SG44701A1 - Adenosine derivatives - Google Patents

Adenosine derivatives

Info

Publication number
SG44701A1
SG44701A1 SG1996005914A SG1996005914A SG44701A1 SG 44701 A1 SG44701 A1 SG 44701A1 SG 1996005914 A SG1996005914 A SG 1996005914A SG 1996005914 A SG1996005914 A SG 1996005914A SG 44701 A1 SG44701 A1 SG 44701A1
Authority
SG
Singapore
Prior art keywords
adenosine derivatives
adenosine
derivatives
Prior art date
Application number
SG1996005914A
Other languages
English (en)
Inventor
Brian Evans
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SG44701A1 publication Critical patent/SG44701A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG1996005914A 1987-12-23 1988-12-22 Adenosine derivatives SG44701A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878729994A GB8729994D0 (en) 1987-12-23 1987-12-23 Chemical compounds

Publications (1)

Publication Number Publication Date
SG44701A1 true SG44701A1 (en) 1997-12-19

Family

ID=10628947

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005914A SG44701A1 (en) 1987-12-23 1988-12-22 Adenosine derivatives

Country Status (35)

Country Link
US (1) US5032583A (enExample)
EP (1) EP0322242B1 (enExample)
JP (1) JP2736088B2 (enExample)
KR (1) KR890009967A (enExample)
CN (1) CN1024198C (enExample)
AT (1) ATA315488A (enExample)
AU (2) AU612747B2 (enExample)
BE (1) BE1002167A5 (enExample)
CA (1) CA1320195C (enExample)
CH (1) CH677495A5 (enExample)
CZ (1) CZ403991A3 (enExample)
DE (2) DE3856154T2 (enExample)
DK (1) DK170894B1 (enExample)
ES (1) ES2012927A6 (enExample)
FI (1) FI90429C (enExample)
FR (1) FR2629715B1 (enExample)
GB (2) GB8729994D0 (enExample)
GR (1) GR1000307B (enExample)
HU (1) HU203364B (enExample)
IE (1) IE61302B1 (enExample)
IL (1) IL88765A (enExample)
IT (1) IT1224840B (enExample)
LU (1) LU87414A1 (enExample)
MX (1) MX14331A (enExample)
NL (1) NL8803140A (enExample)
NO (1) NO171506C (enExample)
NZ (1) NZ227485A (enExample)
PH (1) PH25932A (enExample)
PL (1) PL158800B1 (enExample)
PT (1) PT89328B (enExample)
RU (2) RU1826971C (enExample)
SE (1) SE8804609L (enExample)
SG (1) SG44701A1 (enExample)
YU (1) YU234188A (enExample)
ZA (1) ZA889593B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
FR2665362B1 (fr) * 1990-08-03 1994-12-09 Cepbepe Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application.
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
ES2095960T3 (es) * 1990-09-25 1997-03-01 Rhone Poulenc Rorer Int Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
DK62692D0 (enExample) * 1992-05-14 1992-05-14 Novo Nordisk As
US5672588A (en) * 1992-05-20 1997-09-30 Novo Nordisk A/S Purine derivatives
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
PL316985A1 (en) * 1994-05-10 1997-03-03 Sandoz Ltd Derivatives of adenosine
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
AU2022497A (en) * 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
HUP0103836A3 (en) 1998-06-02 2003-05-28 Osi Pharmaceuticals Inc Uniond Pyrrolo[2,3d]pyrimidine compositions and their use
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6784165B1 (en) * 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB9930077D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
GB0106867D0 (en) 2001-03-20 2001-05-09 Glaxo Group Ltd Process
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
JP2005529062A (ja) 2001-11-30 2005-09-29 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アデノシンａ１及びａ３受容体に特異的な化合物とその使用
KR20040068317A (ko) 2001-12-20 2004-07-30 오에스아이 파마슈티컬스, 인코포레이티드 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도
DE60236458D1 (de) 2001-12-20 2010-07-01 Osi Pharm Inc Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung
WO2004100964A1 (en) * 2003-04-24 2004-11-25 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
US20050118262A1 (en) * 2003-09-17 2005-06-02 Jack Aurora Controlled release formulation
BRPI0619261A2 (pt) * 2005-11-30 2011-09-27 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso desses
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
AU2010288864A1 (en) * 2009-08-31 2012-04-19 Lonza Ltd Process for the preparation of (1S,4R)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130136C (enExample) * 1966-10-20
NL6717061A (enExample) * 1966-12-21 1968-06-24
DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
NL7203984A (enExample) * 1971-04-10 1972-10-12
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
DE2148838A1 (de) * 1971-09-30 1973-04-05 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2157036A1 (de) * 1971-11-17 1973-05-24 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung
DE2244328A1 (de) * 1972-09-09 1974-03-21 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338705A1 (de) * 1973-07-31 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338963A1 (de) * 1973-08-01 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2426682A1 (de) * 1974-06-01 1975-12-11 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines
ZA857998B (en) * 1984-10-26 1986-05-28 Warner Lambert Co N6-substituted adenosines

Also Published As

Publication number Publication date
NO171506B (no) 1992-12-14
SE8804609L (sv) 1989-06-24
MX14331A (es) 1993-12-01
HUT48903A (en) 1989-07-28
KR890009967A (ko) 1989-08-05
IT1224840B (it) 1990-10-24
IL88765A (en) 1993-04-04
AU8589491A (en) 1991-12-12
IE61302B1 (en) 1994-10-19
PL158800B1 (en) 1992-10-30
SE8804609D0 (sv) 1988-12-21
NO885719D0 (no) 1988-12-22
US5032583A (en) 1991-07-16
EP0322242A2 (en) 1989-06-28
PT89328B (pt) 1993-08-31
DK713488A (da) 1989-06-24
GB2212498B (en) 1991-07-24
CN1035295A (zh) 1989-09-06
BE1002167A5 (fr) 1990-08-28
JP2736088B2 (ja) 1998-04-02
FI885943L (fi) 1989-06-24
CH677495A5 (enExample) 1991-05-31
CA1320195C (en) 1993-07-13
GB8729994D0 (en) 1988-02-03
GB8829983D0 (en) 1989-02-15
FI90429C (fi) 1994-02-10
PL276697A1 (en) 1990-02-19
GR1000307B (el) 1992-05-12
LU87414A1 (fr) 1989-07-07
HK1009650A1 (en) 1999-06-04
DE3856154T2 (de) 1998-08-27
PH25932A (en) 1991-12-19
ATA315488A (de) 1994-02-15
GB2212498A (en) 1989-07-26
IE883845L (en) 1989-06-23
IT8848714A0 (it) 1988-12-23
NO885719L (no) 1989-06-26
PT89328A (pt) 1989-12-29
EP0322242B1 (en) 1998-04-01
ES2012927A6 (es) 1990-04-16
RU2060996C1 (ru) 1996-05-27
DE3843609A1 (de) 1989-07-06
YU234188A (en) 1990-12-31
JPH01203400A (ja) 1989-08-16
CN1024198C (zh) 1994-04-13
EP0322242A3 (en) 1990-04-18
IL88765A0 (en) 1989-07-31
NO171506C (no) 1993-03-24
HU203364B (en) 1991-07-29
CZ403991A3 (en) 1993-04-14
RU1826971C (ru) 1993-07-07
AU2740188A (en) 1989-06-29
DE3856154D1 (de) 1998-05-07
NZ227485A (en) 1991-06-25
FI90429B (fi) 1993-10-29
DK713488D0 (da) 1988-12-21
FR2629715A1 (fr) 1989-10-13
DK170894B1 (da) 1996-03-04
FR2629715B1 (fr) 1993-09-03
AU612747B2 (en) 1991-07-18
NL8803140A (nl) 1989-07-17
ZA889593B (en) 1989-09-27

Similar Documents

Publication Publication Date Title
GB2212498B (en) Adenosine derivatives
GR3002864T3 (en) Azolylmethylcyclopropyl derivatives
GB8815258D0 (en) Thiorea derivatives
EP0318704A3 (en) 3-cyano-4-phenyl-pyrrole derivatives
EP0305322A3 (en) Isoxazole-beta-carboline derivatives
PH25577A (en) Purine derivatives
GR3000964T3 (en) Hydroxyethyl-azolyl derivatives
GB2205829B (en) 2-aryl-4-isoxazolin-3-one derivatives
GB8705601D0 (en) Oxo-isoindolinyl derivatives
EP0322164A3 (en) Ethanolamie derivatives
GB8726272D0 (en) 4-demethoxy anthra-cycline derivatives
GB2200910B (en) Thiopilocarpine derivatives
GB8704236D0 (en) Anthracycline-oestrone derivatives
ZA887903B (en) Purine derivatives
GB8700016D0 (en) Quinolizinone derivatives
GB8715925D0 (en) Thiapentanamide derivatives
IE870359L (en) Purine derivatives
GB2211840B (en) Indenofuran derivatives
IE870520L (en) Isohexide nucleoside
IE871681L (en) Cytorhodin s derivatives
IE870091L (en) Azabicyclo-benzyloxyphenyl-urea derivatives
IE872628L (en) Pyrazino-indolo-benzodiazepine derivatives
IE872933L (en) 2 - Azacyclocarboxamide derivatives
GB8714374D0 (en) Dioxopiperidine derivatives
IE872965L (en) Phenyl-2h-benzopyran derivatives