SI3009431T1 - 2- (2,4,5-substituted-anilino) pyrimidine derivatives, as EGFR modulators useful for the treatment of cancer - Google Patents
2- (2,4,5-substituted-anilino) pyrimidine derivatives, as EGFR modulators useful for the treatment of cancer Download PDFInfo
- Publication number
- SI3009431T1 SI3009431T1 SI201231167T SI201231167T SI3009431T1 SI 3009431 T1 SI3009431 T1 SI 3009431T1 SI 201231167 T SI201231167 T SI 201231167T SI 201231167 T SI201231167 T SI 201231167T SI 3009431 T1 SI3009431 T1 SI 3009431T1
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- pharmaceutically acceptable
- acceptable salt
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512061P | 2011-07-27 | 2011-07-27 | |
| US201261591363P | 2012-01-27 | 2012-01-27 | |
| EP15192658.1A EP3009431B1 (en) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3009431T1 true SI3009431T1 (en) | 2018-01-31 |
Family
ID=46875901
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231167T SI3009431T1 (en) | 2011-07-27 | 2012-07-25 | 2- (2,4,5-substituted-anilino) pyrimidine derivatives, as EGFR modulators useful for the treatment of cancer |
| SI201231963T SI3686194T1 (sl) | 2011-07-27 | 2012-07-25 | Spojine 2-(2,4,5-substituiranega-anilino)pirimidina |
| SI201231771T SI3333161T1 (sl) | 2011-07-27 | 2012-07-25 | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
| SI201230455T SI2736895T1 (sl) | 2011-07-27 | 2012-07-25 | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231963T SI3686194T1 (sl) | 2011-07-27 | 2012-07-25 | Spojine 2-(2,4,5-substituiranega-anilino)pirimidina |
| SI201231771T SI3333161T1 (sl) | 2011-07-27 | 2012-07-25 | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
| SI201230455T SI2736895T1 (sl) | 2011-07-27 | 2012-07-25 | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
Country Status (39)
| Country | Link |
|---|---|
| US (6) | US8946235B2 (sr) |
| EP (7) | EP3686193B1 (sr) |
| JP (3) | JP5427321B2 (sr) |
| KR (3) | KR101410902B1 (sr) |
| CN (7) | CN105198862B (sr) |
| AR (1) | AR087336A1 (sr) |
| AU (1) | AU2012288626C1 (sr) |
| BR (4) | BR122014026150B1 (sr) |
| CA (5) | CA2843109C (sr) |
| CL (1) | CL2013003281A1 (sr) |
| CO (1) | CO6811863A2 (sr) |
| CR (1) | CR20130629A (sr) |
| CY (4) | CY1117431T1 (sr) |
| DK (5) | DK3009431T3 (sr) |
| DO (1) | DOP2013000263A (sr) |
| EA (3) | EA029488B1 (sr) |
| EC (1) | ECSP13013033A (sr) |
| ES (5) | ES2564671T3 (sr) |
| GT (1) | GT201300288A (sr) |
| HK (4) | HK1192549A1 (sr) |
| HR (4) | HRP20211682T1 (sr) |
| HU (4) | HUE049060T2 (sr) |
| IL (6) | IL229199A (sr) |
| LT (3) | LT3686194T (sr) |
| ME (3) | ME02382B (sr) |
| MX (2) | MX2014000528A (sr) |
| MY (2) | MY194532A (sr) |
| NI (1) | NI201300134A (sr) |
| PE (1) | PE20141700A1 (sr) |
| PH (1) | PH12015501326B1 (sr) |
| PL (5) | PL3333161T3 (sr) |
| PT (4) | PT3333161T (sr) |
| RS (4) | RS56679B1 (sr) |
| SG (5) | SG194783A1 (sr) |
| SI (4) | SI3009431T1 (sr) |
| SM (1) | SMT201600070B (sr) |
| TW (3) | TWI583386B (sr) |
| UY (1) | UY34219A (sr) |
| WO (1) | WO2013014448A1 (sr) |
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| JP5702288B2 (ja) | 2008-09-18 | 2015-04-15 | ノースウエスタン ユニバーシティ | Ｎｍｄａレセプターモジュレータ及びその用途 |
| NZ597983A (en) | 2009-08-20 | 2014-05-30 | Karus Therapeutics Ltd | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
| CA2832504C (en) | 2011-05-04 | 2019-10-01 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| AU2012288626C1 (en) | 2011-07-27 | 2015-09-17 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as EGFR modulators useful for treating cancer |
| GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
| WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| ES2734405T3 (es) | 2013-01-29 | 2019-12-05 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
| SG11201505942YA (en) * | 2013-01-29 | 2015-08-28 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| RS59790B1 (sr) | 2013-03-15 | 2020-02-28 | G1 Therapeutics Inc | Privremena zaštita normalnih ćelija tokom hemoterapije |
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| KR102339228B1 (ko) | 2013-08-23 | 2021-12-13 | 뉴파마, 인크. | 특정 화학 물질, 조성물, 및 방법 |
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