BR0215913A - Composição de radiofármacos rotulados com 18-f e processo para obtê-los - Google Patents

Composição de radiofármacos rotulados com 18-f e processo para obtê-los

Info

Publication number
BR0215913A
BR0215913A BR0215913-9A BR0215913A BR0215913A BR 0215913 A BR0215913 A BR 0215913A BR 0215913 A BR0215913 A BR 0215913A BR 0215913 A BR0215913 A BR 0215913A
Authority
BR
Brazil
Prior art keywords
composition
obtaining
labeled radiopharmaceuticals
labeled
radiopharmaceuticals
Prior art date
Application number
BR0215913-9A
Other languages
English (en)
Inventor
Maxim Y Kiselev
Vincent Tadino
Original Assignee
Ion Beam Applic Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32311616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0215913(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ion Beam Applic Sa filed Critical Ion Beam Applic Sa
Publication of BR0215913A publication Critical patent/BR0215913A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

"COMPOSIçãO DE RADIOFáRMACOS ROTULADOS COM 18-F E PROCESSO PARA OBTê-LOS". Um radiofármaco de FDG rotulada com isótopo 18F é estabilizado contra a degradação da pureza radioquímica devida à radiólise, usando quantidades seleccionadas de álcool etílico que dependem da concentração da atividade do 18F, com devido respeito pelos limites impostos pelas normas das várias farmacopéias. Podem ser usados quaisquer dos bem conhecidos métodos de produção da FDG e o álcool etílico pode ser adicionado em várias etapas, preferencialmente como parte da etapa normalizada de hidrólise. Este radiofármaco concreto é extensivamente usado em imagiologia de diagnóstico pela técnica de Tomografia por Emissão de Positrons.
BR0215913-9A 2002-11-05 2002-11-05 Composição de radiofármacos rotulados com 18-f e processo para obtê-los BR0215913A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/033616 WO2004043497A1 (en) 2002-11-05 2002-11-05 Stabilzation of radiopharmceuticals labeled with 18-f

Publications (1)

Publication Number Publication Date
BR0215913A true BR0215913A (pt) 2005-08-09

Family

ID=32311616

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215913-9A BR0215913A (pt) 2002-11-05 2002-11-05 Composição de radiofármacos rotulados com 18-f e processo para obtê-los

Country Status (10)

Country Link
EP (2) EP1560601B1 (pt)
JP (1) JP2006505610A (pt)
KR (1) KR101001300B1 (pt)
CN (1) CN100478035C (pt)
AT (1) ATE473019T1 (pt)
AU (1) AU2002337926B8 (pt)
BR (1) BR0215913A (pt)
DE (1) DE60236971D1 (pt)
ES (1) ES2347535T3 (pt)
WO (1) WO2004043497A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100563812C (zh) * 2006-03-22 2009-12-02 上海化工研究院 一种可制备多种氟标试剂的化学合成装置
ATE535527T1 (de) 2006-05-19 2011-12-15 Nihon Mediphysics Co Ltd Verbindung mit affinität zu amyloid
US8496910B2 (en) 2006-06-21 2013-07-30 Ge Healthcare As Stabilisation of radiopharmaceutical precursors
EP2042501B1 (en) 2006-06-21 2017-04-12 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
NZ577511A (en) 2006-11-30 2012-04-27 Nihon Mediphysics Co Ltd 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent
CN101563107B (zh) 2006-12-21 2012-07-11 日本医事物理股份有限公司 放射性诊断显像剂
TWI406674B (zh) 2007-02-13 2013-09-01 Nihon Mediphysics Co Ltd Method for manufacturing diagnostic radiographic diagnostic agents
JP2011503239A (ja) * 2007-11-07 2011-01-27 ジーイー・ヘルスケア・ベスローテン・ヴェンノーツハップ 放射性医薬品の安定化
CA2801530C (en) 2010-06-04 2017-09-12 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
WO2012021882A2 (en) 2010-08-13 2012-02-16 Siemens Medical Solutions Usa, Inc. Formulation, apparatus and method for stabilizing radiopharmaceuticals
CN103270004A (zh) 2010-12-29 2013-08-28 通用电气健康护理有限公司 洗脱溶液
CN103998065A (zh) 2011-12-21 2014-08-20 通用电气健康护理有限公司 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
GB201322456D0 (en) * 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
KR101668724B1 (ko) 2014-05-30 2016-10-24 성균관대학교산학협력단 방사성 화합물 합성모듈
KR101633250B1 (ko) 2014-05-30 2016-06-24 성균관대학교산학협력단 방사성 화합물 합성장치
KR101642091B1 (ko) 2014-05-30 2016-07-22 성균관대학교산학협력단 방사성 화합물 합성장치 및 합성방법
WO2017014599A1 (ko) * 2015-07-22 2017-01-26 주식회사 씨코헬스케어 [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법
CN107198780A (zh) * 2016-03-18 2017-09-26 南京江原安迪科正电子研究发展有限公司 放射性药物组合物及其制备方法、应用
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC2260A1 (fr) 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
ES2150916T3 (es) 1991-08-29 2000-12-16 Mallinckrodt Medical Inc Utilizacion del acido gentisico o del alcohol gentisilico para estabilizar peptidos y proteinas radiomarcados.
US6066309A (en) 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
JP3133250B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 使い捨てカートリッジを使用するｆｄｇ合成装置
JP3279914B2 (ja) * 1996-03-29 2002-04-30 エヌケ−ケ−プラント建設株式会社 オンカラムｆｄｇ合成装置
JP3133253B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 標識反応および加水分解反応をカラムで行うｆｄｇ合成装置
JP3133251B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 陽イオン交換樹脂カラム上で、溶媒除去と加水分解反応を同時に行うｆｄｇ合成装置
JP3133252B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 三方切り替え活栓を組み込んだｆｄｇ合成装置
US5932178A (en) 1996-03-29 1999-08-03 Nkk Plant Engineering Corporation FDG synthesizer using columns
US6027710A (en) 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
WO2001082864A2 (en) * 2000-04-28 2001-11-08 Duke University 18f-labeled choline analogs
AU2002218751A1 (en) * 2000-07-06 2002-01-21 Bristol-Myers Squibb Pharma Company Stable radiopharmaceutical compositions
CN2468490Y (zh) * 2000-09-25 2002-01-02 杜宜奎 氟－18标记药物生产装置
CN1622832A (zh) * 2001-02-23 2005-06-01 布里斯托尔-迈尔斯斯奎布药品公司 用于动脉粥样硬化和易病变性斑块成像的标记的巨噬细胞清除剂受体拮抗剂
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination

Also Published As

Publication number Publication date
CN100478035C (zh) 2009-04-15
EP1560601B1 (en) 2010-07-07
DE60236971D1 (de) 2010-08-19
EP2229957A2 (en) 2010-09-22
AU2002337926A1 (en) 2004-06-03
AU2002337926B8 (en) 2008-02-28
ATE473019T1 (de) 2010-07-15
EP2229957A3 (en) 2010-10-06
KR20060052653A (ko) 2006-05-19
ES2347535T3 (es) 2010-11-02
CN1694733A (zh) 2005-11-09
EP1560601A1 (en) 2005-08-10
KR101001300B1 (ko) 2010-12-14
WO2004043497A1 (en) 2004-05-27
JP2006505610A (ja) 2006-02-16
AU2002337926B2 (en) 2008-01-31

Similar Documents

Publication Publication Date Title
BR0215913A (pt) Composição de radiofármacos rotulados com 18-f e processo para obtê-los
EA200800064A1 (ru) Композиция в виде гранул с модифицированным и немедленным высвобождением мемантина
DE60327745D1 (de) Verwendung von adapalen zur behandlung dermatologischer erkrankungen
CY1109587T1 (el) Μεθοδος κατασκευης για κοκκους που περιεχουν εντακαπονη για στοματικες μορφες δοσολογιας
CY1115416T1 (el) Συνθεση που περιεχει στατινες και ωμεγα-3 λιπαρα οξεα
UY26256A1 (es) Amidas de ácidos carboxílicos, medicamentos que contienen estos compuestos, su utilización y su preparación
BR0307998A (pt) Hidroxietilaminas substituìdas
EA200601288A1 (ru) Производные 1,3-дифенилпроп-2-ен-1-она, способ их получения и применение
BR0110573A (pt) Composto, composição farmacêutica que compreende esse composto, processo para a preparação de uma composição farmacêutica, utilização do composto e processo para o tratamento profilático ou terapêutico e para a preparação do composto
DE60313597D1 (de) Topische pharmazeutische zusammensetzungen mit proanthocyanidinen, glycyrrhetinic säure und telmesteine zur behandlung von dermatitis
DK1467724T3 (da) Farmaceutisk sammensætning med agomelatin til dispergering i mundhulen
ATE307845T1 (de) N-alkylaziridinoprepolymere als dentalmasse
BRPI0410861A (pt) métodos e composições para a produção de aminoácidos
BRPI0617045B8 (pt) composição, processo para preparar uma composição, uso de uma composição e uso cosmético de uma composição
BRPI0407652A (pt) método para acentuar a eficácia de um agente ativo, composição e método para produzir a composição
BRPI0408848A (pt) formulações orais de cladribine
ITMI20022394A1 (it) Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche.
GT200400134A (es) Sistemas emulsionantes que contienen derivados de azetidina
BR0009137A (pt) Composição cosmética que compreende pelo menos uma cera e pelo menos um composto de tipo ceramida, usos e processo de tratamento das matérias queratìnicas
EA200100802A1 (ru) Применение тианептина при приготовлении лекарственных средств, предназначенных для лечения нейродегенеративных патологий
AR057277A1 (es) Utilizacion de agomelatina para la obtencion de medicamentos destinados al tratamiento de los trastornos bipolares
ITMI20031098A0 (it) Composti utili nella terapia del morbo di alzheimer e formulazioni che li contengono
BR0308180A (pt) protéinas de superfìcie de leptospira
ITMI20030827A1 (it) Composizione farmaceutica contenente l'associazione levodopa/carbidopa.
DE60321724D1 (de) 1,2-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.