SK6432002A3 - 5-Membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity - Google Patents

5-Membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Download PDF

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Publication number
SK6432002A3
SK6432002A3 SK643-2002A SK6432002A SK6432002A3 SK 6432002 A3 SK6432002 A3 SK 6432002A3 SK 6432002 A SK6432002 A SK 6432002A SK 6432002 A3 SK6432002 A3 SK 6432002A3
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Slovakia
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substituted
group
compound
formula
groups
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SK643-2002A
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Slovak (sk)
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Yu Momose
Tsuyoshi Maekawa
Hiroyuki Odaka
Hiroyuki Kimura
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Takeda Chemical Industries Ltd
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Publication of SK6432002A3 publication Critical patent/SK6432002A3/sk

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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SK643-2002A 1999-11-10 2000-11-09 5-Membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity SK6432002A3 (en)

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Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7238716B2 (en) 2000-12-28 2007-07-03 Takeda Pharmaceuticals Company Limited Alkanoic acid derivatives process for their production and use thereof
EP1394154A4 (en) * 2001-03-23 2005-05-18 Takeda Pharmaceutical HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID
US6838442B2 (en) * 2001-04-04 2005-01-04 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
CN100577175C (zh) * 2001-04-04 2010-01-06 奥索-麦克尼尔药品公司 包括葡萄糖重吸收抑制剂和ppar调节剂的联合疗法
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
CA2445322C (en) * 2001-04-25 2011-06-14 Takeda Chemical Industries, Ltd. Use of the abc expression promoting agent pioglitazone for the treatment of arteriosclerosis obliterans
US6967212B2 (en) * 2001-05-30 2005-11-22 Bristol-Myers Squibb Company Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
WO2002098840A1 (fr) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
WO2003000685A1 (en) * 2001-06-20 2003-01-03 Takeda Chemical Industries, Ltd. 5-membered heterocycle derivatives
EP1452521A4 (en) 2001-08-17 2007-03-14 Eisai R&D Man Co Ltd CYCLIC COMPOUND AND AGONIST OF PPAR RECEPTOR
WO2003042183A1 (fr) * 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Procede de production de composes pyrazole
US7479504B2 (en) 2002-01-18 2009-01-20 Merck & Co., Inc. Edg receptor agonists
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
JP2004277397A (ja) * 2002-05-24 2004-10-07 Takeda Chem Ind Ltd １，２−アゾール誘導体
CA2487315A1 (en) * 2002-05-24 2003-12-04 Takeda Pharmaceutical Company Limited 1,2-azole derivatives with hypoglycemic and hypolipidemic activity
CA2490972C (en) 2002-07-09 2012-05-29 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004004665A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
JP2004123732A (ja) * 2002-09-10 2004-04-22 Takeda Chem Ind Ltd ５員複素環化合物
WO2004024705A1 (ja) * 2002-09-10 2004-03-25 Takeda Pharmaceutical Company Limited ５員複素環化合物
EP1559422B1 (en) 2002-11-08 2014-04-30 Takeda Pharmaceutical Company Limited Receptor function controlling agent
WO2004048341A1 (ja) * 2002-11-28 2004-06-10 Sumitomo Pharmaceuticals Co., Ltd. 新規ヘテロアリール誘導体
SI1569907T1 (sl) * 2002-12-13 2016-06-30 Ym Biosciences Australia Pty Ltd Na nikotinamidu osnovani kinazni inhibitorji
CA2513102C (en) * 2003-01-27 2011-03-22 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
TW200526588A (en) * 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
WO2005095338A1 (ja) 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited アルコキシフェニルプロパン酸誘導体
SI1731518T1 (sl) * 2004-03-31 2014-11-28 Nippon Soda Co., Ltd. Spojina cikličen amin in sredstvo za nadzorovanje škodljivcev
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
JP4108739B2 (ja) * 2004-06-04 2008-06-25 メルク エンド カムパニー インコーポレーテッド ピラゾール誘導体、かかる化合物を含む組成物及び使用方法
JP5315611B2 (ja) 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
WO2006017055A2 (en) * 2004-07-07 2006-02-16 Merck & Co., Inc. Pyrazole amide derivatives, compositions containing such compounds and methods of use
WO2006036007A2 (en) * 2004-09-30 2006-04-06 Takeda Pharmaceutical Company Limited Modified-release preparation
JPWO2006057448A1 (ja) * 2004-11-26 2008-06-05 武田薬品工業株式会社 アリールアルカン酸誘導体
WO2006075638A1 (ja) * 2005-01-14 2006-07-20 Dainippon Sumitomo Pharma Co., Ltd. 新規ヘテロアリール誘導体
EP2308839B1 (en) 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
JP5000490B2 (ja) 2005-04-28 2012-08-15 武田薬品工業株式会社 チエノピリミドン化合物
WO2006132440A1 (ja) 2005-06-09 2006-12-14 Takeda Pharmaceutical Company Limited 固形製剤
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
EP1932844B1 (en) 2005-10-06 2015-09-02 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
GEP20105033B (en) 2005-12-28 2010-06-25 Takeda Pharmaceuticals Co Therapeutic agent for diabetes
MY154798A (en) 2006-06-27 2015-07-31 Takeda Pharmaceutical Fused cyclic compounds
JPWO2008016131A1 (ja) 2006-08-04 2009-12-24 武田薬品工業株式会社 縮合複素環化合物
AU2007322608A1 (en) 2006-11-24 2008-05-29 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
WO2008121563A2 (en) 2007-03-30 2008-10-09 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
US8318746B2 (en) 2007-04-27 2012-11-27 Takeda Pharmaceutical Company Limited Nitrogen-containing five-membered heterocyclic compound
EP2253630A1 (en) 2007-05-21 2010-11-24 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
MX2009012749A (es) * 2007-05-25 2010-03-10 Abbott Gmbh & Co Kg Compuestos heterociclicos como moduladores positivos del receptor de glutamato metabotropico 2 (receptor mglu2).
CA2720343A1 (en) 2008-04-04 2009-10-08 Takeda Pharmaceutical Company Limited Heterocyclic derivative and use thereof
EP2266983B1 (en) 2008-04-16 2013-06-05 Takeda Pharmaceutical Company Limited Nitrogenated 5-membered heterocyclic compound
EP2322222A4 (en) 2008-08-07 2011-12-21 Takeda Pharmaceutical THERAPEUTIC AGENT FOR IRRITABLE COLON SYNDROME
US8334236B2 (en) 2009-02-03 2012-12-18 Kumiai Chemical Industry Co., Ltd. Ring-fused 2-pyridone derivatives and herbicides
JP2010254623A (ja) 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
CN104829535A (zh) 2010-01-27 2015-08-12 贝林格尔·英格海姆国际有限公司 作为crth2拮抗剂的吡唑化合物
EA026142B1 (ru) 2010-07-23 2017-03-31 Такеда Фармасьютикал Компани Лимитед Конденсированное гетероциклическое соединение и его применение
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
US9206164B2 (en) 2011-03-25 2015-12-08 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
WO2012175513A1 (en) 2011-06-20 2012-12-27 Bayer Intellectual Property Gmbh Thienylpyri(mi)dinylpyrazole
WO2012177896A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
PE20140868A1 (es) 2011-06-24 2014-07-18 Amgen Inc Antagonistas trpm8 y su uso en tratamientos
US9630976B2 (en) 2012-07-03 2017-04-25 Ono Pharmaceutical Co., Ltd. Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
CA2882879A1 (en) 2012-08-24 2014-02-27 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2014064134A1 (en) * 2012-10-26 2014-05-01 F. Hoffmann-La Roche Ag 3,4-disubstituted 1 h-pyrazole and 4,5-disubstituted thiazole inhibitors of syk
DK3053916T3 (en) 2013-09-30 2019-04-15 Ono Pharmaceutical Co RELATIONSHIP WITH SOMATOSTATIN RECEPTOR AGONIST ACTIVITY AND PHARMACEUTICAL USE THEREOF
WO2015103317A1 (en) * 2013-12-30 2015-07-09 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
MX2017004947A (es) 2014-10-24 2017-06-29 Bristol Myers Squibb Co Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos.
MX2017004629A (es) 2014-10-24 2017-06-30 Takeda Pharmaceuticals Co Compuesto heterociclico.
CN110300749A (zh) 2017-02-08 2019-10-01 小野药品工业株式会社 具有生长抑素受体激动活性的化合物及其医药用途
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
KR20190099952A (ko) * 2018-02-20 2019-08-28 주식회사 종근당 포도막염의 예방 또는 치료를 위한 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
DE3600390A1 (de) 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
DE4206041A1 (de) * 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazolylpropensaeurederivate
US5591862A (en) * 1993-06-11 1997-01-07 Takeda Chemical Industries, Ltd. Tetrazole derivatives, their production and use
FR2707641B1 (fr) * 1993-07-16 1995-08-25 Fournier Ind & Sante Composés de l'imidazol-5-carboxamide, leur procédé de préparation leurs intermédiaires et leur utilisation en thérapeutique.
DE19602505A1 (de) 1996-01-25 1997-07-31 Merck Patent Gmbh 1-(Pyrazol-4-Indol-3-yl)-Piperidine
JPH1072434A (ja) 1996-04-08 1998-03-17 Nissan Chem Ind Ltd ２，４−置換アニリン誘導体
PL341984A1 (en) 1998-01-28 2001-05-07 Shionogi & Co Novel tricycle compounds
SK16412000A3 (sk) 1998-05-11 2001-08-06 Takeda Chemical Industries, Ltd. Deriváty kyseliny oxyiminoalkánovej
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method

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CA2390923A1 (en) 2001-05-31
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RU2252939C2 (ru) 2005-05-27
NO20022108L (no) 2002-07-08
JP2001226350A (ja) 2001-08-21
HK1045991B (zh) 2004-12-10
AU780948C (en) 2006-09-14
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HK1045991A1 (en) 2002-12-20
EP1228067A1 (en) 2002-08-07
CZ20021604A3 (cs) 2002-09-11
CO5261501A1 (es) 2003-03-31
AU1303101A (en) 2001-06-04
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IL149493A0 (en) 2002-11-10
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US7179823B1 (en) 2007-02-20
BR0015466A (pt) 2002-08-06
DK1228067T3 (da) 2004-12-06
AR026414A1 (es) 2003-02-12
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WO2001038325A1 (en) 2001-05-31
DE60012213D1 (de) 2004-08-19
JP4416994B2 (ja) 2010-02-17
ATE271049T1 (de) 2004-07-15
EP1457490A1 (en) 2004-09-15
ES2225252T3 (es) 2005-03-16
DE60012213T2 (de) 2005-07-21
AU780948B2 (en) 2005-04-28
SI1228067T1 (en) 2005-02-28
PE20011021A1 (es) 2001-09-19
MY141468A (en) 2010-04-30
KR100518142B1 (ko) 2005-10-04
HUP0203165A2 (hu) 2003-01-28
JP2003137865A (ja) 2003-05-14
TR200402512T4 (tr) 2004-12-21
PT1228067E (pt) 2004-11-30
HUP0203165A3 (en) 2004-03-29
CN1260227C (zh) 2006-06-21

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