SI1228067T1 - 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity - Google Patents

5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity

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Publication number
SI1228067T1
SI1228067T1 SI200030494T SI200030494T SI1228067T1 SI 1228067 T1 SI1228067 T1 SI 1228067T1 SI 200030494 T SI200030494 T SI 200030494T SI 200030494 T SI200030494 T SI 200030494T SI 1228067 T1 SI1228067 T1 SI 1228067T1
Authority
SI
Slovenia
Prior art keywords
hypoglycemic
membered
heterocyclic compounds
hypolipidemic activity
hypolipidemic
Prior art date
Application number
SI200030494T
Other languages
English (en)
Slovenian (sl)
Inventor
Yu Momose
Tsuyoshi Maekawa
Hiroyuki Odaka
Hiroyuki Kimura
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of SI1228067T1 publication Critical patent/SI1228067T1/xx

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    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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SI200030494T 1999-11-10 2000-11-09 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity SI1228067T1 (en)

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Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60139025D1 (de) * 2000-12-28 2009-07-30 Takeda Pharmaceutical Alkansäurederivate, verfahren zu deren herstellung und deren verwendung
EP1394154A4 (en) 2001-03-23 2005-05-18 Takeda Pharmaceutical HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID
EP2065044A1 (en) 2001-04-04 2009-06-03 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
US6838442B2 (en) * 2001-04-04 2005-01-04 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
DE60237594D1 (de) * 2001-04-25 2010-10-21 Takeda Pharmaceutical Verwendung des abc-expressionspromotors pioglitazon zur behandlung von arteriosklerose obliterans
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US6967212B2 (en) * 2001-05-30 2005-11-22 Bristol-Myers Squibb Company Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
JPWO2002098840A1 (ja) 2001-06-04 2004-09-16 エーザイ株式会社 カルボン酸誘導体及びその塩もしくはそのエステルからなる医薬
WO2003000685A1 (en) * 2001-06-20 2003-01-03 Takeda Chemical Industries, Ltd. 5-membered heterocycle derivatives
JPWO2003016265A1 (ja) 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびpparアゴニスト
EP1445254A4 (en) * 2001-11-13 2005-05-04 Takeda Pharmaceutical METHOD FOR PRODUCING PYRAZOL COMPOUNDS
EP1470137B1 (en) * 2002-01-18 2009-09-02 Merck & Co., Inc. Edg receptor agonists
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
JP2004277397A (ja) * 2002-05-24 2004-10-07 Takeda Chem Ind Ltd 1,2−アゾール誘導体
WO2003099793A1 (en) * 2002-05-24 2003-12-04 Takeda Pharmaceutical Company Limited 1,2-azole derivatives with hypoglycemic and hypolipidemic activity
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004004655A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
JP2004123732A (ja) * 2002-09-10 2004-04-22 Takeda Chem Ind Ltd 5員複素環化合物
AU2003262023A1 (en) 2002-09-10 2004-04-30 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
WO2004041266A1 (ja) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited 受容体機能調節剤
WO2004048341A1 (ja) * 2002-11-28 2004-06-10 Sumitomo Pharmaceuticals Co., Ltd. 新規ヘテロアリール誘導体
JP4896518B2 (ja) * 2002-12-13 2012-03-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド ニコチンアミド系キナーゼ阻害薬
JP4560035B2 (ja) * 2003-01-27 2010-10-13 メルク・シャープ・エンド・ドーム・コーポレイション 置換ピラゾール、このような化合物を含有する組成物及び使用方法
TW200526588A (en) * 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
JP4859665B2 (ja) 2004-03-30 2012-01-25 武田薬品工業株式会社 アルコキシフェニルプロパン酸誘導体
PT1731518E (pt) * 2004-03-31 2014-09-18 Nippon Soda Co Composto amina cíclico e agente de controlo de pragas
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び/又は治療のための医薬
WO2005121097A2 (en) * 2004-06-04 2005-12-22 Merck & Co., Inc. Pyrazole derivatives, compositions containing such compounds and methods of use
EP1760071A4 (en) * 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
AU2005272043B2 (en) * 2004-07-07 2010-07-29 Merck Sharp & Dohme Corp. Pyrazole amide derivatives, compositions containing such compounds and methods of use
TW200616679A (en) * 2004-09-30 2006-06-01 Takeda Pharmaceuticals Co Modified-release preparation
WO2006057448A1 (ja) * 2004-11-26 2006-06-01 Takeda Pharmaceutical Company Limited アリールアルカン酸誘導体
EP1837329A4 (en) * 2005-01-14 2009-08-05 Dainippon Sumitomo Pharma Co NEW HETEROARYL DERIVATIVE
WO2006112549A1 (ja) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited 縮合複素環化合物
US7989445B2 (en) 2005-04-28 2011-08-02 Takeda Pharmaceutical Company Limited Thienopyrimidone compound
US20090208584A1 (en) 2005-06-09 2009-08-20 Tomohiro Yoshinari Solid preparation
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
KR101006362B1 (ko) 2005-10-06 2011-01-10 닛뽕소다 가부시키가이샤 고리형 아민 화합물 및 유해 생물 방제제
RU2438671C2 (ru) 2005-12-28 2012-01-10 Такеда Фармасьютикал Компани Лимитед Терапевтическое средство против диабета
PE20080993A1 (es) 2006-06-27 2008-10-06 Takeda Pharmaceutical Compuestos ciclicos fusionados como moduladores del receptor gpr40
WO2008016131A1 (fr) 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Composé hétérocyclique à cycles fusionnés
BRPI0719060A2 (pt) 2006-11-24 2014-02-04 Takeda Pharmaceutical Composto, prodroga, agente farmacêutico, métodos para inibir um receptor de angiotensina ii e/ou ativar um receptor ativado com proliferador de peroxisoma, e para prevenir ou tratar doenças ou condições, e, uso de um composto
BRPI0809583B1 (pt) 2007-03-30 2022-02-22 Ambrx, Inc Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo
WO2008136428A1 (ja) 2007-04-27 2008-11-13 Takeda Pharmaceutical Company Limited 含窒素5員複素環化合物
EP2253630A1 (en) 2007-05-21 2010-11-24 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
TWI443090B (zh) * 2007-05-25 2014-07-01 Abbvie Deutschland 作為代謝性麩胺酸受體2(mglu2 受體)之正向調節劑之雜環化合物
JP5432890B2 (ja) 2008-04-04 2014-03-05 武田薬品工業株式会社 複素環誘導体及びその用途
WO2009128481A1 (ja) 2008-04-16 2009-10-22 武田薬品工業株式会社 含窒素5員複素環化合物
WO2010016552A1 (ja) 2008-08-07 2010-02-11 武田薬品工業株式会社 過敏性腸症候群治療薬
JP5511693B2 (ja) 2009-02-03 2014-06-04 クミアイ化学工業株式会社 縮合環化した2−ピリドン誘導体及び除草剤
JP2010254623A (ja) 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
DK2528901T3 (en) * 2010-01-27 2015-08-17 Boehringer Ingelheim Int Pyrazole compounds as CRTH2 antagonists.
BR112013001634A2 (pt) 2010-07-23 2016-05-24 Takeda Pharmaceutical composto ou sal, medicamento, métodos para a profilaxia ou tratamento da arteriosclerose, da diabete ou obesidade em um mamífero, e, uso do composto ou sal
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
WO2012130633A1 (en) 2011-03-25 2012-10-04 Boehringer Ingelheim International Gmbh Pyrazole compounds as crth2 antagonists
WO2012175513A1 (en) 2011-06-20 2012-12-27 Bayer Intellectual Property Gmbh Thienylpyri(mi)dinylpyrazole
WO2012177896A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
EA201490152A1 (ru) 2011-06-24 2014-05-30 Эмджен Инк. Антагонисты trpm8 и их применение при лечении
WO2014007228A1 (ja) 2012-07-03 2014-01-09 小野薬品工業株式会社 ソマトスタチン受容体作動活性を有する化合物およびその医薬用途
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EP2889291A4 (en) 2012-08-24 2015-10-14 Takeda Pharmaceutical HETEROCYCLIC CONNECTION
JP2015535227A (ja) * 2012-10-26 2015-12-10 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Sykの3,4−二置換1h−ピラゾール及び4,5−二置換チアゾール阻害剤
KR20160062023A (ko) 2013-09-30 2016-06-01 오노 야꾸힝 고교 가부시키가이샤 소마토스타틴 수용체 작동 활성을 갖는 화합물 및 그 의약 용도
EA032713B1 (ru) * 2013-12-30 2019-07-31 Лайфсай Фармасьютикалс, Инк. Терапевтические ингибирующие соединения
PT3210973T (pt) 2014-10-24 2021-02-12 Takeda Pharmaceuticals Co Compostos de heteroarilo para o tratamento de doenças oftálmicas
WO2016065326A2 (en) 2014-10-24 2016-04-28 Bristol-Myers Squibb Company Modified fgf-21 polypeptides and uses thereof
CA3053091A1 (en) 2017-02-08 2018-08-16 Ono Pharmaceutical Co., Ltd. Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
KR20190099952A (ko) * 2018-02-20 2019-08-28 주식회사 종근당 포도막염의 예방 또는 치료를 위한 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06779B2 (ja) 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
DE3600390A1 (de) 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
DE4206041A1 (de) * 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazolylpropensaeurederivate
US5591862A (en) * 1993-06-11 1997-01-07 Takeda Chemical Industries, Ltd. Tetrazole derivatives, their production and use
FR2707641B1 (fr) * 1993-07-16 1995-08-25 Fournier Ind & Sante Composés de l'imidazol-5-carboxamide, leur procédé de préparation leurs intermédiaires et leur utilisation en thérapeutique.
DE19602505A1 (de) 1996-01-25 1997-07-31 Merck Patent Gmbh 1-(Pyrazol-4-Indol-3-yl)-Piperidine
JPH1072434A (ja) 1996-04-08 1998-03-17 Nissan Chem Ind Ltd 2,4−置換アニリン誘導体
AU742641B2 (en) 1998-01-28 2002-01-10 Shionogi & Co., Ltd. Novel tricyclic compound
EP1428531A1 (en) 1998-05-11 2004-06-16 Takeda Chemical Industries, Ltd. Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method

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BR0015466A (pt) 2002-08-06
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EP1228067A1 (en) 2002-08-07
AU780948C (en) 2006-09-14
CN1260227C (zh) 2006-06-21
TR200402512T4 (tr) 2004-12-21
PL356487A1 (en) 2004-06-28
JP4416994B2 (ja) 2010-02-17
KR100518142B1 (ko) 2005-10-04
NO20022108D0 (no) 2002-05-02
ES2225252T3 (es) 2005-03-16
MY141468A (en) 2010-04-30
EP1457490A1 (en) 2004-09-15
PE20011021A1 (es) 2001-09-19
DE60012213D1 (de) 2004-08-19
HUP0203165A3 (en) 2004-03-29
DE60012213T2 (de) 2005-07-21
RU2252939C2 (ru) 2005-05-27
MXPA02004647A (es) 2002-10-31
AU1303101A (en) 2001-06-04
HK1045991B (zh) 2004-12-10
HUP0203165A2 (hu) 2003-01-28
SK6432002A3 (en) 2003-02-04
EP1228067B1 (en) 2004-07-14
JP3723071B2 (ja) 2005-12-07
CZ20021604A3 (cs) 2002-09-11
CN1413207A (zh) 2003-04-23
HK1045991A1 (en) 2002-12-20
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NZ519238A (en) 2003-11-28
CA2390923A1 (en) 2001-05-31
JP2003137865A (ja) 2003-05-14
KR20020049044A (ko) 2002-06-24
PT1228067E (pt) 2004-11-30
IL149493A0 (en) 2002-11-10
WO2001038325A1 (en) 2001-05-31
CO5261501A1 (es) 2003-03-31
ATE271049T1 (de) 2004-07-15
DK1228067T3 (da) 2004-12-06
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