métodos para sintetizar agentes de imagiologia, e seus intermediários - Google Patents
Métodos para sintetizar agentes de imagiologia, e seus intermediáriosInfo
- Publication number
- PT2534136T PT2534136T PT117405464T PT11740546T PT2534136T PT 2534136 T PT2534136 T PT 2534136T PT 117405464 T PT117405464 T PT 117405464T PT 11740546 T PT11740546 T PT 11740546T PT 2534136 T PT2534136 T PT 2534136T
- Authority
- PT
- Portugal
- Prior art keywords
- intermediates
- methods
- imaging agents
- synthesizing imaging
- synthesizing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cameras In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30247710P | 2010-02-08 | 2010-02-08 | |
| US31537610P | 2010-03-18 | 2010-03-18 | |
| US33369310P | 2010-05-11 | 2010-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2534136T true PT2534136T (pt) | 2017-12-15 |
Family
ID=44356121
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117405464T PT2534136T (pt) | 2010-02-08 | 2011-02-08 | Métodos para sintetizar agentes de imagiologia, e seus intermediários |
| PT171894397T PT3323810T (pt) | 2010-02-08 | 2011-02-08 | Sistema de reação automatizado, cassete e dispositivo para sintetizar agentes de imagem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT171894397T PT3323810T (pt) | 2010-02-08 | 2011-02-08 | Sistema de reação automatizado, cassete e dispositivo para sintetizar agentes de imagem |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US8936777B2 (pt) |
| EP (3) | EP3323810B1 (pt) |
| JP (3) | JP6092628B2 (pt) |
| KR (5) | KR101709372B1 (pt) |
| CN (3) | CN113058046A (pt) |
| AU (3) | AU2011213568B2 (pt) |
| BR (1) | BR112012019789A2 (pt) |
| CA (1) | CA2789044C (pt) |
| DK (2) | DK3323810T3 (pt) |
| ES (2) | ES2909318T3 (pt) |
| HK (1) | HK1255702A1 (pt) |
| IL (2) | IL221253B (pt) |
| MX (1) | MX348958B (pt) |
| NO (1) | NO2534136T3 (pt) |
| NZ (1) | NZ602291A (pt) |
| PT (2) | PT2534136T (pt) |
| RU (1) | RU2631500C2 (pt) |
| SG (2) | SG183134A1 (pt) |
| TW (4) | TWI686370B (pt) |
| WO (1) | WO2011097649A2 (pt) |
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| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| EP2474525B1 (en) | 2006-12-26 | 2020-04-15 | Lantheus Medical Imaging, Inc. | Ligands for imaging cardiac innervation |
| PT2257315T (pt) | 2008-02-29 | 2020-01-27 | Lantheus Medical Imaging Inc | Agentes de contraste para aplicações incluindo imagiologia de perfusão |
| PT2419096T (pt) | 2009-04-15 | 2020-02-19 | Lantheus Medical Imaging Inc | Estabilização de composições radiofarmacêuticas utilizando ácido ascórbico |
| US10109385B2 (en) | 2009-09-23 | 2018-10-23 | Abt Molecular Imaging, Inc. | Dose synthesis card for use with automated biomarker production system |
| PT2534136T (pt) * | 2010-02-08 | 2017-12-15 | Lantheus Medical Imaging Inc | Métodos para sintetizar agentes de imagiologia, e seus intermediários |
| CA2798488C (en) | 2010-05-11 | 2019-06-04 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| US11129911B2 (en) | 2011-05-05 | 2021-09-28 | Cedars-Sinai Medical Center | Assessment of coronary heart disease with carbon dioxide |
| CA2845308C (en) * | 2011-05-05 | 2021-01-26 | Cedars-Sinai Medical Center | Assessment of coronary heart disease with carbon dioxide |
| CN104159890B (zh) * | 2011-09-09 | 2018-04-10 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
| CA2852395C (en) * | 2011-10-21 | 2020-04-28 | Lantheus Medical Imaging, Inc. | Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods |
| WO2013070471A1 (en) | 2011-11-11 | 2013-05-16 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| EP2836241B1 (en) * | 2012-04-10 | 2019-02-20 | Lantheus Medical Imaging, Inc. | Radiopharmaceutical synthesis methods |
| CA2794281C (en) * | 2012-04-30 | 2019-07-02 | Elazar A. Bienenstock | Single photon emission computed tomography imaging method |
| WO2013172979A1 (en) * | 2012-05-14 | 2013-11-21 | University Of Southern California | Methods and compositions for positron emission tomography myocardial perfusion imaging |
| AU2013203000B9 (en) * | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| WO2015021078A1 (en) | 2013-08-05 | 2015-02-12 | Cedars-Sinai Medical Center | Methods for reducing ischemia-reperfusion injury |
| JP6190240B2 (ja) | 2013-10-16 | 2017-08-30 | 浜松ホトニクス株式会社 | 癌に対する治療効果の診断剤 |
| US9031300B1 (en) | 2013-10-25 | 2015-05-12 | General Electric Company | System and method reconstructing a nuclear medicine image using deformed attenuation image |
| CN107530455A (zh) * | 2015-02-10 | 2018-01-02 | Abt分子成像公司 | 与自动化生物标记物生产系统联用的剂量合成卡 |
| NL2014828B1 (en) * | 2015-05-20 | 2017-01-31 | Out And Out Chemistry S P R L | Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method. |
| CN105553594B (zh) * | 2015-12-09 | 2018-02-16 | 沈阳东软医疗系统有限公司 | 一种pet时钟同步方法和装置 |
| US11109819B2 (en) | 2016-04-11 | 2021-09-07 | The General Hospital Corporation | System and method for quantitatively mapping mitochondrial membrane potential |
| JP6060302B1 (ja) * | 2016-06-10 | 2017-01-11 | 日本メジフィジックス株式会社 | 心筋核医学画像データの解析方法及び解析装置 |
| TWI649067B (zh) * | 2017-03-01 | 2019-02-01 | 醫百科技股份有限公司 | Positioning corrector |
| CN108129673B (zh) * | 2017-12-26 | 2020-10-13 | 武汉大学 | 一种高灵敏度水溶性树枝状大分子f19显影剂的制备及其应用 |
| GB201805253D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Ltd Ip | Solid phase extraction |
| CN108658868A (zh) * | 2018-05-07 | 2018-10-16 | 四川大学 | 一种碳酸氢盐离子液体及其制备方法以及一种三氨基三硝基苯的重结晶方法 |
| EP3671511B1 (en) | 2018-12-19 | 2022-07-06 | Rohde & Schwarz GmbH & Co. KG | Communication system and method |
| CN109806822B (zh) * | 2019-01-30 | 2021-07-30 | 杭州吉蕊科技有限公司 | 一种模块化、多功能的pet探针自动化合成系统 |
| CN109896934A (zh) * | 2019-03-08 | 2019-06-18 | 山东省药学科学院 | 一种高纯度2-苄氧基溴乙烷的制备方法 |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
| GB201919016D0 (en) * | 2019-12-20 | 2020-02-05 | Ge Healthcare Ltd | Apparatus and method for solid phase extraction |
| CN111333638A (zh) * | 2020-03-17 | 2020-06-26 | 四川大学华西医院 | 18f标记的异喹啉并哒嗪酮类化合物及其合成方法和应用 |
| JP7362561B2 (ja) * | 2020-07-30 | 2023-10-17 | 富士フイルム株式会社 | 放射線画像処理装置、方法およびプログラム |
| WO2022261502A1 (en) * | 2021-06-11 | 2022-12-15 | Jubilant Draximage Inc. | Non-invasive imaging methods of diagnosing peripheral arterial disease |
| GB202108608D0 (en) | 2021-06-16 | 2021-07-28 | Ge Healthcare Ltd | Preparation of a ph-adjusted ascorbic acid solution |
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| CN114700006B (zh) * | 2022-06-07 | 2023-03-24 | 北京先通国际医药科技股份有限公司 | 一种液体组合物的生产设备及其制备方法和用途 |
| CN114716415B (zh) * | 2022-06-09 | 2022-09-02 | 北京先通国际医药科技股份有限公司 | 生产液体组合物的设备及其制备方法和用途 |
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| CN114773179B (zh) * | 2022-06-23 | 2022-09-16 | 北京先通国际医药科技股份有限公司 | 一种化合物ⅰ液体组合物的制备方法、及其在心肌代谢pet显像上的用途 |
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