MX348958B - Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos. - Google Patents

Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos.

Info

Publication number
MX348958B
MX348958B MX2012009174A MX2012009174A MX348958B MX 348958 B MX348958 B MX 348958B MX 2012009174 A MX2012009174 A MX 2012009174A MX 2012009174 A MX2012009174 A MX 2012009174A MX 348958 B MX348958 B MX 348958B
Authority
MX
Mexico
Prior art keywords
methods
imaging
imaging agents
subject
intermediates
Prior art date
Application number
MX2012009174A
Other languages
English (en)
Other versions
MX2012009174A (es
Inventor
S Radeke Heike
R Cesati Richard
H Cheesman Edward
Lazewatsky Joel
F Castner James
Mongeau Enrico
D Zdankiewicz Dianne
Wilburn Siegler Robert
Devine Marybeth
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Publication of MX2012009174A publication Critical patent/MX2012009174A/es
Publication of MX348958B publication Critical patent/MX348958B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere en general a métodos y sistemas para la síntesis de agentes formadores de imagen y precursores de estos. Los métodos pueden presentar rendimientos mejorados y pueden permitir la síntesis a gran escala de agentes formadores de imagen, incluidos los agentes formadores de imagen que comprenden un radioisótopo (p. ej., 18F). Varias modalidades de la invención pueden ser útiles como sensores, herramientas de diagnóstico y similares. En algunos casos, se proporcionan métodos para evaluar la perfusión, incluida la perfusión miocárdica. Los métodos sintéticos de la invención también se han incorporado a una unidad de síntesis automatizada para preparar y purificar agentes formadores de imagen que comprenden un radioisótopo. En algunas modalidades, la presente invención proporciona métodos y sistemas novedosos que comprenden el agente formador de imagen 1, los cuales incluyen métodos para realizar una tomografía en un sujeto que comprenden administrar una composición que comprende el agente formador de imagen 1 a un sujeto mediante inyección, infusión o cualquier otro conocido y realizar una tomografía del área del sujeto en la que se localiza el evento de interés.
MX2012009174A 2010-02-08 2011-02-08 Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos. MX348958B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30247710P 2010-02-08 2010-02-08
US31537610P 2010-03-18 2010-03-18
US33369310P 2010-05-11 2010-05-11
PCT/US2011/024109 WO2011097649A2 (en) 2010-02-08 2011-02-08 Methods and apparatus for synthesizing imaging agents, and intermediates thereof

Publications (2)

Publication Number Publication Date
MX2012009174A MX2012009174A (es) 2012-11-12
MX348958B true MX348958B (es) 2017-07-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012009174A MX348958B (es) 2010-02-08 2011-02-08 Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos.

Country Status (20)

Country Link
US (5) US8936777B2 (es)
EP (3) EP3323810B1 (es)
JP (3) JP6092628B2 (es)
KR (5) KR20180055933A (es)
CN (3) CN102858752B (es)
AU (3) AU2011213568B2 (es)
BR (1) BR112012019789A2 (es)
CA (1) CA2789044C (es)
DK (2) DK3323810T3 (es)
ES (2) ES2651466T3 (es)
HK (1) HK1255702A1 (es)
IL (2) IL221253B (es)
MX (1) MX348958B (es)
NO (1) NO2534136T3 (es)
NZ (1) NZ602291A (es)
PT (2) PT3323810T (es)
RU (1) RU2631500C2 (es)
SG (2) SG10201500929XA (es)
TW (4) TWI660947B (es)
WO (1) WO2011097649A2 (es)

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